TissGeneSummary for FPGS |
Gene summary |
Basic gene information | Gene symbol | FPGS |
Gene name | folylpolyglutamate synthase | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9q34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001018078.2, NM_001288803.1,NM_004957.5,NR_110170.1, | |
Description | folylpoly-gamma-glutamate synthetasefolylpolyglutamate synthase, mitochondrialtetrahydrofolate synthasetetrahydrofolylpolyglutamate synthase | |
Modification date | 20141207 | |
dbXrefs | MIM : 136510 | |
HGNC : HGNC | ||
Ensembl : ENSG00000136877 | ||
HPRD : 00642 | ||
Vega : OTTHUMG00000020716 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FPGS | |
BioGPS: 2356 | ||
Pathway | NCI Pathway Interaction Database: FPGS | |
KEGG: FPGS | ||
REACTOME: FPGS | ||
Pathway Commons: FPGS | ||
Context | iHOP: FPGS | |
ligand binding site mutation search in PubMed: FPGS | ||
UCL Cancer Institute: FPGS | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixOvary | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCOV | |
Reference showing the relevant tissue of FPGS | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FPGS |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FPGS |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FPGS |
TissGeneSNV for FPGS |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.I22V | THCA | 2 |
p.I22V | LGG | 2 |
p.N475K | KIRC | 1 |
p.P175S | SKCM | 1 |
p.S518G | LGG | 1 |
p.Q56* | STAD | 1 |
p.Q56X | STAD | 1 |
p.I22V | UCS | 1 |
p.T568I | PAAD | 1 |
p.N425K | KIRC | 1 |
p.P231L | BLCA | 1 |
p.I22V | PCPG | 1 |
p.S518N | COAD | 1 |
p.T518I | PAAD | 1 |
p.N414S | HNSC | 1 |
p.L224F | SKCM | 1 |
p.R139W | STAD | 1 |
p.L353F | ESCA | 1 |
p.P540S | BRCA | 1 |
p.S468G | LGG | 1 |
p.S528N | STAD | 1 |
p.A451T | UCEC | 1 |
p.D234N | SKCM | 1 |
p.G495S | COAD | 1 |
p.P444L | SKCM | 1 |
p.P494L | SKCM | 1 |
p.T546I | PAAD | 1 |
p.F388L | BLCA | 1 |
p.S478N | STAD | 1 |
p.R137W | SKCM | 1 |
p.G417R | COAD | 1 |
p.R141H | KICH | 1 |
p.S274X | KIRP | 1 |
p.A462T | PAAD | 1 |
p.L163M | LUAD | 1 |
p.S173F | BLCA | 1 |
p.T104M | COAD | 1 |
p.T182A | LUSC | 1 |
p.G122D | STAD | 1 |
p.I22V | READ | 1 |
p.V236M | LGG | 1 |
p.N450S | LIHC | 1 |
p.G233V | LIHC | 1 |
p.R306W | SKCM | 1 |
p.T496I | PAAD | 1 |
p.M365V | HNSC | 1 |
p.R158C | THYM | 1 |
p.D368N | ACC | 1 |
p.R85W | DLBC | 1 |
p.V49M | KIRC | 1 |
p.D234N | LUSC | 1 |
p.A512T | PAAD | 1 |
p.L303F | ESCA | 1 |
p.T443K | UCEC | 1 |
p.S223C | LUAD | 1 |
p.D227N | STAD | 1 |
p.P281L | BLCA | 1 |
p.L76F | STAD | 1 |
p.Q64R | UCEC | 1 |
p.N143S | LGG | 1 |
p.E150Q | BLCA | 1 |
p.G204D | UCEC | 1 |
p.R158C | UCEC | 1 |
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TissGeneCNV for FPGS |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FPGS |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE514681 | COBL-FPGS | chr7:51336612 | chr9:130572003 | |
Chimerdb3.0 | ChiTaRs | NA | CN275141 | FPGS-FPGS | chr9:130565993 | chr9:130565673 | |
Chimerdb3.0 | ChiTaRs | NA | BF772512 | FPGS-FPGS | chr9:130570585 | chr9:130566642 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OG-01A | FPGS-SQSTM1 | Out-of-Frame | chr9:130566979 | chr5:179263435 |
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TissGeneNet for FPGS |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FPGS |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FPGS |
TissGeneDrug for FPGS |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00293 | Raltitrexed | Antagonist | Small molecule | Approved|Investigational |
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TissGeneDisease for FPGS |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023449 | Acute lymphocytic leukemia | 6 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 6 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 4 | CTD_human,GAD |
umls:C0023418 | leukemia | 4 | BeFree |
umls:C1527249 | Colorectal Cancer | 4 | BeFree |
umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 2 | CTD_human,LHGDN |
umls:C0016412 | Folic Acid Deficiency | 2 | BeFree |
umls:C0024305 | Lymphoma, Non-Hodgkin | 2 | CTD_human,GAD |
umls:C0242379 | Malignant neoplasm of lung | 2 | GAD |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C0008625 | Chromosome Aberrations | 1 | GAD |
umls:C0012860 | DNA Damage | 1 | GAD |
umls:C0017178 | Gastrointestinal Diseases | 1 | GAD |
umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0024301 | Lymphoma, Follicular | 1 | GAD |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | GAD |
umls:C0079731 | B-Cell Lymphomas | 1 | GAD |
umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | GAD |
umls:C0079772 | T-Cell Lymphoma | 1 | GAD |
umls:C0080178 | Spina Bifida | 1 | GAD |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | GAD |
umls:C1335146 | Osteogenic Neoplasm | 1 | BeFree |
umls:C2063389 | Retroperitoneal liposarcoma | 1 | BeFree |