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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AKR7A3
check button Gene summary
Basic gene informationGene symbolAKR7A3
Gene namealdo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
SynonymsAFAR2
CytomapUCSC genome browser: 1p36.13
Type of geneprotein-coding
RefGenesNM_012067.2,
DescriptionAFB1 aldehyde reductase 2AFB1-AR 2aflatoxin B1 aldehyde reductase 2aflatoxin B1 aldehyde reductase member 3
Modification date20141207
dbXrefs MIM : 608477
HGNC : HGNC
HPRD : 07089
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR7A3
BioGPS: 22977
PathwayNCI Pathway Interaction Database: AKR7A3
KEGG: AKR7A3
REACTOME: AKR7A3
Pathway Commons: AKR7A3
ContextiHOP: AKR7A3
ligand binding site mutation search in PubMed: AKR7A3
UCL Cancer Institute: AKR7A3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ColonPancreasStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COADPAADSTAD
Reference showing the relevant tissue of AKR7A3
Description by TissGene annotationsProtective TissGene in RFS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for AKR7A3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-1.185788072-2.4286488561.2428607843.52E-079.28E-07
LIHC5.2988973017.956585301-2.6576886.78E-084.99E-07
KIRC3.316482194.769137745-1.4526555561.58E-053.64E-05
BRCA2.8101424241.224796811.5853456149.88E-072.69E-06
LUAD0.039638128-2.4190015272.4586396552.66E-091.31E-08
KICH2.9235273014.873015301-1.9494880.003190.006277464
KIRP3.1491808015.770246426-2.6210656257.52E-050.000265928


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TissGene-miRNA for AKR7A3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for AKR7A3
TissGeneSNV for AKR7A3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P199SSKCM1
p.Y232HUCEC1
p.T181MUCEC1
p.P185SSKCM1
p.A201TUCEC1
p.Y49HSTAD1
p.Y172NSKCM1
p.A318VSKCM1
p.S265LSKCM1
p.A284TLGG1
p.T206ASTAD1
p.R106QHNSC1
p.R106*STAD1
p.T227SLUAD1
p.A147SLIHC1
p.F93SSTAD1
p.E296DLUAD1
p.V48LGBM1
p.E180KLUAD1
p.E243VLUAD1
p.M171ISKCM1
p.A318VPAAD1
p.M271ILUAD1
p.R235CSTAD1
p.R106QLUAD1
p.T119ASTAD1
p.A146VESCA1
p.L109VBRCA1
p.P105LSKCM1
p.G62ESKCM1
p.E51DPAAD1
p.G161DSKCM1
p.R235HCOAD1
p.D116GSKCM1
p.D116NSKCM1
p.A302PLUAD1
p.A302VTHYM1
p.A310VSTAD1


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TissGeneCNV for AKR7A3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for AKR7A3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanBRCATCGA-D8-A1JM-01AAKR7A3-CAPZBIn-Framechr1:19610489chr1:19746244
Chimerdb3.0FusionScanBRCATCGA-B6-A3ZX-01APADI4-AKR7A3Out-of-Framechr1:17657644chr1:19612866


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TissGeneNet for AKR7A3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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COAD (tumor)COAD (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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HNSC (tumor)HNSC (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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KICH (tumor)KICH (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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KIRC (tumor)KIRC (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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KIRP (tumor)KIRP (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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LIHC (tumor)LIHC (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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LUAD (tumor)LUAD (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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LUSC (tumor)LUSC (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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PRAD (tumor)PRAD (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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STAD (tumor)STAD (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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THCA (tumor)THCA (normal)
AKR7A3, TERF2IP, AKR7A2 (tumor)AKR7A3, TERF2IP, AKR7A2 (normal)
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TissGeneProg for AKR7A3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for AKR7A3
TissGeneDrug for AKR7A3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for AKR7A3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource