TissGeneSummary for AKR7A3 |
Gene summary |
Basic gene information | Gene symbol | AKR7A3 |
Gene name | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | |
Synonyms | AFAR2 | |
Cytomap | UCSC genome browser: 1p36.13 | |
Type of gene | protein-coding | |
RefGenes | NM_012067.2, | |
Description | AFB1 aldehyde reductase 2AFB1-AR 2aflatoxin B1 aldehyde reductase 2aflatoxin B1 aldehyde reductase member 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608477 | |
HGNC : HGNC | ||
HPRD : 07089 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AKR7A3 | |
BioGPS: 22977 | ||
Pathway | NCI Pathway Interaction Database: AKR7A3 | |
KEGG: AKR7A3 | ||
REACTOME: AKR7A3 | ||
Pathway Commons: AKR7A3 | ||
Context | iHOP: AKR7A3 | |
ligand binding site mutation search in PubMed: AKR7A3 | ||
UCL Cancer Institute: AKR7A3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonPancreasStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADPAADSTAD | |
Reference showing the relevant tissue of AKR7A3 | ||
Description by TissGene annotations | Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for AKR7A3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.185788072 | -2.428648856 | 1.242860784 | 3.52E-07 | 9.28E-07 |
LIHC | 5.298897301 | 7.956585301 | -2.657688 | 6.78E-08 | 4.99E-07 |
KIRC | 3.31648219 | 4.769137745 | -1.452655556 | 1.58E-05 | 3.64E-05 |
BRCA | 2.810142424 | 1.22479681 | 1.585345614 | 9.88E-07 | 2.69E-06 |
LUAD | 0.039638128 | -2.419001527 | 2.458639655 | 2.66E-09 | 1.31E-08 |
KICH | 2.923527301 | 4.873015301 | -1.949488 | 0.00319 | 0.006277464 |
KIRP | 3.149180801 | 5.770246426 | -2.621065625 | 7.52E-05 | 0.000265928 |
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TissGene-miRNA for AKR7A3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AKR7A3 |
TissGeneSNV for AKR7A3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P199S | SKCM | 1 |
p.Y232H | UCEC | 1 |
p.T181M | UCEC | 1 |
p.P185S | SKCM | 1 |
p.A201T | UCEC | 1 |
p.Y49H | STAD | 1 |
p.Y172N | SKCM | 1 |
p.A318V | SKCM | 1 |
p.S265L | SKCM | 1 |
p.A284T | LGG | 1 |
p.T206A | STAD | 1 |
p.R106Q | HNSC | 1 |
p.R106* | STAD | 1 |
p.T227S | LUAD | 1 |
p.A147S | LIHC | 1 |
p.F93S | STAD | 1 |
p.E296D | LUAD | 1 |
p.V48L | GBM | 1 |
p.E180K | LUAD | 1 |
p.E243V | LUAD | 1 |
p.M171I | SKCM | 1 |
p.A318V | PAAD | 1 |
p.M271I | LUAD | 1 |
p.R235C | STAD | 1 |
p.R106Q | LUAD | 1 |
p.T119A | STAD | 1 |
p.A146V | ESCA | 1 |
p.L109V | BRCA | 1 |
p.P105L | SKCM | 1 |
p.G62E | SKCM | 1 |
p.E51D | PAAD | 1 |
p.G161D | SKCM | 1 |
p.R235H | COAD | 1 |
p.D116G | SKCM | 1 |
p.D116N | SKCM | 1 |
p.A302P | LUAD | 1 |
p.A302V | THYM | 1 |
p.A310V | STAD | 1 |
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TissGeneCNV for AKR7A3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AKR7A3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-D8-A1JM-01A | AKR7A3-CAPZB | In-Frame | chr1:19610489 | chr1:19746244 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-B6-A3ZX-01A | PADI4-AKR7A3 | Out-of-Frame | chr1:17657644 | chr1:19612866 |
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TissGeneNet for AKR7A3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AKR7A3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AKR7A3 |
TissGeneDrug for AKR7A3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AKR7A3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |