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| TissGeneSummary for FOLR1 |
 Gene summary |
| Basic gene information | Gene symbol | FOLR1 |
| Gene name | folate receptor 1 (adult) | |
| Synonyms | FBP|FOLR | |
| Cytomap | UCSC genome browser: 11q13.3-q14.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000802.3, NM_016724.2,NM_016725.2,NM_016729.2,NM_016730.1, | |
| Description | FR-alphaKB cells FBPadult folate-binding proteinfolate binding proteinfolate receptor alphafolate receptor, adultovarian tumor-associated antigen MOv18 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 136430 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000110195 | ||
| HPRD : 00638 | ||
| Vega : OTTHUMG00000167876 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOLR1 | |
| BioGPS: 2348 | ||
| Pathway | NCI Pathway Interaction Database: FOLR1 | |
| KEGG: FOLR1 | ||
| REACTOME: FOLR1 | ||
| Pathway Commons: FOLR1 | ||
| Context | iHOP: FOLR1 | |
| ligand binding site mutation search in PubMed: FOLR1 | ||
| UCL Cancer Institute: FOLR1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLungOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLUAD,LUSCOV | |
| Reference showing the relevant tissue of FOLR1 | ||
| Description by TissGene annotations | Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FOLR1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -0.475897539 | 2.698378776 | -3.174276316 | 1.45E-15 | 7.82E-15 |
| KICH | 1.364454706 | 6.136322706 | -4.771868 | 1.04E-08 | 5.54E-08 |
| KIRP | 4.797935081 | 6.609403831 | -1.81146875 | 1.08E-06 | 5.48E-06 |
| PRAD | -1.722889678 | 0.653385322 | -2.376275 | 9.20E-12 | 3.03E-10 |
| LUAD | 5.046454154 | 7.372636913 | -2.326182759 | 5.61E-08 | 2.28E-07 |
| THCA | 3.886223588 | 5.015811723 | -1.129588136 | 4.81E-08 | 2.18E-07 |
| LUSC | 1.221344824 | 7.16068404 | -5.939339216 | 1.49E-19 | 1.65E-18 |
| COAD | -1.392464678 | -2.733660832 | 1.341196154 | 0.0106 | 0.023040278 |
| HNSC | -1.851121387 | 0.357425125 | -2.208546512 | 0.00263 | 0.007806728 |
| Top |
| TissGene-miRNA for FOLR1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FOLR1 |
| TissGeneSNV for FOLR1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E32A | LIHC | 1 |
| p.E55K | SKCM | 1 |
| p.L130M | UCEC | 1 |
| p.W60* | LGG | 1 |
| p.G48D | STAD | 1 |
| p.Q211H | CESC | 1 |
| p.V78I | LUAD | 1 |
| p.A249S | LUAD | 1 |
| p.W239* | SKCM | 1 |
| p.E223K | SKCM | 1 |
| p.W116* | SKCM | 1 |
| p.P177H | TGCT | 1 |
| p.T24I | PRAD | 1 |
| p.E191K | OV | 1 |
| p.G20E | SKCM | 1 |
| p.A64T | OV | 1 |
| p.R4Q | SKCM | 1 |
| p.G90R | SKCM | 1 |
| p.W239R | LIHC | 1 |
| p.G205W | LUAD | 1 |
| p.E144K | SKCM | 1 |
| p.Q122* | HNSC | 1 |
| p.Q23* | CESC | 1 |
| p.R208H | COAD | 1 |
| p.E223V | BRCA | 1 |
| p.E45K | SKCM | 1 |
| p.R128L | ESCA | 1 |
| p.W239X | SKCM | 1 |
| p.P183S | SKCM | 1 |
| p.A173T | PAAD | 1 |
| p.R125H | GBM | 1 |
| p.C96X | READ | 1 |
| p.G20V | PRAD | 1 |
| p.D77N | SKCM | 1 |
| p.G207S | STAD | 1 |
| Top |
| TissGeneCNV for FOLR1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOLR1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A228-01A | CTTN-FOLR1 | 5'UTR-5'UTR | chr11:70244719 | chr11:71900708 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A228-01A | CTTN-FOLR1 | 5'UTR-5'UTR | chr11:70244719 | chr11:71901619 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A228-01A | CTTN-FOLR1 | 5'UTR-5'UTR | chr11:70244719 | chr11:71903209 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A228-01A | CTTN-FOLR1 | 5'UTR-CDS | chr11:70244719 | chr11:71906314 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A228-01A | LRTOMT-FOLR1 | 5'UTR-5'UTR | chr11:71791930 | chr11:71900708 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E9-A228-01A | LRTOMT-FOLR1 | 5'UTR-5'UTR | chr11:71791930 | chr11:71903209 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A228-01A | CTTN-FOLR1 | 5UTR-5UTR | Chr11:70244720 | Chr11:71903210 |
| TCGAfusionPortal | PRADA | LGG | TCGA-DU-5871-01A | CTTN-FOLR1 | 5UTR-5UTR | Chr11:70244720 | Chr11:71903210 |
| TCGAfusionPortal | PRADA | LGG | TCGA-E1-5302-01A | NUMA1-FOLR1 | 5UTR-5UTR | Chr11:71780888 | Chr11:71903210 |
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| TissGeneNet for FOLR1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (tumor) | FOLR1, UBC, CUL3, LYN, IRAK3, NCAPH2 (normal) |
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| TissGeneProg for FOLR1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOLR1 |
| TissGeneDrug for FOLR1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FOLR1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029925 | Ovarian Carcinoma | 17 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 10 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 9 | BeFree |
| umls:C0001418 | Adenocarcinoma | 6 | BeFree,LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 4 | BeFree |
| umls:C0080178 | Spina Bifida | 4 | BeFree,GAD |
| umls:C0025500 | Mesothelioma | 3 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree,CTD_human |
| umls:C0000768 | Congenital Abnormality | 2 | BeFree,CTD_human |
| umls:C0009375 | Colonic Neoplasms | 2 | CTD_human |
| umls:C0018798 | Congenital Heart Defects | 2 | CTD_human,GAD |
| umls:C0023418 | leukemia | 2 | BeFree,LHGDN |
| umls:C0032019 | Pituitary Neoplasms | 2 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 2 | LHGDN |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0342705 | Folate Malabsorption, Hereditary | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0006111 | Brain Diseases | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0008924 | Cleft Lip | 1 | GAD |
| umls:C0008925 | Cleft Palate | 1 | GAD |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0014544 | Epilepsy | 1 | CTD_human |
| umls:C0014550 | Epilepsies, Myoclonic | 1 | BeFree |
| umls:C0016412 | Folic Acid Deficiency | 1 | BeFree |
| umls:C0019880 | Homocystinuria | 1 | GAD |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
| umls:C0021361 | Female infertility | 1 | GAD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | LHGDN |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree,GAD |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0025312 | Meningomyelocele | 1 | BeFree,GAD |
| umls:C0026650 | Movement Disorders | 1 | CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027794 | Neural Tube Defects | 1 | CTD_human |
| umls:C0029463 | Osteosarcoma | 1 | BeFree,CTD_human |
| umls:C0033922 | Psychomotor Disorders | 1 | CTD_human |
| umls:C0035372 | Rett Syndrome | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0086942 | Rous Sarcoma | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0153567 | Uterine Cancer | 1 | BeFree |
| umls:C0206701 | Cystadenocarcinoma, Serous | 1 | BeFree |
| umls:C0235031 | Neurologic Symptoms | 1 | BeFree |
| umls:C0278689 | Ovarian epithelial cancer recurrent | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0345967 | Malignant mesothelioma | 1 | BeFree |
| umls:C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| umls:C0497327 | Dementia | 1 | GAD |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0598608 | Hyperhomocysteinemia | 1 | BeFree,LHGDN |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0752109 | Brain Diseases, Metabolic, Inborn | 1 | CTD_human |
| umls:C0854988 | Adenocarcinoma of lung, stage IV | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1562113 | Fleck corneal dystrophy | 1 | BeFree |
| umls:C1853144 | Deafness, Congenital, with Inner Ear Agenesis, Microtia, and Microdontia | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | CTD_human |
| umls:C2751584 | Neurodegeneration Due To Cerebral Folate Transport Deficiency | 0 | CLINVAR,CTD_human,ORPHANET |
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