TissGeneSummary for AMBP |
Gene summary |
Basic gene information | Gene symbol | AMBP |
Gene name | alpha-1-microglobulin/bikunin precursor | |
Synonyms | A1M|EDC1|HCP|HI30|IATIL|ITI|ITIL|ITILC|UTI | |
Cytomap | UCSC genome browser: 9q32-q33 | |
Type of gene | protein-coding | |
RefGenes | NM_001633.3, | |
Description | bikunincomplex-forming glycoprotein heterogeneous in chargegrowth-inhibiting protein 19inter-alpha-trypsin inhibitor light chainprotein AMBPprotein HCtrypstatinuristatinuronic-acid-rich protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 176870 | |
HGNC : HGNC | ||
Ensembl : ENSG00000106927 | ||
HPRD : 01467 | ||
Vega : OTTHUMG00000020534 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AMBP | |
BioGPS: 259 | ||
Pathway | NCI Pathway Interaction Database: AMBP | |
KEGG: AMBP | ||
REACTOME: AMBP | ||
Pathway Commons: AMBP | ||
Context | iHOP: AMBP | |
ligand binding site mutation search in PubMed: AMBP | ||
UCL Cancer Institute: AMBP | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of AMBP | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for AMBP |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -3.011961667 | -0.649524412 | -2.362437255 | 1.17E-15 | 7.98E-15 |
KICH | -2.422749902 | 3.215430098 | -5.63818 | 2.93E-22 | 3.08E-20 |
THCA | -3.446829563 | -1.464216004 | -1.982613559 | 6.92E-20 | 2.60E-18 |
KIRC | -0.166067958 | 2.854405653 | -3.020473611 | 1.68E-22 | 1.60E-21 |
LIHC | 12.2395281 | 13.8508501 | -1.611322 | 2.97E-06 | 1.44E-05 |
KIRP | 1.761196973 | 3.407131348 | -1.645934375 | 0.000107 | 0.000361286 |
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TissGene-miRNA for AMBP |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AMBP |
TissGeneSNV for AMBP |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W114* | SKCM | 2 |
p.V69M | UCEC | 1 |
p.P26A | BRCA | 1 |
p.W44G | THCA | 1 |
p.Y151H | LUSC | 1 |
p.Q321* | CESC | 1 |
p.G310R | SKCM | 1 |
p.S253F | SKCM | 1 |
p.F259S | HNSC | 1 |
p.K111N | SKCM | 1 |
p.R62M | LGG | 1 |
p.R185Q | LUAD | 1 |
p.Y261H | STAD | 1 |
p.E72G | UCEC | 1 |
p.P175L | SKCM | 1 |
p.G171S | THYM | 1 |
p.T135S | STAD | 1 |
p.G251S | LGG | 1 |
p.K136N | UCEC | 1 |
p.T24M | KIRP | 1 |
p.H110Q | PAAD | 1 |
p.E159D | COAD | 1 |
p.K57N | OV | 1 |
p.L161F | SKCM | 1 |
p.P54S | SKCM | 1 |
p.R39P | OV | 1 |
p.D104G | LUAD | 1 |
p.E211X | READ | 1 |
p.G338S | UCEC | 1 |
p.S120F | SKCM | 1 |
p.Y261C | UCEC | 1 |
p.R282Q | PAAD | 1 |
p.I116V | LUAD | 1 |
p.I29M | HNSC | 1 |
p.D27N | LUAD | 1 |
p.G217D | LUAD | 1 |
p.G318R | SKCM | 1 |
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TissGeneCNV for AMBP |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AMBP |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for AMBP |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AMBP |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AMBP |
TissGeneDrug for AMBP |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00062 | Human Serum Albumin | Biotech | Approved | |
DB00064 | Serum albumin iodonated | Biotech | Approved |
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TissGeneDisease for AMBP |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027627 | Neoplasm Metastasis | 9 | BeFree,LHGDN |
umls:C0029925 | Ovarian Carcinoma | 8 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 7 | BeFree |
umls:C0262655 | Recurrent urinary tract infection | 5 | BeFree |
umls:C0520575 | Acute pyelonephritis | 5 | BeFree |
umls:C0262380 | Asymptomatic bacteriuria | 4 | BeFree |
umls:C0042029 | Urinary tract infection | 3 | BeFree |
umls:C0042580 | Vesico-Ureteral Reflux | 3 | BeFree |
umls:C0004610 | Bacteremia | 2 | BeFree |
umls:C0004659 | Bacteriuria | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0022650 | Kidney Calculi | 2 | BeFree,GAD |
umls:C0034186 | Pyelonephritis | 2 | BeFree |
umls:C0085293 | Hepatitis E | 2 | LHGDN |
umls:C0002895 | Anemia, Sickle Cell | 1 | BeFree |
umls:C0003850 | Arteriosclerosis | 1 | BeFree |
umls:C0004153 | Atherosclerosis | 1 | BeFree |
umls:C0005697 | Neurogenic Urinary Bladder | 1 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0010692 | Cystitis | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0014118 | Endocarditis | 1 | BeFree |
umls:C0018790 | Cardiac Arrest | 1 | LHGDN |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0021313 | Infection of kidney | 1 | BeFree |
umls:C0024899 | Mastocytosis | 1 | BeFree |
umls:C0025229 | Melioidosis | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | LHGDN |
umls:C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0042111 | Urticaria Pigmentosa | 1 | BeFree |
umls:C0085136 | Central Nervous System Neoplasms | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0392525 | Nephrolithiasis | 1 | RGD |
umls:C0600041 | Infective cystitis | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C2609414 | Acute kidney injury | 1 | CTD_human |