TissGeneSummary for BPIFC |
Gene summary |
Basic gene information | Gene symbol | BPIFC |
Gene name | BPI fold containing family C | |
Synonyms | BPIL2 | |
Cytomap | UCSC genome browser: 22q12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_174932.2, | |
Description | BPI fold-containing family C proteinBPI-like 2bactericidal/permeability-increasing protein-like 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 614109 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184459 | ||
HPRD : 16560 | ||
Vega : OTTHUMG00000058273 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BPIFC | |
BioGPS: 254240 | ||
Pathway | NCI Pathway Interaction Database: BPIFC | |
KEGG: BPIFC | ||
REACTOME: BPIFC | ||
Pathway Commons: BPIFC | ||
Context | iHOP: BPIFC | |
ligand binding site mutation search in PubMed: BPIFC | ||
UCL Cancer Institute: BPIFC | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of BPIFC | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for BPIFC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for BPIFC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for BPIFC |
TissGeneSNV for BPIFC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F88L | LUAD | 1 |
p.S173A | SKCM | 1 |
p.A362T | COAD | 1 |
p.Q164E | ESCA | 1 |
p.G100V | LUAD | 1 |
p.E345D | LIHC | 1 |
p.P254T | THYM | 1 |
p.D150Y | DLBC | 1 |
p.R397I | UCEC | 1 |
p.P267S | SKCM | 1 |
p.E185K | BLCA | 1 |
p.S373Y | THYM | 1 |
p.A105E | SARC | 1 |
p.E413Q | ESCA | 1 |
p.A168T | STAD | 1 |
p.N108K | SKCM | 1 |
p.S317F | LUAD | 1 |
p.S235N | GBM | 1 |
p.G447E | SKCM | 1 |
p.E175X | READ | 1 |
p.L18H | KIRC | 1 |
p.I327T | READ | 1 |
p.R326W | GBM | 1 |
p.W10C | SKCM | 1 |
p.Y162* | LUAD | 1 |
p.F151C | UCEC | 1 |
p.S310F | SKCM | 1 |
p.G298R | SKCM | 1 |
p.G447R | SKCM | 1 |
p.L428I | UCEC | 1 |
p.F120I | SARC | 1 |
p.E479A | COAD | 1 |
p.F268C | UCEC | 1 |
p.L358M | LUAD | 1 |
p.P262S | SKCM | 1 |
p.E345K | SKCM | 1 |
p.A131T | BLCA | 1 |
p.E69D | UCEC | 1 |
p.P336H | HNSC | 1 |
p.R148Q | READ | 1 |
p.Q24E | CESC | 1 |
p.G319D | LIHC | 1 |
p.D382H | ACC | 1 |
p.D475Y | LUSC | 1 |
p.E241D | LUAD | 1 |
p.D127N | SKCM | 1 |
p.R340K | SKCM | 1 |
p.P154S | SKCM | 1 |
p.M381I | KIRC | 1 |
p.L228Q | LUAD | 1 |
p.S94L | LUAD | 1 |
p.S235R | COAD | 1 |
p.E307K | LUSC | 1 |
p.N495K | THYM | 1 |
p.G435A | LUSC | 1 |
p.K57N | UCEC | 1 |
p.S63I | LUSC | 1 |
p.L466P | LUAD | 1 |
p.E467Q | BLCA | 1 |
p.I234F | LIHC | 1 |
p.L228P | ESCA | 1 |
p.E308Q | LUAD | 1 |
p.F286L | UCEC | 1 |
p.K55N | UCEC | 1 |
p.I203N | LUSC | 1 |
p.I427S | BLCA | 1 |
p.L466I | UCS | 1 |
p.E420Q | BLCA | 1 |
p.D462G | LIHC | 1 |
p.S94L | CESC | 1 |
p.A163T | THCA | 1 |
p.P123Q | ESCA | 1 |
p.I360T | LUSC | 1 |
p.T377I | SKCM | 1 |
p.W501C | LUAD | 1 |
p.S289Y | UCS | 1 |
p.T240S | LGG | 1 |
p.G281E | SKCM | 1 |
p.Q315X | SKCM | 1 |
p.Q315* | SKCM | 1 |
p.R37K | SKCM | 1 |
p.P99H | PAAD | 1 |
p.T306A | UCEC | 1 |
p.P7S | SKCM | 1 |
p.V379I | GBM | 1 |
p.P347A | LUAD | 1 |
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TissGeneCNV for BPIFC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for BPIFC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for BPIFC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for BPIFC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for BPIFC |
TissGeneDrug for BPIFC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for BPIFC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |