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| TissGeneSummary for TMEFF2 |
 Gene summary |
| Basic gene information | Gene symbol | TMEFF2 |
| Gene name | transmembrane protein with EGF-like and two follistatin-like domains 2 | |
| Synonyms | CT120.2|HPP1|TENB2|TPEF|TR | |
| Cytomap | UCSC genome browser: 2q32.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_016192.2, | |
| Description | TR-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1tomoregulintomoregulin-2transmembrane protein TENB2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605734 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000144339 | ||
| HPRD : 05760 | ||
| Vega : OTTHUMG00000132723 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TMEFF2 | |
| BioGPS: 23671 | ||
| Pathway | NCI Pathway Interaction Database: TMEFF2 | |
| KEGG: TMEFF2 | ||
| REACTOME: TMEFF2 | ||
| Pathway Commons: TMEFF2 | ||
| Context | iHOP: TMEFF2 | |
| ligand binding site mutation search in PubMed: TMEFF2 | ||
| UCL Cancer Institute: TMEFF2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of TMEFF2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TMEFF2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -0.359736783 | 1.718988217 | -2.078725 | 4.42E-06 | 5.71E-05 |
| PRAD | 10.49824591 | 8.469607448 | 2.028638462 | 4.75E-07 | 3.63E-06 |
| BLCA | -1.442232836 | 1.346698743 | -2.788931579 | 1.09E-06 | 3.61E-05 |
| HNSC | -1.176086202 | 0.427074263 | -1.603160465 | 4.15E-07 | 3.50E-06 |
| COAD | -1.290104091 | 2.073734371 | -3.363838462 | 5.35E-15 | 3.13E-13 |
| KIRP | -1.606902408 | -0.446446158 | -1.16045625 | 3.49E-08 | 2.36E-07 |
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| TissGene-miRNA for TMEFF2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TMEFF2 |
| TissGeneSNV for TMEFF2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E220K | SKCM | 3 |
| p.R34H | STAD | 1 |
| p.G327R | SKCM | 1 |
| p.M28I | UCEC | 1 |
| p.Q285X | LIHC | 1 |
| p.G84R | SKCM | 1 |
| p.D246E | UCEC | 1 |
| p.F67L | LIHC | 1 |
| p.S160Y | BLCA | 1 |
| p.R117Q | STAD | 1 |
| p.P314S | READ | 1 |
| p.D198V | LUAD | 1 |
| p.R34H | COAD | 1 |
| p.S212L | SKCM | 1 |
| p.C150R | HNSC | 1 |
| p.V310I | STAD | 1 |
| p.E173K | HNSC | 1 |
| p.E113K | BLCA | 1 |
| p.T161I | HNSC | 1 |
| p.S212L | LGG | 1 |
| p.T71I | SKCM | 1 |
| p.E126D | OV | 1 |
| p.A196T | STAD | 1 |
| p.D304N | SKCM | 1 |
| p.G147V | ACC | 1 |
| p.A369E | CHOL | 1 |
| p.S212L | BLCA | 1 |
| p.T159K | LGG | 1 |
| p.R226Q | SKCM | 1 |
| p.M284T | BRCA | 1 |
| p.S171F | SKCM | 1 |
| p.D198Y | LUAD | 1 |
| p.K303R | STAD | 1 |
| p.M284I | ESCA | 1 |
| p.G104D | ESCA | 1 |
| p.E210* | ESCA | 1 |
| p.H280N | LUAD | 1 |
| p.H148Y | DLBC | 1 |
| p.R350K | SKCM | 1 |
| p.E279K | BLCA | 1 |
| p.W160* | BLCA | 1 |
| p.C186S | ACC | 1 |
| p.S105Y | BLCA | 1 |
| p.E210X | ESCA | 1 |
| p.G168D | STAD | 1 |
| p.S306N | SKCM | 1 |
| p.S201P | READ | 1 |
| p.T52P | LUAD | 1 |
| p.M284V | SKCM | 1 |
| p.A369V | COAD | 1 |
| p.G313C | LUAD | 1 |
| p.G327A | LGG | 1 |
| p.D174H | CESC | 1 |
| p.L308V | LUAD | 1 |
| p.D203N | BLCA | 1 |
| p.R350I | READ | 1 |
| p.F317C | UCEC | 1 |
| p.S134* | LUSC | 1 |
| p.R316Q | READ | 1 |
| p.S288T | BLCA | 1 |
| p.D304H | KIRC | 1 |
| p.E256D | SKCM | 1 |
| p.D203N | SKCM | 1 |
| p.E267K | BLCA | 1 |
| p.P314T | LUAD | 1 |
| p.E17K | LUAD | 1 |
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| TissGeneCNV for TMEFF2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TMEFF2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AK130344 | TMEFF2-BBS9 | chr2:192915084 | chr7:33408652 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-ZG-A9LM-01A | TMEFF2-TMPRSS11B | In-Frame | chr2:193044393 | chr4:69098134 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-ZG-A9LZ-01A | TMEFF2-ACPP | In-Frame | chr2:192899419 | chr3:132075698 |
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| TissGeneNet for TMEFF2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TMEFF2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TMEFF2 |
| TissGeneDrug for TMEFF2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TMEFF2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1527249 | Colorectal Cancer | 11 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 9 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 8 | BeFree |
| umls:C0600139 | Prostate carcinoma | 8 | BeFree |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 5 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 5 | BeFree |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 3 | LHGDN |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 3 | BeFree |
| umls:C0020676 | Hypothyroidism | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | BeFree,CTD_human |
| umls:C0041234 | Chagas Disease | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0206638 | Giant Cell Tumor of Bone | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 2 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 2 | BeFree |
| umls:C1520166 | Xenograft Model | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0002893 | Refractory anemias | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004763 | Barrett Esophagus | 1 | LHGDN |
| umls:C0005695 | Bladder Neoplasm | 1 | LHGDN |
| umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | GWASCAT |
| umls:C0011849 | Diabetes Mellitus | 1 | GAD,GWASCAT |
| umls:C0014859 | Esophageal Neoplasms | 1 | LHGDN |
| umls:C0020550 | Hyperthyroidism | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0040128 | Thyroid Diseases | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042900 | Vitiligo | 1 | BeFree |
| umls:C0085298 | Sudden Cardiac Death | 1 | GAD |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0278803 | Adenocarcinoma of small intestine | 1 | BeFree |
| umls:C0282612 | Prostatic Intraepithelial Neoplasias | 1 | BeFree |
| umls:C0334276 | Adenocarcinoma in Situ | 1 | BeFree |
| umls:C0346429 | Multiple malignancy | 1 | BeFree |
| umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0740302 | 5q-syndrome | 1 | BeFree |
| umls:C1292779 | Myelodysplastic Syndrome with Isolated del(5q) | 1 | BeFree |
| umls:C1332347 | Atypical Ductal Breast Hyperplasia | 1 | BeFree |
| umls:C1333620 | Flat Ductal Epithelial Atypia of the Breast | 1 | BeFree |
| umls:C1704421 | Skin Pigmentation Disorder | 1 | BeFree |
| umls:C1802398 | Chromosome 5, trisomy 5q | 1 | BeFree |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2981142 | Refractory anemia, without ringed sideroblasts, without excess blasts | 1 | BeFree |
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