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| TissGeneSummary for POU2F3 |
 Gene summary |
| Basic gene information | Gene symbol | POU2F3 |
| Gene name | POU class 2 homeobox 3 | |
| Synonyms | Epoc-1|OCT-11|OCT11|OTF-11|PLA-1|PLA1|Skn-1a | |
| Cytomap | UCSC genome browser: 11q23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001244682.1, NM_014352.3, | |
| Description | POU domain transcription factor OCT11aPOU domain, class 2, transcription factor 3octamer-binding protein 11octamer-binding transcription factor 11transcription factor PLA-1transcription factor Skn-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607394 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000137709 | ||
| HPRD : 09582 | ||
| Vega : OTTHUMG00000166140 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_POU2F3 | |
| BioGPS: 25833 | ||
| Pathway | NCI Pathway Interaction Database: POU2F3 | |
| KEGG: POU2F3 | ||
| REACTOME: POU2F3 | ||
| Pathway Commons: POU2F3 | ||
| Context | iHOP: POU2F3 | |
| ligand binding site mutation search in PubMed: POU2F3 | ||
| UCL Cancer Institute: POU2F3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSKCM | |
| Reference showing the relevant tissue of POU2F3 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0043922 | negative regulation by host of viral transcription | 14645924 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12624109 | GO:0043922 | negative regulation by host of viral transcription | 14645924 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12624109 |
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| TissGeneExp for POU2F3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -3.029506014 | -0.349825458 | -2.679680556 | 7.40E-23 | 7.25E-22 |
| THCA | 2.345015455 | 0.778705286 | 1.566310169 | 2.20E-11 | 1.59E-10 |
| KIRP | -2.338350805 | -0.572188305 | -1.7661625 | 2.84E-05 | 0.000109592 |
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| TissGene-miRNA for POU2F3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-128-3p | MIMAT0000424 | 0.048 | -0.26 | 60 |
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| TissGeneMut for POU2F3 |
| TissGeneSNV for POU2F3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E189K | UCEC | 2 |
| p.E163K | BLCA | 1 |
| p.D302Y | UCEC | 1 |
| p.E291K | READ | 1 |
| p.H152Y | STAD | 1 |
| p.N340D | UCEC | 1 |
| p.R36X | READ | 1 |
| p.L80Q | STAD | 1 |
| p.D87G | UCEC | 1 |
| p.N408Y | UCEC | 1 |
| p.L126I | BRCA | 1 |
| p.S136R | STAD | 1 |
| p.M244T | STAD | 1 |
| p.I316T | STAD | 1 |
| p.P158S | LUAD | 1 |
| p.S418F | LGG | 1 |
| p.L97P | SKCM | 1 |
| p.E194D | STAD | 1 |
| p.L172F | THYM | 1 |
| p.P367S | SARC | 1 |
| p.E323K | SKCM | 1 |
| p.S160F | SKCM | 1 |
| p.R204H | LGG | 1 |
| p.R204C | LIHC | 1 |
| p.L99M | HNSC | 1 |
| p.E163K | SKCM | 1 |
| p.S423L | SKCM | 1 |
| p.D24N | SKCM | 1 |
| p.Q170* | SKCM | 1 |
| p.E321K | SKCM | 1 |
| p.S369Y | ESCA | 1 |
| p.S369F | SKCM | 1 |
| p.Q226H | LUAD | 1 |
| p.Q168X | SKCM | 1 |
| p.N238D | THYM | 1 |
| p.R282K | SKCM | 1 |
| p.A412T | COAD | 1 |
| p.R355Q | SKCM | 1 |
| p.G68E | SKCM | 1 |
| p.P95A | HNSC | 1 |
| p.E161K | SKCM | 1 |
| p.T9R | CESC | 1 |
| p.I314T | STAD | 1 |
| p.R284K | SKCM | 1 |
| p.Q228H | LUAD | 1 |
| p.R334* | OV | 1 |
| p.S158F | SKCM | 1 |
| p.G70E | SKCM | 1 |
| p.L99P | SKCM | 1 |
| p.A236V | HNSC | 1 |
| p.M242T | STAD | 1 |
| p.S260Y | LUAD | 1 |
| p.S161A | BLCA | 1 |
| p.L101M | HNSC | 1 |
| p.P156S | LUAD | 1 |
| p.G104S | STAD | 1 |
| p.R390K | COAD | 1 |
| p.Q88H | ESCA | 1 |
| p.R203M | LGG | 1 |
| p.D18N | SKCM | 1 |
| p.S425L | SKCM | 1 |
| p.E191K | ACC | 1 |
| p.R38* | UCS | 1 |
| p.E189K | ACC | 1 |
| p.H62N | THCA | 1 |
| p.A72P | SKCM | 1 |
| p.P64L | SKCM | 1 |
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| TissGeneCNV for POU2F3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for POU2F3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-C8-A12U-01A | TMEM136-POU2F3 | In-Frame | chr11:120198349 | chr11:120139918 |
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| TissGeneNet for POU2F3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| COAD (tumor) | COAD (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| KICH (tumor) | KICH (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| STAD (tumor) | STAD (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| THCA (tumor) | THCA (normal) |
| POU2F3, BCL6, CREBBP, SPRR2B (tumor) | POU2F3, BCL6, CREBBP, SPRR2B (normal) |
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| TissGeneProg for POU2F3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for POU2F3 |
| TissGeneDrug for POU2F3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for POU2F3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027051 | Myocardial Infarction | 8 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 6 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 4 | BeFree |
| umls:C0010068 | Coronary heart disease | 4 | BeFree |
| umls:C1264031 | Alloimmune thrombocytopenia | 3 | BeFree |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
| umls:C0011884 | Diabetic Retinopathy | 2 | BeFree |
| umls:C0151942 | Arterial thrombosis | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0948201 | Alloimmunisation | 2 | BeFree |
| umls:C1868251 | Neonatal alloimmune thrombocytopenia (NAIT) | 2 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0026975 | Myelitis | 1 | BeFree |
| umls:C0029134 | Optic Neuritis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0039483 | Giant Cell Arteritis | 1 | BeFree |
| umls:C0040015 | Thrombasthenia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0149871 | Deep Vein Thrombosis | 1 | BeFree |
| umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
| umls:C0333186 | Restenosis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0741250 | aspirin sensitivity | 1 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
| umls:C3178801 | Stroke, Lacunar | 1 | BeFree |
| umls:C3665346 | Unspecified visual loss | 1 | BeFree |
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