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| TissGeneSummary for FMO5 |
 Gene summary |
| Basic gene information | Gene symbol | FMO5 |
| Gene name | flavin containing monooxygenase 5 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001144829.2, NM_001144830.2,NM_001461.3, | |
| Description | FMO 5dimethylaniline monooxygenase [N-oxide-forming] 5dimethylaniline oxidase 5hepatic flavin-containing monooxygenase 5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603957 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000131781 | ||
| HPRD : 04904 | ||
| Vega : OTTHUMG00000014607 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FMO5 | |
| BioGPS: 2330 | ||
| Pathway | NCI Pathway Interaction Database: FMO5 | |
| KEGG: FMO5 | ||
| REACTOME: FMO5 | ||
| Pathway Commons: FMO5 | ||
| Context | iHOP: FMO5 | |
| ligand binding site mutation search in PubMed: FMO5 | ||
| UCL Cancer Institute: FMO5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSTAD | |
| Reference showing the relevant tissue of FMO5 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FMO5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.943313064 | 3.685865842 | -2.742552778 | 5.54E-28 | 8.82E-27 |
| KIRP | 1.236825217 | 3.641962717 | -2.4051375 | 3.01E-10 | 3.14E-09 |
| PRAD | 3.129349496 | 1.969072573 | 1.160276923 | 4.00E-06 | 2.49E-05 |
| COAD | 2.206409111 | 4.240336034 | -2.033926923 | 1.21E-10 | 1.70E-09 |
| KICH | 0.948336342 | 3.282600342 | -2.334264 | 2.29E-08 | 1.15E-07 |
| LUSC | 0.000920499 | 3.743012656 | -3.742092157 | 5.58E-24 | 1.06E-22 |
| LIHC | 6.261450342 | 7.470776342 | -1.209326 | 0.000319 | 0.000973213 |
| HNSC | -1.411908868 | -0.117043751 | -1.294865116 | 7.67E-05 | 0.000353637 |
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| TissGene-miRNA for FMO5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FMO5 |
| TissGeneSNV for FMO5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L366V | BLCA | 1 |
| p.T427I | SKCM | 1 |
| p.K166E | COAD | 1 |
| p.D288Y | UCEC | 1 |
| p.Y332F | KIRC | 1 |
| p.I495M | CESC | 1 |
| p.P364L | PAAD | 1 |
| p.E90Q | CESC | 1 |
| p.F212L | UCEC | 1 |
| p.A522V | BLCA | 1 |
| p.G457R | COAD | 1 |
| p.W126* | STAD | 1 |
| p.R175X | COAD | 1 |
| p.I327F | LUAD | 1 |
| p.D439N | COAD | 1 |
| p.R425S | LUSC | 1 |
| p.L461F | SKCM | 1 |
| p.R485Q | UCEC | 1 |
| p.D439N | UCEC | 1 |
| p.E309V | CESC | 1 |
| p.S451R | COAD | 1 |
| p.H426R | UCEC | 1 |
| p.W126X | STAD | 1 |
| p.R34M | READ | 1 |
| p.R292C | SKCM | 1 |
| p.R453I | READ | 1 |
| p.M436I | SKCM | 1 |
| p.M500I | HNSC | 1 |
| p.F393C | UCEC | 1 |
| p.D233N | ESCA | 1 |
| p.P358L | PAAD | 1 |
| p.K3N | COAD | 1 |
| p.R425H | STAD | 1 |
| p.F393S | ESCA | 1 |
| p.A121V | COAD | 1 |
| p.V392A | STAD | 1 |
| p.L452P | KIRP | 1 |
| p.L463S | STAD | 1 |
| p.P470L | SKCM | 1 |
| p.C22R | STAD | 1 |
| p.G457R | ACC | 1 |
| p.S214I | BLCA | 1 |
| p.L213I | BRCA | 1 |
| p.I193N | BRCA | 1 |
| p.G229E | SKCM | 1 |
| p.Q263R | KIRC | 1 |
| p.Q373* | CESC | 1 |
| p.G124V | LUAD | 1 |
| p.E422D | BLCA | 1 |
| p.S18F | KIRC | 1 |
| p.T365P | OV | 1 |
| p.N448Y | SKCM | 1 |
| p.Y420C | BLCA | 1 |
| p.R485Q | READ | 1 |
| p.L339V | BLCA | 1 |
| p.R485Q | SKCM | 1 |
| p.F328C | COAD | 1 |
| p.R277G | STAD | 1 |
| p.D266N | UCEC | 1 |
| p.G163E | SKCM | 1 |
| p.E408* | UCEC | 1 |
| p.D287N | OV | 1 |
| p.P157S | SKCM | 1 |
| p.P438H | COAD | 1 |
| p.A121D | ESCA | 1 |
| p.S17Y | OV | 1 |
| p.L452P | SARC | 1 |
| p.R292S | READ | 1 |
| p.I261T | STAD | 1 |
| p.L240V | LUSC | 1 |
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| TissGeneCNV for FMO5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FMO5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA491849 | FMO5-FMO5 | chr1:146656867 | chr1:146656863 | |
| Chimerdb3.0 | ChiTaRs | NA | AI240595 | MPPE1-FMO5 | chr18:11884109 | chr1:146676325 |
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| TissGeneNet for FMO5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for FMO5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FMO5 |
| TissGeneDrug for FMO5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FMO5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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