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| TissGeneSummary for DECR2 |
 Gene summary |
| Basic gene information | Gene symbol | DECR2 |
| Gene name | 2,4-dienoyl CoA reductase 2, peroxisomal | |
| Synonyms | PDCR|SDR17C1 | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020664.3, | |
| Description | 2,4-dienoyl-CoA reductase 2peroxisomal 2,4-dienoyl-CoA reductaseshort chain dehydrogenase/reductase family 17C, member 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615839 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000242612 | ||
| HPRD : 16789 | ||
| Vega : OTTHUMG00000047846 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DECR2 | |
| BioGPS: 26063 | ||
| Pathway | NCI Pathway Interaction Database: DECR2 | |
| KEGG: DECR2 | ||
| REACTOME: DECR2 | ||
| Pathway Commons: DECR2 | ||
| Context | iHOP: DECR2 | |
| ligand binding site mutation search in PubMed: DECR2 | ||
| UCL Cancer Institute: DECR2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSTAD | |
| Reference showing the relevant tissue of DECR2 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006636 | unsaturated fatty acid biosynthetic process | 11514237 | GO:0006636 | unsaturated fatty acid biosynthetic process | 11514237 |
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| TissGeneExp for DECR2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.648248101 | 0.582027899 | -1.230276 | 3.66E-06 | 1.24E-05 |
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| TissGene-miRNA for DECR2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DECR2 |
| TissGeneSNV for DECR2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F104L | STAD | 1 |
| p.A122T | COAD | 1 |
| p.A187V | UCEC | 1 |
| p.G77D | PRAD | 1 |
| p.R79H | STAD | 1 |
| p.Q237X | PAAD | 1 |
| p.L72R | KIRP | 1 |
| p.V93A | LIHC | 1 |
| p.F42L | GBM | 1 |
| p.Q237* | PAAD | 1 |
| p.A246T | STAD | 1 |
| p.G270E | SKCM | 1 |
| p.A290T | THYM | 1 |
| p.I111V | UCEC | 1 |
| p.P283L | LIHC | 1 |
| p.G52C | LUAD | 1 |
| p.T261M | STAD | 1 |
| p.R170L | KIRC | 1 |
| p.A114V | HNSC | 1 |
| p.L292P | LIHC | 1 |
| p.P198L | SKCM | 1 |
| p.T261M | THCA | 1 |
| p.R64Q | COAD | 1 |
| p.R88* | UCEC | 1 |
| p.R43Q | UCEC | 1 |
| p.P181L | SKCM | 1 |
| p.V133E | LUSC | 1 |
| p.R146C | COAD | 1 |
| p.K242N | LUAD | 1 |
| p.F285L | DLBC | 1 |
| p.S254G | LUAD | 1 |
| p.R50Q | ACC | 1 |
| p.R106K | LUSC | 1 |
| p.T55M | UCEC | 1 |
| p.G221_splice | LUSC | 1 |
| p.R170Q | GBM | 1 |
| p.P181S | SKCM | 1 |
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| TissGeneCNV for DECR2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DECR2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChimerDB 2.0 | NA | NA | DECR2-METTL13 | chr16:402021 | chr1:170030211 | |
| Chimerdb3.0 | ChiTaRs | NA | BF095515 | TSIX-DECR2 | chrX:73047343 | chr16:462329 | |
| Chimerdb3.0 | ChiTaRs | NA | DA633362 | DECR2-UBA1 | chr16:451991 | chrX:47070299 | |
| Chimerdb3.0 | ChiTaRs | NA | EL582516 | DECR2-DDX10 | chr16:460202 | chr11:108727133 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A7HZ-01A | C19orf70-DECR2 | Out-of-Frame | chr19:5679355 | chr16:454955 |
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| TissGeneNet for DECR2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| COAD (tumor) | COAD (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| KICH (tumor) | KICH (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| STAD (tumor) | STAD (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| THCA (tumor) | THCA (normal) |
| DECR2, NEDD4L, EP300 (tumor) | DECR2, NEDD4L, EP300 (normal) |
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| TissGeneProg for DECR2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DECR2 |
| TissGeneDrug for DECR2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DECR2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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