 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for LPAR3 |
 Gene summary |
| Basic gene information | Gene symbol | LPAR3 |
| Gene name | lysophosphatidic acid receptor 3 | |
| Synonyms | EDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3 | |
| Cytomap | UCSC genome browser: 1p22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012152.2, | |
| Description | LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysophosphatidic acid receptor Edg-7 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 605106 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171517 | ||
| HPRD : 05486 | ||
| Vega : OTTHUMG00000009925 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LPAR3 | |
| BioGPS: 23566 | ||
| Pathway | NCI Pathway Interaction Database: LPAR3 | |
| KEGG: LPAR3 | ||
| REACTOME: LPAR3 | ||
| Pathway Commons: LPAR3 | ||
| Context | iHOP: LPAR3 | |
| ligand binding site mutation search in PubMed: LPAR3 | ||
| UCL Cancer Institute: LPAR3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADTGCT | |
| Reference showing the relevant tissue of LPAR3 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for LPAR3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 2.210784346 | 0.322854934 | 1.887929412 | 3.80E-09 | 1.24E-08 |
| HNSC | 3.370997251 | 2.323439111 | 1.04755814 | 0.000695 | 0.002466142 |
| COAD | -2.615657132 | -1.302941747 | -1.312715385 | 0.000502 | 0.001546951 |
| STAD | -2.723988142 | -0.760766267 | -1.963221875 | 7.16E-05 | 0.000580048 |
| Top |
| TissGene-miRNA for LPAR3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-30c-5p | MIMAT0000244 | 0.026 | -0.3 | 56 |
| UCS | hsa-miR-26a-5p | MIMAT0000082 | 0.015 | -0.33 | 56 |
| Top |
| TissGeneMut for LPAR3 |
| TissGeneSNV for LPAR3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G263S | SKCM | 2 |
| p.P163L | LUAD | 1 |
| p.V249L | COAD | 1 |
| p.F39L | SKCM | 1 |
| p.A156T | PAAD | 1 |
| p.I32L | KIRP | 1 |
| p.R231L | LUSC | 1 |
| p.N119S | LUAD | 1 |
| p.N89S | LGG | 1 |
| p.A75T | HNSC | 1 |
| p.F85I | SKCM | 1 |
| p.H62Y | SKCM | 1 |
| p.M307I | BLCA | 1 |
| p.S111N | BLCA | 1 |
| p.L104F | LUSC | 1 |
| p.L113F | BLCA | 1 |
| p.S178F | SKCM | 1 |
| p.S47F | SKCM | 1 |
| p.L200V | LUAD | 1 |
| p.G166C | LUAD | 1 |
| p.V211M | COAD | 1 |
| p.R101C | BLCA | 1 |
| p.D24V | CESC | 1 |
| p.T164A | GBM | 1 |
| p.T243A | BLCA | 1 |
| p.P92L | COAD | 1 |
| p.R105H | OV | 1 |
| p.Q272H | PRAD | 1 |
| p.F85C | UCS | 1 |
| p.R231W | BLCA | 1 |
| p.Q106* | SKCM | 1 |
| p.G255D | UCEC | 1 |
| p.G246W | LIHC | 1 |
| p.D297G | LUSC | 1 |
| p.R215K | SKCM | 1 |
| p.S294F | SKCM | 1 |
| p.H62P | LGG | 1 |
| p.L284R | STAD | 1 |
| p.P163H | LUAD | 1 |
| p.R105H | LGG | 1 |
| p.A75V | SKCM | 1 |
| p.K305N | STAD | 1 |
| p.V287I | COAD | 1 |
| p.F77L | UCEC | 1 |
| p.V33G | STAD | 1 |
| p.V145M | SKCM | 1 |
| p.S343R | PAAD | 1 |
| p.M242T | OV | 1 |
| p.D23Y | UCEC | 1 |
| p.A79T | PRAD | 1 |
| p.M238I | SKCM | 1 |
| p.E314Q | PRAD | 1 |
| Top |
| TissGeneCNV for LPAR3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for LPAR3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | EL582550 | CAMTA1-LPAR3 | chr1:7553553 | chr1:85356606 | |
| Chimerdb3.0 | ChiTaRs | NA | AW593591 | SIPA1L3-LPAR3 | chr19:38535211 | chr1:85355514 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0D0-01A | LPAR3-ST6GALNAC3 | Out-of-frame | Chr1:85331068 | Chr1:77093137 |
| Top |
| TissGeneNet for LPAR3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| LPAR3, GNAI2 (tumor) | LPAR3, GNAI2 (normal) |
 |  |
| Top |
| TissGeneProg for LPAR3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for LPAR3 |
| TissGeneDrug for LPAR3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for LPAR3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 6 | BeFree |
| umls:C0600139 | Prostate carcinoma | 6 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0025202 | melanoma | 4 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 4 | BeFree |
| umls:C0178874 | Tumor Progression | 4 | BeFree |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 4 | BeFree |
| umls:C0004096 | Asthma | 3 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0018801 | Heart failure | 3 | BeFree |
| umls:C0018802 | Congestive heart failure | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree,LHGDN |
| umls:C1519670 | Tumor Angiogenesis | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0235290 | Taste bitter | 2 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree |
| umls:C1384514 | Conn Syndrome | 2 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C0001916 | Albinism | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree,LHGDN |
| umls:C0004936 | Mental disorders | 1 | BeFree |
| umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0017168 | Gastroesophageal reflux disease | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0020179 | Huntington Disease | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C1857451 | Acth-Independent Macronodular Adrenal Hyperplasia | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |