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| TissGeneSummary for FOXG1 |
 Gene summary |
| Basic gene information | Gene symbol | FOXG1 |
| Gene name | forkhead box G1 | |
| Synonyms | BF1|BF2|FHKL3|FKH2|FKHL1|FKHL2|FKHL3|FKHL4|FOXG1A|FOXG1B|FOXG1C|HBF-1|HBF-2|HBF-3|HBF-G2|HBF2|HFK1|HFK2|HFK3|KHL2|QIN | |
| Cytomap | UCSC genome browser: 14q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005249.4, | |
| Description | brain factor 1brain factor 2forkhead box protein G1forkhead-like 1forkhead-like 2forkhead-like 3forkhead-like 4oncogene QIN | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 164874 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000176165 | ||
| HPRD : 01283 | ||
| Vega : OTTHUMG00000140187 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOXG1 | |
| BioGPS: 2290 | ||
| Pathway | NCI Pathway Interaction Database: FOXG1 | |
| KEGG: FOXG1 | ||
| REACTOME: FOXG1 | ||
| Pathway Commons: FOXG1 | ||
| Context | iHOP: FOXG1 | |
| ligand binding site mutation search in PubMed: FOXG1 | ||
| UCL Cancer Institute: FOXG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of FOXG1 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045892 | negative regulation of transcription, DNA-templated | 12657635 | GO:0045892 | negative regulation of transcription, DNA-templated | 12657635 |
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| TissGeneExp for FOXG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.868494724 | -2.194573155 | 1.326078431 | 3.11E-05 | 6.75E-05 |
| COAD | -0.914466443 | -2.128208751 | 1.213742308 | 0.011 | 0.023721457 |
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| TissGene-miRNA for FOXG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-5688 | MIMAT0022479 | 0.022 | -0.27 | 78 |
| ACC | hsa-miR-5688 | MIMAT0022479 | 0.022 | -0.27 | 78 |
| ACC | hsa-miR-200b-3p | MIMAT0000318 | 0.018 | -0.3 | 78 |
| ACC | hsa-miR-200b-3p | MIMAT0000318 | 0.018 | -0.3 | 78 |
| UCS | hsa-miR-499a-5p | MIMAT0002870 | 0.046 | -0.32 | 56 |
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| TissGeneMut for FOXG1 |
| TissGeneSNV for FOXG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E9Q | CESC | 1 |
| p.P445S | UCEC | 1 |
| p.P243L | STAD | 1 |
| p.I211T | STAD | 1 |
| p.P445T | LUAD | 1 |
| p.T269P | SKCM | 1 |
| p.R437S | LUAD | 1 |
| p.L451Q | LUAD | 1 |
| p.G469W | LUSC | 1 |
| p.R244S | ESCA | 1 |
| p.L316P | STAD | 1 |
| p.N176K | LUAD | 1 |
| p.Q478E | BLCA | 1 |
| p.H337N | LUAD | 1 |
| p.K178T | ESCA | 1 |
| p.L402F | BLCA | 1 |
| p.S462R | ESCA | 1 |
| p.P422S | SKCM | 1 |
| p.A282V | COAD | 1 |
| p.Q223H | LUAD | 1 |
| p.Q480H | COAD | 1 |
| p.R320S | ACC | 1 |
| p.H245N | LUSC | 1 |
| p.W255* | SKCM | 1 |
| p.M191V | STAD | 1 |
| p.T465M | ESCA | 1 |
| p.F184L | BLCA | 1 |
| p.S401F | SKCM | 1 |
| p.L410R | LUSC | 1 |
| p.W255C | LUAD | 1 |
| p.A188T | STAD | 1 |
| p.E173A | COAD | 1 |
| p.V242M | COAD | 1 |
| p.T346I | SKCM | 1 |
| p.S311T | LIHC | 1 |
| p.R230G | STAD | 1 |
| p.S449L | BLCA | 1 |
| p.G268R | LUAD | 1 |
| p.T330N | LUSC | 1 |
| p.A382V | ESCA | 1 |
| p.R274Q | LUAD | 1 |
| p.I488V | LUAD | 1 |
| p.K283R | STAD | 1 |
| p.D248N | LUSC | 1 |
| p.S332L | STAD | 1 |
| p.N236Y | LGG | 1 |
| p.R195W | HNSC | 1 |
| p.S401T | SKCM | 1 |
| p.T465M | UCEC | 1 |
| p.E454Q | HNSC | 1 |
| p.P183L | COAD | 1 |
| p.R281P | LUAD | 1 |
| p.S462G | ESCA | 1 |
| p.K237R | PAAD | 1 |
| p.A382T | PAAD | 1 |
| p.R302H | PRAD | 1 |
| p.D6N | PAAD | 1 |
| p.F210L | PRAD | 1 |
| p.S234P | UCEC | 1 |
| p.S484F | SKCM | 1 |
| p.A359T | ESCA | 1 |
| p.C238S | STAD | 1 |
| p.K213N | BLCA | 1 |
| p.S349X | LIHC | 1 |
| p.S449L | LUAD | 1 |
| p.P452L | PAAD | 1 |
| p.P340H | LUAD | 1 |
| p.Q446K | LUAD | 1 |
| p.A375S | HNSC | 1 |
| p.A438V | PRAD | 1 |
| p.A383V | ESCA | 1 |
| p.A188V | UCS | 1 |
| p.S305F | SKCM | 1 |
| p.Y374H | STAD | 1 |
| p.A439V | COAD | 1 |
| p.G304S | HNSC | 1 |
| p.S234A | GBM | 1 |
| p.S449L | HNSC | 1 |
| p.G172A | STAD | 1 |
| p.G296V | LUAD | 1 |
| p.N348H | HNSC | 1 |
| p.S441P | KIRP | 1 |
| p.S349L | UCEC | 1 |
| p.S455F | BLCA | 1 |
| p.R230H | LUAD | 1 |
| p.T278A | STAD | 1 |
| p.E371D | UCEC | 1 |
| p.S19I | HNSC | 1 |
| p.S425P | ESCA | 1 |
| p.R288H | LIHC | 1 |
| p.L204P | LIHC | 1 |
| p.S387* | LUAD | 1 |
| p.G271D | STAD | 1 |
| p.M191I | HNSC | 1 |
| p.T376A | ESCA | 1 |
| p.R274W | STAD | 1 |
| p.R275H | SKCM | 1 |
| p.N360K | LIHC | 1 |
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| TissGeneCNV for FOXG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOXG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW952674 | FOXG1-RNF169 | chr14:29238034 | chr11:74495901 |
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| TissGeneNet for FOXG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| COAD (tumor) | COAD (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| KICH (tumor) | KICH (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| STAD (tumor) | STAD (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| THCA (tumor) | THCA (normal) |
| FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (tumor) | FOXG1, TRAF6, SMAD3, KDM5B, SIRT3, SMAD1, HDAC1, FOXO4, SMAD2, GDF9, SMAD4, FOXO1, EP300, FOXH1, FOXO3, EEF1G, SIRT2, HES1, TLE1, TLE3 (normal) |
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| TissGeneProg for FOXG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOXG1 |
| TissGeneDrug for FOXG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FOXG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C3150705 | FOXG1 syndrome | 16 | BeFree,CLINVAR,CTD_human,UNIPROT |
| umls:C0035372 | Rett Syndrome | 15 | BeFree,GAD,LHGDN |
| umls:C0025958 | Microcephaly | 7 | BeFree,CTD_human |
| umls:C0014544 | Epilepsy | 6 | BeFree,GAD |
| umls:C0085584 | Encephalopathies | 4 | BeFree |
| umls:C0036572 | Seizures | 3 | BeFree,CTD_human |
| umls:C0036857 | Severe mental retardation (I.Q. 20-34) | 3 | BeFree |
| umls:C0037769 | West Syndrome | 3 | BeFree |
| umls:C0008073 | Developmental Disabilities | 2 | BeFree |
| umls:C0025149 | Medulloblastoma | 2 | BeFree,LHGDN |
| umls:C0026650 | Movement Disorders | 2 | BeFree |
| umls:C0424605 | Developmental delay (disorder) | 2 | BeFree |
| umls:C2748910 | Rett Syndrome, Atypical | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0004352 | Autistic Disorder | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0008489 | Chorea | 1 | BeFree |
| umls:C0013384 | Dyskinetic syndrome | 1 | BeFree |
| umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
| umls:C0026827 | Muscle hypotonia | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | CTD_human |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0079541 | Holoprosencephaly | 1 | BeFree |
| umls:C0206624 | Hepatoblastoma | 1 | BeFree |
| umls:C0233715 | Speech impairment | 1 | BeFree |
| umls:C0238111 | Lennox-Gastaut syndrome | 1 | BeFree |
| umls:C0338656 | Impaired cognition | 1 | BeFree |
| umls:C0432072 | Dysmorphic features | 1 | BeFree |
| umls:C0598935 | Tumor Initiation | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0796147 | Acrocallosal Syndrome | 1 | CTD_human |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C1535926 | Neurodevelopmental Disorders | 1 | BeFree |
| umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | CTD_human |
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