TissGeneSummary for SUN3 |
Gene summary |
Basic gene information | Gene symbol | SUN3 |
Gene name | Sad1 and UNC84 domain containing 3 | |
Synonyms | SUNC1 | |
Cytomap | UCSC genome browser: 7p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001030019.1, NM_001284350.1,NM_152782.3, | |
Description | SUN domain-containing protein 3Sad1 and UNC84 domain containing 1hypothetical protein MGC33329sad1/unc-84 domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000164744 | ||
HPRD : 15451 | ||
Vega : OTTHUMG00000155646 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SUN3 | |
BioGPS: 256979 | ||
Pathway | NCI Pathway Interaction Database: SUN3 | |
KEGG: SUN3 | ||
REACTOME: SUN3 | ||
Pathway Commons: SUN3 | ||
Context | iHOP: SUN3 | |
ligand binding site mutation search in PubMed: SUN3 | ||
UCL Cancer Institute: SUN3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SUN3 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SUN3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -0.62686858 | -2.121642999 | 1.494774419 | 6.74E-08 | 6.92E-07 |
LUAD | -0.898636303 | -2.038981131 | 1.140344828 | 6.45E-05 | 0.000167253 |
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TissGene-miRNA for SUN3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SUN3 |
TissGeneSNV for SUN3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E35K | SKCM | 3 |
p.L124I | UCEC | 3 |
p.R334* | SKCM | 2 |
p.E116* | LUAD | 2 |
p.E223K | LUAD | 1 |
p.N149K | STAD | 1 |
p.P261S | HNSC | 1 |
p.G339C | LUAD | 1 |
p.A188D | COAD | 1 |
p.E211K | LUAD | 1 |
p.N335D | LIHC | 1 |
p.T151K | HNSC | 1 |
p.R126K | SKCM | 1 |
p.R88C | STAD | 1 |
p.E198Q | HNSC | 1 |
p.E59K | SKCM | 1 |
p.R166T | HNSC | 1 |
p.E316Q | LUSC | 1 |
p.S256L | BLCA | 1 |
p.T263N | UCEC | 1 |
p.R346X | SKCM | 1 |
p.E186Q | HNSC | 1 |
p.E117K | LUSC | 1 |
p.T5S | LUAD | 1 |
p.E128* | LUAD | 1 |
p.A198T | KIRP | 1 |
p.R88C | SKCM | 1 |
p.E223Q | HNSC | 1 |
p.R121H | UCEC | 1 |
p.R346L | LUSC | 1 |
p.E265Q | LUAD | 1 |
p.R346* | UCEC | 1 |
p.M144I | BLCA | 1 |
p.G351C | LUAD | 1 |
p.E71* | UCEC | 1 |
p.S233F | HNSC | 1 |
p.M132I | BLCA | 1 |
p.I48S | READ | 1 |
p.P273S | HNSC | 1 |
p.E105* | LUAD | 1 |
p.R100C | SKCM | 1 |
p.E253Q | LUAD | 1 |
p.N331D | COAD | 1 |
p.A268S | LUAD | 1 |
p.R178T | HNSC | 1 |
p.E211Q | HNSC | 1 |
p.Q76H | LUSC | 1 |
p.K4N | SKCM | 1 |
p.R109C | SKCM | 1 |
p.F125C | COAD | 1 |
p.K141N | READ | 1 |
p.R100C | STAD | 1 |
p.C17Y | LGG | 1 |
p.T163K | HNSC | 1 |
p.A210T | KIRP | 1 |
p.K77E | STAD | 1 |
p.D34E | COAD | 1 |
p.C281Y | LUAD | 1 |
p.S51I | THCA | 1 |
p.R334Q | LUAD | 1 |
p.D168N | LUAD | 1 |
p.G225R | LGG | 1 |
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TissGeneCNV for SUN3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SUN3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SUN3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SUN3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SUN3 |
TissGeneDrug for SUN3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SUN3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |