TissGeneSummary for KLK13 |
Gene summary |
Basic gene information | Gene symbol | KLK13 |
Gene name | kallikrein-related peptidase 13 | |
Synonyms | KLK-L4|KLKL4 | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_015596.1, | |
Description | kallikrein 13kallikrein-13kallikrein-like gene 4kallikrein-like protein 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605505 | |
HGNC : HGNC | ||
HPRD : 05693 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLK13 | |
BioGPS: 26085 | ||
Pathway | NCI Pathway Interaction Database: KLK13 | |
KEGG: KLK13 | ||
REACTOME: KLK13 | ||
Pathway Commons: KLK13 | ||
Context | iHOP: KLK13 | |
ligand binding site mutation search in PubMed: KLK13 | ||
UCL Cancer Institute: KLK13 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCATGCT | |
Reference showing the relevant tissue of KLK13 | Distribution of 15 human kallikreins in tissues and biological fluids. Shaw JL, Diamandis EP. Clin Chem. 2007 Aug;53(8):1423-32. Epub 2007 Jun 15. (pmid:17573418) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KLK13 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 2.161956804 | -0.635136416 | 2.79709322 | 1.29E-19 | 4.61E-18 |
BRCA | -0.197203588 | 1.060150798 | -1.257354386 | 1.57E-06 | 4.21E-06 |
HNSC | 6.128083805 | 9.231602409 | -3.103518605 | 4.89E-06 | 3.04E-05 |
LUSC | 2.76310054 | 1.295833873 | 1.467266667 | 0.00172 | 0.003086406 |
COAD | -0.76329124 | 0.934601068 | -1.697892308 | 9.61E-05 | 0.000352099 |
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TissGene-miRNA for KLK13 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLK13 |
TissGeneSNV for KLK13 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G161D | COAD | 1 |
p.R190H | COAD | 1 |
p.H121N | UCEC | 1 |
p.Q50* | PCPG | 1 |
p.R184C | UCEC | 1 |
p.Q50R | GBM | 1 |
p.G235R | SKCM | 1 |
p.Q141* | SKCM | 1 |
p.R250H | KIRC | 1 |
p.L53V | PCPG | 1 |
p.L60F | UCEC | 1 |
p.W234X | STAD | 1 |
p.I107V | PAAD | 1 |
p.V64I | UCEC | 1 |
p.V255I | KIRC | 1 |
p.W234* | STAD | 1 |
p.G92E | SKCM | 1 |
p.H105N | LUAD | 1 |
p.P221L | LUAD | 1 |
p.R113Q | SARC | 1 |
p.P45S | UCEC | 1 |
p.R58W | PRAD | 1 |
p.V19L | LUAD | 1 |
p.R263* | LUAD | 1 |
p.E187K | BRCA | 1 |
p.L222V | SARC | 1 |
p.G205D | PAAD | 1 |
p.R184C | SKCM | 1 |
p.E102K | SKCM | 1 |
p.D122G | COAD | 1 |
p.R184H | STAD | 1 |
p.S33I | HNSC | 1 |
p.T32I | SKCM | 1 |
p.K196N | BLCA | 1 |
p.T206R | LUAD | 1 |
p.W176* | SKCM | 1 |
p.H89Q | LUAD | 1 |
p.G235* | LUAD | 1 |
p.E129G | HNSC | 1 |
p.R263Q | STAD | 1 |
p.S233F | SKCM | 1 |
p.R58Q | BRCA | 1 |
p.R263X | READ | 1 |
p.R190H | BLCA | 1 |
p.R190H | THYM | 1 |
p.Q131R | STAD | 1 |
p.S132F | SKCM | 1 |
p.V66G | SKCM | 1 |
p.H109Y | DLBC | 1 |
p.E188G | STAD | 1 |
p.P37Q | STAD | 1 |
p.R263L | LUSC | 1 |
p.Q169H | SARC | 1 |
p.A179S | BLCA | 1 |
p.R150C | UCEC | 1 |
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TissGeneCNV for KLK13 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLK13 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-A8EP-01A | KLK13-CELA1 | In-Frame | chr19:51561794 | chr12:51723617 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-A8EP-01A | KLK13-TMPRSS9 | In-Frame | chr19:51561794 | chr19:2421851 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IC-A6RE-11A | KLK13-TMPRSS9 | In-Frame | chr19:51561794 | chr19:2421851 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IC-A6RE-11A | KLK13-CELA1 | In-Frame | chr19:51561794 | chr12:51723617 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-Q9-A6FW-01A | KLK13-TMPRSS9 | In-Frame | chr19:51561794 | chr19:2421851 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-Q9-A6FW-01A | KLK13-CELA1 | In-Frame | chr19:51561794 | chr12:51723617 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A49M-01A | KLK13-CELA1 | In-Frame | chr19:51561794 | chr12:51723617 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L7-A56G-01A | KLK13-CELA1 | In-Frame | chr19:51561794 | chr12:51723617 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A6FD-01A | KLK13-CELA1 | In-Frame | chr19:51561794 | chr12:51723617 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A6FD-01A | KLK13-TMPRSS9 | In-Frame | chr19:51561794 | chr19:2421851 |
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TissGeneNet for KLK13 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLK13 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLK13 |
TissGeneDrug for KLK13 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLK13 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree,GAD |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0855197 | Testicular malignant germ cell tumor | 2 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |