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TissGeneSummary for CASP14 |
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Basic gene information | Gene symbol | CASP14 |
Gene name | caspase 14, apoptosis-related cysteine peptidase | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_012114.2, | |
Description | CASP-14apoptosis-related cysteine proteasecaspase 14, apoptosis-related cysteine proteasecaspase-14 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605848 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105141 | ||
HPRD : 05788 | ||
Vega : OTTHUMG00000183205 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CASP14 | |
BioGPS: 23581 | ||
Pathway | NCI Pathway Interaction Database: CASP14 | |
KEGG: CASP14 | ||
REACTOME: CASP14 | ||
Pathway Commons: CASP14 | ||
Context | iHOP: CASP14 | |
ligand binding site mutation search in PubMed: CASP14 | ||
UCL Cancer Institute: CASP14 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinUterus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMUCEC,UCS | |
Reference showing the relevant tissue of CASP14 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for CASP14 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 1.494029645 | -0.440780881 | 1.934810526 | 8.82E-08 | 2.66E-07 |
LUSC | 1.398086818 | -0.939887692 | 2.33797451 | 7.33E-06 | 1.69E-05 |
KICH | -0.899313653 | 0.540322347 | -1.439636 | 0.000287 | 0.000692066 |
HNSC | 4.785075464 | 1.725821975 | 3.059253488 | 7.55E-05 | 0.000349537 |
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TissGene-miRNA for CASP14 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CASP14 |
TissGeneSNV for CASP14 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D181N | SKCM | 2 |
p.G97R | SKCM | 2 |
p.D55N | SKCM | 1 |
p.R18P | LUSC | 1 |
p.Q157H | SKCM | 1 |
p.E76K | SKCM | 1 |
p.R44W | READ | 1 |
p.A177T | STAD | 1 |
p.R179* | THCA | 1 |
p.R179Q | STAD | 1 |
p.E40K | SKCM | 1 |
p.H89Q | KIRC | 1 |
p.R75L | ESCA | 1 |
p.E63Q | ESCA | 1 |
p.R44L | GBM | 1 |
p.E33K | SKCM | 1 |
p.G184S | SKCM | 1 |
p.Q45X | THYM | 1 |
p.K53Q | UCEC | 1 |
p.V84M | COAD | 1 |
p.F195I | STAD | 1 |
p.E49K | SKCM | 1 |
p.R54T | HNSC | 1 |
p.H89Y | CESC | 1 |
p.R179Q | UVM | 1 |
p.P78L | SARC | 1 |
p.G134* | KIRC | 1 |
p.V168I | LGG | 1 |
p.Q70K | CESC | 1 |
p.L23R | SKCM | 1 |
p.E49K | UCEC | 1 |
p.K115N | READ | 1 |
p.R212W | READ | 1 |
p.V168I | UCEC | 1 |
p.R121Q | SKCM | 1 |
p.R5W | READ | 1 |
p.R44Q | LUAD | 1 |
p.R47K | LUAD | 1 |
p.R121Q | BLCA | 1 |
p.A224P | LUAD | 1 |
p.G134X | KIRC | 1 |
p.V84M | CESC | 1 |
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TissGeneCNV for CASP14 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CASP14 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG878547 | CASP14-ECT2 | chr19:15168836 | chr3:172471268 |
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TissGeneNet for CASP14 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CASP14 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CASP14 |
TissGeneDrug for CASP14 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CASP14 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0596263 | Carcinogenesis | 5 | BeFree |
umls:C0001430 | Adenoma | 4 | BeFree |
umls:C0003850 | Arteriosclerosis | 4 | BeFree |
umls:C0003864 | Arthritis | 4 | BeFree |
umls:C0004153 | Atherosclerosis | 4 | BeFree |
umls:C0001418 | Adenocarcinoma | 3 | BeFree,GAD |
umls:C0021051 | Immunologic Deficiency Syndromes | 3 | BeFree |
umls:C0036572 | Seizures | 3 | BeFree |
umls:C0085110 | Severe Combined Immunodeficiency | 3 | BeFree |
umls:C0003469 | Anxiety Disorders | 2 | BeFree |
umls:C0004352 | Autistic Disorder | 2 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 2 | BeFree |
umls:C0013595 | Eczema | 2 | BeFree |
umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 2 | BeFree |
umls:C0019069 | Hemophilia A | 2 | BeFree |
umls:C0021400 | Influenza | 2 | BeFree |
umls:C0024167 | Luteoma | 2 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
umls:C0032002 | Pituitary Diseases | 2 | BeFree |
umls:C0032019 | Pituitary Neoplasms | 2 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 2 | BeFree,GAD |
umls:C0035335 | Retinoblastoma | 2 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree |
umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 2 | BeFree |
umls:C0002940 | Aneurysm | 1 | BeFree |
umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0004565 | Melanoma, B16 | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007194 | Hypertrophic Cardiomyopathy | 1 | BeFree |
umls:C0007370 | Catalepsy | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0009207 | Cockayne Syndrome | 1 | BeFree |
umls:C0009319 | Colitis | 1 | BeFree |
umls:C0011311 | Dengue Fever | 1 | BeFree |
umls:C0011603 | Dermatitis | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0014038 | Encephalitis | 1 | BeFree |
umls:C0015397 | Disorder of eye | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0017921 | Glycogen storage disease type II | 1 | BeFree |
umls:C0018206 | granulosa cell tumor | 1 | BeFree |
umls:C0018799 | Heart Diseases | 1 | BeFree |
umls:C0018801 | Heart failure | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0018889 | Helminthiasis | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0020479 | Hyperlipoproteinemia Type III | 1 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
umls:C0022658 | Kidney Diseases | 1 | BeFree |
umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0024266 | Lymphocytic Choriomeningitis | 1 | BeFree |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0024534 | Malaria, Cerebral | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0026850 | Muscular Dystrophy | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | BeFree |
umls:C0029454 | Osteopetrosis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0030354 | Papilloma | 1 | BeFree |
umls:C0032285 | Pneumonia | 1 | BeFree |
umls:C0032584 | polyps | 1 | BeFree |
umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
umls:C0037286 | Skin Neoplasms | 1 | LHGDN |
umls:C0037354 | Smallpox | 1 | BeFree |
umls:C0038012 | Spondylitis | 1 | BeFree |
umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
umls:C0153014 | Non-arthropod borne lymphocytic choriomeningitis | 1 | BeFree |
umls:C0156259 | Hypertrophy of kidney | 1 | BeFree |
umls:C0205734 | Diabetes, Autoimmune | 1 | BeFree |
umls:C0221355 | Macrocephaly | 1 | BeFree |
umls:C0221376 | Hydrosalpinx (disease) | 1 | BeFree |
umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | GAD |
umls:C0271708 | Fasting Hypoglycemia | 1 | BeFree |
umls:C0275522 | Asymptomatic Infections | 1 | BeFree |
umls:C0276653 | Invasive Pulmonary Aspergillosis | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0346627 | Intestinal Cancer | 1 | BeFree |
umls:C0584960 | Factor V Leiden mutation | 1 | BeFree |
umls:C0684275 | Hemophilia, NOS | 1 | BeFree |
umls:C0751483 | Familial Retinoblastoma | 1 | BeFree |
umls:C0858600 | Taste sweet | 1 | BeFree |
umls:C0947751 | Vascular inflammations | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1519346 | Skin Carcinogenesis | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |
umls:C1852467 | Creutzfeldt-Jakob Disease, Sporadic | 1 | BeFree |
umls:C1861735 | Dementia, familial Danish | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree,LHGDN |