TissGeneSummary for C1orf101 |
Gene summary |
Basic gene information | Gene symbol | C1orf101 |
Gene name | chromosome 1 open reading frame 101 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q44 | |
Type of gene | protein-coding | |
RefGenes | NM_001130957.1, NM_001242340.1,NM_173807.4, | |
Description | uncharacterized protein C1orf101 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000179397 | ||
HPRD : 14561 | ||
Vega : OTTHUMG00000040103 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C1orf101 | |
BioGPS: 257044 | ||
Pathway | NCI Pathway Interaction Database: C1orf101 | |
KEGG: C1orf101 | ||
REACTOME: C1orf101 | ||
Pathway Commons: C1orf101 | ||
Context | iHOP: C1orf101 | |
ligand binding site mutation search in PubMed: C1orf101 | ||
UCL Cancer Institute: C1orf101 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C1orf101 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C1orf101 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.775486361 | 0.419440028 | -1.194926389 | 1.02E-17 | 6.49E-17 |
KICH | -1.816037639 | 0.872794361 | -2.688832 | 1.14E-17 | 5.13E-16 |
LUSC | -1.369650658 | -0.343678109 | -1.025972549 | 6.04E-07 | 1.55E-06 |
KIRP | -0.807814139 | 0.462845236 | -1.270659375 | 2.07E-08 | 1.48E-07 |
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TissGene-miRNA for C1orf101 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C1orf101 |
TissGeneSNV for C1orf101 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R874C | UCEC | 2 |
p.R928W | UCEC | 2 |
p.L821F | READ | 1 |
p.E96D | LIHC | 1 |
p.S286R | KIRC | 1 |
p.Q204H | LUAD | 1 |
p.L941I | UCEC | 1 |
p.L619V | BRCA | 1 |
p.R311H | OV | 1 |
p.D845H | SARC | 1 |
p.D435Y | READ | 1 |
p.P822T | LUAD | 1 |
p.L570V | HNSC | 1 |
p.F501C | STAD | 1 |
p.G325S | PRAD | 1 |
p.G317E | LUAD | 1 |
p.M176I | HNSC | 1 |
p.S453P | UCEC | 1 |
p.Y124H | STAD | 1 |
p.S171C | BRCA | 1 |
p.K629Q | CESC | 1 |
p.E127K | CESC | 1 |
p.Y23X | ESCA | 1 |
p.Y566X | STAD | 1 |
p.S237N | HNSC | 1 |
p.F543L | BLCA | 1 |
p.M176I | SKCM | 1 |
p.F724C | UCEC | 1 |
p.E174K | READ | 1 |
p.L509F | UCEC | 1 |
p.K378I | LUAD | 1 |
p.P753S | SKCM | 1 |
p.D777N | DLBC | 1 |
p.H498L | THCA | 1 |
p.I728T | OV | 1 |
p.A78T | HNSC | 1 |
p.D277G | STAD | 1 |
p.R315K | SKCM | 1 |
p.I815T | LGG | 1 |
p.R167I | COAD | 1 |
p.R91H | STAD | 1 |
p.N487H | UCEC | 1 |
p.D791V | STAD | 1 |
p.Q736* | CESC | 1 |
p.S242P | UCEC | 1 |
p.F543L | UCEC | 1 |
p.K267R | BLCA | 1 |
p.R294Q | COAD | 1 |
p.E89X | THYM | 1 |
p.S172L | HNSC | 1 |
p.S547F | COAD | 1 |
p.S574R | UCEC | 1 |
p.R91L | COAD | 1 |
p.Y793C | LUAD | 1 |
p.T537S | BRCA | 1 |
p.G346V | UCEC | 1 |
p.I359M | SKCM | 1 |
p.D435H | UCEC | 1 |
p.C71F | OV | 1 |
p.R36X | SKCM | 1 |
p.S495N | PAAD | 1 |
p.V765L | LUAD | 1 |
p.V108G | CESC | 1 |
p.R285Q | STAD | 1 |
p.D324Y | LUAD | 1 |
p.T888I | BRCA | 1 |
p.P900S | SKCM | 1 |
p.F217L | STAD | 1 |
p.L366F | SKCM | 1 |
p.D503G | LIHC | 1 |
p.P323S | SKCM | 1 |
p.T56N | SARC | 1 |
p.R36* | SKCM | 1 |
p.R682* | UCEC | 1 |
p.K629Q | BLCA | 1 |
p.V679F | LUAD | 1 |
p.P131S | SKCM | 1 |
p.P628S | SKCM | 1 |
p.F420V | UCEC | 1 |
p.Y566* | STAD | 1 |
p.E174D | COAD | 1 |
p.P737A | OV | 1 |
p.L924F | BRCA | 1 |
p.Y613C | LUSC | 1 |
p.F782S | ESCA | 1 |
p.K648N | UCEC | 1 |
p.Y106C | LUAD | 1 |
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TissGeneCNV for C1orf101 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C1orf101 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DN998404 | C1orf101-C1orf101 | chr1:244724250 | chr1:244724247 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1F6-01A | SDCCAG8-C1orf101 | In-Frame | chr1:243581378 | chr1:244715623 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1F6-01A | SDCCAG8-C1orf101 | In-frame | Chr1:243581378 | Chr1:244715624 |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A203-01A | RPS6KC1-C1orf101 | Out-of-frame | Chr1:213277911 | Chr1:244715624 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CN-6992-01A | PPPDE1-C1orf101 | Out-of-frame | Chr1:244816657 | Chr1:244798791 |
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TissGeneNet for C1orf101 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C1orf101 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C1orf101 |
TissGeneDrug for C1orf101 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C1orf101 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |