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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SUZ12
check button Gene summary
Basic gene informationGene symbolSUZ12
Gene nameSUZ12 polycomb repressive complex 2 subunit
SynonymsCHET9|JJAZ1
CytomapUCSC genome browser: 17q11.2
Type of geneprotein-coding
RefGenesNM_015355.2,
DescriptionchET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinpolycomb protein SUZ12suppressor of zeste 12 homologsuppressor of zeste 12 protein homolog
Modification date20141222
dbXrefs MIM : 606245
HGNC : HGNC
Ensembl : ENSG00000178691
HPRD : 06949
Vega : OTTHUMG00000132813
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SUZ12
BioGPS: 23512
PathwayNCI Pathway Interaction Database: SUZ12
KEGG: SUZ12
REACTOME: SUZ12
Pathway Commons: SUZ12
ContextiHOP: SUZ12
ligand binding site mutation search in PubMed: SUZ12
UCL Cancer Institute: SUZ12
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Bone marrowTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LAMLTGCT
Reference showing the relevant tissue of SUZ12
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
TissgsLTS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SUZ12

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for SUZ12

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-186-5pMIMAT00004560.041-0.2760
THYMhsa-miR-520a-3pMIMAT00028340.0033-0.27122
THYMhsa-miR-520eMIMAT00028250.012-0.28122
LUADhsa-miR-16-5pMIMAT00000690.027-0.2960
THYMhsa-miR-520d-3pMIMAT00028560.0017-0.3122
LUADhsa-miR-195-5pMIMAT00004610.0098-0.3360


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TissGeneMut for SUZ12
TissGeneSNV for SUZ12

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Q387RLIHC1
p.A332TSTAD1
p.D665YUCEC1
p.D725YUCEC1
p.K223*KIRC1
p.S604CBLCA1
p.E421KGBM1
p.Q441HUCEC1
p.E347KREAD1
p.L529VBRCA1
p.E601QBLCA1
p.K223XKIRC1
p.N216HUCEC1
p.A401VLIHC1
p.C325YUCEC1
p.P207SSKCM1
p.R458HESCA1
p.A332VLUSC1
p.E364*LUSC1
p.E142DUCEC1
p.R101QUCEC1
p.L377FBLCA1
p.V581EOV1
p.Q221*BLCA1
p.I491VLIHC1
p.P228TTHYM1
p.R286QSTAD1
p.G163DLAML1
p.N477TKIRC1
p.I671MUCEC1
p.H471RCOAD1
p.D290NSKCM1
p.Q95HBRCA1
p.R458HLUSC1
p.S233FSKCM1
p.K521EBLCA1
p.R682CUCEC1
p.F432CUCEC1
p.K459ELUSC1
p.R575CSTAD1
p.R103QLAML1
p.K143ECOAD1
p.M265IBLCA1
p.Y480CHNSC1
p.Q80HTHYM1
p.E388XKIRP1
p.K650NCOAD1
p.R439MUCEC1
p.S693FBLCA1
p.H620RKIRP1
p.K468NHNSC1
p.R286*LGG1
p.L338HKIRC1
p.E383KBRCA1
p.S583IBLCA1


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TissGeneCNV for SUZ12

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SUZ12

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAW369467SUZ12-SUZ12chr17:30320303chr17:30310084
Chimerdb3.0FusionScanLGGTCGA-DU-5874-01ASUZ12-LRRC37A2CDS-5'UTRchr17:30303633chr17:44623620
Chimerdb3.0FusionScanLGGTCGA-DU-5874-01ASUZ12-LRRC37ACDS-5'UTRchr17:30303633chr17:44405757
Chimerdb3.0FusionScanBRCATCGA-A2-A0YT-01ASUZ12-IARSIn-Framechr17:30264539chr9:94985771
Chimerdb3.0FusionScanBRCATCGA-BH-A18R-01ASUZ12-USP32Out-of-Framechr17:30264539chr17:58332619


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TissGeneNet for SUZ12

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SUZ12, RBL2, USP7, CREB1, E2F4, CTCF, SIRT1, RBBP4, AEBP2, CBX5, MED17, RB1, RBL1, HIST1H1C, CDK19, EED, KDM5A, HIC1, MTF2, CDYL, JARID2 (tumor)SUZ12, RELA, RBL2, RELB, USP7, CREB1, E2F4, CDK8, CTCF, PML, SIRT1, RBBP4, AEBP2, CEBPD, CBX5, RBL1, DNMT1, KDM5A, HIC1, PHF1, CDYL (normal)
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COAD (tumor)COAD (normal)
SUZ12, ELAVL1, RELB, HDAC2, CREB1, RBBP7, WDR77, SIRT1, RBBP4, AEBP2, CBX5, MED17, RBL1, H2AFY, HIST1H1C, DNMT1, KDM5A, HIC1, MTF2, SETD8, H2AFY2 (tumor)SUZ12, ELAVL1, SUMO2, E2F1, RELB, CREB1, CDK8, CTCF, UBE2I, SIRT1, RBBP4, AEBP2, EZH2, RBL1, DNMT1, UHRF1, CTNNA1, EED, HIC1, PHF1, MTF2 (normal)
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HNSC (tumor)HNSC (normal)
SUZ12, RBL2, USP7, CREB1, CDK8, CTCF, RBBP4, AEBP2, EZH2, MED17, RB1, RBL1, HIST1H1C, DNMT1, CDK19, UHRF1, CTNNA1, KDM5A, PHF1, MTF2, JARID2 (tumor)SUZ12, ELAVL1, RBL2, HDAC2, CREB1, CDK8, CTCF, RBBP7, SIRT1, RBBP4, AEBP2, EZH2, CBX5, RB1, RBL1, DNMT1, PPP1R8, CDK19, UHRF1, KDM5A, MTF2 (normal)
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KICH (tumor)KICH (normal)
SUZ12, ELAVL1, SNAI1, USP7, PJA1, CTCF, EWSR1, RBBP7, WDR77, AEBP2, CBX5, RBL1, H2AFY, DNMT1, PPP1R8, CDK19, CTNNA1, KDM5A, JARID2, EZH1, H2AFY2 (tumor)SUZ12, ELAVL1, HDAC2, CREB1, E2F4, CDK8, UBE2I, RBBP7, PML, RBBP4, AEBP2, CBX5, MED17, RB1, RBL1, HIST1H1C, CDK19, KDM5A, CDYL, SETD8, H2AFY2 (normal)
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KIRC (tumor)KIRC (normal)
SUZ12, RBL2, HDAC2, USP7, CREB1, CDK8, MED6, SIRT1, RBBP4, AEBP2, CBX5, MED17, RB1, RBL1, CDK19, EED, KDM5A, PHF1, MTF2, CDYL, JARID2 (tumor)SUZ12, RELA, RBL2, RELB, HDAC2, USP7, CREB1, PJA1, CDK8, CTCF, UBE2I, PML, SIRT1, RBBP4, AEBP2, MED17, RB1, RBL1, HIST1H1C, KDM5A, CDYL (normal)
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KIRP (tumor)KIRP (normal)
SUZ12, RELA, E2F1, RBL2, RELB, SETDB1, CREB1, CTCF, WDR77, PML, SIRT1, AEBP2, CEBPD, RBL1, H2AFY, RARG, CTNNA1, KDM5A, HIC1, PHF1, H2AFY2 (tumor)SUZ12, RBL2, RELB, HDAC2, VAV1, CREB1, CDK8, CTCF, PML, SIRT1, RBBP4, AEBP2, CEBPD, MED17, RB1, RBL1, DNMT1, CDK19, KDM5A, PHF1, CDYL (normal)
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LIHC (tumor)LIHC (normal)
SUZ12, RELA, RBL2, USP7, CREB1, CDK8, CTCF, WDR77, SIRT1, RBBP4, AEBP2, MED17, RB1, RBL1, HIST1H1C, DNMT1, CDK19, EED, KDM5A, MTF2, CDYL (tumor)SUZ12, E2F1, SETDB1, CREB1, CDK8, CTCF, SIRT1, RBBP4, AEBP2, EZH2, CEBPD, MED17, RBL1, DNMT1, CDK19, UHRF1, EED, KDM5A, MTF2, CDYL, JARID2 (normal)
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LUAD (tumor)LUAD (normal)
SUZ12, ELAVL1, RELA, E2F1, RBL2, USP7, CREB1, E2F4, PJA1, UBE2I, WDR77, PML, SIRT1, AEBP2, RB1, RBL1, RARG, GATA4, CDK19, KDM5A, MTF2 (tumor)SUZ12, ELAVL1, E2F1, HDAC2, CREB1, CDK8, CTCF, RBBP7, SIRT1, RBBP4, AEBP2, EZH2, CEBPD, CBX5, RBL1, DNMT1, UHRF1, KDM5A, PHF1, MTF2, JARID2 (normal)
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LUSC (tumor)LUSC (normal)
SUZ12, RBL2, HDAC2, USP7, CREB1, E2F4, CTCF, EWSR1, PML, SIRT1, RBBP4, AEBP2, CEBPD, CBX5, MED17, RB1, RBL1, CDK19, KDM5A, HIC1, MTF2 (tumor)SUZ12, ELAVL1, SUMO2, E2F1, SETDB1, HDAC2, USP7, CTCF, PML, AEBP2, EZH2, CEBPD, RBL1, DNMT1, GATA4, CDK19, UHRF1, KDM5A, HIC1, PHF1, EZH1 (normal)
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PRAD (tumor)PRAD (normal)
SUZ12, RBL2, HDAC2, CREB1, E2F4, CDK8, SIRT1, RBBP4, CEBPD, MED17, RB1, RBL1, DNMT1, GATA4, CTNNA1, HIST1H1A, KDM5A, PHF1, CDYL, SETD8, JARID2 (tumor)SUZ12, RBL2, USP7, CREB1, CDK8, CTCF, SIRT1, RBBP4, AEBP2, CEBPD, MED17, RB1, RBL1, DNMT1, PPP1R8, CTNNA1, KDM5A, PHF1, MTF2, CDYL, JARID2 (normal)
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STAD (tumor)STAD (normal)
SUZ12, ELAVL1, E2F1, RBL2, USP7, CREB1, RBBP7, SIRT1, RBBP4, AEBP2, CBX5, MED17, RB1, HIST1H1C, GATA4, CDK19, EED, WT1, CDYL, EZH1, H2AFY2 (tumor)SUZ12, E2F1, RELB, SETDB1, HDAC2, USP7, CTCF, EWSR1, PML, SIRT1, RBBP4, EZH2, CEBPD, RBL1, DNMT1, CDK19, UHRF1, EED, HIC1, PHF1, MTF2 (normal)
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THCA (tumor)THCA (normal)
SUZ12, RBL2, USP7, CREB1, CDK8, CTCF, UBE2I, SIRT1, RBBP4, AEBP2, MED17, RB1, RBL1, HIST1H1C, DNMT1, CDK19, KDM5A, PHF1, MTF2, CDYL, H2AFY2 (tumor)SUZ12, SUMO2, RBL2, USP7, CREB1, CDK8, CTCF, EWSR1, PML, SIRT1, RBBP4, AEBP2, CBX5, RB1, RBL1, HIST1H1C, CDK19, KDM5A, PHF1, CDYL, H2AFY2 (normal)
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TissGeneProg for SUZ12

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SUZ12
TissGeneDrug for SUZ12

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SUZ12

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0206630Endometrial Stromal Sarcoma13BeFree,ORPHANET
umls:C0334695Endometrial Stromal Tumors6BeFree,LHGDN
umls:C0027627Neoplasm Metastasis5BeFree
umls:C0699791Stomach Carcinoma4BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0017636Glioblastoma2BeFree,CTD_human
umls:C0017638Glioma2BeFree,CTD_human
umls:C0019163Hepatitis B2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0023903Liver neoplasms2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0025202melanoma2BeFree,CTD_human
umls:C0027830neurofibroma2BeFree,CTD_human
umls:C0178874Tumor Progression2BeFree
umls:C0206727Nerve Sheath Tumors2BeFree,CTD_human
umls:C0206728Plexiform Neurofibroma2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C0751690Malignant Peripheral Nerve Sheath Tumor2BeFree
umls:C1527249Colorectal Cancer2BeFree
umls:C0001430Adenoma1CTD_human
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0006118Brain Neoplasms1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0014170Endometrial Neoplasms1CTD_human
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0024301Lymphoma, Follicular1BeFree
umls:C0027809Neurilemmoma1CTD_human
umls:C0027831Neurofibromatosis 11BeFree,LHGDN
umls:C0027962Melanocytic nevus1CTD_human
umls:C0033027Preleukemia1BeFree
umls:C0038356Stomach Neoplasms1BeFree
umls:C0080178Spina Bifida1RGD
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0334485Endometrial stromal nodule1BeFree
umls:C0334486Low Grade Endometrial Stromal Sarcoma1BeFree
umls:C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0346429Multiple malignancy1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0553580Ewings sarcoma1BeFree
umls:C0598766Leukemogenesis1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0936223Metastatic Prostate Carcinoma1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C2239246Endometrial stromal sarcoma, high grade1BeFree
umls:C2745900Promyelocytic leukemia1BeFree
umls:C3463824MYELODYSPLASTIC SYNDROME1BeFree