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| TissGeneSummary for CD93 |
 Gene summary |
| Basic gene information | Gene symbol | CD93 |
| Gene name | CD93 molecule | |
| Synonyms | C1QR1|C1qR(P)|C1qRP|CDw93|ECSM3|MXRA4|dJ737E23.1 | |
| Cytomap | UCSC genome browser: 20p11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012072.3, | |
| Description | C1q receptor 1C1q/MBL/SPA receptorC1qRCD93 antigencomplement component 1 q subcomponent receptor 1complement component 1, q subcomponent, receptor 1complement component C1q receptormatrix-remodeling-associated protein 4matrix-remodelling associate | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 120577 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125810 | ||
| HPRD : 00396 | ||
| Vega : OTTHUMG00000032058 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CD93 | |
| BioGPS: 22918 | ||
| Pathway | NCI Pathway Interaction Database: CD93 | |
| KEGG: CD93 | ||
| REACTOME: CD93 | ||
| Pathway Commons: CD93 | ||
| Context | iHOP: CD93 | |
| ligand binding site mutation search in PubMed: CD93 | ||
| UCL Cancer Institute: CD93 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSARC | |
| Reference showing the relevant tissue of CD93 | ||
| Description by TissGene annotations | Cancer gene TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016337 | single organismal cell-cell adhesion | 11994479 | GO:0016337 | single organismal cell-cell adhesion | 11994479 |
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| TissGeneExp for CD93 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 2.063460748 | 0.957219081 | 1.106241667 | 1.62E-16 | 9.17E-16 |
| KIRP | -0.79877328 | 0.561173595 | -1.359946875 | 4.10E-08 | 2.74E-07 |
| LUSC | -0.283527079 | 2.63339449 | -2.916921569 | 4.31E-28 | 1.43E-26 |
| LUAD | 0.557826505 | 2.46034547 | -1.902518966 | 3.66E-23 | 1.17E-21 |
| BLCA | -0.73245453 | 0.606824418 | -1.339278947 | 0.000264 | 0.002436249 |
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| TissGene-miRNA for CD93 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CD93 |
| TissGeneSNV for CD93 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D482N | SKCM | 2 |
| p.R303Q | SKCM | 2 |
| p.G314E | SKCM | 2 |
| p.G177D | SKCM | 1 |
| p.G405D | STAD | 1 |
| p.Y585H | ESCA | 1 |
| p.D429H | BLCA | 1 |
| p.A552T | STAD | 1 |
| p.Q426K | LUAD | 1 |
| p.I586T | LGG | 1 |
| p.A530S | UCEC | 1 |
| p.G172R | BLCA | 1 |
| p.S629F | ESCA | 1 |
| p.Q206X | SKCM | 1 |
| p.E484Q | BLCA | 1 |
| p.G363E | SKCM | 1 |
| p.V428L | BRCA | 1 |
| p.G491E | SKCM | 1 |
| p.K324I | SKCM | 1 |
| p.T528A | LUAD | 1 |
| p.S629F | SKCM | 1 |
| p.R607H | COAD | 1 |
| p.E380D | PRAD | 1 |
| p.G364D | ESCA | 1 |
| p.R292W | LGG | 1 |
| p.G448R | SKCM | 1 |
| p.A315V | PAAD | 1 |
| p.A418V | SKCM | 1 |
| p.G96R | GBM | 1 |
| p.V318I | COAD | 1 |
| p.P375L | KIRP | 1 |
| p.L532V | THCA | 1 |
| p.P204L | SKCM | 1 |
| p.F584L | BRCA | 1 |
| p.R312S | HNSC | 1 |
| p.Q356* | BRCA | 1 |
| p.T647K | READ | 1 |
| p.C271* | SKCM | 1 |
| p.E227Q | SKCM | 1 |
| p.S41L | ESCA | 1 |
| p.P541S | COAD | 1 |
| p.S253L | LUAD | 1 |
| p.C389S | LUAD | 1 |
| p.P245S | LGG | 1 |
| p.D231E | LUAD | 1 |
| p.T327M | LGG | 1 |
| p.E618K | STAD | 1 |
| p.E232K | SKCM | 1 |
| p.T87M | STAD | 1 |
| p.A220V | READ | 1 |
| p.P510L | HNSC | 1 |
| p.Q559* | SKCM | 1 |
| p.S41* | LIHC | 1 |
| p.G33A | LUAD | 1 |
| p.A35T | ESCA | 1 |
| p.R82W | ESCA | 1 |
| p.F584L | LUSC | 1 |
| p.T38M | STAD | 1 |
| p.R496S | LUAD | 1 |
| p.V568M | HNSC | 1 |
| p.P378S | BLCA | 1 |
| p.C396X | COAD | 1 |
| p.L44M | UCEC | 1 |
| p.C188* | LUAD | 1 |
| p.C396W | LUAD | 1 |
| p.E618K | SKCM | 1 |
| p.G575A | LUAD | 1 |
| p.A625T | STAD | 1 |
| p.E420K | LIHC | 1 |
| p.D421N | HNSC | 1 |
| p.G186D | SKCM | 1 |
| p.S149C | BLCA | 1 |
| p.P260L | LUAD | 1 |
| p.P289T | BLCA | 1 |
| p.S210F | SKCM | 1 |
| p.S523C | BLCA | 1 |
| p.P378L | SKCM | 1 |
| p.E560K | SKCM | 1 |
| p.A49T | SKCM | 1 |
| p.W458G | ACC | 1 |
| p.V318I | STAD | 1 |
| p.Q206* | SKCM | 1 |
| p.E368K | SKCM | 1 |
| p.G364V | BRCA | 1 |
| p.G508S | SKCM | 1 |
| p.P107S | SARC | 1 |
| p.A88E | ESCA | 1 |
| p.S170F | BLCA | 1 |
| p.S41X | LIHC | 1 |
| p.R607H | LUSC | 1 |
| p.P632L | SKCM | 1 |
| p.F182L | LIHC | 1 |
| p.V318I | DLBC | 1 |
| p.R609Q | LGG | 1 |
| p.S210F | UCEC | 1 |
| p.G113V | OV | 1 |
| p.K612N | HNSC | 1 |
| p.P510H | LUAD | 1 |
| p.E636G | LUAD | 1 |
| p.Q559K | OV | 1 |
| p.G422A | HNSC | 1 |
| p.F450I | LUAD | 1 |
| p.N54K | LUAD | 1 |
| p.P646L | UCEC | 1 |
| p.G279R | SKCM | 1 |
| p.L595I | LUSC | 1 |
| p.A220V | LGG | 1 |
| p.D337N | COAD | 1 |
| p.D482N | HNSC | 1 |
| p.K159* | PAAD | 1 |
| p.K533R | LGG | 1 |
| p.A220V | STAD | 1 |
| p.E348K | SKCM | 1 |
| p.D342Y | LUAD | 1 |
| p.E121D | STAD | 1 |
| p.E618Q | BLCA | 1 |
| p.N127S | PAAD | 1 |
| p.R607H | STAD | 1 |
| p.S253L | STAD | 1 |
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| TissGeneCNV for CD93 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CD93 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CD93 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| COAD (tumor) | COAD (normal) |
| CD93, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| KICH (tumor) | KICH (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CD93, FAM46A, COPS5, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, ARHGAP15, F12 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CD93, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| STAD (tumor) | STAD (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15, F12 (normal) |
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| THCA (tumor) | THCA (normal) |
| CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15 (tumor) | CD93, FAM46A, COPS5, UBQLN2, COL1A1, COL4A3, COL1A2, COL4A1, SFTPA2, CRK, MSN, COL4A5, KNG1, COL4A6, RANBP1, MBL2, MYD88, C1QA, COL4A4, SCYL1, ARHGAP15 (normal) |
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| TissGeneProg for CD93 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CD93 |
| TissGeneDrug for CD93 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CD93 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010068 | Coronary heart disease | 3 | BeFree,GAD |
| umls:C0020445 | Hypercholesterolemia, Familial | 2 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0021655 | Insulin Resistance | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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