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TissGeneSummary for AKNAD1 |
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Basic gene information | Gene symbol | AKNAD1 |
Gene name | AKNA domain containing 1 | |
Synonyms | C1orf62 | |
Cytomap | UCSC genome browser: 1p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_152763.4, NR_049760.1, | |
Description | protein AKNAD1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162641 | ||
HPRD : 11325 | ||
Vega : OTTHUMG00000011231 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AKNAD1 | |
BioGPS: 254268 | ||
Pathway | NCI Pathway Interaction Database: AKNAD1 | |
KEGG: AKNAD1 | ||
REACTOME: AKNAD1 | ||
Pathway Commons: AKNAD1 | ||
Context | iHOP: AKNAD1 | |
ligand binding site mutation search in PubMed: AKNAD1 | ||
UCL Cancer Institute: AKNAD1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of AKNAD1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for AKNAD1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -1.447425305 | -0.43484718 | -1.012578125 | 0.0016 | 0.00765617 |
COAD | -0.357870498 | -1.361158959 | 1.003288462 | 0.00239 | 0.006286303 |
KICH | -0.161468805 | -1.208820805 | 1.047352 | 0.000736 | 0.001630295 |
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TissGene-miRNA for AKNAD1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AKNAD1 |
TissGeneSNV for AKNAD1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K620R | HNSC | 2 |
p.P553L | UCEC | 1 |
p.A99V | OV | 1 |
p.D571Y | COAD | 1 |
p.S726F | CESC | 1 |
p.E42G | GBM | 1 |
p.Y485C | LGG | 1 |
p.M757I | STAD | 1 |
p.S760I | LGG | 1 |
p.K392E | ESCA | 1 |
p.T747K | ESCA | 1 |
p.E683X | READ | 1 |
p.D16N | SKCM | 1 |
p.T659N | LUAD | 1 |
p.R729Q | SKCM | 1 |
p.G40C | LUAD | 1 |
p.V617M | PRAD | 1 |
p.R608C | STAD | 1 |
p.E397X | COAD | 1 |
p.K75T | READ | 1 |
p.E101Q | BLCA | 1 |
p.Q372E | LUSC | 1 |
p.S720C | CESC | 1 |
p.K295I | COAD | 1 |
p.T813A | KICH | 1 |
p.S137L | SKCM | 1 |
p.G519S | COAD | 1 |
p.T238N | THYM | 1 |
p.E341K | LGG | 1 |
p.R734I | UCEC | 1 |
p.D140N | SKCM | 1 |
p.E449K | SKCM | 1 |
p.N100H | LIHC | 1 |
p.Q236H | LGG | 1 |
p.K274N | BLCA | 1 |
p.C549R | LUAD | 1 |
p.F398L | READ | 1 |
p.E478D | UCEC | 1 |
p.H640Y | PRAD | 1 |
p.Q615K | LIHC | 1 |
p.C654Y | COAD | 1 |
p.G539R | SKCM | 1 |
p.P589S | SKCM | 1 |
p.P407A | HNSC | 1 |
p.S309* | CESC | 1 |
p.D412N | UCEC | 1 |
p.I71T | LUAD | 1 |
p.G250S | SKCM | 1 |
p.E86D | UCEC | 1 |
p.E793Q | BLCA | 1 |
p.E745K | STAD | 1 |
p.I97F | LUSC | 1 |
p.N616K | COAD | 1 |
p.E811* | UCEC | 1 |
p.E56D | UCEC | 1 |
p.S483R | STAD | 1 |
p.Q319* | LUSC | 1 |
p.D2Y | LUAD | 1 |
p.A80D | LGG | 1 |
p.E163* | UCS | 1 |
p.G40S | BLCA | 1 |
p.R608H | UCEC | 1 |
p.C680F | COAD | 1 |
p.H517Q | HNSC | 1 |
p.V709F | BLCA | 1 |
p.P553L | PRAD | 1 |
p.P674S | KIRC | 1 |
p.S33I | UCEC | 1 |
p.S508T | BLCA | 1 |
p.W160C | LUAD | 1 |
p.K620R | STAD | 1 |
p.R831S | LUAD | 1 |
p.K162E | LUSC | 1 |
p.G377E | SKCM | 1 |
p.E167* | UCEC | 1 |
p.R525* | STAD | 1 |
p.G623* | UCEC | 1 |
p.K620R | LUAD | 1 |
p.D823N | UCEC | 1 |
p.E745D | BLCA | 1 |
p.N616Y | KIRC | 1 |
p.S713Y | UCEC | 1 |
p.E418K | LUAD | 1 |
p.F456L | LUAD | 1 |
p.E163X | UCS | 1 |
p.K484T | UCEC | 1 |
p.I264S | STAD | 1 |
p.Y692H | STAD | 1 |
p.K320R | LGG | 1 |
p.A503V | SKCM | 1 |
p.D111H | BRCA | 1 |
p.R525X | STAD | 1 |
p.D52H | STAD | 1 |
p.L352V | COAD | 1 |
p.E756K | SARC | 1 |
p.P540S | SKCM | 1 |
p.R525* | UCEC | 1 |
p.E618Q | BLCA | 1 |
p.D39E | BRCA | 1 |
p.K620R | LIHC | 1 |
p.K37N | STAD | 1 |
p.P639T | LUAD | 1 |
p.R609K | SARC | 1 |
p.A638T | STAD | 1 |
p.S24C | BLCA | 1 |
p.P166S | LIHC | 1 |
p.L352F | COAD | 1 |
p.G623R | COAD | 1 |
p.M480I | SKCM | 1 |
p.C669Y | HNSC | 1 |
p.E788K | BLCA | 1 |
p.L172F | PAAD | 1 |
p.D656H | BLCA | 1 |
p.E386* | CESC | 1 |
p.D177Y | LUAD | 1 |
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TissGeneCNV for AKNAD1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AKNAD1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BC002939 | AKNAD1-FAP | chr1:109506079 | chr2:163053462 | |
Chimerdb3.0 | ChiTaRs | NA | CN347114 | AKNAD1-LANCL1 | chr1:109477273 | chr2:211329631 | |
Chimerdb3.0 | ChiTaRs | NA | BF923967 | AKNAD1-ABAT | chr1:109465171 | chr16:8839711 | |
Chimerdb3.0 | ChiTaRs | NA | AA367789 | AKNAD1-ITGA5 | chr1:109460693 | chr12:54796070 | |
Chimerdb3.0 | ChiTaRs | NA | BF919493 | DNAJC21-AKNAD1 | chr5:34945098 | chr1:109473768 | |
Chimerdb3.0 | ChiTaRs | NA | BE766583 | AKNAD1-SAMD4A | chr1:109503824 | chr14:55257212 | |
Chimerdb3.0 | ChiTaRs | NA | AW389983 | AKNAD1-FEM1C | chr1:109426414 | chr5:114858823 |
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TissGeneNet for AKNAD1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AKNAD1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AKNAD1 |
TissGeneDrug for AKNAD1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AKNAD1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |