TissGeneSummary for METAP1 |
Gene summary |
Basic gene information | Gene symbol | METAP1 |
Gene name | methionyl aminopeptidase 1 | |
Synonyms | MAP1A|MetAP1A | |
Cytomap | UCSC genome browser: 4q23 | |
Type of gene | protein-coding | |
RefGenes | NM_015143.2, | |
Description | MAP 1metAP 1methionine aminopeptidase 1peptidase M 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610151 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164024 | ||
HPRD : 10071 | ||
Vega : OTTHUMG00000161231 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_METAP1 | |
BioGPS: 23173 | ||
Pathway | NCI Pathway Interaction Database: METAP1 | |
KEGG: METAP1 | ||
REACTOME: METAP1 | ||
Pathway Commons: METAP1 | ||
Context | iHOP: METAP1 | |
ligand binding site mutation search in PubMed: METAP1 | ||
UCL Cancer Institute: METAP1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of METAP1 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for METAP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 2.470249276 | 1.338986531 | 1.131262745 | 1.13E-17 | 9.90E-17 |
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TissGene-miRNA for METAP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-410-3p | MIMAT0002171 | 0.025 | -0.3 | 60 |
UVM | hsa-miR-26a-5p | MIMAT0000082 | 0.0037 | -0.32 | 80 |
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TissGeneMut for METAP1 |
TissGeneSNV for METAP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R140* | STAD | 2 |
p.R140Q | UCEC | 2 |
p.R140X | STAD | 2 |
p.M329V | UCEC | 2 |
p.Q127E | BLCA | 1 |
p.H301Y | SKCM | 1 |
p.G334R | LUAD | 1 |
p.E148K | LUAD | 1 |
p.D12G | UCEC | 1 |
p.D231Y | BRCA | 1 |
p.V306A | UCEC | 1 |
p.L362R | LUSC | 1 |
p.R88I | MESO | 1 |
p.R246Q | UCEC | 1 |
p.R268L | SKCM | 1 |
p.R289Q | UCEC | 1 |
p.P328S | UCEC | 1 |
p.R268Q | STAD | 1 |
p.M139I | LUSC | 1 |
p.A169T | STAD | 1 |
p.S132L | ESCA | 1 |
p.G334R | UCEC | 1 |
p.P328S | THYM | 1 |
p.E148* | UCEC | 1 |
p.R379W | ESCA | 1 |
p.R289Q | COAD | 1 |
p.S384F | PAAD | 1 |
p.R140P | LUAD | 1 |
p.I157N | SKCM | 1 |
p.E369Q | BLCA | 1 |
p.E70X | KIRC | 1 |
p.A280V | PAAD | 1 |
p.D376H | HNSC | 1 |
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TissGeneCNV for METAP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for METAP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW352239 | PERP-METAP1 | chr6:138412275 | chr4:99983432 |
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TissGeneNet for METAP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for METAP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for METAP1 |
TissGeneDrug for METAP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for METAP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0030524 | Paratuberculosis | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C3887873 | Hearing Loss | 1 | GAD |