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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FMO2
check button Gene summary
Basic gene informationGene symbolFMO2
Gene nameflavin containing monooxygenase 2 (non-functional)
SynonymsFMO1B1
CytomapUCSC genome browser: 1q24.3
Type of geneprotein-coding
RefGenesNM_001301347.1,
NM_001460.4,
DescriptionFMO, pulmonarydimethylaniline monooxygenase [N-oxide-forming] 2dimethylaniline oxidase 2pulmonary flavin-containing monooxygenase 2
Modification date20141207
dbXrefs MIM : 603955
HGNC : HGNC
HPRD : 04903
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FMO2
BioGPS: 2327
PathwayNCI Pathway Interaction Database: FMO2
KEGG: FMO2
REACTOME: FMO2
Pathway Commons: FMO2
ContextiHOP: FMO2
ligand binding site mutation search in PubMed: FMO2
UCL Cancer Institute: FMO2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Lung
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LUAD,LUSC
Reference showing the relevant tissue of FMO2
Description by TissGene annotationsHave significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006082organic acid metabolic process11744609
GO:0006739NADP metabolic process11744609
GO:0006805xenobiotic metabolic process11744609
GO:0009404toxin metabolic process11744609
GO:0017144drug metabolic process11744609
GO:0070995NADPH oxidation15144220
GO:0006082organic acid metabolic process11744609
GO:0006739NADP metabolic process11744609
GO:0006805xenobiotic metabolic process11744609
GO:0009404toxin metabolic process11744609
GO:0017144drug metabolic process11744609
GO:0070995NADPH oxidation15144220


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TissGeneExp for FMO2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP0.5659813993.014697024-2.4487156251.91E-057.55E-05
KICH-2.5400027263.505565274-6.0455682.36E-166.94E-15
THCA-1.2567874041.937415985-3.194203391.47E-195.09E-18
BRCA1.778741875.889356782-4.1106149128.92E-474.68E-45
HNSC0.2564904835.568334669-5.3118441867.89E-194.47E-16
LUAD3.316680866.649503274-3.3328224141.64E-302.30E-28
LUSC2.5914258236.601072881-4.0096470597.96E-251.68E-23
LIHC-0.9540307260.733495274-1.6875261.55E-071.05E-06
COAD-2.143735188-0.368431342-1.7753038460.0004720.001466882


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TissGene-miRNA for FMO2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-7153-5pMIMAT00282160.015-0.2878
ACChsa-miR-7153-5pMIMAT00282160.015-0.2878
UCShsa-miR-421MIMAT00033390.023-0.3156


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TissGeneMut for FMO2
TissGeneSNV for FMO2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P457SSKCM4
p.R249QSKCM2
p.R240CSKCM2
p.G193ESKCM2
p.R186CLUAD2
p.K44_spliceLUSC1
p.E65*BRCA1
p.R249XCOAD1
p.E45DREAD1
p.S351LPRAD1
p.G38ESKCM1
p.E226KSKCM1
p.V324GUCEC1
p.G466RCESC1
p.G270SLUAD1
p.N321KKIRP1
p.E226KCESC1
p.G38EHNSC1
p.G168SSKCM1
p.M242ILUAD1
p.D36GCOAD1
p.P358SSARC1
p.W41CBRCA1
p.E32QBLCA1
p.L384HPAAD1
p.S451TLIHC1
p.E314KBLCA1
p.S334FSKCM1
p.G370ASKCM1
p.R223HSTAD1
p.R114IUCEC1
p.F333LREAD1
p.S137RBLCA1
p.P79SSKCM1
p.K97NUCEC1
p.L243FPRAD1
p.T60IBLCA1
p.A208TACC1
p.V59ILUAD1
p.R174HCOAD1
p.G270DSKCM1
p.P179LSKCM1
p.R240CUCEC1
p.W254*SKCM1
p.A208SSTAD1
p.A445VSTAD1
p.F119LUCEC1
p.A142TUCEC1
p.W219RLUSC1
p.W254LLUAD1
p.P230LSKCM1
p.R291CCOAD1
p.R244HPAAD1
p.G181ABLCA1
p.S195LCOAD1
p.R387HUVM1
p.R92KBLCA1
p.R223SKIRC1
p.F81SDLBC1
p.L459QSARC1
p.D323HLUAD1
p.G168DLUSC1
p.A142TLUAD1
p.P230SSKCM1
p.P336SSKCM1
p.V201GHNSC1
p.F379SLIHC1
p.L87RSTAD1
p.A2TLUAD1
p.S225FHNSC1
p.F182SCOAD1
p.N132KLUAD1
p.D99NSKCM1
p.Q56KHNSC1
p.P374HLUAD1
p.M1ICOAD1
p.I187TLUAD1
p.R249QSTAD1
p.E346QLIHC1
p.D340YBLCA1
p.R387HDLBC1
p.P75LLUAD1
p.E438KCOAD1
p.R186HSTAD1
p.P79LSKCM1
p.G133DSKCM1
p.V22LLUAD1
p.E346DUCEC1
p.E32DBRCA1


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TissGeneCNV for FMO2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for FMO2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAI452615FMO2-FMO2chr1:171176903chr1:171173038


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TissGeneNet for FMO2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for FMO2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for FMO2
TissGeneDrug for FMO2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for FMO2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0023470Myeloid Leukemia3GAD
umls:C0011053Deafness1GAD
umls:C0014175Endometriosis1CTD_human
umls:C0018772Hearing Loss, Partial1GAD
umls:C0031117Peripheral Neuropathy1CTD_human
umls:C0279565Invasive Lobular Breast Carcinoma1BeFree
umls:C0746883Febrile Neutropenia1BeFree
umls:C1134719Invasive Ductal Breast Carcinoma1BeFree
umls:C1384666hearing impairment1GAD
umls:C3887873Hearing Loss1GAD