TissGeneSummary for WDR72 |
Gene summary |
Basic gene information | Gene symbol | WDR72 |
Gene name | WD repeat domain 72 | |
Synonyms | AI2A3 | |
Cytomap | UCSC genome browser: 15q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001277176.1, NM_182758.3,NR_102334.1,NR_102335.1,NR_102336.1, | |
Description | WD repeat-containing protein 72 | |
Modification date | 20141207 | |
dbXrefs | MIM : 613214 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166415 | ||
HPRD : 10987 | ||
Vega : OTTHUMG00000131939 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WDR72 | |
BioGPS: 256764 | ||
Pathway | NCI Pathway Interaction Database: WDR72 | |
KEGG: WDR72 | ||
REACTOME: WDR72 | ||
Pathway Commons: WDR72 | ||
Context | iHOP: WDR72 | |
ligand binding site mutation search in PubMed: WDR72 | ||
UCL Cancer Institute: WDR72 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTHCA | |
Reference showing the relevant tissue of WDR72 | ||
Description by TissGene annotations | Protective TissGene in OS Risk TissGene in RFS Protective TissGene in RFS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for WDR72 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 1.397826029 | -2.622386471 | 4.0202125 | 2.62E-08 | 9.82E-07 |
THCA | 2.428477248 | 4.999909451 | -2.571432203 | 1.04E-23 | 9.21E-22 |
LUSC | 2.334547537 | -2.336552463 | 4.6711 | 1.12E-16 | 8.64E-16 |
KIRP | 2.874116654 | 5.047094779 | -2.172978125 | 1.72E-06 | 8.33E-06 |
KIRC | 2.84107221 | 5.13838471 | -2.2973125 | 5.70E-17 | 3.34E-16 |
LIHC | 0.442565654 | 3.720161654 | -3.277596 | 1.73E-09 | 1.79E-08 |
HNSC | 1.956911422 | 0.295497468 | 1.661413953 | 0.0046 | 0.012530266 |
COAD | 0.205010885 | -2.058612192 | 2.263623077 | 0.00359 | 0.008928138 |
ESCA | 2.945941654 | -1.0767038 | 4.022645455 | 0.000225 | 0.005647461 |
BLCA | 2.69356797 | -1.061010977 | 3.754578947 | 0.000707 | 0.005294168 |
PRAD | -4.18509873 | -2.8319045 | -1.353194231 | 0.00168 | 0.005033262 |
Top |
TissGene-miRNA for WDR72 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for WDR72 |
TissGeneSNV for WDR72 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S928Y | UCEC | 2 |
p.S829Y | UCEC | 2 |
p.E748K | SKCM | 2 |
p.R601Q | SKCM | 2 |
p.E1035K | SKCM | 2 |
p.R886K | SKCM | 2 |
p.H680Y | SKCM | 2 |
p.S775F | SKCM | 1 |
p.T66S | BRCA | 1 |
p.F839L | UCEC | 1 |
p.Y952D | HNSC | 1 |
p.K777E | LUAD | 1 |
p.D536Y | LUAD | 1 |
p.M329I | BLCA | 1 |
p.F258V | ESCA | 1 |
p.V997F | HNSC | 1 |
p.W674* | SKCM | 1 |
p.R219* | UCEC | 1 |
p.A741T | LGG | 1 |
p.D1071N | READ | 1 |
p.V925I | ESCA | 1 |
p.S652L | STAD | 1 |
p.A373D | DLBC | 1 |
p.A1094S | HNSC | 1 |
p.P306L | COAD | 1 |
p.E545K | LUAD | 1 |
p.R151K | UCEC | 1 |
p.L668S | PAAD | 1 |
p.P355T | LUSC | 1 |
p.D356E | ACC | 1 |
p.S928Y | READ | 1 |
p.F244L | SKCM | 1 |
p.C1076* | THCA | 1 |
p.M121I | LUAD | 1 |
p.L921S | SKCM | 1 |
p.K773T | BRCA | 1 |
p.L647P | STAD | 1 |
p.S191L | HNSC | 1 |
p.E996K | STAD | 1 |
p.R268G | ESCA | 1 |
p.Q981E | COAD | 1 |
p.K722M | SKCM | 1 |
p.L144M | LUSC | 1 |
p.L686V | KIRC | 1 |
p.S976P | UCEC | 1 |
p.S864F | SKCM | 1 |
p.G364S | PRAD | 1 |
p.C534Y | STAD | 1 |
p.E206* | UCEC | 1 |
p.T404S | HNSC | 1 |
p.K717N | UCEC | 1 |
p.G535V | LUAD | 1 |
p.P358S | SKCM | 1 |
p.E598X | READ | 1 |
p.S167F | SKCM | 1 |
p.D609N | SKCM | 1 |
p.R298K | BLCA | 1 |
p.W565* | UCEC | 1 |
p.A995V | UCEC | 1 |
p.V186L | READ | 1 |
p.R896* | LGG | 1 |
p.Q378X | SKCM | 1 |
p.S833Y | READ | 1 |
p.S19N | STAD | 1 |
p.V667F | PRAD | 1 |
p.S475L | GBM | 1 |
p.E889* | LUSC | 1 |
p.V568I | SKCM | 1 |
p.V1069A | KIRP | 1 |
p.K449N | THYM | 1 |
p.F909V | LGG | 1 |
p.G35E | SKCM | 1 |
p.A995V | HNSC | 1 |
p.S291N | LIHC | 1 |
p.M1001I | SKCM | 1 |
p.S152L | SKCM | 1 |
p.I619F | LUSC | 1 |
p.M772R | HNSC | 1 |
p.G131V | DLBC | 1 |
p.P1008L | SKCM | 1 |
p.A716V | UCEC | 1 |
p.W158* | SKCM | 1 |
p.E520K | BLCA | 1 |
p.C534* | UCEC | 1 |
p.C221R | STAD | 1 |
p.D899H | STAD | 1 |
p.E569D | UCEC | 1 |
p.T588A | STAD | 1 |
p.S466L | SKCM | 1 |
p.Q282E | CESC | 1 |
p.F707L | UCEC | 1 |
p.Q37H | STAD | 1 |
p.H307L | SARC | 1 |
p.I619N | BLCA | 1 |
p.S64L | SKCM | 1 |
p.V997I | PAAD | 1 |
p.G852L | LUAD | 1 |
p.D793N | SKCM | 1 |
p.P567L | STAD | 1 |
p.E1036X | COAD | 1 |
p.I391F | UCEC | 1 |
p.M562I | SKCM | 1 |
p.T104I | COAD | 1 |
p.L544F | SKCM | 1 |
p.C1099* | SARC | 1 |
p.E183D | LUSC | 1 |
p.S871L | LUAD | 1 |
p.R956Q | SKCM | 1 |
p.R896Q | SKCM | 1 |
p.K627Q | STAD | 1 |
p.C421R | KICH | 1 |
p.R601Q | BRCA | 1 |
p.I854K | BRCA | 1 |
p.S704F | SKCM | 1 |
p.W11X | SKCM | 1 |
p.H680L | BLCA | 1 |
p.K142R | LUAD | 1 |
p.G403E | SKCM | 1 |
p.E897Q | LUAD | 1 |
p.R728K | SKCM | 1 |
p.L551Q | GBM | 1 |
p.W805* | BLCA | 1 |
p.G852V | LUAD | 1 |
p.S1081F | PAAD | 1 |
p.K785I | SARC | 1 |
p.Q197R | COAD | 1 |
p.N820S | BRCA | 1 |
p.F707L | ESCA | 1 |
p.D764N | SKCM | 1 |
p.G852* | LUAD | 1 |
p.M1024I | LUAD | 1 |
p.Q378* | SKCM | 1 |
p.D810Y | BLCA | 1 |
p.D73N | SKCM | 1 |
p.A509V | SKCM | 1 |
p.R219Q | UCEC | 1 |
p.P106L | SKCM | 1 |
p.S635I | UCEC | 1 |
p.F798C | COAD | 1 |
p.S4Y | PRAD | 1 |
p.Y279N | LUAD | 1 |
p.S894Y | READ | 1 |
p.Q37K | OV | 1 |
p.S749T | ESCA | 1 |
p.M326I | SKCM | 1 |
p.I934K | LUAD | 1 |
p.G125D | THYM | 1 |
p.G806* | LUSC | 1 |
p.D872G | PRAD | 1 |
p.D478Y | CESC | 1 |
p.S976F | HNSC | 1 |
p.I602N | KIRC | 1 |
p.R219Q | UCS | 1 |
p.F505L | UCEC | 1 |
p.E206X | COAD | 1 |
p.P918S | UCEC | 1 |
p.D1068E | LUSC | 1 |
p.E520K | SKCM | 1 |
p.V94G | SKCM | 1 |
p.F665L | LUSC | 1 |
p.R525M | PRAD | 1 |
p.V491L | LUAD | 1 |
p.E585K | SKCM | 1 |
p.V677I | GBM | 1 |
p.Q1040K | THYM | 1 |
p.R601Q | COAD | 1 |
p.S538F | SKCM | 1 |
p.M1R | DLBC | 1 |
p.S703P | LUAD | 1 |
p.Y337* | SKCM | 1 |
p.L834F | HNSC | 1 |
p.S207F | SKCM | 1 |
p.F74L | LUAD | 1 |
p.D379Y | READ | 1 |
p.G255W | LUAD | 1 |
p.S4F | SKCM | 1 |
p.W674X | SKCM | 1 |
p.S475L | SKCM | 1 |
p.H556P | LUSC | 1 |
p.S851G | KIRC | 1 |
p.S775C | LUAD | 1 |
p.P1073S | LGG | 1 |
p.L487M | STAD | 1 |
p.A54V | BRCA | 1 |
p.A265V | THYM | 1 |
p.G510V | LUAD | 1 |
p.S174Y | PRAD | 1 |
p.S1003I | UCS | 1 |
p.R554Q | PRAD | 1 |
p.R896Q | BLCA | 1 |
p.Q13E | LUSC | 1 |
p.W11* | SKCM | 1 |
p.H1090N | READ | 1 |
p.R601* | LGG | 1 |
p.L727M | LUSC | 1 |
p.Q981* | SKCM | 1 |
p.V1069M | HNSC | 1 |
p.G12R | SKCM | 1 |
p.R30* | BRCA | 1 |
p.A145D | SARC | 1 |
p.M1016I | LUAD | 1 |
p.D382N | LUAD | 1 |
p.L819F | COAD | 1 |
p.Q779P | LUAD | 1 |
p.D495N | SKCM | 1 |
p.E889K | SKCM | 1 |
p.S1102F | SKCM | 1 |
Top |
TissGeneCNV for WDR72 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for WDR72 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1KY-01A | IL11RA-WDR72 | 5'UTR-CDS | chr9:34652230 | chr15:53889471 |
Top |
TissGeneNet for WDR72 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for WDR72 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for WDR72 |
TissGeneDrug for WDR72 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for WDR72 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002452 | Amelogenesis Imperfecta | 6 | BeFree |
umls:C1561535 | Creatinine finding | 2 | GAD |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | GAD |
umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C1561643 | Chronic Kidney Diseases | 1 | GWASCAT |
umls:C1561955 | Fibrinogen Adverse Event | 1 | GAD |
umls:C0399372 | Amelogenesis Imperfecta hypomaturation type | 0 | ORPHANET |
umls:C2750771 | Amelogenesis Imperfecta, Hypomaturation Type, Iia3 | 0 | CLINVAR,CTD_human,MGD |