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| TissGeneSummary for KLK5 |
 Gene summary |
| Basic gene information | Gene symbol | KLK5 |
| Gene name | kallikrein-related peptidase 5 | |
| Synonyms | KLK-L2|KLKL2|SCTE | |
| Cytomap | UCSC genome browser: 19q13.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001077491.1, NM_001077492.1,NM_012427.4, | |
| Description | kallikrein 5kallikrein-5kallikrein-like protein 2stratum corneum tryptic enzyme | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605643 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167754 | ||
| HPRD : 05732 | ||
| Vega : OTTHUMG00000183097 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KLK5 | |
| BioGPS: 25818 | ||
| Pathway | NCI Pathway Interaction Database: KLK5 | |
| KEGG: KLK5 | ||
| REACTOME: KLK5 | ||
| Pathway Commons: KLK5 | ||
| Context | iHOP: KLK5 | |
| ligand binding site mutation search in PubMed: KLK5 | ||
| UCL Cancer Institute: KLK5 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvarySkinStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVSKCMSTAD | |
| Reference showing the relevant tissue of KLK5 | Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer. Yousef GM, Polymeris ME, Grass L, Soosaipillai A, Chan PC, Scorilas A, Borgoño C, Harbeck N, Schmalfeldt B, Dorn J, Schmitt M, Diamandis EP. Cancer Res. 2003 Jul 15;63(14):3958-65. Erratum in: Cancer Res. 2003 Sep 1;63(17):5647. (pmid:12873991) go to articleIsomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7. Oliveira JP, Freitas RF, Melo LS, Barros TG, Santos JA, Juliano MA, Pinheiro S, Blaber M, Juliano L, Muri EM, Puzer L. ACS Med Chem Lett. 2013 Dec 6;5(2):128-32. doi: 10.1021/ml4003698. eCollection 2014 Feb 13. (pmid:24900785) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 16885167 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 16885167 |
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| TissGeneExp for KLK5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.06344741 | -0.62635141 | -2.437096 | 3.02E-05 | 8.75E-05 |
| KIRP | -1.963631535 | 0.340893465 | -2.304525 | 4.52E-06 | 2.01E-05 |
| BRCA | 2.251233432 | 5.563907116 | -3.312673684 | 3.57E-14 | 1.76E-13 |
| KIRC | -2.822039521 | -0.112142299 | -2.709897222 | 2.82E-16 | 1.57E-15 |
| LUAD | -0.883729272 | 0.557858659 | -1.441587931 | 0.00736 | 0.013509394 |
| THCA | -0.153425444 | -1.577535613 | 1.424110169 | 4.61E-05 | 0.000133593 |
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| TissGene-miRNA for KLK5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KLK5 |
| TissGeneSNV for KLK5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R164C | SKCM | 6 |
| p.T276M | ESCA | 1 |
| p.S124L | LUAD | 1 |
| p.P43H | STAD | 1 |
| p.G257R | SKCM | 1 |
| p.D226A | KIRP | 1 |
| p.R271K | SKCM | 1 |
| p.K167I | SKCM | 1 |
| p.A181V | STAD | 1 |
| p.T276M | UCEC | 1 |
| p.P222S | SKCM | 1 |
| p.N40H | KIRC | 1 |
| p.V11A | LIHC | 1 |
| p.L123Q | LUSC | 1 |
| p.S64N | UCEC | 1 |
| p.P148A | LUAD | 1 |
| p.K202E | GBM | 1 |
| p.D244N | SKCM | 1 |
| p.R164H | UCEC | 1 |
| p.S260F | SKCM | 1 |
| p.H177D | CESC | 1 |
| p.R117H | BLCA | 1 |
| p.L123M | LGG | 1 |
| p.D57N | SKCM | 1 |
| p.S46C | LUSC | 1 |
| p.R66L | LUAD | 1 |
| p.A267V | COAD | 1 |
| p.P222L | STAD | 1 |
| p.Q224H | HNSC | 1 |
| p.S34F | SKCM | 1 |
| p.Q205X | SKCM | 1 |
| p.S175Y | BLCA | 1 |
| p.G55R | BRCA | 1 |
| p.D227N | ESCA | 1 |
| p.G191E | SKCM | 1 |
| p.Q205* | SKCM | 1 |
| p.A107D | LUAD | 1 |
| p.G144V | STAD | 1 |
| p.H37N | LUAD | 1 |
| p.Q205H | BRCA | 1 |
| p.D49N | SKCM | 1 |
| p.G262R | SKCM | 1 |
| p.G262E | SKCM | 1 |
| p.V11G | SKCM | 1 |
| p.H147Q | LUAD | 1 |
| p.P79L | HNSC | 1 |
| p.N173K | LUAD | 1 |
| p.E128K | SKCM | 1 |
| p.A107T | BLCA | 1 |
| p.V42M | CHOL | 1 |
| p.R117C | SKCM | 1 |
| p.L212R | HNSC | 1 |
| p.T228N | LUAD | 1 |
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| TissGeneCNV for KLK5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KLK5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KLK5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| COAD (tumor) | COAD (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| KICH (tumor) | KICH (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| STAD (tumor) | STAD (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| THCA (tumor) | THCA (normal) |
| KLK5, SERPINA1, DSG1 (tumor) | KLK5, SERPINA1, DSG1 (normal) |
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| TissGeneProg for KLK5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KLK5 |
| TissGeneDrug for KLK5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KLK5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 10 | BeFree |
| umls:C0678222 | Breast Carcinoma | 10 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 7 | BeFree,GAD |
| umls:C0029925 | Ovarian Carcinoma | 6 | BeFree |
| umls:C0600139 | Prostate carcinoma | 6 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 6 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 3 | CTD_human,LHGDN |
| umls:C0265962 | Ichthyosis linearis circumflexa | 3 | BeFree |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree,LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0013595 | Eczema | 2 | BeFree |
| umls:C0033860 | Psoriasis | 2 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree |
| umls:C0003962 | Ascites | 1 | LHGDN |
| umls:C0005695 | Bladder Neoplasm | 1 | BeFree,LHGDN |
| umls:C0011606 | Exfoliative dermatitis | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0033774 | Pruritus | 1 | BeFree |
| umls:C0239849 | Harlequin Fetus | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C1328504 | Hormone refractory prostate cancer | 1 | BeFree |
| umls:C1654637 | androgen independent prostate cancer | 1 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
| umls:C3539909 | Allergic disposition | 1 | BeFree |
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