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| TissGeneSummary for NCAPD3 |
 Gene summary |
| Basic gene information | Gene symbol | NCAPD3 |
| Gene name | non-SMC condensin II complex, subunit D3 | |
| Synonyms | CAP-D3|CAPD3|hCAP-D3|hHCP-6|hcp-6 | |
| Cytomap | UCSC genome browser: 11q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015261.2, | |
| Description | condensin-2 complex subunit D3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609276 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151503 | ||
| HPRD : 11062 | ||
| Vega : OTTHUMG00000167172 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NCAPD3 | |
| BioGPS: 23310 | ||
| Pathway | NCI Pathway Interaction Database: NCAPD3 | |
| KEGG: NCAPD3 | ||
| REACTOME: NCAPD3 | ||
| Pathway Commons: NCAPD3 | ||
| Context | iHOP: NCAPD3 | |
| ligand binding site mutation search in PubMed: NCAPD3 | ||
| UCL Cancer Institute: NCAPD3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of NCAPD3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007076 | mitotic chromosome condensation | 14532007 | GO:0007076 | mitotic chromosome condensation | 14532007 |
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| TissGeneExp for NCAPD3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 0.345086995 | -0.68954738 | 1.034634375 | 1.37E-08 | 5.93E-07 |
| LUSC | 0.469899005 | -0.893895113 | 1.363794118 | 1.52E-21 | 2.22E-20 |
| BLCA | 0.3031666 | -0.876759716 | 1.179926316 | 4.32E-07 | 1.75E-05 |
| COAD | 0.577747572 | -0.458156274 | 1.035903846 | 5.70E-12 | 1.24E-10 |
| PRAD | 3.434787956 | 2.348916802 | 1.085871154 | 0.00134 | 0.004159197 |
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| TissGene-miRNA for NCAPD3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NCAPD3 |
| TissGeneSNV for NCAPD3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S231F | SKCM | 2 |
| p.E68K | COAD | 2 |
| p.R318C | SKCM | 1 |
| p.L4F | LUSC | 1 |
| p.P770S | LUAD | 1 |
| p.E950K | COAD | 1 |
| p.P1475S | BLCA | 1 |
| p.R958H | COAD | 1 |
| p.A91E | THYM | 1 |
| p.V557I | UCEC | 1 |
| p.V781G | COAD | 1 |
| p.A599T | STAD | 1 |
| p.A599P | LUAD | 1 |
| p.G1277W | LUAD | 1 |
| p.P1377L | SKCM | 1 |
| p.R505I | READ | 1 |
| p.R596Q | KIRP | 1 |
| p.S1034R | DLBC | 1 |
| p.V1180A | ESCA | 1 |
| p.G623V | LUAD | 1 |
| p.N751H | LUAD | 1 |
| p.E1400G | STAD | 1 |
| p.C1059F | LUSC | 1 |
| p.Y512H | LIHC | 1 |
| p.R731K | DLBC | 1 |
| p.E1253Q | BRCA | 1 |
| p.Q302H | COAD | 1 |
| p.S1414G | LUAD | 1 |
| p.A44E | SARC | 1 |
| p.D1172H | LUSC | 1 |
| p.C1059Y | ESCA | 1 |
| p.Y370C | HNSC | 1 |
| p.P1346S | LIHC | 1 |
| p.M1308I | UCEC | 1 |
| p.P907T | DLBC | 1 |
| p.S682I | LUAD | 1 |
| p.I1352V | HNSC | 1 |
| p.R1490X | STAD | 1 |
| p.P591H | LGG | 1 |
| p.I765N | ESCA | 1 |
| p.A340T | PAAD | 1 |
| p.L883M | LUAD | 1 |
| p.R213* | SKCM | 1 |
| p.S511F | SKCM | 1 |
| p.L157F | LUAD | 1 |
| p.S1139I | PAAD | 1 |
| p.A319T | UCEC | 1 |
| p.D1172N | LUAD | 1 |
| p.H891R | ACC | 1 |
| p.T1424M | STAD | 1 |
| p.R213X | SKCM | 1 |
| p.R874S | SARC | 1 |
| p.E677K | STAD | 1 |
| p.E192A | UCEC | 1 |
| p.A91S | LUAD | 1 |
| p.K221N | STAD | 1 |
| p.H218Y | STAD | 1 |
| p.S735N | UCEC | 1 |
| p.P386S | LUAD | 1 |
| p.R1490* | STAD | 1 |
| p.L444M | STAD | 1 |
| p.C572Y | COAD | 1 |
| p.R402* | UCEC | 1 |
| p.K167T | COAD | 1 |
| p.E154K | UCEC | 1 |
| p.K1444R | SKCM | 1 |
| p.Q1314H | LUAD | 1 |
| p.S715L | UCEC | 1 |
| p.R1371Q | BRCA | 1 |
| p.M965I | LUAD | 1 |
| p.Y58N | OV | 1 |
| p.R1020Q | UCEC | 1 |
| p.L232M | KIRC | 1 |
| p.R1490P | LUAD | 1 |
| p.T712M | UCEC | 1 |
| p.R971H | STAD | 1 |
| p.E1386K | HNSC | 1 |
| p.Y1226C | BLCA | 1 |
| p.K442R | BLCA | 1 |
| p.H653Y | STAD | 1 |
| p.H359Y | COAD | 1 |
| p.S1401L | COAD | 1 |
| p.A391T | STAD | 1 |
| p.R1096Q | UCEC | 1 |
| p.R159Q | COAD | 1 |
| p.V635L | LUAD | 1 |
| p.P717H | UCEC | 1 |
| p.N518S | HNSC | 1 |
| p.L431P | LIHC | 1 |
| p.V353I | HNSC | 1 |
| p.E1058* | UCEC | 1 |
| p.T1424M | KIRP | 1 |
| p.W741L | LUAD | 1 |
| p.598_599QA>HP | LUAD | 1 |
| p.D1240H | THCA | 1 |
| p.D1274H | BLCA | 1 |
| p.I691F | STAD | 1 |
| p.P1460H | LGG | 1 |
| p.L1136V | KIRP | 1 |
| p.P491L | SKCM | 1 |
| p.I75M | BLCA | 1 |
| p.G825V | LUAD | 1 |
| p.A609V | BRCA | 1 |
| p.C613Y | KIRC | 1 |
| p.L883M | COAD | 1 |
| p.Q598H | LUAD | 1 |
| p.K1246R | KIRC | 1 |
| p.E553K | BLCA | 1 |
| p.E1008D | PRAD | 1 |
| p.W668R | ESCA | 1 |
| p.P813S | COAD | 1 |
| p.V955M | COAD | 1 |
| p.R207Q | PRAD | 1 |
| p.R1490* | UCEC | 1 |
| p.V295F | LIHC | 1 |
| p.R371C | UCEC | 1 |
| p.D1172E | PAAD | 1 |
| p.K694N | LUSC | 1 |
| p.E43D | BRCA | 1 |
| p.R1096L | LUSC | 1 |
| p.H1042R | STAD | 1 |
| p.T710S | LUAD | 1 |
| p.F1241L | COAD | 1 |
| p.N1196D | PAAD | 1 |
| p.A479V | STAD | 1 |
| p.R402Q | UCEC | 1 |
| p.E900* | BLCA | 1 |
| p.S60T | LUAD | 1 |
| p.C471Y | KICH | 1 |
| p.S205F | SKCM | 1 |
| p.S339N | DLBC | 1 |
| p.R1235Q | PRAD | 1 |
| p.R1369W | UCS | 1 |
| p.A334V | PAAD | 1 |
| p.S1419C | HNSC | 1 |
| p.K939R | THYM | 1 |
| p.H218Y | CESC | 1 |
| p.L89M | ESCA | 1 |
| p.S796I | ESCA | 1 |
| p.F93L | LUSC | 1 |
| p.T1388M | KICH | 1 |
| p.S480L | ESCA | 1 |
| p.E900D | BLCA | 1 |
| p.E872D | UCEC | 1 |
| p.S1430T | HNSC | 1 |
| p.T1278S | MESO | 1 |
| p.L1156H | LUSC | 1 |
| p.R1436Q | COAD | 1 |
| p.S511P | HNSC | 1 |
| p.V1180A | COAD | 1 |
| p.R519H | BLCA | 1 |
| p.A479V | HNSC | 1 |
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| TissGeneCNV for NCAPD3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NCAPD3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW819720 | CDK5RAP3-NCAPD3 | chr17:46053273 | chr11:134029879 |
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| TissGeneNet for NCAPD3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| COAD (tumor) | COAD (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| KICH (tumor) | KICH (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| STAD (tumor) | STAD (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| THCA (tumor) | THCA (normal) |
| NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (tumor) | NCAPD3, UBC, SUMO2, MYC, SMC2, NCAPG2, PRSS23, SMC4, NCAPH2 (normal) |
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| TissGeneProg for NCAPD3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NCAPD3 |
| TissGeneDrug for NCAPD3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NCAPD3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
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