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| TissGeneSummary for FOXE1 |
 Gene summary |
| Basic gene information | Gene symbol | FOXE1 |
| Gene name | forkhead box E1 | |
| Synonyms | FKHL15|FOXE2|HFKH4|HFKL5|TITF2|TTF-2|TTF2 | |
| Cytomap | UCSC genome browser: 9q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004473.3, | |
| Description | HNF-3/fork head-like protein 5forkhead box E2forkhead box protein E1forkhead box protein E2forkhead, drosophila, homolog-like 15forkhead-related protein FKHL15thyroid transcription factor 2 | |
| Modification date | 20141220 | |
| dbXrefs | MIM : 602617 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000178919 | ||
| HPRD : 04014 | ||
| HPRD : 06188 | ||
| Vega : OTTHUMG00000020333 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOXE1 | |
| BioGPS: 2304 | ||
| Pathway | NCI Pathway Interaction Database: FOXE1 | |
| KEGG: FOXE1 | ||
| REACTOME: FOXE1 | ||
| Pathway Commons: FOXE1 | ||
| Context | iHOP: FOXE1 | |
| ligand binding site mutation search in PubMed: FOXE1 | ||
| UCL Cancer Institute: FOXE1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
| Reference showing the relevant tissue of FOXE1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045893 | positive regulation of transcription, DNA-templated | 9697705 | GO:0045893 | positive regulation of transcription, DNA-templated | 9697705 |
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| TissGeneExp for FOXE1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.256623132 | -1.534407903 | 1.791031034 | 1.88E-05 | 5.31E-05 |
| BRCA | -2.057514497 | -0.933950462 | -1.123564035 | 1.15E-09 | 4.09E-09 |
| KICH | -2.663372041 | 0.111311959 | -2.774684 | 1.30E-14 | 2.33E-13 |
| KIRC | -1.954519541 | -0.014061207 | -1.940458333 | 4.76E-12 | 1.91E-11 |
| LUSC | 5.636105214 | -0.933008511 | 6.569113725 | 1.58E-18 | 1.53E-17 |
| HNSC | 6.99990982 | 5.597486564 | 1.402423256 | 0.0139 | 0.032714435 |
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| TissGene-miRNA for FOXE1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FOXE1 |
| TissGeneSNV for FOXE1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A178T | LIHC | 4 |
| p.R91C | STAD | 1 |
| p.R146H | STAD | 1 |
| p.A361T | STAD | 1 |
| p.E117Q | CESC | 1 |
| p.A349P | LUAD | 1 |
| p.Y58* | BLCA | 1 |
| p.G52R | LIHC | 1 |
| p.A133T | UCEC | 1 |
| p.A360V | PAAD | 1 |
| p.E319Q | BLCA | 1 |
| p.S100I | STAD | 1 |
| p.P70H | LUAD | 1 |
| p.F142L | BLCA | 1 |
| p.R91H | STAD | 1 |
| p.A248G | THCA | 1 |
| p.S152L | BLCA | 1 |
| p.G331S | STAD | 1 |
| p.F324V | STAD | 1 |
| p.E71K | BLCA | 1 |
| p.R146C | BLCA | 1 |
| p.R116C | COAD | 1 |
| p.G124S | BLCA | 1 |
| p.R144C | STAD | 1 |
| p.G122D | STAD | 1 |
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| TissGeneCNV for FOXE1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOXE1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for FOXE1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| COAD (tumor) | COAD (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| KICH (tumor) | KICH (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| STAD (tumor) | STAD (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| THCA (tumor) | THCA (normal) |
| FOXE1, PLCB3 (tumor) | FOXE1, PLCB3 (normal) |
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| TissGeneProg for FOXE1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOXE1 |
| TissGeneDrug for FOXE1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FOXE1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0238463 | Papillary thyroid carcinoma | 15 | BeFree,ORPHANET |
| umls:C0008925 | Cleft Palate | 14 | BeFree,GAD,LHGDN |
| umls:C0010308 | Congenital Hypothyroidism | 14 | BeFree,GAD,LHGDN |
| umls:C0342200 | Endemic Cretinism | 13 | BeFree |
| umls:C1563716 | Thyroid Dysgenesis | 13 | BeFree,GAD,LHGDN |
| umls:C0549473 | Thyroid carcinoma | 10 | BeFree,GAD |
| umls:C0007115 | Malignant neoplasm of thyroid | 8 | BeFree |
| umls:C0008924 | Cleft Lip | 7 | BeFree,GAD |
| umls:C1855794 | Bamforth syndrome | 6 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 5 | BeFree |
| umls:C0000768 | Congenital Abnormality | 4 | BeFree,GAD |
| umls:C0008297 | Choanal Atresia | 4 | BeFree |
| umls:C0020676 | Hypothyroidism | 4 | BeFree,GAD |
| umls:C0040136 | Thyroid Neoplasm | 3 | BeFree,GAD |
| umls:C0339864 | Bifid epiglottis | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0025322 | Premature Menopause | 2 | BeFree |
| umls:C0085215 | Ovarian Failure, Premature | 2 | BeFree,LHGDN |
| umls:C0553723 | Squamous cell carcinoma of skin | 2 | BeFree |
| umls:C0749420 | Thyroid Agenesis | 2 | BeFree |
| umls:C0810364 | Cleft Lip with or without Cleft Palate | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 2 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | GAD |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0027666 | Neoplasms, Radiation-Induced | 1 | GAD |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238461 | Anaplastic thyroid carcinoma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C1519346 | Skin Carcinogenesis | 1 | BeFree |
| umls:C1837217 | Cleft lip, isolated | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3501843 | Nonmedullary Thyroid Carcinoma | 1 | BeFree |
| umls:C1869118 | HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS | 0 | MGD |
| umls:C1968699 | Hypothyroidism, Thyroidal, With Spiky Hair And Cleft Palate | 0 | CLINVAR |
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