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| TissGeneSummary for CHRDL2 |
 Gene summary |
| Basic gene information | Gene symbol | CHRDL2 |
| Gene name | chordin-like 2 | |
| Synonyms | BNF1|CHL2|FKSG37 | |
| Cytomap | UCSC genome browser: 11q14 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001278473.1, NM_015424.4, | |
| Description | BNF-1breast tumor novel factor 1chordin-like protein 2chordin-related protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 613127 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000054938 | ||
| HPRD : 09881 | ||
| Vega : OTTHUMG00000165623 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CHRDL2 | |
| BioGPS: 25884 | ||
| Pathway | NCI Pathway Interaction Database: CHRDL2 | |
| KEGG: CHRDL2 | ||
| REACTOME: CHRDL2 | ||
| Pathway Commons: CHRDL2 | ||
| Context | iHOP: CHRDL2 | |
| ligand binding site mutation search in PubMed: CHRDL2 | ||
| UCL Cancer Institute: CHRDL2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyStomachUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHSTADUCEC,UCS | |
| Reference showing the relevant tissue of CHRDL2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CHRDL2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 2.065919323 | 0.586708978 | 1.479210345 | 3.08E-07 | 1.12E-06 |
| BLCA | 2.26253965 | 4.636008071 | -2.373468421 | 0.0114 | 0.049134884 |
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| TissGene-miRNA for CHRDL2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CHRDL2 |
| TissGeneSNV for CHRDL2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P48L | SKCM | 2 |
| p.D199N | SKCM | 2 |
| p.D362N | KIRC | 1 |
| p.I313V | SARC | 1 |
| p.S224N | COAD | 1 |
| p.C111S | LUAD | 1 |
| p.T86M | STAD | 1 |
| p.S10C | COAD | 1 |
| p.S64* | ACC | 1 |
| p.G262R | SKCM | 1 |
| p.E416K | SKCM | 1 |
| p.R286H | READ | 1 |
| p.G234R | SARC | 1 |
| p.A221T | ESCA | 1 |
| p.W419R | HNSC | 1 |
| p.T329A | COAD | 1 |
| p.T258M | GBM | 1 |
| p.A106T | BLCA | 1 |
| p.A15T | COAD | 1 |
| p.I226V | DLBC | 1 |
| p.E185K | LUAD | 1 |
| p.R353C | CESC | 1 |
| p.H99D | BLCA | 1 |
| p.A15V | STAD | 1 |
| p.E376K | MESO | 1 |
| p.P101L | BLCA | 1 |
| p.K249E | SKCM | 1 |
| p.P211L | PRAD | 1 |
| p.S361* | LUSC | 1 |
| p.Y57X | READ | 1 |
| p.G262E | SKCM | 1 |
| p.A334V | LGG | 1 |
| p.E122D | UCEC | 1 |
| p.R353C | UCEC | 1 |
| p.G206E | SKCM | 1 |
| p.H127R | STAD | 1 |
| p.S203N | LGG | 1 |
| p.E122X | UCS | 1 |
| p.G262R | LIHC | 1 |
| p.S402T | OV | 1 |
| p.W369* | SARC | 1 |
| p.R133C | COAD | 1 |
| p.P299S | SKCM | 1 |
| p.R60H | GBM | 1 |
| p.H113Y | COAD | 1 |
| p.R301H | ESCA | 1 |
| p.L191I | STAD | 1 |
| p.A67T | PRAD | 1 |
| p.E122* | UCS | 1 |
| p.V409I | PRAD | 1 |
| p.P52L | SKCM | 1 |
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| TissGeneCNV for CHRDL2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CHRDL2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NI-01A | PGM2L1-CHRDL2 | Out-of-Frame | chr11:74109095 | chr11:74429877 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-DQ-5624-01A | ERP44-CHRDL2 | In-frame | Chr9:102814699 | Chr11:74429877 |
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| TissGeneNet for CHRDL2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| COAD (tumor) | COAD (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| KICH (tumor) | KICH (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| STAD (tumor) | STAD (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| THCA (tumor) | THCA (normal) |
| CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (tumor) | CHRDL2, BMP2, BMP7, BMP6, GDF5, INHBA, BMP4, BMP5 (normal) |
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| TissGeneProg for CHRDL2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CHRDL2 |
| TissGeneDrug for CHRDL2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CHRDL2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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