TissGeneSummary for TSSK2 |
Gene summary |
Basic gene information | Gene symbol | TSSK2 |
Gene name | testis-specific serine kinase 2 | |
Synonyms | DGS-G|SPOGA2|STK22B|TSK2 | |
Cytomap | UCSC genome browser: 22q11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_053006.4, | |
Description | TSK-2TSSK-2diGeorge syndrome protein Gserine/threonine kinase 22B (spermiogenesis associated)serine/threonine-protein kinase 22Bspermiogenesis associated 2testis specific serine threonine kinase 2testis-specific kinase 2testis-specific serine/thre | |
Modification date | 20141207 | |
dbXrefs | MIM : 610710 | |
HGNC : HGNC | ||
Ensembl : ENSG00000206203 | ||
HPRD : 10255 | ||
Vega : OTTHUMG00000150118 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSSK2 | |
BioGPS: 23617 | ||
Pathway | NCI Pathway Interaction Database: TSSK2 | |
KEGG: TSSK2 | ||
REACTOME: TSSK2 | ||
Pathway Commons: TSSK2 | ||
Context | iHOP: TSSK2 | |
ligand binding site mutation search in PubMed: TSSK2 | ||
UCL Cancer Institute: TSSK2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TSSK2 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0046777 | protein autophosphorylation | 20729278 | GO:0046777 | protein autophosphorylation | 20729278 |
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TissGeneExp for TSSK2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TSSK2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TSSK2 |
TissGeneSNV for TSSK2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D335G | STAD | 1 |
p.P255S | COAD | 1 |
p.R45H | HNSC | 1 |
p.G212S | COAD | 1 |
p.G354E | BRCA | 1 |
p.S178L | UCEC | 1 |
p.I249T | STAD | 1 |
p.R168H | UCEC | 1 |
p.R294H | UCEC | 1 |
p.E230K | BLCA | 1 |
p.S172C | SKCM | 1 |
p.V204M | UCEC | 1 |
p.L137P | HNSC | 1 |
p.F56V | UCEC | 1 |
p.R168C | PRAD | 1 |
p.S178L | PRAD | 1 |
p.S213Y | PRAD | 1 |
p.A180T | PAAD | 1 |
p.Q273R | LIHC | 1 |
p.Q188H | PRAD | 1 |
p.S28P | HNSC | 1 |
p.Y87* | HNSC | 1 |
p.V124G | SARC | 1 |
p.Q193H | LUSC | 1 |
p.K35E | STAD | 1 |
p.A183T | PAAD | 1 |
p.D3N | HNSC | 1 |
p.R160C | LGG | 1 |
p.R260W | HNSC | 1 |
p.G70S | STAD | 1 |
p.E339K | ESCA | 1 |
p.V53G | HNSC | 1 |
p.D44N | READ | 1 |
p.D247N | SKCM | 1 |
p.C139Y | STAD | 1 |
p.R310Q | SKCM | 1 |
p.K27R | DLBC | 1 |
p.C243Y | UCEC | 1 |
p.P236Q | LUSC | 1 |
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TissGeneCNV for TSSK2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSSK2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TSSK2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSSK2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSSK2 |
TissGeneDrug for TSSK2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSSK2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009782 | Connective Tissue Diseases | 1 | BeFree |
umls:C0036421 | Systemic Scleroderma | 1 | BeFree |