TissGeneSummary for ATP6V0D2 |
Gene summary |
Basic gene information | Gene symbol | ATP6V0D2 |
Gene name | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | |
Synonyms | ATP6D2|VMA6 | |
Cytomap | UCSC genome browser: - | |
Type of gene | protein-coding | |
RefGenes | NM_152565.1, | |
Description | V-ATPase subunit d 2V-type proton ATPase subunit d 2vacuolar proton pump subunit d 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000147614 | ||
HPRD : 16522 | ||
Vega : OTTHUMG00000163637 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ATP6V0D2 | |
BioGPS: 245972 | ||
Pathway | NCI Pathway Interaction Database: ATP6V0D2 | |
KEGG: ATP6V0D2 | ||
REACTOME: ATP6V0D2 | ||
Pathway Commons: ATP6V0D2 | ||
Context | iHOP: ATP6V0D2 | |
ligand binding site mutation search in PubMed: ATP6V0D2 | ||
UCL Cancer Institute: ATP6V0D2 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of ATP6V0D2 | Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. Smith AN, Borthwick KJ, Karet FE. Gene. 2002 Sep 4;297(1-2):169-77. (pmid:12384298) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ATP6V0D2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 10.87500014 | 8.09860814 | 2.776392 | 1.57E-05 | 4.76E-05 |
KIRC | 0.55059764 | 7.901112918 | -7.350515278 | 1.15E-38 | 4.37E-37 |
KIRP | 0.989688265 | 7.927550765 | -6.9378625 | 1.32E-15 | 4.00E-14 |
PRAD | 0.196448602 | 1.71871014 | -1.522261538 | 4.25E-06 | 2.63E-05 |
BRCA | 1.269953123 | -0.514560912 | 1.784514035 | 2.51E-12 | 1.10E-11 |
COAD | 1.49779091 | 2.768183217 | -1.270392308 | 0.00511 | 0.012236077 |
BLCA | -0.311276702 | -2.306160912 | 1.994884211 | 7.97E-05 | 0.000926475 |
HNSC | 0.713436885 | -0.854937534 | 1.568374419 | 0.000155 | 0.000655545 |
STAD | 1.192944515 | -0.94306486 | 2.136009375 | 5.72E-05 | 0.000485311 |
LUSC | 1.870450337 | 3.201624846 | -1.33117451 | 8.99E-05 | 0.000187285 |
LIHC | -0.42029386 | -1.93583186 | 1.515538 | 4.37E-05 | 0.000163122 |
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TissGene-miRNA for ATP6V0D2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ATP6V0D2 |
TissGeneSNV for ATP6V0D2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E157K | SKCM | 2 |
p.E124K | SKCM | 2 |
p.M300L | LUAD | 1 |
p.R77S | SKCM | 1 |
p.D260Y | READ | 1 |
p.R237Q | BLCA | 1 |
p.G272R | DLBC | 1 |
p.M300I | BRCA | 1 |
p.R340Q | COAD | 1 |
p.E157K | UCEC | 1 |
p.V302M | LGG | 1 |
p.C334R | UCEC | 1 |
p.T101M | COAD | 1 |
p.E139Q | HNSC | 1 |
p.V11M | ESCA | 1 |
p.G282R | UCEC | 1 |
p.Y186C | READ | 1 |
p.V281G | COAD | 1 |
p.R21Q | UCEC | 1 |
p.K195T | READ | 1 |
p.V273I | LUAD | 1 |
p.G55S | SKCM | 1 |
p.R182C | BLCA | 1 |
p.D107Y | UCEC | 1 |
p.D262E | LIHC | 1 |
p.L126M | UCEC | 1 |
p.R219C | GBM | 1 |
p.M300I | LIHC | 1 |
p.H48Y | UCEC | 1 |
p.H48Y | SKCM | 1 |
p.R21X | STAD | 1 |
p.Y194H | LUAD | 1 |
p.E83* | LUAD | 1 |
p.A144T | COAD | 1 |
p.R253L | CHOL | 1 |
p.S227F | SKCM | 1 |
p.E235K | SKCM | 1 |
p.E175* | BRCA | 1 |
p.P249T | ACC | 1 |
p.D174E | LUSC | 1 |
p.A5V | STAD | 1 |
p.R21* | STAD | 1 |
p.A268V | UCEC | 1 |
p.D217N | SKCM | 1 |
p.P210H | THYM | 1 |
p.T95K | LUAD | 1 |
p.P147L | SKCM | 1 |
p.E137K | SKCM | 1 |
p.N63T | STAD | 1 |
p.I70M | LUSC | 1 |
p.A332E | HNSC | 1 |
p.K319Q | SKCM | 1 |
p.K184* | LUAD | 1 |
p.E157K | READ | 1 |
p.D71N | SKCM | 1 |
p.R219H | UCEC | 1 |
p.E3Q | CESC | 1 |
p.S336L | SKCM | 1 |
p.V267I | LUAD | 1 |
p.H61D | LUAD | 1 |
p.A280V | SKCM | 1 |
p.E279K | SKCM | 1 |
p.E295G | HNSC | 1 |
p.P64H | UCEC | 1 |
p.D166Y | UCEC | 1 |
p.R340Q | UCEC | 1 |
p.R326K | STAD | 1 |
p.R21* | LGG | 1 |
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TissGeneCNV for ATP6V0D2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ATP6V0D2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ATP6V0D2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ATP6V0D2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ATP6V0D2 |
TissGeneDrug for ATP6V0D2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ATP6V0D2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029927 | Ovarian Cysts | 1 | CTD_human |
umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |