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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CASP14
check button Gene summary
Basic gene informationGene symbolCASP14
Gene namecaspase 14, apoptosis-related cysteine peptidase
Synonyms-
CytomapUCSC genome browser: 19p13.1
Type of geneprotein-coding
RefGenesNM_012114.2,
DescriptionCASP-14apoptosis-related cysteine proteasecaspase 14, apoptosis-related cysteine proteasecaspase-14
Modification date20141207
dbXrefs MIM : 605848
HGNC : HGNC
Ensembl : ENSG00000105141
HPRD : 05788
Vega : OTTHUMG00000183205
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CASP14
BioGPS: 23581
PathwayNCI Pathway Interaction Database: CASP14
KEGG: CASP14
REACTOME: CASP14
Pathway Commons: CASP14
ContextiHOP: CASP14
ligand binding site mutation search in PubMed: CASP14
UCL Cancer Institute: CASP14
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)SkinUterus
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)SKCMUCEC,UCS
Reference showing the relevant tissue of CASP14
Description by TissGene annotationsFused withOncogene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CASP14

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA1.494029645-0.4407808811.9348105268.82E-082.66E-07
LUSC1.398086818-0.9398876922.337974517.33E-061.69E-05
KICH-0.8993136530.540322347-1.4396360.0002870.000692066
HNSC4.7850754641.7258219753.0592534887.55E-050.000349537


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TissGene-miRNA for CASP14

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CASP14
TissGeneSNV for CASP14

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D181NSKCM2
p.G97RSKCM2
p.D55NSKCM1
p.R18PLUSC1
p.Q157HSKCM1
p.E76KSKCM1
p.R44WREAD1
p.A177TSTAD1
p.R179*THCA1
p.R179QSTAD1
p.E40KSKCM1
p.H89QKIRC1
p.R75LESCA1
p.E63QESCA1
p.R44LGBM1
p.E33KSKCM1
p.G184SSKCM1
p.Q45XTHYM1
p.K53QUCEC1
p.V84MCOAD1
p.F195ISTAD1
p.E49KSKCM1
p.R54THNSC1
p.H89YCESC1
p.R179QUVM1
p.P78LSARC1
p.G134*KIRC1
p.V168ILGG1
p.Q70KCESC1
p.L23RSKCM1
p.E49KUCEC1
p.K115NREAD1
p.R212WREAD1
p.V168IUCEC1
p.R121QSKCM1
p.R5WREAD1
p.R44QLUAD1
p.R47KLUAD1
p.R121QBLCA1
p.A224PLUAD1
p.G134XKIRC1
p.V84MCESC1


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TissGeneCNV for CASP14

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CASP14

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABG878547CASP14-ECT2chr19:15168836chr3:172471268


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TissGeneNet for CASP14

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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COAD (tumor)COAD (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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HNSC (tumor)HNSC (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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KICH (tumor)KICH (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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KIRC (tumor)KIRC (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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KIRP (tumor)KIRP (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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LIHC (tumor)LIHC (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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LUAD (tumor)LUAD (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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LUSC (tumor)LUSC (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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PRAD (tumor)PRAD (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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STAD (tumor)STAD (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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THCA (tumor)THCA (normal)
CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (tumor)CASP14, CUL2, CASP8, TCF3, CASP10, CASP1, CASP4, UCHL5, KRT17, PRKAB1, OTUB1, CAPN1, USP53, CASP2 (normal)
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TissGeneProg for CASP14

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CASP14
TissGeneDrug for CASP14

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CASP14

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0596263Carcinogenesis5BeFree
umls:C0001430Adenoma4BeFree
umls:C0003850Arteriosclerosis4BeFree
umls:C0003864Arthritis4BeFree
umls:C0004153Atherosclerosis4BeFree
umls:C0001418Adenocarcinoma3BeFree,GAD
umls:C0021051Immunologic Deficiency Syndromes3BeFree
umls:C0036572Seizures3BeFree
umls:C0085110Severe Combined Immunodeficiency3BeFree
umls:C0003469Anxiety Disorders2BeFree
umls:C0004352Autistic Disorder2BeFree
umls:C0007124Noninfiltrating Intraductal Carcinoma2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0011615Dermatitis, Atopic2BeFree
umls:C0013595Eczema2BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis2BeFree
umls:C0019069Hemophilia A2BeFree
umls:C0021400Influenza2BeFree
umls:C0024167Luteoma2BeFree
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0032002Pituitary Diseases2BeFree
umls:C0032019Pituitary Neoplasms2BeFree
umls:C0033578Prostatic Neoplasms2BeFree,GAD
umls:C0035335Retinoblastoma2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C3811653Experimental Organism Basal Cell Carcinoma2BeFree
umls:C0002940Aneurysm1BeFree
umls:C0003486Aortic Aneurysm1BeFree
umls:C0004096Asthma1BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0004565Melanoma, B161BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007194Hypertrophic Cardiomyopathy1BeFree
umls:C0007370Catalepsy1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0009207Cockayne Syndrome1BeFree
umls:C0009319Colitis1BeFree
umls:C0011311Dengue Fever1BeFree
umls:C0011603Dermatitis1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0014038Encephalitis1BeFree
umls:C0015397Disorder of eye1BeFree
umls:C0017638Glioma1BeFree
umls:C0017921Glycogen storage disease type II1BeFree
umls:C0018206granulosa cell tumor1BeFree
umls:C0018799Heart Diseases1BeFree
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0018889Helminthiasis1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0020479Hyperlipoproteinemia Type III1BeFree
umls:C0021390Inflammatory Bowel Diseases1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0024266Lymphocytic Choriomeningitis1BeFree
umls:C0024305Lymphoma, Non-Hodgkin1GAD
umls:C0024534Malaria, Cerebral1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0026850Muscular Dystrophy1BeFree
umls:C0027051Myocardial Infarction1BeFree
umls:C0029454Osteopetrosis1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0030354Papilloma1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0032584polyps1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0037286Skin Neoplasms1LHGDN
umls:C0037354Smallpox1BeFree
umls:C0038012Spondylitis1BeFree
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0153014Non-arthropod borne lymphocytic choriomeningitis1BeFree
umls:C0156259Hypertrophy of kidney1BeFree
umls:C0205734Diabetes, Autoimmune1BeFree
umls:C0221355Macrocephaly1BeFree
umls:C0221376Hydrosalpinx (disease)1BeFree
umls:C0238198Gastrointestinal Stromal Tumors1GAD
umls:C0271708Fasting Hypoglycemia1BeFree
umls:C0275522Asymptomatic Infections1BeFree
umls:C0276653Invasive Pulmonary Aspergillosis1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0346627Intestinal Cancer1BeFree
umls:C0584960Factor V Leiden mutation1BeFree
umls:C0684275Hemophilia, NOS1BeFree
umls:C0751483Familial Retinoblastoma1BeFree
umls:C0858600Taste sweet1BeFree
umls:C0947751Vascular inflammations1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1519346Skin Carcinogenesis1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1852467Creutzfeldt-Jakob Disease, Sporadic1BeFree
umls:C1861735Dementia, familial Danish1BeFree
umls:C2239176Liver carcinoma1BeFree,LHGDN