TissGeneSummary for TRIM29 |
Gene summary |
Basic gene information | Gene symbol | TRIM29 |
Gene name | tripartite motif containing 29 | |
Synonyms | ATDC | |
Cytomap | UCSC genome browser: 11q23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_012101.3, NM_058193.1, | |
Description | ataxia telangiectasia group D-associated proteinataxia-telangiectasia group D-associated proteintripartite motif protein TRIM29tripartite motif-containing 29tripartite motif-containing protein 29 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610658 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137699 | ||
HPRD : 10280 | ||
Vega : OTTHUMG00000140377 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRIM29 | |
BioGPS: 23650 | ||
Pathway | NCI Pathway Interaction Database: TRIM29 | |
KEGG: TRIM29 | ||
REACTOME: TRIM29 | ||
Pathway Commons: TRIM29 | ||
Context | iHOP: TRIM29 | |
ligand binding site mutation search in PubMed: TRIM29 | ||
UCL Cancer Institute: TRIM29 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderCervixSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCACESCSKCM | |
Reference showing the relevant tissue of TRIM29 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TRIM29 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -5.810745473 | -0.402785473 | -5.40796 | 1.67E-17 | 7.22E-16 |
THCA | -0.516825744 | -3.355385066 | 2.838559322 | 9.38E-11 | 6.29E-10 |
BRCA | 0.784196141 | 3.300158421 | -2.515962281 | 1.33E-12 | 5.94E-12 |
KIRC | -3.756531418 | -1.442623084 | -2.313908333 | 1.12E-10 | 3.97E-10 |
COAD | 2.568438988 | -1.456211012 | 4.02465 | 5.42E-15 | 3.13E-13 |
PRAD | 1.903508219 | 3.849337065 | -1.945828846 | 2.22E-07 | 1.87E-06 |
LIHC | -4.798171473 | -3.213497473 | -1.584674 | 3.17E-06 | 1.53E-05 |
LUSC | 5.274930919 | 0.445517193 | 4.829413725 | 2.35E-31 | 1.36E-29 |
STAD | 2.847166152 | -0.001011973 | 2.848178125 | 0.00298 | 0.012717306 |
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TissGene-miRNA for TRIM29 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TRIM29 |
TissGeneSNV for TRIM29 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D431Y | LUAD | 2 |
p.E64K | SKCM | 2 |
p.S133L | LIHC | 1 |
p.H198Y | LUAD | 1 |
p.G445V | UCEC | 1 |
p.M427L | LUAD | 1 |
p.R335Q | SKCM | 1 |
p.E403V | LUAD | 1 |
p.R150Q | STAD | 1 |
p.R77* | STAD | 1 |
p.T566N | LUAD | 1 |
p.H211Y | SKCM | 1 |
p.R422H | STAD | 1 |
p.R422H | COAD | 1 |
p.R150Q | SKCM | 1 |
p.D88H | LUAD | 1 |
p.A68T | STAD | 1 |
p.R128H | PRAD | 1 |
p.G57D | SKCM | 1 |
p.L199P | DLBC | 1 |
p.P465L | STAD | 1 |
p.P118H | LUAD | 1 |
p.E401K | SKCM | 1 |
p.L246F | SKCM | 1 |
p.D351E | LUAD | 1 |
p.P201L | SKCM | 1 |
p.F302L | BLCA | 1 |
p.D87A | COAD | 1 |
p.D157N | GBM | 1 |
p.R449H | STAD | 1 |
p.T498A | STAD | 1 |
p.R136Q | SKCM | 1 |
p.S26N | STAD | 1 |
p.S388T | OV | 1 |
p.R319W | LGG | 1 |
p.A156T | PRAD | 1 |
p.C420F | LUSC | 1 |
p.S164F | SKCM | 1 |
p.A156V | SKCM | 1 |
p.A331V | COAD | 1 |
p.E284V | LGG | 1 |
p.F249S | LIHC | 1 |
p.S373F | BRCA | 1 |
p.K355T | LUAD | 1 |
p.K230N | BLCA | 1 |
p.E147K | SKCM | 1 |
p.E311K | SKCM | 1 |
p.D174N | SKCM | 1 |
p.S552N | UCEC | 1 |
p.D39N | SARC | 1 |
p.V424F | LUAD | 1 |
p.G146R | STAD | 1 |
p.K124* | SKCM | 1 |
p.A156V | LUAD | 1 |
p.R364W | STAD | 1 |
p.V227M | LIHC | 1 |
p.T566N | UCEC | 1 |
p.P391L | SKCM | 1 |
p.K102M | LUAD | 1 |
p.V424I | UCEC | 1 |
p.V374L | LUAD | 1 |
p.R77X | STAD | 1 |
p.G24D | STAD | 1 |
p.K500N | COAD | 1 |
p.R482W | SKCM | 1 |
p.L375F | PRAD | 1 |
p.S540F | SKCM | 1 |
p.T395I | COAD | 1 |
p.L127V | UCEC | 1 |
p.A587S | LUAD | 1 |
p.D287N | SKCM | 1 |
p.S562F | SKCM | 1 |
p.V343L | DLBC | 1 |
p.T257I | LUAD | 1 |
p.R77L | LUAD | 1 |
p.E221D | CHOL | 1 |
p.A331V | LGG | 1 |
p.P201L | PRAD | 1 |
p.S168P | UCEC | 1 |
p.C236Y | COAD | 1 |
p.K89N | CESC | 1 |
p.T494I | SKCM | 1 |
p.P390L | SKCM | 1 |
p.A122D | LUAD | 1 |
p.A206T | STAD | 1 |
p.R298H | COAD | 1 |
p.G11R | GBM | 1 |
p.P557L | SKCM | 1 |
p.V516F | LUAD | 1 |
p.R77Q | SKCM | 1 |
p.F235C | BRCA | 1 |
p.P391S | SKCM | 1 |
p.Q558H | READ | 1 |
p.E196K | UCEC | 1 |
p.S488L | SKCM | 1 |
p.H255Y | SKCM | 1 |
p.K124X | SKCM | 1 |
p.S23L | BLCA | 1 |
p.K361R | UCEC | 1 |
p.G581R | ACC | 1 |
p.R549Q | COAD | 1 |
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TissGeneCNV for TRIM29 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TRIM29 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI055855 | TRIM29-SDC1 | chr11:119991324 | chr2:20403811 | |
Chimerdb3.0 | ChiTaRs | NA | BG993058 | PLEKHA5-TRIM29 | chr12:19410412 | chr11:119999118 | |
Chimerdb3.0 | ChiTaRs | NA | DB107228 | TRIM29-TRIM29 | chr11:120008821 | chr11:120008174 | |
Chimerdb3.0 | ChiTaRs | NA | BF842536 | TRIM29-TRIM29 | chr11:119996549 | chr11:119996568 | |
Chimerdb3.0 | ChiTaRs | NA | BG996534 | TRIM29-TRIM29 | chr11:119996519 | chr11:119996566 | |
Chimerdb3.0 | ChiTaRs | NA | BG992093 | TSPAN11-TRIM29 | chr12:31126522 | chr11:119988930 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NW-01A | TRIM29-RHCG | In-Frame | chr11:119998043 | chr15:90021205 |
TCGAfusionPortal | PRADA | OV | TCGA-23-1030-01A | UVRAG-TRIM29 | In-frame | Chr11:75572825 | Chr11:119983184 |
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TissGeneNet for TRIM29 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TRIM29 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TRIM29 |
TissGeneDrug for TRIM29 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TRIM29 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004135 | Ataxia Telangiectasia | 7 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
umls:C0302592 | Cervix carcinoma | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
umls:C1301034 | Pancreatic intraepithelial neoplasia | 1 | BeFree |