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| TissGeneSummary for SERPINA11 |
 Gene summary |
| Basic gene information | Gene symbol | SERPINA11 |
| Gene name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 14q32.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001080451.1, | |
| Description | antiproteinase-like 2serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11serpin A11 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000186910 | ||
| Vega : OTTHUMG00000171348 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SERPINA11 | |
| BioGPS: 256394 | ||
| Pathway | NCI Pathway Interaction Database: SERPINA11 | |
| KEGG: SERPINA11 | ||
| REACTOME: SERPINA11 | ||
| Pathway Commons: SERPINA11 | ||
| Context | iHOP: SERPINA11 | |
| ligand binding site mutation search in PubMed: SERPINA11 | ||
| UCL Cancer Institute: SERPINA11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SERPINA11 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SERPINA11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.867148154 | -2.521352076 | 1.654203922 | 7.47E-07 | 1.90E-06 |
| LIHC | 7.568834277 | 10.90416428 | -3.33533 | 1.45E-10 | 1.85E-09 |
| PRAD | 2.868341815 | -0.017231261 | 2.885573077 | 7.85E-10 | 1.30E-08 |
| HNSC | -1.612948793 | -0.233862746 | -1.379086047 | 6.93E-05 | 0.000325522 |
| Top |
| TissGene-miRNA for SERPINA11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SERPINA11 |
| TissGeneSNV for SERPINA11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E249K | SKCM | 2 |
| p.G104E | SKCM | 2 |
| p.S200N | LUSC | 1 |
| p.L14Q | LUAD | 1 |
| p.D325Y | LUAD | 1 |
| p.Q329H | UCEC | 1 |
| p.S41T | LUAD | 1 |
| p.H116Y | SKCM | 1 |
| p.D235N | SKCM | 1 |
| p.A93S | LUAD | 1 |
| p.P328S | SKCM | 1 |
| p.M284I | SKCM | 1 |
| p.S173Y | ESCA | 1 |
| p.R297T | GBM | 1 |
| p.G32R | SKCM | 1 |
| p.E236* | BRCA | 1 |
| p.A66V | THYM | 1 |
| p.S306G | STAD | 1 |
| p.V193M | COAD | 1 |
| p.E366G | UCEC | 1 |
| p.A272V | LIHC | 1 |
| p.L100M | BLCA | 1 |
| p.G12E | SKCM | 1 |
| p.F74L | UCEC | 1 |
| p.S379Y | LUAD | 1 |
| p.L332F | SKCM | 1 |
| p.K355N | STAD | 1 |
| p.G26E | SKCM | 1 |
| p.W299L | SKCM | 1 |
| p.F166L | STAD | 1 |
| p.G414E | SKCM | 1 |
| p.L378I | COAD | 1 |
| p.R146Q | SKCM | 1 |
| p.P111S | SKCM | 1 |
| p.T203K | LUAD | 1 |
| p.G368R | SKCM | 1 |
| p.P313S | GBM | 1 |
| p.S156N | CESC | 1 |
| p.A66V | LUAD | 1 |
| p.G118S | SKCM | 1 |
| p.G162R | HNSC | 1 |
| p.T188S | STAD | 1 |
| p.Q329* | SKCM | 1 |
| p.A163D | UCEC | 1 |
| p.C19* | LUAD | 1 |
| p.N72D | STAD | 1 |
| p.L278V | READ | 1 |
| p.Q348L | LUSC | 1 |
| p.F232L | UCEC | 1 |
| p.E230A | COAD | 1 |
| p.K136Q | SKCM | 1 |
| p.A274V | GBM | 1 |
| p.S379F | SKCM | 1 |
| p.T125N | LGG | 1 |
| p.P313L | SKCM | 1 |
| p.Y189* | LUAD | 1 |
| p.E370K | BLCA | 1 |
| p.G270E | SKCM | 1 |
| p.F232I | SKCM | 1 |
| p.T262N | LUAD | 1 |
| p.D325Y | READ | 1 |
| p.P281L | COAD | 1 |
| p.R150Q | STAD | 1 |
| p.Q329K | LUAD | 1 |
| p.R120L | LUAD | 1 |
| p.F74L | COAD | 1 |
| p.Q380K | LUAD | 1 |
| p.P52L | LIHC | 1 |
| p.P197T | LUAD | 1 |
| p.N350K | UCEC | 1 |
| p.T203R | LUSC | 1 |
| p.P197S | SKCM | 1 |
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| TissGeneCNV for SERPINA11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SERPINA11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SERPINA11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SERPINA11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SERPINA11 |
| TissGeneDrug for SERPINA11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SERPINA11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
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