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| TissGeneSummary for TTLL5 |
 Gene summary |
| Basic gene information | Gene symbol | TTLL5 |
| Gene name | tubulin tyrosine ligase-like family, member 5 | |
| Synonyms | CORD19|KIAA0998|STAMP | |
| Cytomap | UCSC genome browser: 14q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015072.4, | |
| Description | SRC1 and TIF2 associated binding proteinSRC1 and TIF2-associated modulatory proteintubulin polyglutamylase TTLL5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612268 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000119685 | ||
| HPRD : 08309 | ||
| Vega : OTTHUMG00000171611 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TTLL5 | |
| BioGPS: 23093 | ||
| Pathway | NCI Pathway Interaction Database: TTLL5 | |
| KEGG: TTLL5 | ||
| REACTOME: TTLL5 | ||
| Pathway Commons: TTLL5 | ||
| Context | iHOP: TTLL5 | |
| ligand binding site mutation search in PubMed: TTLL5 | ||
| UCL Cancer Institute: TTLL5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of TTLL5 | ||
| Description by TissGene annotations | TissgsLTS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TTLL5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for TTLL5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TTLL5 |
| TissGeneSNV for TTLL5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R964X | COAD | 2 |
| p.F1267S | COAD | 2 |
| p.H151Y | SKCM | 2 |
| p.E599K | UCS | 1 |
| p.R479* | UCEC | 1 |
| p.Y290C | BLCA | 1 |
| p.R188Q | CESC | 1 |
| p.R565S | LUAD | 1 |
| p.R260I | UCEC | 1 |
| p.A575T | BRCA | 1 |
| p.D436Y | THYM | 1 |
| p.P123A | STAD | 1 |
| p.R484C | UCEC | 1 |
| p.F700L | STAD | 1 |
| p.R512H | CESC | 1 |
| p.S978T | UCEC | 1 |
| p.R554C | PAAD | 1 |
| p.S114F | ACC | 1 |
| p.N54I | STAD | 1 |
| p.A767D | STAD | 1 |
| p.S916F | BRCA | 1 |
| p.K769R | LUAD | 1 |
| p.S997L | SKCM | 1 |
| p.L364F | LUAD | 1 |
| p.P922L | SKCM | 1 |
| p.E1100K | UCEC | 1 |
| p.R512H | STAD | 1 |
| p.A682T | STAD | 1 |
| p.V230M | COAD | 1 |
| p.E1013K | LGG | 1 |
| p.K68E | PRAD | 1 |
| p.E606K | SKCM | 1 |
| p.M1190I | BLCA | 1 |
| p.P1085S | SKCM | 1 |
| p.R188W | STAD | 1 |
| p.R111H | UCEC | 1 |
| p.Q1097E | HNSC | 1 |
| p.R738* | STAD | 1 |
| p.Q573P | ACC | 1 |
| p.R737Q | PRAD | 1 |
| p.R1172W | STAD | 1 |
| p.P28S | LUAD | 1 |
| p.A1151S | STAD | 1 |
| p.R484C | SKCM | 1 |
| p.V1126M | SARC | 1 |
| p.P40S | SKCM | 1 |
| p.A749S | LUAD | 1 |
| p.R71Q | UCEC | 1 |
| p.R964* | SARC | 1 |
| p.Q1206* | BRCA | 1 |
| p.Q1149X | PAAD | 1 |
| p.P451L | LUAD | 1 |
| p.F150C | SKCM | 1 |
| p.T623S | UCEC | 1 |
| p.R737Q | STAD | 1 |
| p.N1232Y | LUAD | 1 |
| p.P926S | OV | 1 |
| p.T637S | UCEC | 1 |
| p.A149V | COAD | 1 |
| p.Y1161H | LUSC | 1 |
| p.I1176V | LGG | 1 |
| p.Q711H | BLCA | 1 |
| p.W177* | UCEC | 1 |
| p.R71X | STAD | 1 |
| p.A1201T | COAD | 1 |
| p.L1211V | BLCA | 1 |
| p.E162D | KIRP | 1 |
| p.S345G | BRCA | 1 |
| p.E801X | THYM | 1 |
| p.K658T | UCEC | 1 |
| p.G697S | STAD | 1 |
| p.G1193V | BLCA | 1 |
| p.R343C | HNSC | 1 |
| p.V1134A | STAD | 1 |
| p.E550D | HNSC | 1 |
| p.R71* | STAD | 1 |
| p.W32R | PAAD | 1 |
| p.R1170* | SKCM | 1 |
| p.S603F | SKCM | 1 |
| p.R690H | LUAD | 1 |
| p.S1273C | STAD | 1 |
| p.I211S | KIRP | 1 |
| p.E860X | PAAD | 1 |
| p.E632* | BLCA | 1 |
| p.E860* | PAAD | 1 |
| p.R75H | COAD | 1 |
| p.Q931E | STAD | 1 |
| p.R343H | UCEC | 1 |
| p.Q1149* | PAAD | 1 |
| p.R493* | UCEC | 1 |
| p.R428C | THYM | 1 |
| p.R1035Q | DLBC | 1 |
| p.L549P | SKCM | 1 |
| p.G1193C | BLCA | 1 |
| p.T820N | STAD | 1 |
| p.H840Y | BLCA | 1 |
| p.T64K | SKCM | 1 |
| p.S114F | BLCA | 1 |
| p.R71G | BRCA | 1 |
| p.R721Q | COAD | 1 |
| p.R479Q | BLCA | 1 |
| p.A1277T | UCEC | 1 |
| p.S681C | LUAD | 1 |
| p.K878T | UCEC | 1 |
| p.G697S | UCEC | 1 |
| p.H1004Y | THCA | 1 |
| p.P1230S | SKCM | 1 |
| p.R677Q | UCEC | 1 |
| p.G1114W | LUAD | 1 |
| p.V1226I | ACC | 1 |
| p.L153P | STAD | 1 |
| p.R447W | SKCM | 1 |
| p.H90Y | SKCM | 1 |
| p.F150S | LIHC | 1 |
| p.P1231S | SKCM | 1 |
| p.Y495H | ESCA | 1 |
| p.A1194T | PRAD | 1 |
| p.R75H | LGG | 1 |
| p.S940F | BLCA | 1 |
| p.Q1168H | BLCA | 1 |
| p.E306Q | LUSC | 1 |
| p.L1258F | SKCM | 1 |
| p.G102R | SKCM | 1 |
| p.A48T | STAD | 1 |
| p.G35S | LIHC | 1 |
| p.A1151V | SKCM | 1 |
| p.H899Y | SKCM | 1 |
| p.T1131A | STAD | 1 |
| p.S114F | LUAD | 1 |
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| TissGeneCNV for TTLL5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TTLL5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DB522390 | TTLL5-CXADR | chr14:76231116 | chr21:18937743 | |
| Chimerdb3.0 | ChiTaRs | NA | AI904047 | TTLL5-AATF | chr14:76204242 | chr17:35314642 | |
| Chimerdb3.0 | ChiTaRs | NA | BG984526 | TTLL5-NAPA | chr14:76129543 | chr19:48006703 | |
| Chimerdb3.0 | ChiTaRs | NA | BG257644 | TTLL5-TTLL5 | chr14:76420980 | chr14:76420951 | |
| Chimerdb3.0 | FusionScan | THYM | TCGA-ZB-A965-01A | TTLL5-IFT43 | Out-of-Frame | chr14:76368567 | chr14:76455227 |
| Chimerdb3.0 | FusionScan | LGG | TCGA-DU-7306-01A | TTLL5-IFT43 | In-Frame | chr14:76330205 | chr14:76455227 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OQ-01A | TTLL5-JDP2 | In-Frame | chr14:76259443 | chr14:75928128 |
| Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5LC-01A | TTLL5-IFT43 | Out-of-Frame | chr14:76368567 | chr14:76455227 |
| Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5JL-01A | MATR3-TTLL5 | 5'UTR-CDS | chr5:138629494 | chr14:76368484 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-77-A5G6-01A | EML1-TTLL5 | Out-of-Frame | chr14:100259880 | chr14:76349027 |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-77-A5G6-01A | TTLL5-RGS6 | In-Frame | chr14:76249873 | chr14:72921235 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A1AP-01A | TTLL5-TSHR | In-frame | Chr14:76286504 | Chr14:81528492 |
| TCGAfusionPortal | PRADA | GBM | TCGA-27-1835-01A | RP4-761I2.2-TTLL5 | Out-of-frame | Chr6:11094622 | Chr14:76184204 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-6961-01A | TMED10-TTLL5 | In-frame | Chr14:75643058 | Chr14:76286350 |
| TCGAfusionPortal | PRADA | OV | TCGA-23-2084-01A | IFT43-TTLL5 | Out-of-frame | Chr14:76455320 | Chr14:76420767 |
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| TissGeneNet for TTLL5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| COAD (tumor) | COAD (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| KICH (tumor) | KICH (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| STAD (tumor) | STAD (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TTLL5, TP53, UBC, CDKN1A, TP73 (tumor) | TTLL5, TP53, UBC, CDKN1A, TP73 (normal) |
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| TissGeneProg for TTLL5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TTLL5 |
| TissGeneDrug for TTLL5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TTLL5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0854723 | Retinal Dystrophies | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C3495559 | Juvenile arthritis | 1 | CTD_human |
| umls:C4014501 | CONE-ROD DYSTROPHY 19 | 1 | UNIPROT |
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