TissGeneSummary for PRND |
Gene summary |
Basic gene information | Gene symbol | PRND |
Gene name | prion protein 2 (dublet) | |
Synonyms | DOPPEL|DPL|PrPLP|dJ1068H6.4 | |
Cytomap | UCSC genome browser: 20p13 | |
Type of gene | protein-coding | |
RefGenes | NM_012409.3, | |
Description | prion gene complex, downstreamprion-like protein doppel | |
Modification date | 20141207 | |
dbXrefs | MIM : 604263 | |
HGNC : HGNC | ||
Ensembl : ENSG00000171864 | ||
HPRD : 05039 | ||
Vega : OTTHUMG00000031789 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRND | |
BioGPS: 23627 | ||
Pathway | NCI Pathway Interaction Database: PRND | |
KEGG: PRND | ||
REACTOME: PRND | ||
Pathway Commons: PRND | ||
Context | iHOP: PRND | |
ligand binding site mutation search in PubMed: PRND | ||
UCL Cancer Institute: PRND | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PRND | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PRND |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 1.676650416 | -0.459359306 | 2.136009722 | 2.93E-09 | 9.39E-09 |
LIHC | -0.408369806 | -2.276461806 | 1.868092 | 8.95E-09 | 7.89E-08 |
THCA | -0.544363332 | -1.903556552 | 1.35919322 | 8.32E-07 | 3.18E-06 |
KICH | 0.970516194 | -0.900815806 | 1.871332 | 0.00018 | 0.000450306 |
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TissGene-miRNA for PRND |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PRND |
TissGeneSNV for PRND |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E138K | SKCM | 2 |
p.R37W | STAD | 1 |
p.W35* | SKCM | 1 |
p.A39V | THCA | 1 |
p.H90D | LUSC | 1 |
p.R134Q | STAD | 1 |
p.I89N | STAD | 1 |
p.S95Y | UCEC | 1 |
p.R156Q | STAD | 1 |
p.E53K | BLCA | 1 |
p.C14S | LUAD | 1 |
p.R64C | UCEC | 1 |
p.K176R | UCEC | 1 |
p.A114V | BRCA | 1 |
p.R64H | BRCA | 1 |
p.N54D | UCEC | 1 |
p.R156W | SKCM | 1 |
p.R156W | PAAD | 1 |
p.T106I | UCEC | 1 |
p.W172R | STAD | 1 |
p.P123S | BLCA | 1 |
p.Q84K | BRCA | 1 |
p.S19N | UCEC | 1 |
p.R32I | STAD | 1 |
p.K65* | LUAD | 1 |
p.G88S | HNSC | 1 |
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TissGeneCNV for PRND |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PRND |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | HNSC | TCGA-CR-5243-01A | RAGE-PRND | CDS-5UTR | Chr14:102717149 | Chr20:4705187 |
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TissGeneNet for PRND |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PRND |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PRND |
TissGeneDrug for PRND |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PRND |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004114 | Astrocytoma | 5 | BeFree |
umls:C0162534 | Prion Diseases | 5 | BeFree,GAD |
umls:C0022336 | Creutzfeldt-Jakob disease | 4 | BeFree,GAD,LHGDN |
umls:C0002395 | Alzheimer's Disease | 3 | BeFree,GAD |
umls:C1852467 | Creutzfeldt-Jakob Disease, Sporadic | 2 | BeFree |
umls:C0004134 | Ataxia | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0085584 | Encephalopathies | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |