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| TissGeneSummary for TPSG1 |
 Gene summary |
| Basic gene information | Gene symbol | TPSG1 |
| Gene name | tryptase gamma 1 | |
| Synonyms | PRSS31|TMT|trpA | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012467.3, | |
| Description | gamma Igamma IIlung tryptasemast cell protease IImast cell tryptasepituitary tryptaseserine protease 31skin tryptasetransmembrane tryptasetryptase gammatryptase gamma Itryptase gamma II | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609341 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000116176 | ||
| HPRD : 07160 | ||
| Vega : OTTHUMG00000090466 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TPSG1 | |
| BioGPS: 25823 | ||
| Pathway | NCI Pathway Interaction Database: TPSG1 | |
| KEGG: TPSG1 | ||
| REACTOME: TPSG1 | ||
| Pathway Commons: TPSG1 | ||
| Context | iHOP: TPSG1 | |
| ligand binding site mutation search in PubMed: TPSG1 | ||
| UCL Cancer Institute: TPSG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
| Reference showing the relevant tissue of TPSG1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TPSG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | -1.782884114 | -0.752489884 | -1.030394231 | 8.45E-06 | 4.84E-05 |
| COAD | 2.200844732 | 5.032863963 | -2.832019231 | 8.31E-06 | 3.91E-05 |
| LUSC | -2.832320879 | -1.458007154 | -1.374313725 | 2.01E-13 | 1.00E-12 |
| KIRP | -2.234499739 | -1.212540364 | -1.021959375 | 0.000693 | 0.001984299 |
| KICH | -2.422953114 | -0.978037114 | -1.444916 | 0.000201 | 0.000497757 |
| STAD | -1.098168489 | 1.144753386 | -2.242921875 | 3.34E-05 | 0.000307855 |
| BLCA | -2.416267009 | -0.383209114 | -2.033057895 | 1.54E-05 | 0.000265169 |
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| TissGene-miRNA for TPSG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TPSG1 |
| TissGeneSNV for TPSG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V60M | COAD | 4 |
| p.R193H | COAD | 2 |
| p.G170R | SKCM | 2 |
| p.T239I | BRCA | 1 |
| p.F288L | COAD | 1 |
| p.R267C | PRAD | 1 |
| p.G163C | LUAD | 1 |
| p.P199T | LUSC | 1 |
| p.R193H | UCEC | 1 |
| p.S277C | BLCA | 1 |
| p.S138F | BRCA | 1 |
| p.G215E | SKCM | 1 |
| p.R248H | UCEC | 1 |
| p.P280S | UCS | 1 |
| p.G163S | STAD | 1 |
| p.P280L | COAD | 1 |
| p.R56H | CESC | 1 |
| p.G253R | SKCM | 1 |
| p.G170E | SKCM | 1 |
| p.E95K | SKCM | 1 |
| p.S178C | SKCM | 1 |
| p.R212Q | STAD | 1 |
| p.Q109K | ESCA | 1 |
| p.G314D | SKCM | 1 |
| p.R257C | BLCA | 1 |
| p.L137I | THYM | 1 |
| p.S18F | SKCM | 1 |
| p.G232D | SKCM | 1 |
| p.R257C | SKCM | 1 |
| p.G170R | DLBC | 1 |
| p.L128M | SKCM | 1 |
| p.L22F | CESC | 1 |
| p.D207N | SKCM | 1 |
| p.L209M | COAD | 1 |
| p.V258A | LIHC | 1 |
| p.R248H | READ | 1 |
| p.C159S | LUAD | 1 |
| p.P291S | SKCM | 1 |
| p.L112M | UCEC | 1 |
| p.R266C | SARC | 1 |
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| TissGeneCNV for TPSG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TPSG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for TPSG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TPSG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TPSG1 |
| TissGeneDrug for TPSG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TPSG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024899 | Mastocytosis | 3 | BeFree |
| umls:C0042111 | Urticaria Pigmentosa | 3 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 2 | BeFree |
| umls:C0036341 | Schizophrenia | 2 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0018916 | Hemangioma | 1 | BeFree |
| umls:C0020429 | Hyperalgesia | 1 | BeFree |
| umls:C0020542 | Pulmonary Hypertension | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0029172 | Oral Submucous Fibrosis | 1 | BeFree |
| umls:C0039730 | Thalassemia | 1 | BeFree |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
| umls:C0235989 | Renal interstitial fibrosis | 1 | BeFree |
| umls:C0409952 | Idiopathic osteoarthritis | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1384584 | Generalized osteoarthritis | 1 | BeFree |
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