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| TissGeneSummary for GAST |
 Gene summary |
| Basic gene information | Gene symbol | GAST |
| Gene name | gastrin | |
| Synonyms | GAS | |
| Cytomap | UCSC genome browser: 17q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000805.4, | |
| Description | preprogastrin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 137250 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000184502 | ||
| HPRD : 00671 | ||
| Vega : OTTHUMG00000133496 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GAST | |
| BioGPS: 2520 | ||
| Pathway | NCI Pathway Interaction Database: GAST | |
| KEGG: GAST | ||
| REACTOME: GAST | ||
| Pathway Commons: GAST | ||
| Context | iHOP: GAST | |
| ligand binding site mutation search in PubMed: GAST | ||
| UCL Cancer Institute: GAST | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of GAST | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GAST |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 1.570763786 | -1.891154819 | 3.461918605 | 5.09E-15 | 4.09E-13 |
| LUSC | -0.139191344 | -2.562603109 | 2.423411765 | 8.64E-10 | 2.97E-09 |
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| TissGene-miRNA for GAST |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GAST |
| TissGeneSNV for GAST |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.N39D | UCEC | 1 |
| p.D41N | SKCM | 1 |
| p.R95H | READ | 1 |
| p.S22C | CESC | 1 |
| p.K74N | UCS | 1 |
| p.D91Y | PAAD | 1 |
| p.R3* | PRAD | 1 |
| p.A16V | UCEC | 1 |
| p.R40G | STAD | 1 |
| p.R3X | PRAD | 1 |
| p.V8M | STAD | 1 |
| p.R95C | LIHC | 1 |
| p.G88E | SKCM | 1 |
| p.Q2K | LUAD | 1 |
| p.R57* | UCEC | 1 |
| p.G37E | LGG | 1 |
| p.V8A | LIHC | 1 |
| p.E100D | UCEC | 1 |
| p.G93D | SKCM | 1 |
| p.K75M | SKCM | 1 |
| Top |
| TissGeneCNV for GAST |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GAST |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A62V-01A | HAP1-GAST | CDS-5UTR | Chr17:39887745 | Chr17:39871684 |
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| TissGeneNet for GAST |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| GAST, MEP1B, MME, CCKBR, TF, CPE, CP (tumor) | GAST, MEP1B, MME, CCKBR, TF, CPE, CP (normal) |
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| Top |
| TissGeneProg for GAST |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for GAST |
| TissGeneDrug for GAST |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GAST |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0699791 | Stomach Carcinoma | 35 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 32 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 21 | BeFree |
| umls:C0699790 | Colon Carcinoma | 21 | BeFree |
| umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 19 | BeFree |
| umls:C0596263 | Carcinogenesis | 19 | BeFree |
| umls:C0017150 | Gastrinoma | 17 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 15 | BeFree |
| umls:C1527249 | Colorectal Cancer | 15 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 12 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 12 | BeFree |
| umls:C0007095 | Carcinoid Tumor | 11 | BeFree |
| umls:C0001418 | Adenocarcinoma | 10 | BeFree,CTD_human,LHGDN |
| umls:C0850666 | Helicobacter pylori infection | 10 | BeFree |
| umls:C0031350 | Pharyngitis | 8 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 8 | BeFree |
| umls:C0013295 | Duodenal Ulcer | 6 | BeFree |
| umls:C0043515 | Zollinger-Ellison syndrome | 6 | BeFree,LHGDN |
| umls:C0278701 | Gastric Adenocarcinoma | 6 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 5 | BeFree,LHGDN |
| umls:C0025267 | Multiple Endocrine Neoplasia Type 1 | 5 | BeFree |
| umls:C0032002 | Pituitary Diseases | 5 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 5 | BeFree,CTD_human,LHGDN |
| umls:C0206754 | Neuroendocrine Tumors | 5 | BeFree |
| umls:C0334299 | Carcinoid tumor no ICD-O subtype | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 4 | BeFree,CTD_human,LHGDN |
| umls:C0017154 | Gastritis, Atrophic | 4 | BeFree |
| umls:C0020437 | Hypercalcemia | 4 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C0030297 | Pancreatic Neoplasm | 4 | BeFree |
| umls:C0036285 | Scarlet Fever | 4 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0001430 | Adenoma | 3 | BeFree |
| umls:C0004114 | Astrocytoma | 3 | BeFree |
| umls:C0013395 | Dyspepsia | 3 | BeFree |
| umls:C0017152 | Gastritis | 3 | BeFree |
| umls:C0030920 | Peptic Ulcer | 3 | BeFree,CTD_human |
| umls:C0035436 | Rheumatic Fever | 3 | BeFree |
| umls:C0035439 | Rheumatic Heart Disease | 3 | BeFree |
| umls:C0038395 | Streptococcal Infections | 3 | BeFree |
| umls:C0151514 | Atrophic condition of skin | 3 | BeFree |
| umls:C0178874 | Tumor Progression | 3 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C0002892 | Anemia, Pernicious | 2 | BeFree |
| umls:C0014132 | Endocrine Gland Neoplasms | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0020502 | Hyperparathyroidism | 2 | BeFree |
| umls:C0021099 | Impetigo | 2 | BeFree |
| umls:C0021670 | insulinoma | 2 | BeFree |
| umls:C0022387 | Jervell-Lange Nielsen Syndrome | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | CTD_human,LHGDN |
| umls:C0025289 | Meningitis | 2 | BeFree |
| umls:C0025568 | Metaplasia | 2 | LHGDN |
| umls:C0032580 | Adenomatous Polyposis Coli | 2 | BeFree |
| umls:C0032927 | Precancerous Conditions | 2 | BeFree |
| umls:C0040425 | Tonsillitis | 2 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 2 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 2 | BeFree |
| umls:C0242363 | Islet Cell Tumor | 2 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 2 | BeFree |
| umls:C0555198 | Malignant Glioma | 2 | BeFree |
| umls:C1266029 | Enterochromaffin-like cell carcinoid | 2 | BeFree |
| umls:C1368066 | pancreatic gastrinoma | 2 | BeFree |
| umls:C0001361 | Acute tonsillitis | 1 | BeFree |
| umls:C0004610 | Bacteremia | 1 | BeFree |
| umls:C0004763 | Barrett Esophagus | 1 | CTD_human |
| umls:C0005426 | Biliary Tract Neoplasm | 1 | LHGDN |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0014869 | Peptic Esophagitis | 1 | BeFree |
| umls:C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
| umls:C0017185 | Gastrointestinal Neoplasms | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0018799 | Heart Diseases | 1 | BeFree |
| umls:C0018995 | Hemochromatosis | 1 | BeFree,LHGDN |
| umls:C0019270 | Hernia | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0023976 | Long QT Syndrome | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0028259 | Nodule | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0030517 | Parathyroid Diseases | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | CTD_human |
| umls:C0036690 | Septicemia | 1 | BeFree |
| umls:C0037299 | Skin Ulcer | 1 | BeFree |
| umls:C0038358 | Gastric ulcer | 1 | BeFree |
| umls:C0040147 | Thyroiditis | 1 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0086438 | Hypogammaglobulinemia | 1 | BeFree |
| umls:C0149778 | Soft Tissue Infections | 1 | BeFree |
| umls:C0156221 | Acute glomerulonephritis | 1 | BeFree |
| umls:C0206663 | Neuroectodermal Tumor, Primitive | 1 | BeFree |
| umls:C0206677 | Adenomatous Polyps | 1 | BeFree |
| umls:C0206726 | gliosarcoma | 1 | BeFree |
| umls:C0221002 | Hyperparathyroidism, Primary | 1 | BeFree |
| umls:C0221026 | X-linked agammaglobulinemia | 1 | BeFree |
| umls:C0238124 | Necrotizing fasciitis | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | BeFree |
| umls:C0271846 | Familial hyperparathyroidism | 1 | BeFree |
| umls:C0333293 | Healing ulcer | 1 | BeFree |
| umls:C0343532 | Streptococcal toxic shock syndrome | 1 | BeFree |
| umls:C0349529 | Gastric Carcinoid Tumor | 1 | BeFree |
| umls:C0677659 | Gastro-esophageal reflux disease with esophagitis | 1 | BeFree |
| umls:C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | BeFree |
| umls:C0850572 | Adenomatous polyp of colon | 1 | BeFree |
| umls:C0876973 | Infectious disease of lung | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1257915 | Intestinal Polyposis | 1 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1955745 | Multiple endocrine neoplasia (MEN) Syndrome | 1 | BeFree |
| umls:C3150911 | GASTRIC CANCER, INTESTINAL | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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