TissGeneSummary for SULT4A1 |
Gene summary |
Basic gene information | Gene symbol | SULT4A1 |
Gene name | sulfotransferase family 4A, member 1 | |
Synonyms | BR-STL-1|BRSTL1|DJ388M5.3|NST|SULTX3|hBR-STL-1 | |
Cytomap | UCSC genome browser: 22q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_014351.3, NM_176874.1, | |
Description | ST4A1brain sulfotransferase-like proteinhBR-STLnervous system cytosolic sulfotransferasenervous system sulfotransferasesulfotransferase 4A1sulfotransferase-related protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 608359 | |
HGNC : HGNC | ||
Ensembl : ENSG00000130540 | ||
HPRD : 07462 | ||
Vega : OTTHUMG00000141314 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SULT4A1 | |
BioGPS: 25830 | ||
Pathway | NCI Pathway Interaction Database: SULT4A1 | |
KEGG: SULT4A1 | ||
REACTOME: SULT4A1 | ||
Pathway Commons: SULT4A1 | ||
Context | iHOP: SULT4A1 | |
ligand binding site mutation search in PubMed: SULT4A1 | ||
UCL Cancer Institute: SULT4A1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of SULT4A1 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SULT4A1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.444236471 | -2.327851029 | 2.7720875 | 1.31E-07 | 7.73E-07 |
LUAD | -1.282982279 | -3.047040899 | 1.764058621 | 1.89E-06 | 6.06E-06 |
COAD | -2.138436125 | 0.381221568 | -2.519657692 | 9.10E-06 | 4.22E-05 |
LUSC | -0.380097965 | -3.093105808 | 2.713007843 | 5.40E-10 | 1.90E-09 |
THCA | -2.024099228 | -3.691494143 | 1.667394915 | 2.84E-09 | 1.54E-08 |
LIHC | -1.759106279 | -2.830224279 | 1.071118 | 0.0242 | 0.04597793 |
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TissGene-miRNA for SULT4A1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-125b-5p | MIMAT0000423 | 0.018 | -0.31 | 60 |
LUAD | hsa-miR-125a-5p | MIMAT0000443 | 0.0022 | -0.39 | 60 |
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TissGeneMut for SULT4A1 |
TissGeneSNV for SULT4A1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E160* | UCEC | 2 |
p.H185Q | CHOL | 1 |
p.M152I | SKCM | 1 |
p.D281N | LUAD | 1 |
p.P9S | LGG | 1 |
p.S141F | SKCM | 1 |
p.P118L | SKCM | 1 |
p.D168N | SKCM | 1 |
p.Q144* | SKCM | 1 |
p.T58I | LIHC | 1 |
p.D83E | LUAD | 1 |
p.L60M | LUAD | 1 |
p.R150W | STAD | 1 |
p.M273I | LUAD | 1 |
p.G78C | COAD | 1 |
p.D277G | UCEC | 1 |
p.D281N | SKCM | 1 |
p.G173S | COAD | 1 |
p.M152L | PRAD | 1 |
p.R133C | SKCM | 1 |
p.T227M | CESC | 1 |
p.M80R | KIRC | 1 |
p.D83N | STAD | 1 |
p.R155* | HNSC | 1 |
p.D137Y | LUAD | 1 |
p.D137N | SKCM | 1 |
p.P42T | COAD | 1 |
p.T157I | SKCM | 1 |
p.E63K | SKCM | 1 |
p.R254Q | SKCM | 1 |
p.Q144L | LUAD | 1 |
p.G171S | SKCM | 1 |
p.V88I | SARC | 1 |
p.H111Y | SKCM | 1 |
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TissGeneCNV for SULT4A1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SULT4A1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SULT4A1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SULT4A1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SULT4A1 |
TissGeneDrug for SULT4A1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SULT4A1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 5 | BeFree,GAD |
umls:C0025202 | melanoma | 2 | BeFree |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0007133 | Carcinoma, Papillary | 1 | BeFree |
umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
umls:C0020429 | Hyperalgesia | 1 | BeFree |
umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
umls:C0030193 | Pain | 1 | BeFree |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
umls:C0036337 | Schizoaffective Disorder | 1 | BeFree |
umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
umls:C0221355 | Macrocephaly | 1 | BeFree |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0338831 | Manic | 1 | BeFree |
umls:C0406810 | Carney Complex | 1 | BeFree |
umls:C0751214 | Hyperalgesia, Thermal | 1 | BeFree |
umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |