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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for NR5A2
check button Gene summary
Basic gene informationGene symbolNR5A2
Gene namenuclear receptor subfamily 5, group A, member 2
SynonymsB1F|B1F2|CPF|FTF|FTZ-F1|FTZ-F1beta|LRH-1|LRH1|hB1F-2
CytomapUCSC genome browser: 1q32.1
Type of geneprotein-coding
RefGenesNM_001276464.1,
NM_003822.4,NM_205860.2,
DescriptionCYP7A promoter-binding factoralpha-1-fetoprotein transcription factorb1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virusfetoprotein-alpha 1 (AFP) transcription factorhepatocytic transcription factor hB1F
Modification date20141207
dbXrefs MIM : 604453
HGNC : HGNC
Ensembl : ENSG00000116833
HPRD : 06830
Vega : OTTHUMG00000035635
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NR5A2
BioGPS: 2494
PathwayNCI Pathway Interaction Database: NR5A2
KEGG: NR5A2
REACTOME: NR5A2
Pathway Commons: NR5A2
ContextiHOP: NR5A2
ligand binding site mutation search in PubMed: NR5A2
UCL Cancer Institute: NR5A2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverPancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCPAAD
Reference showing the relevant tissue of NR5A2
Description by TissGene annotationsHave significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006355regulation of transcription, DNA-templated15723037
GO:0045070positive regulation of viral genome replication19264593
GO:0045893positive regulation of transcription, DNA-templated15143342
GO:0006355regulation of transcription, DNA-templated15723037
GO:0045070positive regulation of viral genome replication19264593
GO:0045893positive regulation of transcription, DNA-templated15143342


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TissGeneExp for NR5A2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD1.9280100374.566752345-2.6387423082.32E-137.26E-12
KIRC2.3652399510.7033385631.6619013899.15E-207.02E-19
LUSC0.0337138082.163804004-2.1300901964.16E-183.84E-17
BRCA1.0501229922.475685273-1.4255622813.12E-273.46E-26
BLCA-0.2560191131.098991413-1.3550105260.001930.012334253
LIHC4.5363697295.540333729-1.0039640.000520.001503802


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TissGene-miRNA for NR5A2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UCShsa-miR-125a-5pMIMAT00004430.029-0.2956
UCShsa-miR-219a-5pMIMAT00002760.027-0.356
ESCAhsa-miR-153-3pMIMAT00004390.0000029-0.33192
ESCAhsa-miR-153-3pMIMAT00004390.0000029-0.33192
ESCAhsa-miR-153-3pMIMAT00004390.0000029-0.33192


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TissGeneMut for NR5A2
TissGeneSNV for NR5A2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R439CSKCM3
p.E80KCESC2
p.D9NSKCM2
p.D525NSKCM2
p.N439YSKCM2
p.C103WLUAD1
p.I209TCOAD1
p.E224VSKCM1
p.N355HSKCM1
p.G57WLUAD1
p.K462NCOAD1
p.D389NREAD1
p.E471QHNSC1
p.L329MSKCM1
p.G253DUCEC1
p.S355PSKCM1
p.D275NLUSC1
p.A219VUCEC1
p.Q144*SKCM1
p.S197FSKCM1
p.E312QBLCA1
p.K31MSKCM1
p.Q327KLUSC1
p.G262VLUAD1
p.K170MSTAD1
p.R439HSTAD1
p.A479VHNSC1
p.L185HBRCA1
p.H430RREAD1
p.R162HLGG1
p.E368*UCEC1
p.Q115HLUAD1
p.T162KLGG1
p.S292TGBM1
p.L393XSKCM1
p.G222SSKCM1
p.R174TESCA1
p.Q61HLUAD1
p.K243MSKCM1
p.T208IUCEC1
p.C28SACC1
p.R142HHNSC1
p.Q181HUCEC1
p.L501FSKCM1
p.G164EBLCA1
p.R28PACC1
p.S243FSKCM1
p.T202IESCA1
p.H108NSKCM1
p.P170LSTAD1
p.V9MSKCM1
p.H252YBLCA1
p.T412RSKCM1
p.G421RESCA1
p.G164ESKCM1
p.G262FLUAD1
p.E505KSKCM1
p.K334IESCA1
p.R357SUCS1
p.N424YESCA1
p.R393QSKCM1
p.G421RLUAD1
p.E542DSTAD1
p.H252YBRCA1
p.M20LLIHC1
p.E505KUCEC1
p.R142HUCEC1
p.R112QSKCM1
p.N226YLUAD1
p.D412GSKCM1
p.A177DLUSC1
p.L339VBLCA1
p.Q410KLUAD1
p.X421KESCA1
p.A202VESCA1
p.R439CUCEC1
p.L100ILUAD1
p.L18RUCEC1
p.D91NESCA1
p.R160KLIHC1
p.K501XSKCM1
p.R439HSKCM1
p.E272QBLCA1
p.X61CESCA1
p.P281HLUAD1
p.S87FSKCM1
p.Q379RLUAD1
p.T360ITHYM1
p.L230MBLCA1
p.S31FSKCM1
p.D81HLUAD1
p.L85FBRCA1
p.P224LSKCM1
p.S94PUCEC1
p.R367*LUSC1
p.V455MSTAD1
p.P87LSKCM1
p.E56*UCEC1
p.P232LSKCM1
p.G262CLUAD1
p.N426HOV1
p.R112*UCEC1
p.L427PPRAD1
p.N523TUCEC1
p.A188SHNSC1
p.T112NSKCM1
p.R439HCOAD1
p.Y528CLUSC1
p.E337KSKCM1
p.E329KSKCM1
p.V449ICOAD1


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TissGeneCNV for NR5A2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for NR5A2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for NR5A2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
NR5A2, NCOA3, ILF3, SRC, NR0B2, CTNNB1, NRIP1, BCKDK, UBE2I, ALB, HNF1A, FTH1, SMARCD3, CYP19A1, PROX1, EDF1, PNRC1, NPPA, CYP7A1, ADIPOQ, ABCC3 (tumor)NR5A2, NCOA3, ILF3, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, BCKDK, UBE2I, ALB, PPARGC1A, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1, ADIPOQ, ABCC3 (normal)
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COAD (tumor)COAD (normal)
NR5A2, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, NRIP1, POLR2D, UBE2I, HNF1A, FTH1, PPARGC1A, SMARCD3, EDF1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1, ABCC3 (tumor)NR5A2, NCOA3, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, UBE2I, HNF1A, FTH1, PPARGC1A, CYP19A1, EDF1, PNRC2, NPPA, CYP7A1, ABCC3 (normal)
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HNSC (tumor)HNSC (normal)
NR5A2, NCOA3, HNF4A, ILF3, SRC, NRIP1, POLR2D, BCKDK, UBE2I, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1, ADIPOQ, ABCC3 (tumor)NR5A2, NCOA3, HNF4A, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, BCKDK, UBE2I, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1, ADIPOQ (normal)
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KICH (tumor)KICH (normal)
NR5A2, NCOA3, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, COPS5, POLR2D, BCKDK, UBE2I, ALB, HNF1A, FTH1, PROX1, EDF1, PNRC2, GPS2, CYP7A1, ABCC3 (tumor)NR5A2, ILF3, NR0B2, CTNNB1, NRIP1, POLR2D, BCKDK, ALB, HNF1A, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1, ADIPOQ, ABCC3 (normal)
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KIRC (tumor)KIRC (normal)
NR5A2, NCOA3, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, UBE2I, ALB, HNF1A, FTH1, SMARCD3, PROX1, PNRC2, PNRC1, GPS2, CYP7A1 (tumor)NR5A2, NCOA3, HNF4A, SRC, NR0B2, CTNNB1, COPS5, NRIP1, POLR2D, BCKDK, UBE2I, FTH1, PPARGC1A, SMARCD3, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1, ABCC3 (normal)
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KIRP (tumor)KIRP (normal)
NR5A2, HNF4A, ILF3, SRC, SUMO1, CTNNB1, NRIP1, POLR2D, UBE2I, ALB, HNF1A, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, NPPA, CYP7A1, ABCC3 (tumor)NR5A2, NCOA3, HNF4A, ILF3, NR0B2, SUMO1, CTNNB1, NRIP1, POLR2D, BCKDK, HNF1A, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1, ABCC3 (normal)
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LIHC (tumor)LIHC (normal)
NR5A2, ILF3, SRC, NR0B2, CTNNB1, NRIP1, POLR2D, BCKDK, ALB, HNF1A, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1, ADIPOQ (tumor)NR5A2, NCOA3, HNF4A, ILF3, NR0B2, SUMO1, COPS5, NRIP1, BCKDK, UBE2I, ALB, HNF1A, FTH1, PPARGC1A, CYP19A1, PROX1, EDF1, GPS2, CYP7A1, ADIPOQ, ABCC3 (normal)
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LUAD (tumor)LUAD (normal)
NR5A2, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, COPS5, POLR2D, HNF1A, FTH1, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1, ADIPOQ, ABCC3 (tumor)NR5A2, NCOA3, HNF4A, ILF3, NR0B2, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, BCKDK, UBE2I, ALB, PPARGC1A, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1 (normal)
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LUSC (tumor)LUSC (normal)
NR5A2, NCOA3, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, NRIP1, POLR2D, FTH1, PPARGC1A, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, NPPA, GPS2, ADIPOQ, ABCC3 (tumor)NR5A2, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, UBE2I, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1 (normal)
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PRAD (tumor)PRAD (normal)
NR5A2, NCOA3, HNF4A, ILF3, SRC, NR0B2, SUMO1, CTNNB1, COPS5, NRIP1, POLR2D, BCKDK, UBE2I, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, GPS2, ABCC3 (tumor)NR5A2, NCOA3, ILF3, SRC, SUMO1, CTNNB1, COPS5, NRIP1, BCKDK, UBE2I, HNF1A, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, NPPA, GPS2, CYP7A1, ABCC3 (normal)
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STAD (tumor)STAD (normal)
NR5A2, NCOA3, HNF4A, ILF3, SRC, NR0B2, CTNNB1, NRIP1, POLR2D, HNF1A, PPARGC1A, SMARCD3, PROX1, EDF1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1, ADIPOQ, ABCC3 (tumor)NR5A2, NCOA3, HNF4A, SRC, NR0B2, CTNNB1, COPS5, NRIP1, BCKDK, UBE2I, ALB, HNF1A, PPARGC1A, SMARCD3, PROX1, PNRC2, PNRC1, NPPA, GPS2, CYP7A1, ABCC3 (normal)
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THCA (tumor)THCA (normal)
NR5A2, NCOA3, ILF3, NR0B2, SUMO1, COPS5, NRIP1, POLR2D, UBE2I, ALB, HNF1A, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, PNRC2, NPPA, CYP7A1, ADIPOQ, ABCC3 (tumor)NR5A2, NCOA3, SRC, SUMO1, CTNNB1, COPS5, BCKDK, UBE2I, HNF1A, FTH1, PPARGC1A, SMARCD3, CYP19A1, PROX1, EDF1, PNRC2, PNRC1, GPS2, CYP7A1, ADIPOQ, ABCC3 (normal)
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TissGeneProg for NR5A2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for NR5A2
TissGeneDrug for NR5A2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for NR5A2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast12BeFree
umls:C0678222Breast Carcinoma12BeFree
umls:C0346647Malignant neoplasm of pancreas7BeFree,GAD,GWASCAT
umls:C0235974Pancreatic carcinoma6BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0178874Tumor Progression3BeFree
umls:C0007102Malignant tumor of colon2BeFree
umls:C0009324Ulcerative Colitis2BeFree,GWASCAT
umls:C0021841Intestinal Neoplasms2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0030297Pancreatic Neoplasm2CTD_human,GAD
umls:C0699790Colon Carcinoma2BeFree
umls:C1458155Mammary Neoplasms2BeFree,LHGDN
umls:C0003128Anovulation1CTD_human
umls:C0007124Noninfiltrating Intraductal Carcinoma1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0009404Colorectal Neoplasms1BeFree
umls:C0010346Crohn Disease1BeFree
umls:C0014170Endometrial Neoplasms1LHGDN
umls:C0018133Graft-vs-Host Disease1BeFree
umls:C0019163Hepatitis B1BeFree,LHGDN
umls:C0021361Female infertility1CTD_human
umls:C0021367Mammary Ductal Carcinoma1BeFree
umls:C0021390Inflammatory Bowel Diseases1BeFree
umls:C0023418leukemia1LHGDN
umls:C0023470Myeloid Leukemia1BeFree
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0029456Osteoporosis1GAD
umls:C0029463Osteosarcoma1BeFree
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0040336Tobacco Use Disorder1GAD
umls:C0206659Embryonal Carcinoma1BeFree
umls:C0206701Cystadenocarcinoma, Serous1BeFree
umls:C0346627Intestinal Cancer1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0853879Invasive breast carcinoma1BeFree
umls:C0858252Breast adenocarcinoma1BeFree
umls:C1134719Invasive Ductal Breast Carcinoma1BeFree
umls:C1260954Morphologically altered structure1BeFree
umls:C1527249Colorectal Cancer1BeFree