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| TissGeneSummary for AMACR |
 Gene summary |
| Basic gene information | Gene symbol | AMACR |
| Gene name | alpha-methylacyl-CoA racemase | |
| Synonyms | AMACRD|CBAS4|RACE|RM | |
| Cytomap | UCSC genome browser: 5p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001167595.1, NM_014324.5,NM_203382.2,NM_001167596.1,NM_001167597.1, NM_001167598.1, | |
| Description | 2-methylacyl-CoA racemase | |
| Modification date | 20141209 | |
| dbXrefs | MIM : 604489 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000242110 | ||
| HPRD : 05134 | ||
| Vega : OTTHUMG00000090734 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AMACR | |
| BioGPS: 23600 | ||
| Pathway | NCI Pathway Interaction Database: AMACR | |
| KEGG: AMACR | ||
| REACTOME: AMACR | ||
| Pathway Commons: AMACR | ||
| Context | iHOP: AMACR | |
| ligand binding site mutation search in PubMed: AMACR | ||
| UCL Cancer Institute: AMACR | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPRAD | |
| Reference showing the relevant tissue of AMACR | ||
| Description by TissGene annotations | Risk TissGene in OS Risk TissGene in RFS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0008206 | bile acid metabolic process | 10655068 | GO:0008206 | bile acid metabolic process | 10655068 |
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| TissGeneExp for AMACR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 3.684389632 | 0.498745401 | 3.185644231 | 9.79E-25 | 2.19E-21 |
| KICH | 0.287186555 | 1.346038555 | -1.058852 | 0.00587 | 0.011114674 |
| KIRP | 3.203829055 | 1.737385305 | 1.46644375 | 0.00035 | 0.001064722 |
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| TissGene-miRNA for AMACR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AMACR |
| TissGeneSNV for AMACR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V9M | BRCA | 3 |
| p.E362K | UCEC | 2 |
| p.N376D | STAD | 1 |
| p.D181N | CESC | 1 |
| p.P100T | LUSC | 1 |
| p.R342K | SKCM | 1 |
| p.E282K | BLCA | 1 |
| p.H349D | KICH | 1 |
| p.V323A | LGG | 1 |
| p.Q96H | STAD | 1 |
| p.P143L | READ | 1 |
| p.H349Y | ESCA | 1 |
| p.G5V | COAD | 1 |
| p.E277K | COAD | 1 |
| p.M159I | LUAD | 1 |
| p.K250R | BLCA | 1 |
| p.R118W | STAD | 1 |
| p.E348* | UCEC | 1 |
| p.Q261* | BLCA | 1 |
| p.I147T | UCEC | 1 |
| p.G121C | LUAD | 1 |
| p.E93D | UCEC | 1 |
| p.C117G | LIHC | 1 |
| p.P207S | UCEC | 1 |
| p.R45H | SKCM | 1 |
| p.M253I | BLCA | 1 |
| p.T279M | COAD | 1 |
| p.S7L | BLCA | 1 |
| p.S44R | HNSC | 1 |
| p.W264R | BRCA | 1 |
| p.R138K | CESC | 1 |
| p.Y126C | LIHC | 1 |
| p.Y167H | KIRP | 1 |
| p.Y126N | UCS | 1 |
| p.T221M | COAD | 1 |
| p.S52L | BLCA | 1 |
| p.R208G | HNSC | 1 |
| p.E277A | STAD | 1 |
| p.I6M | BLCA | 1 |
| p.S130P | SARC | 1 |
| p.T174A | KIRC | 1 |
| p.H305L | LUAD | 1 |
| p.V224L | BLCA | 1 |
| p.H308Y | LUAD | 1 |
| p.F287V | ESCA | 1 |
| p.G247_splice | LUSC | 1 |
| p.A276T | KIRC | 1 |
| p.I353M | PAAD | 1 |
| p.F19L | STAD | 1 |
| p.Q258E | LUAD | 1 |
| p.P296L | UCEC | 1 |
| p.R171H | STAD | 1 |
| p.L244P | SKCM | 1 |
| p.E301D | LUAD | 1 |
| p.E311* | BLCA | 1 |
| p.M159T | KIRP | 1 |
| p.E363D | READ | 1 |
| p.L119I | ESCA | 1 |
| p.R326S | BLCA | 1 |
| p.P92S | SKCM | 1 |
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| TissGeneCNV for AMACR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AMACR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE267449 | PSMG3-AMACR | chr7:1608998 | chr5:34007940 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-2A-A8W3-01A | COLEC12-AMACR | In-Frame | chr18:480706 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6377-01A | VGLL4-AMACR | In-Frame | chr3:11684910 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-8474-01A | AMACR-NDUFAF2 | In-Frame | chr5:33998745 | chr5:60368951 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8SC-01A | MATR3-AMACR | 5'UTR-CDS | chr5:138629494 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KC-A7FD-01A | CTNND1-AMACR | 5'UTR-CDS | chr11:57529518 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-8213-01A | NCK1-AMACR | 5'UTR-CDS | chr3:136581161 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7AP-01A | PHF21B-AMACR | Out-of-Frame | chr22:45404425 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-ZG-A9L5-01A | TRIM35-AMACR | Out-of-Frame | chr8:27168317 | chr5:33989607 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5501-01A | PHF21B-AMACR | Out-of-Frame | chr22:45404425 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7318-01B | PCA3-AMACR | 5'UTR-CDS | chr9:79379471 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7818-01A | SF1-AMACR | In-Frame | chr11:64543969 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-7792-01A | BLCAP-AMACR | 5'UTR-CDS | chr20:36156194 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-VP-A87B-01A | SMARCA2-AMACR | 5'UTR-CDS | chr9:2015404 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6348-01A | CCAR1-AMACR | In-Frame | chr10:70532856 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KC-A7FD-01A | CPE-AMACR | In-Frame | chr4:166300680 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7749-01A | C3orf78-AMACR | In-Frame | chr3:52570922 | chr5:34006004 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7749-01A | RHBDD1-AMACR | In-Frame | chr2:227779067 | chr5:34006004 |
| TCGAfusionPortal | PRADA | BLCA | TCGA-BL-A0C8-01A | SLC45A2-AMACR | In-frame | Chr5:33982341 | Chr5:34006004 |
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| TissGeneNet for AMACR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| AMACR, HNF4A (tumor) | AMACR, HNF4A (normal) |
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| TissGeneProg for AMACR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AMACR |
| TissGeneDrug for AMACR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AMACR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 46 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 43 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 17 | BeFree,CTD_human,LHGDN |
| umls:C0007134 | Renal Cell Carcinoma | 10 | BeFree,LHGDN |
| umls:C0001430 | Adenoma | 6 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0001418 | Adenocarcinoma | 5 | BeFree,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C2239176 | Liver carcinoma | 4 | BeFree,LHGDN |
| umls:C2931456 | Prostate cancer, familial | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 3 | CTD_human,LHGDN |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 3 | BeFree |
| umls:C1306837 | Papillary Renal Cell Carcinoma | 3 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 3 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree,GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree,GAD |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 2 | BeFree |
| umls:C1378703 | Renal carcinoma | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 2 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 2 | BeFree |
| umls:C3280428 | Alpha-Methylacyl-CoA Racemase Deficiency | 2 | BeFree,MGD,UNIPROT |
| umls:C0004763 | Barrett Esophagus | 1 | BeFree,LHGDN |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007112 | Adenocarcinoma of prostate | 1 | BeFree |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
| umls:C0007873 | Uterine Cervical Neoplasm | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | GAD |
| umls:C0018799 | Heart Diseases | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | LHGDN |
| umls:C0023798 | Lipoma | 1 | BeFree |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| umls:C0023895 | Liver diseases | 1 | CTD_human |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0027888 | Hereditary Motor and Sensory Neuropathies | 1 | CTD_human |
| umls:C0034885 | Rectal Neoplasms | 1 | GAD |
| umls:C0035372 | Rett Syndrome | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0039101 | synovial sarcoma | 1 | BeFree |
| umls:C0041107 | Trisomy | 1 | BeFree |
| umls:C0041696 | Unipolar Depression | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0151468 | Thyroid Gland Follicular Adenoma | 1 | BeFree |
| umls:C0205851 | Germ cell tumor | 1 | BeFree |
| umls:C0206695 | Carcinoma, Neuroendocrine | 1 | BeFree |
| umls:C0235025 | Peripheral motor neuropathy | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0282528 | Peroxisomal Disorders | 1 | LHGDN |
| umls:C0282612 | Prostatic Intraepithelial Neoplasias | 1 | LHGDN |
| umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
| umls:C0343284 | Chondrodysplasia | 1 | BeFree |
| umls:C0343641 | Human papilloma virus infection | 1 | BeFree |
| umls:C0600327 | Toxic Shock Syndrome | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0949541 | Hurthle Cell Tumor | 1 | BeFree |
| umls:C1168327 | High-Grade Prostatic Intraepithelial Neoplasia | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 1 | BeFree |
| umls:C1292753 | Primary Effusion Lymphoma | 1 | BeFree |
| umls:C1300346 | Desmoplastic fibroblastoma | 1 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
| umls:C1333064 | Classical Hodgkin's Lymphoma | 1 | BeFree |
| umls:C1378050 | Oncocytic Neoplasm | 1 | BeFree |
| umls:C1510502 | Oxyphilic Adenoma | 1 | BeFree |
| umls:C1840451 | MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 1 | BeFree |
| umls:C1858328 | Bile acid synthesis defect, congenital, 4 | 1 | CTD_human,ORPHANET,UNIPROT |
| umls:C2937421 | Prostatic Hyperplasia | 1 | LHGDN |
| umls:C3714524 | Fibromyxosarcoma | 1 | BeFree |
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