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| TissGeneSummary for FOLH1 |
 Gene summary |
| Basic gene information | Gene symbol | FOLH1 |
| Gene name | folate hydrolase (prostate-specific membrane antigen) 1 | |
| Synonyms | FGCP|FOLH|GCP2|GCPII|NAALAD1|NAALAdase|PSM|PSMA|mGCP | |
| Cytomap | UCSC genome browser: 11p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001014986.1, NM_001193471.1,NM_001193472.1,NM_001193473.1,NM_004476.1, | |
| Description | N-acetylated alpha-linked acidic dipeptidase 1N-acetylated-alpha-linked acidic dipeptidase INAALADase Icell growth-inhibiting gene 27 proteinfolylpoly-gamma-glutamate carboxypeptidaseglutamate carboxylase IIglutamate carboxypeptidase 2glutamate car | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600934 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000086205 | ||
| HPRD : 02961 | ||
| Vega : OTTHUMG00000166625 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOLH1 | |
| BioGPS: 2346 | ||
| Pathway | NCI Pathway Interaction Database: FOLH1 | |
| KEGG: FOLH1 | ||
| REACTOME: FOLH1 | ||
| Pathway Commons: FOLH1 | ||
| Context | iHOP: FOLH1 | |
| ligand binding site mutation search in PubMed: FOLH1 | ||
| UCL Cancer Institute: FOLH1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of FOLH1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FOLH1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 3.106953001 | 1.644151612 | 1.462801389 | 3.08E-09 | 9.83E-09 |
| PRAD | 6.852211548 | 4.191173086 | 2.661038462 | 1.02E-07 | 9.64E-07 |
| LUSC | 0.458436171 | -1.043306967 | 1.501743137 | 3.55E-06 | 8.45E-06 |
| THCA | -0.572735747 | -3.243856086 | 2.671120339 | 1.38E-18 | 3.82E-17 |
| KIRP | -1.215241097 | 1.694055778 | -2.909296875 | 4.62E-08 | 3.03E-07 |
| BRCA | -0.193952994 | 0.918562796 | -1.112515789 | 8.17E-09 | 2.72E-08 |
| LIHC | 1.619775778 | 3.531887778 | -1.912112 | 1.78E-08 | 1.50E-07 |
| KICH | -0.248296222 | 1.087431778 | -1.335728 | 0.00137 | 0.002892222 |
| Top |
| TissGene-miRNA for FOLH1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FOLH1 |
| TissGeneSNV for FOLH1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D158Y | LUAD | 3 |
| p.R281H | UVM | 3 |
| p.R281H | PCPG | 2 |
| p.R565Q | THCA | 2 |
| p.A628S | LUAD | 2 |
| p.E480K | SKCM | 2 |
| p.G692E | SKCM | 2 |
| p.R519I | LUAD | 2 |
| p.P234L | HNSC | 1 |
| p.E424D | ESCA | 1 |
| p.K485R | LGG | 1 |
| p.A217T | DLBC | 1 |
| p.R281C | UCEC | 1 |
| p.S31T | SKCM | 1 |
| p.E168K | HNSC | 1 |
| p.R580* | KICH | 1 |
| p.L233F | LGG | 1 |
| p.G168R | ESCA | 1 |
| p.I456V | STAD | 1 |
| p.D244N | CESC | 1 |
| p.I676M | BLCA | 1 |
| p.I708M | ESCA | 1 |
| p.L291I | PAAD | 1 |
| p.K178* | SARC | 1 |
| p.A263S | SKCM | 1 |
| p.D99Y | READ | 1 |
| p.F418I | UCEC | 1 |
| p.N574S | COAD | 1 |
| p.T86R | PAAD | 1 |
| p.Q340R | STAD | 1 |
| p.K718N | ESCA | 1 |
| p.E102Q | UCEC | 1 |
| p.K500E | LUSC | 1 |
| p.S626I | PAAD | 1 |
| p.A601T | LUSC | 1 |
| p.R580* | GBM | 1 |
| p.D173Y | LUAD | 1 |
| p.E522Q | LUSC | 1 |
| p.Y356D | LUAD | 1 |
| p.V177G | STAD | 1 |
| p.C597Y | ESCA | 1 |
| p.Q79H | UCEC | 1 |
| p.K703N | ESCA | 1 |
| p.I693M | ESCA | 1 |
| p.A11P | LIHC | 1 |
| p.G493D | COAD | 1 |
| p.P110S | SKCM | 1 |
| p.I717M | ESCA | 1 |
| p.V358M | UCEC | 1 |
| p.S477F | SKCM | 1 |
| p.R527Q | OV | 1 |
| p.N42Y | LUAD | 1 |
| p.D173N | STAD | 1 |
| p.G702R | LUSC | 1 |
| p.E276X | THYM | 1 |
| p.G349R | SKCM | 1 |
| p.G209A | LUAD | 1 |
| p.E701K | SKCM | 1 |
| p.G206R | STAD | 1 |
| p.R669K | SKCM | 1 |
| p.E409D | ESCA | 1 |
| p.S628* | LUSC | 1 |
| p.Q203* | SKCM | 1 |
| p.G493D | LGG | 1 |
| p.P643L | SKCM | 1 |
| p.Q79H | CESC | 1 |
| p.E64A | UCEC | 1 |
| p.G209R | SKCM | 1 |
| p.D106N | UCEC | 1 |
| p.M669I | UCEC | 1 |
| p.Y341D | LUAD | 1 |
| p.Y677C | LUAD | 1 |
| p.F75S | BLCA | 1 |
| p.R512* | SKCM | 1 |
| p.G306R | SKCM | 1 |
| p.S611I | PAAD | 1 |
| p.K545R | KIRC | 1 |
| p.G196V | SKCM | 1 |
| p.G503E | SKCM | 1 |
| p.T624K | ESCA | 1 |
| p.H538D | LUAD | 1 |
| p.E712Q | SKCM | 1 |
| p.G211X | ESCA | 1 |
| p.R17C | BLCA | 1 |
| p.G283* | LUAD | 1 |
| p.S695G | LUSC | 1 |
| p.K622R | LUAD | 1 |
| p.E183* | LUAD | 1 |
| p.H381Y | SKCM | 1 |
| p.M1K | LUAD | 1 |
| p.L5F | HNSC | 1 |
| p.M494I | LUAD | 1 |
| p.R730K | UCEC | 1 |
| p.K479E | UCEC | 1 |
| p.G665E | SKCM | 1 |
| p.E137* | HNSC | 1 |
| p.P66L | SKCM | 1 |
| p.V719A | STAD | 1 |
| p.R166Q | SKCM | 1 |
| p.A535T | UCEC | 1 |
| p.I691M | LUAD | 1 |
| p.G250* | LUAD | 1 |
| p.H280N | LUAD | 1 |
| p.I693L | LUAD | 1 |
| p.P249L | HNSC | 1 |
| p.E422D | COAD | 1 |
| p.E152* | HNSC | 1 |
| p.D158N | THCA | 1 |
| p.Q203L | LUAD | 1 |
| p.G196* | ESCA | 1 |
| p.L306I | PAAD | 1 |
| p.R281L | LUSC | 1 |
| p.A593V | COAD | 1 |
| p.G687R | LUAD | 1 |
| p.D581H | LUAD | 1 |
| p.N444K | SARC | 1 |
| p.D230H | HNSC | 1 |
| p.I732M | ESCA | 1 |
| p.D705N | SKCM | 1 |
| p.G235* | LUAD | 1 |
| p.G153R | ESCA | 1 |
| p.G241R | SKCM | 1 |
| p.G267E | SKCM | 1 |
| p.C582Y | ESCA | 1 |
| p.P489S | SKCM | 1 |
| p.D158N | SKCM | 1 |
| p.S575F | SKCM | 1 |
| p.R266C | STAD | 1 |
| p.M601I | SKCM | 1 |
| p.D699N | SKCM | 1 |
| p.T528I | BLCA | 1 |
| p.K637R | LUAD | 1 |
| p.S30F | SKCM | 1 |
| p.L92P | STAD | 1 |
| p.N153S | UCEC | 1 |
| p.N444K | SKCM | 1 |
| p.N121S | BRCA | 1 |
| p.V588F | LUAD | 1 |
| p.G267R | SKCM | 1 |
| p.R590K | BLCA | 1 |
| p.Q288E | STAD | 1 |
| p.D470N | SKCM | 1 |
| p.D505N | SKCM | 1 |
| p.A643S | LUAD | 1 |
| p.L143S | LIHC | 1 |
| p.Y445C | SKCM | 1 |
| p.E425V | BRCA | 1 |
| p.A163S | LUSC | 1 |
| p.G191R | SKCM | 1 |
| p.A735D | LUAD | 1 |
| p.M669L | UCEC | 1 |
| p.R280M | LUAD | 1 |
| p.G211V | STAD | 1 |
| p.G248V | HNSC | 1 |
| p.T71R | PAAD | 1 |
| p.E22D | CESC | 1 |
| p.A728V | LUAD | 1 |
| p.V675I | SKCM | 1 |
| p.K56R | LUAD | 1 |
| p.R266H | KIRP | 1 |
| p.K684N | PRAD | 1 |
| p.S619F | SKCM | 1 |
| p.G514* | LUAD | 1 |
| p.R17C | COAD | 1 |
| p.T624K | LUSC | 1 |
| p.Q239H | HNSC | 1 |
| p.M177I | SARC | 1 |
| p.D215H | HNSC | 1 |
| p.R511_splice | LUSC | 1 |
| p.E130K | LUAD | 1 |
| p.G311C | HNSC | 1 |
| p.Q203X | SKCM | 1 |
| p.I96F | CESC | 1 |
| p.G296C | HNSC | 1 |
| p.S517Y | LUSC | 1 |
| p.E168* | LUAD | 1 |
| p.R266C | LUAD | 1 |
| p.E421D | COAD | 1 |
| p.Y625D | BRCA | 1 |
| p.R265M | LUAD | 1 |
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| TissGeneCNV for FOLH1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOLH1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6384-01A | FOLH1-FOLH1B | Out-of-Frame | chr11:49179503 | chr11:89413776 |
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| TissGeneNet for FOLH1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| COAD (tumor) | COAD (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| KICH (tumor) | KICH (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| FOLH1, MME, EGR1, AR, RPS3, MTAP (tumor) | FOLH1, MME, EGR1, AR, RPS3, MTAP (normal) |
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| Top |
| TissGeneProg for FOLH1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOLH1 |
| TissGeneDrug for FOLH1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00089 | Capromab | Other/unknown | Biotech | Approved |
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| TissGeneDisease for FOLH1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 122 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 120 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 12 | BeFree |
| umls:C1519666 | Tumor-Associated Vasculature | 11 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 9 | BeFree,CTD_human,LHGDN |
| umls:C0007112 | Adenocarcinoma of prostate | 5 | BeFree |
| umls:C0280100 | Solid tumour | 5 | BeFree |
| umls:C1527249 | Colorectal Cancer | 5 | BeFree,GAD |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree,LHGDN |
| umls:C0009402 | Colorectal Carcinoma | 4 | BeFree |
| umls:C0598608 | Hyperhomocysteinemia | 4 | BeFree,GAD |
| umls:C0936223 | Metastatic Prostate Carcinoma | 4 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 3 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree,GAD |
| umls:C0010068 | Coronary heart disease | 2 | GAD |
| umls:C0027794 | Neural Tube Defects | 2 | GAD |
| umls:C0035335 | Retinoblastoma | 2 | BeFree |
| umls:C0036341 | Schizophrenia | 2 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 2 | BeFree,GAD |
| umls:C0080178 | Spina Bifida | 2 | BeFree,GAD |
| umls:C0153690 | Secondary malignant neoplasm of bone | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 2 | BeFree |
| umls:C1328504 | Hormone refractory prostate cancer | 2 | BeFree |
| umls:C1378703 | Renal carcinoma | 2 | BeFree |
| umls:C1519176 | Salivary Gland Pleomorphic Adenoma | 2 | BeFree |
| umls:C3495426 | Homocysteinemia | 2 | BeFree |
| umls:C0001168 | Complete obstruction | 1 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0008625 | Chromosome Aberrations | 1 | GAD |
| umls:C0008924 | Cleft Lip | 1 | GAD |
| umls:C0008925 | Cleft Palate | 1 | GAD |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0012860 | DNA Damage | 1 | GAD |
| umls:C0016412 | Folic Acid Deficiency | 1 | GAD |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0019340 | Herpes NOS | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree,GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD,LHGDN |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | GAD |
| umls:C0025007 | Measles | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0031157 | Peritonsillar Abscess | 1 | BeFree |
| umls:C0031485 | Phenylketonurias | 1 | GAD |
| umls:C0038160 | Staphylococcal Infections | 1 | BeFree |
| umls:C0039614 | Tetanus | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0042850 | Vitamin B Deficiency | 1 | GAD |
| umls:C0086132 | Depressive Symptoms | 1 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | GAD |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278838 | Prostate cancer recurrent | 1 | BeFree |
| umls:C1739363 | Prostatic Hypertrophy | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C3806347 | Hyperhomocystinemia | 1 | GAD |
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