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| TissGeneSummary for FLG |
 Gene summary |
| Basic gene information | Gene symbol | FLG |
| Gene name | filaggrin | |
| Synonyms | ATOD2 | |
| Cytomap | UCSC genome browser: 1q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002016.1, | |
| Description | epidermal filaggrin | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 135940 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143631 | ||
| HPRD : 15920 | ||
| Vega : OTTHUMG00000012202 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FLG | |
| BioGPS: 2312 | ||
| Pathway | NCI Pathway Interaction Database: FLG | |
| KEGG: FLG | ||
| REACTOME: FLG | ||
| Pathway Commons: FLG | ||
| Context | iHOP: FLG | |
| ligand binding site mutation search in PubMed: FLG | ||
| UCL Cancer Institute: FLG | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of FLG | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for FLG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.904279766 | 2.812254766 | -1.907975 | 1.85E-12 | 7.71E-12 |
| BRCA | -0.803492676 | 0.811963465 | -1.61545614 | 9.06E-18 | 5.55E-17 |
| STAD | -1.539424748 | 0.688306502 | -2.22773125 | 0.016 | 0.049360768 |
| KIRP | 1.307622127 | 2.601453377 | -1.29383125 | 0.000834 | 0.002348896 |
| Top |
| TissGene-miRNA for FLG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for FLG |
| TissGeneSNV for FLG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S2847L | SKCM | 3 |
| p.E116K | SKCM | 3 |
| p.E1255K | SKCM | 3 |
| p.G1464E | SKCM | 3 |
| p.E990K | SKCM | 3 |
| p.E1563K | SKCM | 2 |
| p.Q3488K | LUAD | 2 |
| p.R2430Q | SKCM | 2 |
| p.E3583K | SKCM | 2 |
| p.R1798Q | SKCM | 2 |
| p.R3277C | STAD | 2 |
| p.R1236H | STAD | 2 |
| p.R1474Q | SKCM | 2 |
| p.G444E | SKCM | 2 |
| p.D2120N | SKCM | 2 |
| p.R2239W | SKCM | 2 |
| p.G491E | SKCM | 2 |
| p.G2509E | SKCM | 2 |
| p.G610E | STAD | 2 |
| p.G194E | SKCM | 2 |
| p.A2503V | HNSC | 2 |
| p.G610E | SKCM | 2 |
| p.G2175R | SKCM | 2 |
| p.R122K | SKCM | 2 |
| p.S3158F | SKCM | 2 |
| p.H1961Y | SKCM | 2 |
| p.S1215R | ESCA | 2 |
| p.D2520N | SKCM | 2 |
| p.R3166H | BLCA | 2 |
| p.E40K | SKCM | 2 |
| p.R2857H | STAD | 2 |
| p.D302N | SKCM | 2 |
| p.E3775K | SKCM | 2 |
| p.G387S | STAD | 2 |
| p.R788X | COAD | 2 |
| p.D411N | SKCM | 2 |
| p.R2037Q | BLCA | 2 |
| p.G3536E | SKCM | 2 |
| p.E2879Q | BLCA | 2 |
| p.R2886H | GBM | 2 |
| p.S2188R | STAD | 2 |
| p.G1526E | SKCM | 2 |
| p.R3892L | UCEC | 1 |
| p.G1823V | CESC | 1 |
| p.W326S | LUAD | 1 |
| p.S3330T | BLCA | 1 |
| p.R2540Q | STAD | 1 |
| p.H2853N | HNSC | 1 |
| p.S1683F | LUSC | 1 |
| p.G2791E | SKCM | 1 |
| p.V536A | LUAD | 1 |
| p.S2275L | LUAD | 1 |
| p.R3726W | GBM | 1 |
| p.V816L | LIHC | 1 |
| p.T1134N | LUSC | 1 |
| p.G3345R | SKCM | 1 |
| p.R446T | BRCA | 1 |
| p.R412H | THYM | 1 |
| p.E374* | BLCA | 1 |
| p.A2861T | SKCM | 1 |
| p.R3090H | PRAD | 1 |
| p.R3878S | LUSC | 1 |
| p.D675Y | STAD | 1 |
| p.P660R | LUAD | 1 |
| p.G3997E | SKCM | 1 |
| p.R1909K | LUAD | 1 |
| p.S495L | DLBC | 1 |
| p.D1811H | LUAD | 1 |
| p.S2532L | BLCA | 1 |
| p.S2554* | LUAD | 1 |
| p.Q3431K | LIHC | 1 |
| p.E1300G | COAD | 1 |
| p.R1388L | HNSC | 1 |
| p.E804* | GBM | 1 |
| p.Q2877K | LGG | 1 |
| p.G1988* | UCEC | 1 |
| p.H2491Q | BLCA | 1 |
| p.D70H | BLCA | 1 |
| p.G2436R | LUAD | 1 |
| p.G2795R | ESCA | 1 |
| p.E1547K | STAD | 1 |
| p.K1424N | SKCM | 1 |
| p.S1777C | LIHC | 1 |
| p.P520T | LUAD | 1 |
| p.R826Q | SKCM | 1 |
| p.E2555A | CHOL | 1 |
| p.S504P | PRAD | 1 |
| p.V1270F | LUAD | 1 |
| p.E3870D | UCEC | 1 |
| p.R1150X | PAAD | 1 |
| p.R1264K | BLCA | 1 |
| p.R415W | STAD | 1 |
| p.P3438L | STAD | 1 |
| p.A1427T | HNSC | 1 |
| p.G3285E | SKCM | 1 |
| p.S2324L | SKCM | 1 |
| p.R782W | LUSC | 1 |
| p.S1508T | STAD | 1 |
| p.G3444E | SKCM | 1 |
| p.R4056K | SKCM | 1 |
| p.R1793C | HNSC | 1 |
| p.S1035C | HNSC | 1 |
| p.A920V | STAD | 1 |
| p.D2579H | BRCA | 1 |
| p.Q2183H | HNSC | 1 |
| p.D62N | SKCM | 1 |
| p.H4041N | UCEC | 1 |
| p.D241N | SKCM | 1 |
| p.G994S | DLBC | 1 |
| p.H1470Y | LUAD | 1 |
| p.H630Q | UCEC | 1 |
| p.G2429E | STAD | 1 |
| p.A3151S | STAD | 1 |
| p.S2470R | HNSC | 1 |
| p.H2294Q | TGCT | 1 |
| p.S1440A | LGG | 1 |
| p.G459V | LUAD | 1 |
| p.G1644R | LUAD | 1 |
| p.S1242C | BLCA | 1 |
| p.P2109S | SKCM | 1 |
| p.S1035Y | LUAD | 1 |
| p.Q3936L | LUAD | 1 |
| p.S3543N | SKCM | 1 |
| p.S3208G | UCEC | 1 |
| p.L2415N | LUAD | 1 |
| p.S2188R | LUAD | 1 |
| p.R312K | SKCM | 1 |
| p.W1064R | STAD | 1 |
| p.I2867S | STAD | 1 |
| p.E242D | COAD | 1 |
| p.E1023K | BLCA | 1 |
| p.S2107C | BLCA | 1 |
| p.H765N | LUAD | 1 |
| p.Q942K | LUAD | 1 |
| p.S906F | KIRC | 1 |
| p.R296I | LUAD | 1 |
| p.S2100Y | LGG | 1 |
| p.R412C | SKCM | 1 |
| p.V3243A | ESCA | 1 |
| p.R1656H | LGG | 1 |
| p.Q838K | LUAD | 1 |
| p.G3212R | BLCA | 1 |
| p.A1427T | GBM | 1 |
| p.Q1301K | HNSC | 1 |
| p.S2029C | KIRP | 1 |
| p.D3821V | SKCM | 1 |
| p.Q3755H | UCEC | 1 |
| p.S1676C | KIRC | 1 |
| p.H482R | THYM | 1 |
| p.A2770T | HNSC | 1 |
| p.D2784G | PAAD | 1 |
| p.R884S | LUAD | 1 |
| p.S1184L | COAD | 1 |
| p.S535L | SKCM | 1 |
| p.S2013* | LUAD | 1 |
| p.E3624K | BRCA | 1 |
| p.S535L | UCEC | 1 |
| p.Q3794* | HNSC | 1 |
| p.S2985T | BRCA | 1 |
| p.S3213F | SKCM | 1 |
| p.R1303G | STAD | 1 |
| p.K150E | COAD | 1 |
| p.R1781C | UCEC | 1 |
| p.G1678R | SKCM | 1 |
| p.S3781Y | LUAD | 1 |
| p.R1699H | GBM | 1 |
| p.S1453Y | THYM | 1 |
| p.H2592Y | SKCM | 1 |
| p.S530P | LUAD | 1 |
| p.R292C | BLCA | 1 |
| p.H3717N | UCEC | 1 |
| p.Q1266K | LUAD | 1 |
| p.G1988V | LUAD | 1 |
| p.S2126C | LUAD | 1 |
| p.V3355L | READ | 1 |
| p.S803Y | ESCA | 1 |
| p.Q1507* | UCEC | 1 |
| p.R711H | ESCA | 1 |
| p.D3190N | READ | 1 |
| p.R3706H | HNSC | 1 |
| p.V1833E | LIHC | 1 |
| p.K138N | SARC | 1 |
| p.H753L | HNSC | 1 |
| p.S1874L | SKCM | 1 |
| p.G139E | SKCM | 1 |
| p.H3393D | LUAD | 1 |
| p.H1037Q | LUAD | 1 |
| p.Q3431* | CESC | 1 |
| p.G1432E | SKCM | 1 |
| p.G2585V | LUAD | 1 |
| p.L2415I | LUAD | 1 |
| p.S2758I | BRCA | 1 |
| p.E3816Q | BLCA | 1 |
| p.S3613L | SKCM | 1 |
| p.H2802Q | LUSC | 1 |
| p.G2331E | SKCM | 1 |
| p.S2476Y | ESCA | 1 |
| p.S105I | UCEC | 1 |
| p.T581S | THCA | 1 |
| p.G1678E | SKCM | 1 |
| p.T2433A | GBM | 1 |
| p.S1874L | LUSC | 1 |
| p.N969Y | DLBC | 1 |
| p.L445V | STAD | 1 |
| p.S338Y | LUAD | 1 |
| p.R2839T | LUAD | 1 |
| p.G885W | LUAD | 1 |
| p.G3574C | LUAD | 1 |
| p.S2468* | STAD | 1 |
| p.P3529H | LUAD | 1 |
| p.H450Q | STAD | 1 |
| p.G2899E | SKCM | 1 |
| p.V1121A | LUSC | 1 |
| p.A2076T | DLBC | 1 |
| p.R3907H | PAAD | 1 |
| p.R2824S | LUAD | 1 |
| p.S544F | BLCA | 1 |
| p.G2475A | KIRC | 1 |
| p.S880Y | COAD | 1 |
| p.S2188G | ESCA | 1 |
| p.T581N | LUAD | 1 |
| p.R897C | COAD | 1 |
| p.S1592Y | OV | 1 |
| p.Q1084* | BLCA | 1 |
| p.D479H | BLCA | 1 |
| p.E2133K | SKCM | 1 |
| p.D1073N | SKCM | 1 |
| p.Q2551P | SKCM | 1 |
| p.Q2183H | LUSC | 1 |
| p.E3259K | PAAD | 1 |
| p.S1027* | HNSC | 1 |
| p.A3586T | UCEC | 1 |
| p.S743G | STAD | 1 |
| p.R1798Q | STAD | 1 |
| p.T581A | UVM | 1 |
| p.Q1790K | LIHC | 1 |
| p.E1887K | SKCM | 1 |
| p.D433E | LUAD | 1 |
| p.S1928L | HNSC | 1 |
| p.E1648Q | ESCA | 1 |
| p.G2564X | KIRP | 1 |
| p.R2221I | LUAD | 1 |
| p.S829F | UCEC | 1 |
| p.R3314X | STAD | 1 |
| p.H496Q | KIRC | 1 |
| p.Q715E | BLCA | 1 |
| p.G3085R | OV | 1 |
| p.R3314* | STAD | 1 |
| p.T550A | THCA | 1 |
| p.G2711R | CESC | 1 |
| p.D3432H | LUAD | 1 |
| p.E1601Q | LUAD | 1 |
| p.S2910F | SKCM | 1 |
| p.E2003Q | LUAD | 1 |
| p.G553E | SKCM | 1 |
| p.G2764E | SKCM | 1 |
| p.R501Q | LUAD | 1 |
| p.E2768Q | STAD | 1 |
| p.Q570K | STAD | 1 |
| p.P2067S | CHOL | 1 |
| p.S2497P | BRCA | 1 |
| p.G3528R | ESCA | 1 |
| p.Q3568H | LUSC | 1 |
| p.T2235I | ESCA | 1 |
| p.E1580K | SKCM | 1 |
| p.R1699H | ESCA | 1 |
| p.G3997R | SKCM | 1 |
| p.R2139C | SKCM | 1 |
| p.S2539T | STAD | 1 |
| p.S1056F | SKCM | 1 |
| p.S3160G | ESCA | 1 |
| p.L204R | ESCA | 1 |
| p.E3927K | SKCM | 1 |
| p.E2555X | STAD | 1 |
| p.T759A | UCEC | 1 |
| p.S2455T | LUSC | 1 |
| p.S1703L | SKCM | 1 |
| p.N3815Y | CESC | 1 |
| p.E1808G | PAAD | 1 |
| p.R293S | THYM | 1 |
| p.R1150* | PAAD | 1 |
| p.H1063Q | LUAD | 1 |
| p.E2254Q | BLCA | 1 |
| p.E3593K | BLCA | 1 |
| p.K39N | LUAD | 1 |
| p.Q1718* | SKCM | 1 |
| p.A3418S | LUAD | 1 |
| p.D2903N | GBM | 1 |
| p.S2777T | SARC | 1 |
| p.R3240C | UCEC | 1 |
| p.E452D | STAD | 1 |
| p.G2475* | LUAD | 1 |
| p.R3166H | HNSC | 1 |
| p.S829Y | LUAD | 1 |
| p.S3267F | CESC | 1 |
| p.P2067S | UCEC | 1 |
| p.G3123W | ESCA | 1 |
| p.G1809S | SKCM | 1 |
| p.R2259Q | UCEC | 1 |
| p.H2267L | LIHC | 1 |
| p.R1316T | BLCA | 1 |
| p.S1246I | STAD | 1 |
| p.S1844I | LUAD | 1 |
| p.R1651K | PRAD | 1 |
| p.H2050N | HNSC | 1 |
| p.G929V | DLBC | 1 |
| p.R782G | COAD | 1 |
| p.S2434R | LIHC | 1 |
| p.W326X | LIHC | 1 |
| p.D1893N | HNSC | 1 |
| p.E1471Q | LUAD | 1 |
| p.R1545T | BLCA | 1 |
| p.G954R | SKCM | 1 |
| p.S495L | ESCA | 1 |
| p.R961K | SKCM | 1 |
| p.S1889F | SKCM | 1 |
| p.R3409Q | HNSC | 1 |
| p.E189K | SKCM | 1 |
| p.E38K | SKCM | 1 |
| p.E218K | ACC | 1 |
| p.G2063R | SKCM | 1 |
| p.R3726W | SKCM | 1 |
| p.S1919I | STAD | 1 |
| p.S1615F | HNSC | 1 |
| p.E73Q | HNSC | 1 |
| p.G2471R | SKCM | 1 |
| p.E258K | SARC | 1 |
| p.G2232W | SKCM | 1 |
| p.Q3995E | CESC | 1 |
| p.S2793R | CESC | 1 |
| p.L2091F | SKCM | 1 |
| p.Q3865R | UCEC | 1 |
| p.D1690G | UCEC | 1 |
| p.S1215R | TGCT | 1 |
| p.S2836N | SARC | 1 |
| p.E1757K | SKCM | 1 |
| p.G1253X | DLBC | 1 |
| p.S316L | COAD | 1 |
| p.G441R | STAD | 1 |
| p.D3985H | LUSC | 1 |
| p.H3831Q | HNSC | 1 |
| p.G1760A | LUAD | 1 |
| p.R3477C | SKCM | 1 |
| p.G1143E | SKCM | 1 |
| p.H970N | LGG | 1 |
| p.E111K | BLCA | 1 |
| p.D3342N | SKCM | 1 |
| p.E2905K | BLCA | 1 |
| p.S3499C | CESC | 1 |
| p.R3445K | LUAD | 1 |
| p.S3850L | UCEC | 1 |
| p.G3303E | SKCM | 1 |
| p.R3210C | MESO | 1 |
| p.E2768A | STAD | 1 |
| p.D3492Y | OV | 1 |
| p.R789C | PAAD | 1 |
| p.S1676G | STAD | 1 |
| p.S406T | STAD | 1 |
| p.A595V | UCEC | 1 |
| p.G929S | SKCM | 1 |
| p.A3268V | UCEC | 1 |
| p.R971C | LUSC | 1 |
| p.F71C | ESCA | 1 |
| p.R2540W | STAD | 1 |
| p.G2228R | SKCM | 1 |
| p.S1539R | ESCA | 1 |
| p.K109E | BLCA | 1 |
| p.D2936G | CESC | 1 |
| p.H3400N | BLCA | 1 |
| p.S1515* | BRCA | 1 |
| p.R554S | LUAD | 1 |
| p.G1654S | SKCM | 1 |
| p.G3565E | SKCM | 1 |
| p.A3485V | KIRP | 1 |
| p.S1359T | HNSC | 1 |
| p.R1793C | UCEC | 1 |
| p.E252Q | BLCA | 1 |
| p.G769D | LUSC | 1 |
| p.H1033Q | LUAD | 1 |
| p.R1761H | LGG | 1 |
| p.R3435C | UCEC | 1 |
| p.G1030A | LUAD | 1 |
| p.S155I | LUAD | 1 |
| p.S2157L | BLCA | 1 |
| p.G1780R | SKCM | 1 |
| p.L1766F | SKCM | 1 |
| p.G2810V | HNSC | 1 |
| p.S156Y | UCEC | 1 |
| p.R203I | STAD | 1 |
| p.S3350X | ESCA | 1 |
| p.E6K | CESC | 1 |
| p.G3377E | SKCM | 1 |
| p.G2226D | LUSC | 1 |
| p.E915K | LUAD | 1 |
| p.G3587S | DLBC | 1 |
| p.E2905Q | BRCA | 1 |
| p.G2888E | KIRC | 1 |
| p.E511K | SKCM | 1 |
| p.P336R | SKCM | 1 |
| p.Q1362E | ESCA | 1 |
| p.D3921G | BRCA | 1 |
| p.G2049E | SKCM | 1 |
| p.Q1162E | BLCA | 1 |
| p.R3878K | SKCM | 1 |
| p.E3416K | BRCA | 1 |
| p.S1613L | BRCA | 1 |
| p.Q2174H | STAD | 1 |
| p.E1011Q | HNSC | 1 |
| p.G585E | THCA | 1 |
| p.H3581Y | LUSC | 1 |
| p.S3504L | LUAD | 1 |
| p.S2089A | UCEC | 1 |
| p.H2360Q | KIRC | 1 |
| p.G1143* | HNSC | 1 |
| p.R3111H | COAD | 1 |
| p.E1871K | SKCM | 1 |
| p.R2829S | LUAD | 1 |
| p.S2512R | STAD | 1 |
| p.Q818E | STAD | 1 |
| p.E899Q | HNSC | 1 |
| p.Q1162* | LUAD | 1 |
| p.R3435H | GBM | 1 |
| p.A1010P | BRCA | 1 |
| p.P3254H | PRAD | 1 |
| p.A3851V | SARC | 1 |
| p.G2226S | LUAD | 1 |
| p.G2240R | SKCM | 1 |
| p.Q3969R | STAD | 1 |
| p.D2460E | LUAD | 1 |
| p.S3180L | HNSC | 1 |
| p.R3409* | HNSC | 1 |
| p.E960K | LUAD | 1 |
| p.S1574* | BRCA | 1 |
| p.E1125K | HNSC | 1 |
| p.S127G | STAD | 1 |
| p.G846R | SKCM | 1 |
| p.P3762Q | LIHC | 1 |
| p.G1678R | COAD | 1 |
| p.T1262R | BLCA | 1 |
| p.S1852F | UCEC | 1 |
| p.G1875V | LUAD | 1 |
| p.R203K | SKCM | 1 |
| p.G1065R | SKCM | 1 |
| p.G3990R | BLCA | 1 |
| p.R319K | SKCM | 1 |
| p.E153K | SKCM | 1 |
| p.E3553Q | BLCA | 1 |
| p.S1977* | HNSC | 1 |
| p.S2262Y | LUAD | 1 |
| p.D3514E | PRAD | 1 |
| p.G3334W | STAD | 1 |
| p.S3540I | STAD | 1 |
| p.S3271C | CESC | 1 |
| p.G656S | SKCM | 1 |
| p.S787Y | LIHC | 1 |
| p.A4019V | THYM | 1 |
| p.P2142Q | HNSC | 1 |
| p.S2512G | STAD | 1 |
| p.S967F | SKCM | 1 |
| p.G3284R | LUAD | 1 |
| p.R1761C | STAD | 1 |
| p.R288G | UCEC | 1 |
| p.Q824* | SKCM | 1 |
| p.S2199L | SKCM | 1 |
| p.R3483S | OV | 1 |
| p.R782Q | BRCA | 1 |
| p.I1373T | SKCM | 1 |
| p.A3235T | PCPG | 1 |
| p.E2555A | COAD | 1 |
| p.G1464R | LUAD | 1 |
| p.S1939F | SKCM | 1 |
| p.R1369I | LUAD | 1 |
| p.H1885R | BRCA | 1 |
| p.F9V | LUSC | 1 |
| p.G2147R | STAD | 1 |
| p.G2412W | PRAD | 1 |
| p.A1019V | PRAD | 1 |
| p.E2308K | GBM | 1 |
| p.G2761E | SKCM | 1 |
| p.G1464R | LGG | 1 |
| p.G2823E | SKCM | 1 |
| p.R3382C | SARC | 1 |
| p.A1317D | LUAD | 1 |
| p.R3892Q | STAD | 1 |
| p.R197M | STAD | 1 |
| p.R683H | CESC | 1 |
| p.N1397K | GBM | 1 |
| p.R3907H | STAD | 1 |
| p.E2581D | LUAD | 1 |
| p.Q1201K | LUAD | 1 |
| p.G2151E | LUAD | 1 |
| p.H1532N | LUAD | 1 |
| p.A3279G | STAD | 1 |
| p.E3429D | KIRP | 1 |
| p.R2032X | READ | 1 |
| p.G1815E | ESCA | 1 |
| p.S3504L | COAD | 1 |
| p.R1987H | ESCA | 1 |
| p.D1315E | LUSC | 1 |
| p.P2109L | SKCM | 1 |
| p.A2189E | ESCA | 1 |
| p.G294R | SKCM | 1 |
| p.D340E | STAD | 1 |
| p.T1847M | LUSC | 1 |
| p.S1668L | SKCM | 1 |
| p.S2664N | BRCA | 1 |
| p.G174E | SKCM | 1 |
| p.H1681Y | BRCA | 1 |
| p.G2006R | ESCA | 1 |
| p.R2259Q | STAD | 1 |
| p.R343K | SKCM | 1 |
| p.S1269R | HNSC | 1 |
| p.D2201Y | LUAD | 1 |
| p.S1468F | SKCM | 1 |
| p.Q2154* | LUAD | 1 |
| p.S761T | KIRC | 1 |
| p.A3279T | HNSC | 1 |
| p.R3382C | UCEC | 1 |
| p.H497Q | OV | 1 |
| p.R2869G | STAD | 1 |
| p.D2784H | BRCA | 1 |
| p.S3460L | LUAD | 1 |
| p.S911L | UCS | 1 |
| p.A1689V | LUAD | 1 |
| p.H1960R | UCEC | 1 |
| p.D2936G | OV | 1 |
| p.G1724R | SKCM | 1 |
| p.S3737F | SKCM | 1 |
| p.E3604K | GBM | 1 |
| p.G2162A | LUAD | 1 |
| p.T1846N | ACC | 1 |
| p.H771Y | SKCM | 1 |
| p.H1332R | DLBC | 1 |
| p.G1756R | LUAD | 1 |
| p.E3849K | SKCM | 1 |
| p.R1791K | SKCM | 1 |
| p.R1712X | COAD | 1 |
| p.G1305S | BLCA | 1 |
| p.H2286Y | ESCA | 1 |
| p.S757X | THYM | 1 |
| p.G3123R | LUAD | 1 |
| p.S1257P | SKCM | 1 |
| p.E1608D | LUAD | 1 |
| p.R3829H | LUAD | 1 |
| p.Y18* | LIHC | 1 |
| p.R1221H | STAD | 1 |
| p.A1206T | OV | 1 |
| p.G888E | SKCM | 1 |
| p.R3121M | BRCA | 1 |
| p.G1629S | SKCM | 1 |
| p.R2018K | OV | 1 |
| p.R461W | BRCA | 1 |
| p.R3765G | LUAD | 1 |
| p.R2760T | BRCA | 1 |
| p.R130T | HNSC | 1 |
| p.R203T | BRCA | 1 |
| p.H2853Y | STAD | 1 |
| p.R2139S | LUAD | 1 |
| p.G1551E | SKCM | 1 |
| p.E2257Q | BLCA | 1 |
| p.R2829C | UCEC | 1 |
| p.R1610W | GBM | 1 |
| p.G2406E | SKCM | 1 |
| p.S1777Y | LUAD | 1 |
| p.R517C | PAAD | 1 |
| p.P1008L | SKCM | 1 |
| p.R2149K | LIHC | 1 |
| p.L469F | SKCM | 1 |
| p.R3270H | HNSC | 1 |
| p.R1135G | STAD | 1 |
| p.K103R | UCS | 1 |
| p.R2787C | SKCM | 1 |
| p.R3572K | SKCM | 1 |
| p.S1999P | PRAD | 1 |
| p.H3315P | LUAD | 1 |
| p.V3179L | SKCM | 1 |
| p.V1918A | SKCM | 1 |
| p.R3490C | READ | 1 |
| p.S1839P | STAD | 1 |
| p.E160K | SKCM | 1 |
| p.S1759Y | LUAD | 1 |
| p.R2430W | READ | 1 |
| p.G3968S | SKCM | 1 |
| p.G1756E | SKCM | 1 |
| p.S2912A | LUAD | 1 |
| p.G512D | SKCM | 1 |
| p.T1982K | LUSC | 1 |
| p.H1077Y | READ | 1 |
| p.G1877V | LUAD | 1 |
| p.H646N | UCEC | 1 |
| p.A2030E | BRCA | 1 |
| p.R912C | OV | 1 |
| p.R1589H | BLCA | 1 |
| p.S761L | SKCM | 1 |
| p.R2518C | STAD | 1 |
| p.G403R | LGG | 1 |
| p.E129D | UCEC | 1 |
| p.H1492R | BLCA | 1 |
| p.S2468X | STAD | 1 |
| p.S530F | UCEC | 1 |
| p.A920S | BRCA | 1 |
| p.H1843Q | LUAD | 1 |
| p.H3249Q | LIHC | 1 |
| p.D3108G | PAAD | 1 |
| p.E253Q | BLCA | 1 |
| p.R2410C | COAD | 1 |
| p.E574K | SKCM | 1 |
| p.S829* | LUAD | 1 |
| p.H645D | LUSC | 1 |
| p.R1428C | STAD | 1 |
| p.R1560H | BRCA | 1 |
| p.T1586K | LUSC | 1 |
| p.T2820I | SARC | 1 |
| p.G2782D | SKCM | 1 |
| p.T2785N | LUAD | 1 |
| p.D1151N | ESCA | 1 |
| p.H2505R | STAD | 1 |
| p.S2157L | GBM | 1 |
| p.R3240H | HNSC | 1 |
| p.A3750E | KIRP | 1 |
| p.S883C | LUAD | 1 |
| p.D921N | BLCA | 1 |
| p.S642F | SKCM | 1 |
| p.S1726* | HNSC | 1 |
| p.E2479A | BLCA | 1 |
| p.S1447Y | UCEC | 1 |
| p.E1547K | HNSC | 1 |
| p.R2500S | SKCM | 1 |
| p.G3223V | STAD | 1 |
| p.H2333N | LUAD | 1 |
| p.R2882M | COAD | 1 |
| p.E212Q | BLCA | 1 |
| p.G3943E | SKCM | 1 |
| p.S847P | CHOL | 1 |
| p.K182T | STAD | 1 |
| p.E218K | SKCM | 1 |
| p.D1205V | SKCM | 1 |
| p.T2840S | STAD | 1 |
| p.P1524H | LUAD | 1 |
| p.T3731I | HNSC | 1 |
| p.N537H | STAD | 1 |
| p.T3676A | UCEC | 1 |
| p.G403R | ACC | 1 |
| p.S2532L | LGG | 1 |
| p.V3198I | SKCM | 1 |
| p.I3944M | STAD | 1 |
| p.K1872E | STAD | 1 |
| p.R2473S | LUAD | 1 |
| p.E2098K | CESC | 1 |
| p.G2143R | ESCA | 1 |
| p.Q2551H | PRAD | 1 |
| p.D1324N | LUAD | 1 |
| p.G3805E | BLCA | 1 |
| p.G1915E | SKCM | 1 |
| p.H1208R | ESCA | 1 |
| p.E1125K | SKCM | 1 |
| p.Q1525R | COAD | 1 |
| p.V3198G | PAAD | 1 |
| p.D1799N | LUAD | 1 |
| p.D579Y | LUAD | 1 |
| p.D433H | LUAD | 1 |
| p.H388N | GBM | 1 |
| p.A1991V | ESCA | 1 |
| p.G1988* | LUAD | 1 |
| p.E1335* | LUAD | 1 |
| p.H1265N | HNSC | 1 |
| p.S1398R | STAD | 1 |
| p.R3240C | SKCM | 1 |
| p.G3471E | SKCM | 1 |
| p.R3118T | SKCM | 1 |
| p.S3175F | SKCM | 1 |
| p.E1728D | PAAD | 1 |
| p.E1659K | LGG | 1 |
| p.A1342V | SKCM | 1 |
| p.R1113S | BRCA | 1 |
| p.S2538A | COAD | 1 |
| p.R1793H | THYM | 1 |
| p.E2048K | SKCM | 1 |
| p.R3780T | KIRP | 1 |
| p.Q3293E | READ | 1 |
| p.E2905D | LUAD | 1 |
| p.E1433K | SKCM | 1 |
| p.S1898L | UCEC | 1 |
| p.A3513V | GBM | 1 |
| p.H1843D | BLCA | 1 |
| p.A350V | ACC | 1 |
| p.R3759C | UCEC | 1 |
| p.S998Y | LUSC | 1 |
| p.S1014F | SKCM | 1 |
| p.G1330D | LUSC | 1 |
| p.E2898K | SKCM | 1 |
| p.T2304I | UCEC | 1 |
| p.P2067T | STAD | 1 |
| p.S3659T | UCEC | 1 |
| p.D1324N | OV | 1 |
| p.Q650K | LUAD | 1 |
| p.R711C | SKCM | 1 |
| p.S2223L | SKCM | 1 |
| p.S3828L | STAD | 1 |
| p.G1372D | SKCM | 1 |
| p.E146K | SKCM | 1 |
| p.S1440P | HNSC | 1 |
| p.H3630Y | DLBC | 1 |
| p.R1814C | STAD | 1 |
| p.S2310F | SKCM | 1 |
| p.S2188C | LUAD | 1 |
| p.A3603G | SKCM | 1 |
| p.G3265R | HNSC | 1 |
| p.S1158C | LUSC | 1 |
| p.G483V | GBM | 1 |
| p.P3902L | UCEC | 1 |
| p.G3795R | SKCM | 1 |
| p.P2067H | LUAD | 1 |
| p.G888V | HNSC | 1 |
| p.G3977D | LGG | 1 |
| p.A2307G | SKCM | 1 |
| p.D3311H | LUAD | 1 |
| p.R3699Q | STAD | 1 |
| p.K159X | SKCM | 1 |
| p.E1962K | SKCM | 1 |
| p.G2436E | SKCM | 1 |
| p.E3753D | BLCA | 1 |
| p.R1527W | SKCM | 1 |
| p.R1036C | LGG | 1 |
| p.R2842L | LUAD | 1 |
| p.H1099N | LUAD | 1 |
| p.A3910D | SARC | 1 |
| p.R903T | HNSC | 1 |
| p.R1003G | THYM | 1 |
| p.S2208L | READ | 1 |
| p.H2286Q | STAD | 1 |
| p.S2560T | MESO | 1 |
| p.G865V | COAD | 1 |
| p.D3329E | LUAD | 1 |
| p.R1700T | COAD | 1 |
| p.G1234E | SKCM | 1 |
| p.A2964T | CESC | 1 |
| p.D3868G | UCEC | 1 |
| p.R3240H | ESCA | 1 |
| p.E2328K | LUAD | 1 |
| p.S3232F | ESCA | 1 |
| p.P2790T | LUAD | 1 |
| p.R1133W | BLCA | 1 |
| p.T1164P | STAD | 1 |
| p.R788Q | COAD | 1 |
| p.S1539R | SARC | 1 |
| p.D3218E | LUAD | 1 |
| p.S3777L | SKCM | 1 |
| p.G2545A | UCEC | 1 |
| p.E3416K | SKCM | 1 |
| p.R1469L | COAD | 1 |
| p.H822N | KIRP | 1 |
| p.S1043N | SKCM | 1 |
| p.G1741V | LUAD | 1 |
| p.G3948C | LUAD | 1 |
| p.D1811Y | LIHC | 1 |
| p.G3702E | SKCM | 1 |
| p.H3783Y | LUAD | 1 |
| p.D1639N | LUAD | 1 |
| p.R402S | UCEC | 1 |
| p.G2278V | LUAD | 1 |
| p.S3242F | HNSC | 1 |
| p.E40Q | CESC | 1 |
| p.E2212D | STAD | 1 |
| p.R3892Q | OV | 1 |
| p.E1830Q | LUSC | 1 |
| p.G2564* | KIRP | 1 |
| p.G2464E | SKCM | 1 |
| p.D3875Y | BRCA | 1 |
| p.N3534Y | KIRC | 1 |
| p.G1579R | SKCM | 1 |
| p.S1371A | KIRC | 1 |
| p.S324P | LIHC | 1 |
| p.H3505Y | ESCA | 1 |
| p.R1172K | SKCM | 1 |
| p.H771N | LUSC | 1 |
| p.R1218T | HNSC | 1 |
| p.Q1914* | UCEC | 1 |
| p.R1610Q | STAD | 1 |
| p.G3447E | SKCM | 1 |
| p.E242K | SKCM | 1 |
| p.E915K | SKCM | 1 |
| p.P3902H | GBM | 1 |
| p.R2403W | LGG | 1 |
| p.G1108E | BLCA | 1 |
| p.S2501F | SKCM | 1 |
| p.G2081R | LUSC | 1 |
| p.P1742H | BLCA | 1 |
| p.G1536A | BLCA | 1 |
| p.G466V | GBM | 1 |
| p.E1079X | COAD | 1 |
| p.F2414S | SKCM | 1 |
| p.R134T | LUAD | 1 |
| p.R842C | SKCM | 1 |
| p.S495L | UCEC | 1 |
| p.E2521K | CESC | 1 |
| p.S3861F | STAD | 1 |
| p.S2190R | READ | 1 |
| p.G3728V | STAD | 1 |
| p.K142M | BRCA | 1 |
| p.S2161C | LIHC | 1 |
| p.D2542N | SKCM | 1 |
| p.Q942R | LUAD | 1 |
| p.R890K | CESC | 1 |
| p.R1360C | HNSC | 1 |
| p.T2454M | UCEC | 1 |
| p.Q2069* | CESC | 1 |
| p.E3280Q | HNSC | 1 |
| p.S2565Y | KIRC | 1 |
| p.S1274R | SKCM | 1 |
| p.S3891F | SARC | 1 |
| p.N176K | STAD | 1 |
| p.G1882E | LUAD | 1 |
| p.H3788Q | LUAD | 1 |
| p.D2218E | CESC | 1 |
| p.Q602* | UCEC | 1 |
| p.R2239L | SKCM | 1 |
| p.G3827W | LUAD | 1 |
| p.E3184K | BLCA | 1 |
| p.H775N | LUAD | 1 |
| p.S3891A | STAD | 1 |
| p.R484W | COAD | 1 |
| p.R1980S | LUSC | 1 |
| p.H1009D | DLBC | 1 |
| p.R2842H | HNSC | 1 |
| p.R3210C | OV | 1 |
| p.R992K | CESC | 1 |
| p.R740Q | HNSC | 1 |
| p.Y18X | LIHC | 1 |
| p.S3862R | LUSC | 1 |
| p.R1712X | PAAD | 1 |
| p.R2540W | COAD | 1 |
| p.Q3969K | LUAD | 1 |
| p.R2885W | LAML | 1 |
| p.G2002E | SKCM | 1 |
| p.S2577* | LUSC | 1 |
| p.S1268Y | STAD | 1 |
| p.R3193G | SKCM | 1 |
| p.S2249T | PRAD | 1 |
| p.R1987L | LUAD | 1 |
| p.S1257L | SKCM | 1 |
| p.S3764* | HNSC | 1 |
| p.R3947C | LUAD | 1 |
| p.R1761H | READ | 1 |
| p.H1077Y | COAD | 1 |
| p.R1469H | HNSC | 1 |
| p.R1987H | LGG | 1 |
| p.E327K | SKCM | 1 |
| p.S3700L | CESC | 1 |
| p.K159* | SKCM | 1 |
| p.G2148R | LGG | 1 |
| p.R1036H | OV | 1 |
| p.A1582V | PAAD | 1 |
| p.T725I | DLBC | 1 |
| p.R2410H | UCEC | 1 |
| p.G305E | BLCA | 1 |
| p.D3985N | SKCM | 1 |
| p.D3131E | LIHC | 1 |
| p.S1107* | LUAD | 1 |
| p.Q2115* | ESCA | 1 |
| p.D1799Y | LGG | 1 |
| p.D3474H | UCEC | 1 |
| p.H2306Y | SKCM | 1 |
| p.E2422K | SKCM | 1 |
| p.D433Y | STAD | 1 |
| p.E3775* | LUSC | 1 |
| p.Q1256K | KIRC | 1 |
| p.Q650K | KIRC | 1 |
| p.W227* | HNSC | 1 |
| p.A1658V | SKCM | 1 |
| p.R3554S | ACC | 1 |
| p.R3530K | SKCM | 1 |
| p.K1224E | ESCA | 1 |
| p.E6K | SKCM | 1 |
| p.E2052* | LUSC | 1 |
| p.R484P | LUSC | 1 |
| p.V2806A | LUAD | 1 |
| p.G2432R | PAAD | 1 |
| p.S3891F | SKCM | 1 |
| p.K39N | OV | 1 |
| p.R3878W | LUAD | 1 |
| p.R3382H | COAD | 1 |
| p.D2053E | HNSC | 1 |
| p.H1333D | SKCM | 1 |
| p.A1990D | SARC | 1 |
| p.D2120G | BLCA | 1 |
| p.G3725* | SKCM | 1 |
| p.G1569S | SKCM | 1 |
| p.E202* | LUAD | 1 |
| p.Q3735R | UCEC | 1 |
| p.S1550* | GBM | 1 |
| p.S1653L | LIHC | 1 |
| p.S702* | LUSC | 1 |
| p.R1051C | LUAD | 1 |
| p.R740G | LIHC | 1 |
| p.Q2474E | BRCA | 1 |
| p.Q1831K | KIRP | 1 |
| p.A1057E | ESCA | 1 |
| p.S4012Y | UCEC | 1 |
| p.S3938Y | UCEC | 1 |
| p.R42W | READ | 1 |
| p.H1618N | CESC | 1 |
| p.G3439V | LUAD | 1 |
| p.P1817S | LUAD | 1 |
| p.V2243F | STAD | 1 |
| p.G174R | SKCM | 1 |
| p.S1855F | SKCM | 1 |
| p.S3915Y | STAD | 1 |
| p.A405G | HNSC | 1 |
| p.E2048D | LUAD | 1 |
| p.G705E | STAD | 1 |
| p.Q3170K | LUAD | 1 |
| p.H2334Q | LUAD | 1 |
| p.T1488N | DLBC | 1 |
| p.P660H | LUSC | 1 |
| p.R1236C | GBM | 1 |
| p.S1055L | SKCM | 1 |
| p.S2510T | LUAD | 1 |
| p.A768V | GBM | 1 |
| p.D1599E | GBM | 1 |
| p.H3128N | LUSC | 1 |
| p.R3320C | BRCA | 1 |
| p.D2178N | BRCA | 1 |
| p.Q1590R | SKCM | 1 |
| p.S3904F | SKCM | 1 |
| p.G2823E | LUSC | 1 |
| p.G3119E | SARC | 1 |
| p.S1191T | BLCA | 1 |
| p.V1918F | COAD | 1 |
| p.A2044T | SKCM | 1 |
| p.A3268E | STAD | 1 |
| p.E1995K | SKCM | 1 |
| p.Q368E | KIRC | 1 |
| p.R2787H | SKCM | 1 |
| p.S2586P | UCEC | 1 |
| p.S963Y | UCEC | 1 |
| p.H3278Y | LUAD | 1 |
| p.R3410* | KIRC | 1 |
| p.E2845G | STAD | 1 |
| p.G3587C | UCEC | 1 |
| p.K1222N | ESCA | 1 |
| p.H2915N | LUSC | 1 |
| p.S2413F | SKCM | 1 |
| p.G221E | SKCM | 1 |
| p.S88Y | GBM | 1 |
| p.G2437* | SKCM | 1 |
| p.R971C | SKCM | 1 |
| p.S1733L | SKCM | 1 |
| p.S2836N | GBM | 1 |
| p.H770Y | SKCM | 1 |
| p.E258K | SKCM | 1 |
| p.A344V | STAD | 1 |
| p.Q1266H | GBM | 1 |
| p.G3471V | SKCM | 1 |
| p.K142N | HNSC | 1 |
| p.R412C | READ | 1 |
| p.G1644R | COAD | 1 |
| p.H1772D | HNSC | 1 |
| p.G3768E | SKCM | 1 |
| p.S3915C | BLCA | 1 |
| p.E3893* | GBM | 1 |
| p.S1539R | LUAD | 1 |
| p.R1110M | LUAD | 1 |
| p.Q3366E | HNSC | 1 |
| p.S566R | ESCA | 1 |
| p.Q1670K | LUAD | 1 |
| p.T2495I | SKCM | 1 |
| p.N3534S | KIRC | 1 |
| p.S1937C | CESC | 1 |
| p.D2772E | BLCA | 1 |
| p.A1130V | COAD | 1 |
| p.S805F | SKCM | 1 |
| p.S2912C | ESCA | 1 |
| p.R817T | BLCA | 1 |
| p.S2765C | BLCA | 1 |
| p.G3795E | SKCM | 1 |
| p.G2795R | HNSC | 1 |
| p.G2113E | SKCM | 1 |
| p.S2199* | HNSC | 1 |
| p.E327X | LIHC | 1 |
| p.G1175E | SKCM | 1 |
| p.G3802R | SKCM | 1 |
| p.R740L | LUAD | 1 |
| p.S365Y | LUSC | 1 |
| p.P3254H | LUAD | 1 |
| p.S3828L | SKCM | 1 |
| p.R1236H | BRCA | 1 |
| p.G2552E | HNSC | 1 |
| p.R366H | BLCA | 1 |
| p.G2440A | LUAD | 1 |
| p.G2175E | SKCM | 1 |
| p.R3885I | LUAD | 1 |
| p.Q2780X | SKCM | 1 |
| p.H3825R | UCEC | 1 |
| p.R1560C | COAD | 1 |
| p.Q2712H | UCEC | 1 |
| p.R343K | HNSC | 1 |
| p.G1494R | LUAD | 1 |
| p.R3375W | DLBC | 1 |
| p.E2425V | LUAD | 1 |
| p.R1567W | OV | 1 |
| p.A1946V | LIHC | 1 |
| p.Q451K | LUAD | 1 |
| p.D3985N | BLCA | 1 |
| p.E1727K | HNSC | 1 |
| p.H3830R | STAD | 1 |
| p.G1526R | SKCM | 1 |
| p.E575K | SKCM | 1 |
| p.G2232V | LIHC | 1 |
| p.G1229C | LUAD | 1 |
| p.R134K | SKCM | 1 |
| p.F3991Y | LUAD | 1 |
| p.R3402Q | SKCM | 1 |
| p.H104Y | READ | 1 |
| p.D781G | LUAD | 1 |
| p.E2287K | SKCM | 1 |
| p.E2273K | SKCM | 1 |
| p.D64H | CESC | 1 |
| p.R3402Q | LUAD | 1 |
| p.R1221C | UCEC | 1 |
| p.S609* | BRCA | 1 |
| p.K39N | PRAD | 1 |
| p.S1434R | KIRC | 1 |
| p.R2857C | STAD | 1 |
| p.A768D | LIHC | 1 |
| p.G1414E | SKCM | 1 |
| p.L3711P | LGG | 1 |
| p.R3153C | UCEC | 1 |
| p.R786M | LUSC | 1 |
| p.G3846S | GBM | 1 |
| p.S829P | LUAD | 1 |
| p.R3410X | KIRC | 1 |
| p.S1271I | LUAD | 1 |
| p.S3484N | SKCM | 1 |
| p.Q1732* | UCEC | 1 |
| p.S3178L | SKCM | 1 |
| p.S2497F | SKCM | 1 |
| p.E1580Q | BLCA | 1 |
| p.S141F | BLCA | 1 |
| p.E32Q | BLCA | 1 |
| p.G2088E | SKCM | 1 |
| p.S3350* | ESCA | 1 |
| p.R1987H | UCEC | 1 |
| p.A1946T | UCS | 1 |
| p.S2532L | BRCA | 1 |
| p.S2157L | LIHC | 1 |
| p.H532N | LUAD | 1 |
| p.G1840R | SKCM | 1 |
| p.S3469Y | LUAD | 1 |
| p.S3236F | SKCM | 1 |
| p.H3957N | UCS | 1 |
| p.P985R | HNSC | 1 |
| p.Y3388H | LUAD | 1 |
| p.R782L | LUAD | 1 |
| p.Q2456K | LUAD | 1 |
| p.G3334E | COAD | 1 |
| p.E1995Q | BLCA | 1 |
| p.Q2115X | ESCA | 1 |
| p.G1174E | SKCM | 1 |
| p.S1621F | UCEC | 1 |
| p.A3513V | STAD | 1 |
| p.G2349E | SKCM | 1 |
| p.R292H | GBM | 1 |
| p.Q3428E | BLCA | 1 |
| p.S3297I | READ | 1 |
| p.E189V | PAAD | 1 |
| p.K150E | UCEC | 1 |
| p.R2533H | STAD | 1 |
| p.G2063E | SKCM | 1 |
| p.S1298F | HNSC | 1 |
| p.S3935P | DLBC | 1 |
| p.S1970C | CESC | 1 |
| p.S1832W | LUAD | 1 |
| p.R3814H | LUSC | 1 |
| p.R2561S | HNSC | 1 |
| p.T3813A | STAD | 1 |
| p.G1678A | LUAD | 1 |
| p.E1612Q | LUAD | 1 |
| p.S3117I | LUSC | 1 |
| p.Q3307K | LIHC | 1 |
| p.A2271S | HNSC | 1 |
| p.S480P | LGG | 1 |
| p.K159E | LIHC | 1 |
| p.G1400R | SKCM | 1 |
| p.R788G | STAD | 1 |
| p.H482Q | SKCM | 1 |
| p.R3305H | LAML | 1 |
| p.G413R | STAD | 1 |
| p.G1358R | SKCM | 1 |
| p.Q3713L | LUAD | 1 |
| p.E3092K | SKCM | 1 |
| p.S1890F | SKCM | 1 |
| p.R1166C | READ | 1 |
| p.R1567L | HNSC | 1 |
| p.R538T | UCEC | 1 |
| p.Q1625* | UCEC | 1 |
| p.P2466Q | LUAD | 1 |
| p.G2782S | STAD | 1 |
| p.S3174G | READ | 1 |
| p.E2425D | BRCA | 1 |
| p.Q1949P | LUAD | 1 |
| p.G629E | SKCM | 1 |
| p.E2768K | SKCM | 1 |
| p.G2185E | SKCM | 1 |
| p.S3891A | COAD | 1 |
| p.E3259K | SKCM | 1 |
| p.S1898L | KIRC | 1 |
| p.Q3217H | STAD | 1 |
| p.S2586F | STAD | 1 |
| p.P2238A | STAD | 1 |
| p.G3263D | LUAD | 1 |
| p.R788Q | STAD | 1 |
| p.E1452Q | HNSC | 1 |
| p.Q1701K | HNSC | 1 |
| p.S2854A | HNSC | 1 |
| p.G3481E | SKCM | 1 |
| p.S2547L | GBM | 1 |
| p.G1358R | LUAD | 1 |
| p.Q2474K | THYM | 1 |
| p.R683C | SKCM | 1 |
| p.G585R | SKCM | 1 |
| p.L1943F | SKCM | 1 |
| p.S1832L | STAD | 1 |
| p.S438L | LUAD | 1 |
| p.W1064* | STAD | 1 |
| p.G2795V | HNSC | 1 |
| p.G2552R | SKCM | 1 |
| p.G2475A | BLCA | 1 |
| p.E1255D | BLCA | 1 |
| p.E3370Q | LUSC | 1 |
| p.E1723K | SKCM | 1 |
| p.S2708L | CESC | 1 |
| p.G2813E | HNSC | 1 |
| p.Q3713H | LUAD | 1 |
| p.A3279T | UCEC | 1 |
| p.I4045K | UCEC | 1 |
| p.Q1301L | HNSC | 1 |
| p.W3503* | SKCM | 1 |
| p.R3270H | LIHC | 1 |
| p.R1303G | LUAD | 1 |
| p.P2142L | STAD | 1 |
| p.E2844D | STAD | 1 |
| p.H2210N | COAD | 1 |
| p.R412C | STAD | 1 |
| p.S2302* | BLCA | 1 |
| p.S1496R | LUAD | 1 |
| p.S1274N | SKCM | 1 |
| p.H1803Y | UCEC | 1 |
| p.S3296* | STAD | 1 |
| p.Q1904K | LUSC | 1 |
| p.G935W | PRAD | 1 |
| p.A3279T | STAD | 1 |
| p.H1519Y | BRCA | 1 |
| p.S710F | SKCM | 1 |
| p.R3435C | SKCM | 1 |
| p.R3373H | PAAD | 1 |
| p.E35K | SKCM | 1 |
| p.Q1004K | LUAD | 1 |
| p.S3205P | LUAD | 1 |
| p.R1036S | LUAD | 1 |
| p.S1557L | BLCA | 1 |
| p.Q628E | LUAD | 1 |
| p.G2880W | LUAD | 1 |
| p.S417C | LUAD | 1 |
| p.R2401C | UCEC | 1 |
| p.D2460N | SKCM | 1 |
| p.S1642T | HNSC | 1 |
| p.S3101* | HNSC | 1 |
| p.S662F | SKCM | 1 |
| p.A1736V | UCEC | 1 |
| p.G323V | LUAD | 1 |
| p.A1689P | HNSC | 1 |
| p.S1539R | READ | 1 |
| p.H1816R | PAAD | 1 |
| p.G2585W | LUAD | 1 |
| p.S1291F | SKCM | 1 |
| p.T2454M | READ | 1 |
| p.R788Q | LGG | 1 |
| p.S3935X | READ | 1 |
| p.L2415H | LUAD | 1 |
| p.G1788E | SKCM | 1 |
| p.R3814H | DLBC | 1 |
| p.G1860E | SKCM | 1 |
| p.S154C | LUAD | 1 |
| p.E3881Q | BLCA | 1 |
| p.W227C | UCEC | 1 |
| p.G3948C | GBM | 1 |
| p.R912C | READ | 1 |
| p.N4033S | STAD | 1 |
| p.G2207R | BLCA | 1 |
| p.E2844K | SKCM | 1 |
| p.G905V | LUAD | 1 |
| p.G1485D | SKCM | 1 |
| p.H1843Y | SKCM | 1 |
| p.S2275P | LUAD | 1 |
| p.S2220P | SARC | 1 |
| p.H989Y | STAD | 1 |
| p.S620I | LUAD | 1 |
| p.E1983K | SKCM | 1 |
| p.A1473G | HNSC | 1 |
| p.H2396R | LIHC | 1 |
| p.G2799R | SKCM | 1 |
| p.P1677A | HNSC | 1 |
| p.G3645R | SKCM | 1 |
| p.R1712* | PAAD | 1 |
| p.E3753D | PRAD | 1 |
| p.D836N | LUAD | 1 |
| p.S436* | CESC | 1 |
| p.H2024Y | LIHC | 1 |
| p.S4046L | COAD | 1 |
| p.H1942N | LUAD | 1 |
| p.V3863F | LUAD | 1 |
| p.S1806A | HNSC | 1 |
| p.S3495L | STAD | 1 |
| p.G1467E | SKCM | 1 |
| p.E3753D | LUAD | 1 |
| p.Q2780* | SKCM | 1 |
| p.G2207A | LUSC | 1 |
| p.S872R | SKCM | 1 |
| p.S3665T | OV | 1 |
| p.G994D | OV | 1 |
| p.S3899C | LUAD | 1 |
| p.E40D | KIRC | 1 |
| p.S2129P | GBM | 1 |
| p.G3265W | PAAD | 1 |
| p.H697N | GBM | 1 |
| p.S1792F | SARC | 1 |
| p.E2555* | STAD | 1 |
| p.G540E | SKCM | 1 |
| p.G1857E | SKCM | 1 |
| p.G629E | HNSC | 1 |
| p.R1437H | COAD | 1 |
| p.N254Y | SKCM | 1 |
| p.G1267R | SKCM | 1 |
| p.S1570G | LUAD | 1 |
| p.R2533H | GBM | 1 |
| p.G1432V | ACC | 1 |
| p.S1001N | SKCM | 1 |
| p.S1704C | BLCA | 1 |
| p.D675H | BLCA | 1 |
| p.R501Q | SKCM | 1 |
| p.Q2771R | STAD | 1 |
| p.G1090E | ESCA | 1 |
| p.Q2459E | BLCA | 1 |
| p.S1704Y | LIHC | 1 |
| p.Q767H | STAD | 1 |
| p.R1299Q | STAD | 1 |
| p.H2802Y | LUAD | 1 |
| p.Q3684* | UCEC | 1 |
| p.S1535* | BLCA | 1 |
| Top |
| TissGeneCNV for FLG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for FLG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for FLG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (tumor) | FLG, CSNK2A1, CUL2, KIAA0101, FOS, VHL, USP1, UCHL5, PCSK6, F9 (normal) |
 |  |
| Top |
| TissGeneProg for FLG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for FLG |
| TissGeneDrug for FLG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for FLG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011615 | Dermatitis, Atopic | 183 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0013595 | Eczema | 180 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0079584 | Ichthyosis Vulgaris | 57 | BeFree,CLINVAR,CTD_human,GAD,LHGDN |
| umls:C0004096 | Asthma | 41 | BeFree,GAD,LHGDN |
| umls:C0037274 | Dermatologic disorders | 17 | BeFree |
| umls:C3539909 | Allergic disposition | 17 | BeFree |
| umls:C0011603 | Dermatitis | 11 | BeFree |
| umls:C3662483 | Allergic sensitization | 9 | BeFree |
| umls:C0151908 | Dry skin | 8 | BeFree |
| umls:C0239816 | Hand eczema | 8 | BeFree |
| umls:C0033860 | Psoriasis | 7 | BeFree,GAD,LHGDN |
| umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 7 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 7 | BeFree |
| umls:C0079588 | Ichthyosis, X-Linked | 6 | BeFree,LHGDN |
| umls:C0264408 | Childhood asthma | 6 | BeFree |
| umls:C2720163 | Placental Steroid Sulfatase Deficiency | 6 | BeFree |
| umls:C0018621 | Hay fever | 5 | BeFree,GAD |
| umls:C0155877 | Allergic asthma | 5 | BeFree |
| umls:C0162820 | Dermatitis, Allergic Contact | 5 | BeFree,GAD |
| umls:C0162823 | Dermatitis, Irritant | 5 | BeFree,GAD |
| umls:C0259817 | Xerosis | 5 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 4 | BeFree,GAD,LHGDN |
| umls:C0020523 | Immediate hypersensitivity | 4 | GAD |
| umls:C0020757 | Ichthyoses | 4 | BeFree,GAD |
| umls:C0020758 | Congenital ichthyosis | 4 | BeFree |
| umls:C0559470 | Allergy to peanuts | 4 | BeFree |
| umls:C0263361 | Psoriasis vulgaris | 3 | BeFree |
| umls:C0263383 | Keratosis pilaris | 3 | BeFree |
| umls:C0265962 | Ichthyosis linearis circumflexa | 3 | BeFree |
| umls:C0476227 | pricking of skin | 3 | BeFree |
| umls:C0477474 | Dermatitis and eczema | 3 | GAD |
| umls:C0002171 | Alopecia Areata | 2 | BeFree,LHGDN |
| umls:C0002873 | Anemia of chronic disease | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0011616 | Contact Dermatitis | 2 | BeFree,CTD_human |
| umls:C0014522 | Epidermodysplasia Verruciformis | 2 | BeFree |
| umls:C0018567 | Hand Dermatoses | 2 | GAD |
| umls:C0020517 | Hypersensitivity | 2 | GAD |
| umls:C0035455 | Rhinitis | 2 | BeFree |
| umls:C0079154 | Congenital Nonbullous Ichthyosiform Erythroderma | 2 | BeFree |
| umls:C0341106 | Eosinophilic esophagitis | 2 | BeFree |
| umls:C0936250 | Eczema Herpeticum | 2 | BeFree |
| umls:C1275685 | Avellino corneal dystrophy | 2 | BeFree |
| umls:C1276071 | Childhood atopic dermatitis | 2 | BeFree |
| umls:C1304345 | Occupational irritant contact dermatitis | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C0003872 | Arthritis, Psoriatic | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0016470 | Food Allergy | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree,GAD |
| umls:C0022504 | Kaposi Varicelliform Eruption | 1 | GAD |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023652 | Lichen Sclerosus et Atrophicus | 1 | BeFree |
| umls:C0028796 | Dermatitis, Occupational | 1 | GAD |
| umls:C0037278 | Skin Diseases, Infectious | 1 | BeFree |
| umls:C0038218 | Status Asthmaticus | 1 | BeFree |
| umls:C0041834 | Erythema | 1 | BeFree |
| umls:C0042109 | Urticaria | 1 | BeFree |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0043144 | Wheezing | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0085129 | Bronchial Hyperreactivity | 1 | GAD |
| umls:C0162627 | Skin Diseases, Bacterial | 1 | BeFree |
| umls:C0262974 | Subacute dermatitis | 1 | BeFree |
| umls:C0263224 | Flexural atopic dermatitis | 1 | BeFree |
| umls:C0263454 | Chloracne | 1 | BeFree |
| umls:C0265334 | Pachyonychia Congenita | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0343641 | Human papilloma virus infection | 1 | BeFree |
| umls:C0344183 | Exercise anaphylaxis | 1 | BeFree |
| umls:C0474892 | Inherited disorder of keratinization | 1 | BeFree |
| umls:C0475811 | Disorder of keratinization | 1 | BeFree |
| umls:C0497391 | atopic eczema/dermatitis (non-specific) | 1 | BeFree |
| umls:C0577627 | Metal allergy | 1 | BeFree |
| umls:C0578870 | Chronic idiopathic urticaria | 1 | BeFree |
| umls:C0586407 | Skin symptom | 1 | BeFree |
| umls:C0850803 | Anaphylaxis (non medication) | 1 | BeFree |
| umls:C1276092 | Chronic hand eczema | 1 | BeFree |
| umls:C1304136 | Onset of psoriasis in childhood (1-10 years) | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C2717836 | Steroid Sulfatase Deficiency Disease | 1 | BeFree |
| umls:C1853965 | Dermatitis, Atopic, 2 | 0 | CLINVAR,CTD_human |
| umls:C1864155 | Dermatitis, Atopic, 1 | 0 | CTD_human |
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