TissGeneSummary for DZIP1 |
Gene summary |
Basic gene information | Gene symbol | DZIP1 |
Gene name | DAZ interacting zinc finger protein 1 | |
Synonyms | DZIP|DZIPt1 | |
Cytomap | UCSC genome browser: 13q32.1 | |
Type of gene | protein-coding | |
RefGenes | NM_014934.4, NM_198968.3, | |
Description | DAZ interacting protein 1DAZ interacting protein testis1DAZ-interacting protein 1/2zinc finger DAZ interacting protein 1zinc finger protein DZIP1zinc-finger protein DZIPt1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608671 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134874 | ||
HPRD : 16363 | ||
Vega : OTTHUMG00000017224 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DZIP1 | |
BioGPS: 22873 | ||
Pathway | NCI Pathway Interaction Database: DZIP1 | |
KEGG: DZIP1 | ||
REACTOME: DZIP1 | ||
Pathway Commons: DZIP1 | ||
Context | iHOP: DZIP1 | |
ligand binding site mutation search in PubMed: DZIP1 | ||
UCL Cancer Institute: DZIP1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTGCT | |
Reference showing the relevant tissue of DZIP1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for DZIP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.740851555 | 2.276682805 | -1.53583125 | 1.64E-06 | 7.96E-06 |
BRCA | -0.512953763 | 0.503420798 | -1.016374561 | 5.09E-18 | 3.15E-17 |
KICH | -2.66407457 | 2.25178543 | -4.91586 | 1.64E-13 | 2.27E-12 |
PRAD | -0.599815032 | 0.543063814 | -1.142878846 | 3.42E-12 | 1.45E-10 |
BLCA | -0.35664236 | 0.82987343 | -1.186515789 | 0.00296 | 0.017601711 |
COAD | -1.626688109 | -0.404838109 | -1.22185 | 0.000234 | 0.000782739 |
STAD | -1.14318907 | 0.29107968 | -1.43426875 | 5.41E-05 | 0.000463482 |
Top |
TissGene-miRNA for DZIP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for DZIP1 |
TissGeneSNV for DZIP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G804E | SKCM | 3 |
p.P698S | SKCM | 2 |
p.R757C | SKCM | 2 |
p.P702S | SKCM | 2 |
p.E728K | SKCM | 2 |
p.P683S | SKCM | 2 |
p.E314X | COAD | 1 |
p.A721T | LIHC | 1 |
p.R576X | SKCM | 1 |
p.E314X | READ | 1 |
p.S498L | STAD | 1 |
p.R400Q | SKCM | 1 |
p.E751K | SKCM | 1 |
p.R595* | STAD | 1 |
p.R219L | PAAD | 1 |
p.A36V | STAD | 1 |
p.R738C | SKCM | 1 |
p.R581K | SKCM | 1 |
p.S655Y | UCEC | 1 |
p.E348K | SKCM | 1 |
p.S848* | CESC | 1 |
p.F413L | UCEC | 1 |
p.A832T | HNSC | 1 |
p.L701R | UCEC | 1 |
p.G540R | SKCM | 1 |
p.G721E | SKCM | 1 |
p.A824T | HNSC | 1 |
p.D405H | KIRP | 1 |
p.Q325* | BLCA | 1 |
p.K178T | STAD | 1 |
p.D345H | CESC | 1 |
p.D549N | COAD | 1 |
p.K671Q | STAD | 1 |
p.E709K | SKCM | 1 |
p.S807F | UCEC | 1 |
p.P679L | SKCM | 1 |
p.K805Q | BLCA | 1 |
p.P679S | SKCM | 1 |
p.R595* | SKCM | 1 |
p.I569M | COAD | 1 |
p.E535K | SKCM | 1 |
p.Q59X | LIHC | 1 |
p.E237K | COAD | 1 |
p.S498P | STAD | 1 |
p.S111L | UCEC | 1 |
p.E580Q | SARC | 1 |
p.Q125K | LUAD | 1 |
p.E711K | COAD | 1 |
p.P637S | SKCM | 1 |
p.G521R | SKCM | 1 |
p.E751K | BLCA | 1 |
p.L315* | OV | 1 |
p.R219C | STAD | 1 |
p.P657L | SKCM | 1 |
p.R581K | HNSC | 1 |
p.E146K | BLCA | 1 |
p.E397D | UCEC | 1 |
p.G707R | SKCM | 1 |
p.A677T | COAD | 1 |
p.K386N | LUAD | 1 |
p.D615Y | UCEC | 1 |
p.Q423L | LUAD | 1 |
p.Q601E | HNSC | 1 |
p.N411D | SKCM | 1 |
p.P62L | SKCM | 1 |
p.R595* | UCEC | 1 |
p.V80L | HNSC | 1 |
p.D287H | BLCA | 1 |
p.A476D | UCEC | 1 |
p.P26L | LUAD | 1 |
p.E492X | COAD | 1 |
p.A478S | STAD | 1 |
p.P700R | BLCA | 1 |
p.P355S | UCEC | 1 |
p.E510K | SKCM | 1 |
p.G726R | SKCM | 1 |
p.E729K | SKCM | 1 |
p.K119E | SKCM | 1 |
p.A832E | SARC | 1 |
p.E491K | SKCM | 1 |
p.P838S | STAD | 1 |
p.P355S | SKCM | 1 |
p.P638L | SKCM | 1 |
p.H382Y | BLCA | 1 |
p.S618I | LUAD | 1 |
p.M208I | READ | 1 |
p.V858M | GBM | 1 |
p.D359N | UCEC | 1 |
p.R391P | LUAD | 1 |
p.M364V | LIHC | 1 |
p.T172M | COAD | 1 |
p.I562R | UCEC | 1 |
p.R400X | COAD | 1 |
p.K171E | UCEC | 1 |
p.E554K | SKCM | 1 |
p.E136Q | CESC | 1 |
p.R581* | SKCM | 1 |
p.E169K | SKCM | 1 |
p.E748K | SKCM | 1 |
p.T724A | LIHC | 1 |
p.I774M | LUAD | 1 |
p.P470S | BLCA | 1 |
p.V455M | SKCM | 1 |
p.G713R | LGG | 1 |
p.R400X | READ | 1 |
p.A817V | LGG | 1 |
p.A81V | STAD | 1 |
p.P115L | CESC | 1 |
p.R595Q | OV | 1 |
p.R595X | STAD | 1 |
p.R576X | READ | 1 |
p.H361Y | LUAD | 1 |
p.G156D | PAAD | 1 |
p.R417K | SKCM | 1 |
p.P669S | SKCM | 1 |
p.D860N | CESC | 1 |
p.E147* | LUAD | 1 |
p.H153R | BLCA | 1 |
p.Y198C | READ | 1 |
p.S536C | BLCA | 1 |
p.P717S | COAD | 1 |
p.E291G | BLCA | 1 |
p.R757C | HNSC | 1 |
p.E104K | SKCM | 1 |
p.E732K | SKCM | 1 |
p.E685K | CESC | 1 |
Top |
TissGeneCNV for DZIP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for DZIP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF083373 | STX5-DZIP1 | chr11:62591747 | chr13:96283045 | |
Chimerdb3.0 | ChiTaRs | NA | BF083368 | STX5-DZIP1 | chr11:62591741 | chr13:96283045 | |
Chimerdb3.0 | ChiTaRs | NA | CB851408 | DZIP1-DZIP1 | chr13:96242573 | chr13:96237088 | |
Chimerdb3.0 | ChiTaRs | NA | AK055823 | DZIP1-PKP4 | chr13:96274660 | chr2:159389687 | |
Chimerdb3.0 | ChiTaRs | NA | BU675977 | YWHAB-DZIP1 | chr20:43537082 | chr13:96271828 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-B6-A400-01A | DZIP1-PCCA | Out-of-frame | Chr13:96293549 | Chr13:100982815 |
Top |
TissGeneNet for DZIP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for DZIP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for DZIP1 |
TissGeneDrug for DZIP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for DZIP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |