TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AMACR
check button Gene summary
Basic gene informationGene symbolAMACR
Gene namealpha-methylacyl-CoA racemase
SynonymsAMACRD|CBAS4|RACE|RM
CytomapUCSC genome browser: 5p13
Type of geneprotein-coding
RefGenesNM_001167595.1,
NM_014324.5,NM_203382.2,NM_001167596.1,NM_001167597.1,
NM_001167598.1,
Description2-methylacyl-CoA racemase
Modification date20141209
dbXrefs MIM : 604489
HGNC : HGNC
Ensembl : ENSG00000242110
HPRD : 05134
Vega : OTTHUMG00000090734
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AMACR
BioGPS: 23600
PathwayNCI Pathway Interaction Database: AMACR
KEGG: AMACR
REACTOME: AMACR
Pathway Commons: AMACR
ContextiHOP: AMACR
ligand binding site mutation search in PubMed: AMACR
UCL Cancer Institute: AMACR
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyProstate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHPRAD
Reference showing the relevant tissue of AMACR
Description by TissGene annotationsRisk TissGene in OS
Risk TissGene in RFS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0008206bile acid metabolic process10655068
GO:0008206bile acid metabolic process10655068


Top
TissGeneExp for AMACR

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD3.6843896320.4987454013.1856442319.79E-252.19E-21
KICH0.2871865551.346038555-1.0588520.005870.011114674
KIRP3.2038290551.7373853051.466443750.000350.001064722


Top
TissGene-miRNA for AMACR

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for AMACR
TissGeneSNV for AMACR

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V9MBRCA3
p.E362KUCEC2
p.N376DSTAD1
p.D181NCESC1
p.P100TLUSC1
p.R342KSKCM1
p.E282KBLCA1
p.H349DKICH1
p.V323ALGG1
p.Q96HSTAD1
p.P143LREAD1
p.H349YESCA1
p.G5VCOAD1
p.E277KCOAD1
p.M159ILUAD1
p.K250RBLCA1
p.R118WSTAD1
p.E348*UCEC1
p.Q261*BLCA1
p.I147TUCEC1
p.G121CLUAD1
p.E93DUCEC1
p.C117GLIHC1
p.P207SUCEC1
p.R45HSKCM1
p.M253IBLCA1
p.T279MCOAD1
p.S7LBLCA1
p.S44RHNSC1
p.W264RBRCA1
p.R138KCESC1
p.Y126CLIHC1
p.Y167HKIRP1
p.Y126NUCS1
p.T221MCOAD1
p.S52LBLCA1
p.R208GHNSC1
p.E277ASTAD1
p.I6MBLCA1
p.S130PSARC1
p.T174AKIRC1
p.H305LLUAD1
p.V224LBLCA1
p.H308YLUAD1
p.F287VESCA1
p.G247_spliceLUSC1
p.A276TKIRC1
p.I353MPAAD1
p.F19LSTAD1
p.Q258ELUAD1
p.P296LUCEC1
p.R171HSTAD1
p.L244PSKCM1
p.E301DLUAD1
p.E311*BLCA1
p.M159TKIRP1
p.E363DREAD1
p.L119IESCA1
p.R326SBLCA1
p.P92SSKCM1


Top
TissGeneCNV for AMACR

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for AMACR

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE267449PSMG3-AMACRchr7:1608998chr5:34007940
Chimerdb3.0FusionScanPRADTCGA-2A-A8W3-01ACOLEC12-AMACRIn-Framechr18:480706chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-G9-6377-01AVGLL4-AMACRIn-Framechr3:11684910chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-EJ-8474-01AAMACR-NDUFAF2In-Framechr5:33998745chr5:60368951
Chimerdb3.0FusionScanPRADTCGA-YL-A8SC-01AMATR3-AMACR5'UTR-CDSchr5:138629494chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-KC-A7FD-01ACTNND1-AMACR5'UTR-CDSchr11:57529518chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-HC-8213-01ANCK1-AMACR5'UTR-CDSchr3:136581161chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-KK-A7AP-01APHF21B-AMACROut-of-Framechr22:45404425chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-ZG-A9L5-01ATRIM35-AMACROut-of-Framechr8:27168317chr5:33989607
Chimerdb3.0FusionScanPRADTCGA-EJ-5501-01APHF21B-AMACROut-of-Framechr22:45404425chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-EJ-7318-01BPCA3-AMACR5'UTR-CDSchr9:79379471chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-HC-7818-01ASF1-AMACRIn-Framechr11:64543969chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-EJ-7792-01ABLCAP-AMACR5'UTR-CDSchr20:36156194chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-VP-A87B-01ASMARCA2-AMACR5'UTR-CDSchr9:2015404chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-G9-6348-01ACCAR1-AMACRIn-Framechr10:70532856chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-KC-A7FD-01ACPE-AMACRIn-Framechr4:166300680chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-HC-7749-01AC3orf78-AMACRIn-Framechr3:52570922chr5:34006004
Chimerdb3.0FusionScanPRADTCGA-HC-7749-01ARHBDD1-AMACRIn-Framechr2:227779067chr5:34006004
TCGAfusionPortalPRADABLCATCGA-BL-A0C8-01ASLC45A2-AMACRIn-frameChr5:33982341Chr5:34006004


Top
TissGeneNet for AMACR

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
AMACR, HNF4A (tumor)AMACR, HNF4A (normal)
bullet pointbullet point


Top
TissGeneProg for AMACR

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for AMACR
TissGeneDrug for AMACR

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for AMACR

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0376358Malignant neoplasm of prostate46BeFree,GAD
umls:C0600139Prostate carcinoma43BeFree
umls:C0033578Prostatic Neoplasms17BeFree,CTD_human,LHGDN
umls:C0007134Renal Cell Carcinoma10BeFree,LHGDN
umls:C0001430Adenoma6BeFree,CTD_human,GAD,LHGDN
umls:C0001418Adenocarcinoma5BeFree,LHGDN
umls:C0027627Neoplasm Metastasis4BeFree
umls:C2239176Liver carcinoma4BeFree,LHGDN
umls:C2931456Prostate cancer, familial4BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0009404Colorectal Neoplasms3CTD_human,LHGDN
umls:C0596263Carcinogenesis3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0740457Malignant neoplasm of kidney3BeFree
umls:C1306837Papillary Renal Cell Carcinoma3BeFree
umls:C1704272Benign Prostatic Hyperplasia3BeFree
umls:C0005684Malignant neoplasm of urinary bladder2BeFree,GAD
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0028754Obesity2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree,GAD
umls:C0699791Stomach Carcinoma2BeFree
umls:C0936223Metastatic Prostate Carcinoma2BeFree
umls:C1378703Renal carcinoma2BeFree
umls:C1527249Colorectal Cancer2BeFree
umls:C1709246Non-Neoplastic Disorder2BeFree
umls:C2931822Nasopharyngeal carcinoma2BeFree
umls:C3280428Alpha-Methylacyl-CoA Racemase Deficiency2BeFree,MGD,UNIPROT
umls:C0004763Barrett Esophagus1BeFree,LHGDN
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007112Adenocarcinoma of prostate1BeFree
umls:C0007124Noninfiltrating Intraductal Carcinoma1BeFree
umls:C0007873Uterine Cervical Neoplasm1BeFree
umls:C0009375Colonic Neoplasms1GAD
umls:C0018799Heart Diseases1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0021390Inflammatory Bowel Diseases1LHGDN
umls:C0023798Lipoma1BeFree
umls:C0023893Liver Cirrhosis, Experimental1CTD_human
umls:C0023895Liver diseases1CTD_human
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0027819Neuroblastoma1BeFree
umls:C0027888Hereditary Motor and Sensory Neuropathies1CTD_human
umls:C0034885Rectal Neoplasms1GAD
umls:C0035372Rett Syndrome1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0039101synovial sarcoma1BeFree
umls:C0041107Trisomy1BeFree
umls:C0041696Unipolar Depression1BeFree
umls:C0079731B-Cell Lymphomas1BeFree
umls:C0151468Thyroid Gland Follicular Adenoma1BeFree
umls:C0205851Germ cell tumor1BeFree
umls:C0206695Carcinoma, Neuroendocrine1BeFree
umls:C0235025Peripheral motor neuropathy1BeFree
umls:C0238198Gastrointestinal Stromal Tumors1BeFree
umls:C0238339Hereditary pancreatitis1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0279702Conventional (Clear Cell) Renal Cell Carcinoma1BeFree
umls:C0282528Peroxisomal Disorders1LHGDN
umls:C0282612Prostatic Intraepithelial Neoplasias1LHGDN
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0343284Chondrodysplasia1BeFree
umls:C0343641Human papilloma virus infection1BeFree
umls:C0600327Toxic Shock Syndrome1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0949541Hurthle Cell Tumor1BeFree
umls:C1168327High-Grade Prostatic Intraepithelial Neoplasia1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1266044Collecting Duct Carcinoma of the Kidney1BeFree
umls:C1269683Major Depressive Disorder1BeFree
umls:C1292753Primary Effusion Lymphoma1BeFree
umls:C1300346Desmoplastic fibroblastoma1BeFree
umls:C1302401Adenoma of large intestine1BeFree
umls:C1333064Classical Hodgkin's Lymphoma1BeFree
umls:C1378050Oncocytic Neoplasm1BeFree
umls:C1510502Oxyphilic Adenoma1BeFree
umls:C1840451MULTICYSTIC RENAL DYSPLASIA, BILATERAL1BeFree
umls:C1858328Bile acid synthesis defect, congenital, 41CTD_human,ORPHANET,UNIPROT
umls:C2937421Prostatic Hyperplasia1LHGDN
umls:C3714524Fibromyxosarcoma1BeFree