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| TissGeneSummary for AKNAD1 |
 Gene summary |
| Basic gene information | Gene symbol | AKNAD1 |
| Gene name | AKNA domain containing 1 | |
| Synonyms | C1orf62 | |
| Cytomap | UCSC genome browser: 1p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152763.4, NR_049760.1, | |
| Description | protein AKNAD1 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000162641 | ||
| HPRD : 11325 | ||
| Vega : OTTHUMG00000011231 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AKNAD1 | |
| BioGPS: 254268 | ||
| Pathway | NCI Pathway Interaction Database: AKNAD1 | |
| KEGG: AKNAD1 | ||
| REACTOME: AKNAD1 | ||
| Pathway Commons: AKNAD1 | ||
| Context | iHOP: AKNAD1 | |
| ligand binding site mutation search in PubMed: AKNAD1 | ||
| UCL Cancer Institute: AKNAD1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of AKNAD1 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for AKNAD1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -1.447425305 | -0.43484718 | -1.012578125 | 0.0016 | 0.00765617 |
| COAD | -0.357870498 | -1.361158959 | 1.003288462 | 0.00239 | 0.006286303 |
| KICH | -0.161468805 | -1.208820805 | 1.047352 | 0.000736 | 0.001630295 |
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| TissGene-miRNA for AKNAD1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AKNAD1 |
| TissGeneSNV for AKNAD1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K620R | HNSC | 2 |
| p.P553L | UCEC | 1 |
| p.A99V | OV | 1 |
| p.D571Y | COAD | 1 |
| p.S726F | CESC | 1 |
| p.E42G | GBM | 1 |
| p.Y485C | LGG | 1 |
| p.M757I | STAD | 1 |
| p.S760I | LGG | 1 |
| p.K392E | ESCA | 1 |
| p.T747K | ESCA | 1 |
| p.E683X | READ | 1 |
| p.D16N | SKCM | 1 |
| p.T659N | LUAD | 1 |
| p.R729Q | SKCM | 1 |
| p.G40C | LUAD | 1 |
| p.V617M | PRAD | 1 |
| p.R608C | STAD | 1 |
| p.E397X | COAD | 1 |
| p.K75T | READ | 1 |
| p.E101Q | BLCA | 1 |
| p.Q372E | LUSC | 1 |
| p.S720C | CESC | 1 |
| p.K295I | COAD | 1 |
| p.T813A | KICH | 1 |
| p.S137L | SKCM | 1 |
| p.G519S | COAD | 1 |
| p.T238N | THYM | 1 |
| p.E341K | LGG | 1 |
| p.R734I | UCEC | 1 |
| p.D140N | SKCM | 1 |
| p.E449K | SKCM | 1 |
| p.N100H | LIHC | 1 |
| p.Q236H | LGG | 1 |
| p.K274N | BLCA | 1 |
| p.C549R | LUAD | 1 |
| p.F398L | READ | 1 |
| p.E478D | UCEC | 1 |
| p.H640Y | PRAD | 1 |
| p.Q615K | LIHC | 1 |
| p.C654Y | COAD | 1 |
| p.G539R | SKCM | 1 |
| p.P589S | SKCM | 1 |
| p.P407A | HNSC | 1 |
| p.S309* | CESC | 1 |
| p.D412N | UCEC | 1 |
| p.I71T | LUAD | 1 |
| p.G250S | SKCM | 1 |
| p.E86D | UCEC | 1 |
| p.E793Q | BLCA | 1 |
| p.E745K | STAD | 1 |
| p.I97F | LUSC | 1 |
| p.N616K | COAD | 1 |
| p.E811* | UCEC | 1 |
| p.E56D | UCEC | 1 |
| p.S483R | STAD | 1 |
| p.Q319* | LUSC | 1 |
| p.D2Y | LUAD | 1 |
| p.A80D | LGG | 1 |
| p.E163* | UCS | 1 |
| p.G40S | BLCA | 1 |
| p.R608H | UCEC | 1 |
| p.C680F | COAD | 1 |
| p.H517Q | HNSC | 1 |
| p.V709F | BLCA | 1 |
| p.P553L | PRAD | 1 |
| p.P674S | KIRC | 1 |
| p.S33I | UCEC | 1 |
| p.S508T | BLCA | 1 |
| p.W160C | LUAD | 1 |
| p.K620R | STAD | 1 |
| p.R831S | LUAD | 1 |
| p.K162E | LUSC | 1 |
| p.G377E | SKCM | 1 |
| p.E167* | UCEC | 1 |
| p.R525* | STAD | 1 |
| p.G623* | UCEC | 1 |
| p.K620R | LUAD | 1 |
| p.D823N | UCEC | 1 |
| p.E745D | BLCA | 1 |
| p.N616Y | KIRC | 1 |
| p.S713Y | UCEC | 1 |
| p.E418K | LUAD | 1 |
| p.F456L | LUAD | 1 |
| p.E163X | UCS | 1 |
| p.K484T | UCEC | 1 |
| p.I264S | STAD | 1 |
| p.Y692H | STAD | 1 |
| p.K320R | LGG | 1 |
| p.A503V | SKCM | 1 |
| p.D111H | BRCA | 1 |
| p.R525X | STAD | 1 |
| p.D52H | STAD | 1 |
| p.L352V | COAD | 1 |
| p.E756K | SARC | 1 |
| p.P540S | SKCM | 1 |
| p.R525* | UCEC | 1 |
| p.E618Q | BLCA | 1 |
| p.D39E | BRCA | 1 |
| p.K620R | LIHC | 1 |
| p.K37N | STAD | 1 |
| p.P639T | LUAD | 1 |
| p.R609K | SARC | 1 |
| p.A638T | STAD | 1 |
| p.S24C | BLCA | 1 |
| p.P166S | LIHC | 1 |
| p.L352F | COAD | 1 |
| p.G623R | COAD | 1 |
| p.M480I | SKCM | 1 |
| p.C669Y | HNSC | 1 |
| p.E788K | BLCA | 1 |
| p.L172F | PAAD | 1 |
| p.D656H | BLCA | 1 |
| p.E386* | CESC | 1 |
| p.D177Y | LUAD | 1 |
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| TissGeneCNV for AKNAD1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AKNAD1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BC002939 | AKNAD1-FAP | chr1:109506079 | chr2:163053462 | |
| Chimerdb3.0 | ChiTaRs | NA | CN347114 | AKNAD1-LANCL1 | chr1:109477273 | chr2:211329631 | |
| Chimerdb3.0 | ChiTaRs | NA | BF923967 | AKNAD1-ABAT | chr1:109465171 | chr16:8839711 | |
| Chimerdb3.0 | ChiTaRs | NA | AA367789 | AKNAD1-ITGA5 | chr1:109460693 | chr12:54796070 | |
| Chimerdb3.0 | ChiTaRs | NA | BF919493 | DNAJC21-AKNAD1 | chr5:34945098 | chr1:109473768 | |
| Chimerdb3.0 | ChiTaRs | NA | BE766583 | AKNAD1-SAMD4A | chr1:109503824 | chr14:55257212 | |
| Chimerdb3.0 | ChiTaRs | NA | AW389983 | AKNAD1-FEM1C | chr1:109426414 | chr5:114858823 |
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| TissGeneNet for AKNAD1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for AKNAD1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AKNAD1 |
| TissGeneDrug for AKNAD1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AKNAD1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
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