TissGeneSummary for AHCTF1 |
Gene summary |
Basic gene information | Gene symbol | AHCTF1 |
Gene name | AT hook containing transcription factor 1 | |
Synonyms | ELYS|MST108|TMBS62 | |
Cytomap | UCSC genome browser: 1q44 | |
Type of gene | protein-coding | |
RefGenes | NM_015446.4, | |
Description | ELYS transcription factor like protein TMBS62ELYS transcription factor-like protein TMBS62embryonic large molecule derived from yolk sacprotein ELYSputative AT-hook-containing transcription factor 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610853 | |
HGNC : HGNC | ||
Ensembl : ENSG00000153207 | ||
HPRD : 09935 | ||
Vega : OTTHUMG00000040706 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AHCTF1 | |
BioGPS: 25909 | ||
Pathway | NCI Pathway Interaction Database: AHCTF1 | |
KEGG: AHCTF1 | ||
REACTOME: AHCTF1 | ||
Pathway Commons: AHCTF1 | ||
Context | iHOP: AHCTF1 | |
ligand binding site mutation search in PubMed: AHCTF1 | ||
UCL Cancer Institute: AHCTF1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisUterus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUCEC,UCS | |
Reference showing the relevant tissue of AHCTF1 | ||
Description by TissGene annotations | TissgsLTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for AHCTF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for AHCTF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-106a-5p | MIMAT0000103 | 0.038 | -0.28 | 56 |
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TissGeneMut for AHCTF1 |
TissGeneSNV for AHCTF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L829I | UCEC | 2 |
p.L1540I | UCEC | 2 |
p.R396* | SKCM | 2 |
p.R635T | BLCA | 1 |
p.R315P | LUAD | 1 |
p.S410L | SKCM | 1 |
p.H372Y | CESC | 1 |
p.E1320K | STAD | 1 |
p.V445A | KIRP | 1 |
p.S384L | SKCM | 1 |
p.L13P | UCEC | 1 |
p.N963S | HNSC | 1 |
p.S2132N | SKCM | 1 |
p.A147V | THYM | 1 |
p.R1916T | LUSC | 1 |
p.T1573A | STAD | 1 |
p.E455K | BLCA | 1 |
p.A1191S | OV | 1 |
p.S2129F | SKCM | 1 |
p.D204H | ESCA | 1 |
p.C1270F | LIHC | 1 |
p.A1383T | UCEC | 1 |
p.R996H | SKCM | 1 |
p.I548M | HNSC | 1 |
p.D693_splice | LUSC | 1 |
p.A31V | STAD | 1 |
p.V965L | UCEC | 1 |
p.S1647R | OV | 1 |
p.G1329V | LUAD | 1 |
p.M1222L | LUAD | 1 |
p.S2158L | HNSC | 1 |
p.R2130H | LUAD | 1 |
p.E1510D | ESCA | 1 |
p.D2187N | UVM | 1 |
p.S1997C | STAD | 1 |
p.Q2148X | LIHC | 1 |
p.N883S | COAD | 1 |
p.R370X | SKCM | 1 |
p.R600G | LUAD | 1 |
p.R1225Q | UCEC | 1 |
p.V197A | SKCM | 1 |
p.K1096* | HNSC | 1 |
p.T1466A | UCEC | 1 |
p.G2058* | SKCM | 1 |
p.P1249S | LUSC | 1 |
p.Q289R | LUAD | 1 |
p.S1177X | LIHC | 1 |
p.E1639* | LUAD | 1 |
p.N357K | SKCM | 1 |
p.L989F | SKCM | 1 |
p.E66D | PAAD | 1 |
p.H992R | ESCA | 1 |
p.D981H | OV | 1 |
p.R1063* | SKCM | 1 |
p.R159X | STAD | 1 |
p.A1213P | LUAD | 1 |
p.A1248P | LUAD | 1 |
p.G751E | SARC | 1 |
p.I1887S | PAAD | 1 |
p.T803S | LUAD | 1 |
p.Q2180P | OV | 1 |
p.I1922S | PAAD | 1 |
p.A2121V | SKCM | 1 |
p.V767I | STAD | 1 |
p.R2219Q | STAD | 1 |
p.S1069P | CESC | 1 |
p.E1245Q | LUSC | 1 |
p.D1890N | UCEC | 1 |
p.E1402G | STAD | 1 |
p.E1329K | STAD | 1 |
p.A1195V | CHOL | 1 |
p.R1777T | HNSC | 1 |
p.S1771F | SKCM | 1 |
p.S576Y | UCEC | 1 |
p.P1403L | UCEC | 1 |
p.P2172S | SKCM | 1 |
p.I1896S | PAAD | 1 |
p.V776I | STAD | 1 |
p.H966R | ESCA | 1 |
p.N388T | BRCA | 1 |
p.S415L | UCEC | 1 |
p.S1083R | ESCA | 1 |
p.K1868E | DLBC | 1 |
p.E711Q | BLCA | 1 |
p.R2135Q | ESCA | 1 |
p.L141F | SKCM | 1 |
p.P2236T | ESCA | 1 |
p.V415F | SKCM | 1 |
p.K312M | BRCA | 1 |
p.G1598C | LUAD | 1 |
p.Y1590F | HNSC | 1 |
p.S1682C | LUAD | 1 |
p.V974L | UCEC | 1 |
p.G486E | STAD | 1 |
p.R600T | BLCA | 1 |
p.P964T | HNSC | 1 |
p.T341A | ESCA | 1 |
p.R1908K | HNSC | 1 |
p.E1204Q | BLCA | 1 |
p.E746Q | BLCA | 1 |
p.N2114S | STAD | 1 |
p.E94K | OV | 1 |
p.P473A | CESC | 1 |
p.R2135W | BLCA | 1 |
p.A1969S | HNSC | 1 |
p.E1168G | SKCM | 1 |
p.R747C | LGG | 1 |
p.R1208* | UCEC | 1 |
p.S2106N | SKCM | 1 |
p.E40D | PAAD | 1 |
p.N1574S | LIHC | 1 |
p.G1975W | PRAD | 1 |
p.E328K | LUAD | 1 |
p.Q324R | LUAD | 1 |
p.L1478I | UCEC | 1 |
p.E1290K | BLCA | 1 |
p.P1252S | SKCM | 1 |
p.P1123H | LGG | 1 |
p.E469Q | CESC | 1 |
p.G243R | KIRP | 1 |
p.G1569R | SARC | 1 |
p.L176I | COAD | 1 |
p.E918* | BRCA | 1 |
p.A1110T | ESCA | 1 |
p.A2199V | COAD | 1 |
p.Q427H | BLCA | 1 |
p.F798L | UCEC | 1 |
p.D208H | ESCA | 1 |
p.G1460S | BRCA | 1 |
p.S1682I | LUAD | 1 |
p.E720K | KIRP | 1 |
p.L688V | BLCA | 1 |
p.F86L | UCEC | 1 |
p.C1296F | LIHC | 1 |
p.G192A | OV | 1 |
p.L1411H | OV | 1 |
p.E75* | BRCA | 1 |
p.G391* | LUAD | 1 |
p.S1087Y | UCEC | 1 |
p.T890A | COAD | 1 |
p.A2225T | UCEC | 1 |
p.P501L | SKCM | 1 |
p.R70H | SKCM | 1 |
p.D1367H | CESC | 1 |
p.R1234X | COAD | 1 |
p.T1291A | HNSC | 1 |
p.P1480S | STAD | 1 |
p.R2059C | PAAD | 1 |
p.M214V | LIHC | 1 |
p.M447I | SARC | 1 |
p.D1324Y | LUSC | 1 |
p.T1256A | HNSC | 1 |
p.E927K | ESCA | 1 |
p.D1393H | CESC | 1 |
p.D568H | BLCA | 1 |
p.N921S | LUAD | 1 |
p.Q952* | LUSC | 1 |
p.S1188T | UCEC | 1 |
p.E1325K | BLCA | 1 |
p.P496L | SKCM | 1 |
p.E2079K | LUAD | 1 |
p.D721N | UCEC | 1 |
p.T1723I | BLCA | 1 |
p.P470L | SKCM | 1 |
p.G503D | UCEC | 1 |
p.R44H | SKCM | 1 |
p.D182H | ESCA | 1 |
p.E1781* | UCEC | 1 |
p.R2201L | LUSC | 1 |
p.R735* | PAAD | 1 |
p.R1234Q | UCEC | 1 |
p.N1628S | COAD | 1 |
p.G217R | KIRP | 1 |
p.I583M | HNSC | 1 |
p.R2228Q | STAD | 1 |
p.V405L | LUAD | 1 |
p.L2143F | BRCA | 1 |
p.D1936G | READ | 1 |
p.E1023D | LUAD | 1 |
p.E363K | LUAD | 1 |
p.E2114K | LUAD | 1 |
p.E443Q | CESC | 1 |
p.S1935G | LGG | 1 |
p.T2052A | PAAD | 1 |
p.E31D | PAAD | 1 |
p.E1142G | SKCM | 1 |
p.E1393G | STAD | 1 |
p.N345I | PCPG | 1 |
p.A2131V | COAD | 1 |
p.G1633C | LUAD | 1 |
p.M1761V | PCPG | 1 |
p.Q1298E | LUSC | 1 |
p.S1332G | KIRC | 1 |
p.S2060* | UCEC | 1 |
p.H791Y | SKCM | 1 |
p.N283K | SKCM | 1 |
p.L225V | BLCA | 1 |
p.R635G | LUAD | 1 |
p.E1484D | ESCA | 1 |
p.P1945S | UCEC | 1 |
p.S2048L | READ | 1 |
p.R2109Q | ESCA | 1 |
p.N383K | SKCM | 1 |
p.P51S | SKCM | 1 |
p.P2250S | SKCM | 1 |
p.N319I | PCPG | 1 |
p.G426* | LUAD | 1 |
p.D1733Y | BRCA | 1 |
p.S2018Y | LGG | 1 |
p.D1899N | UCEC | 1 |
p.G1306V | LUAD | 1 |
p.S432P | STAD | 1 |
p.D183G | COAD | 1 |
p.P475L | SKCM | 1 |
p.G495E | STAD | 1 |
p.F941L | UCEC | 1 |
p.E1500D | LIHC | 1 |
p.A316T | CESC | 1 |
p.D178H | ESCA | 1 |
p.T1725S | UCEC | 1 |
p.R2015T | CESC | 1 |
p.N998S | HNSC | 1 |
p.R590H | UCEC | 1 |
p.F383L | STAD | 1 |
p.E1504K | HNSC | 1 |
p.R581H | UCEC | 1 |
p.D2213N | UVM | 1 |
p.R2095H | LUAD | 1 |
p.R2262C | UCEC | 1 |
p.T1582A | STAD | 1 |
p.L299F | BRCA | 1 |
p.G1341V | LUAD | 1 |
p.A2004S | HNSC | 1 |
p.R706H | BLCA | 1 |
p.P310S | LIHC | 1 |
p.P1506S | STAD | 1 |
p.L115F | SKCM | 1 |
p.N1548S | LIHC | 1 |
p.V733L | HNSC | 1 |
p.P1325A | BRCA | 1 |
p.F392L | STAD | 1 |
p.Y1555F | HNSC | 1 |
p.T1345M | COAD | 1 |
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TissGeneCNV for AHCTF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AHCTF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DB091102 | AHCTF1-GIGYF2 | chr1:247041194 | chr2:233681467 | |
Chimerdb3.0 | ChiTaRs | NA | BF806754 | FBP1-AHCTF1 | chr9:97365780 | chr1:247075362 |
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TissGeneNet for AHCTF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AHCTF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AHCTF1 |
TissGeneDrug for AHCTF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AHCTF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |