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| TissGeneSummary for FGF21 |
 Gene summary |
| Basic gene information | Gene symbol | FGF21 |
| Gene name | fibroblast growth factor 21 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 19q13.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_019113.2, | |
| Description | - | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 609436 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000105550 | ||
| HPRD : 09447 | ||
| Vega : OTTHUMG00000183326 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGF21 | |
| BioGPS: 26291 | ||
| Pathway | NCI Pathway Interaction Database: FGF21 | |
| KEGG: FGF21 | ||
| REACTOME: FGF21 | ||
| Pathway Commons: FGF21 | ||
| Context | iHOP: FGF21 | |
| ligand binding site mutation search in PubMed: FGF21 | ||
| UCL Cancer Institute: FGF21 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of FGF21 | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0046326 | positive regulation of glucose import | 17623664 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17623664 | GO:0046326 | positive regulation of glucose import | 17623664 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17623664 |
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| TissGeneExp for FGF21 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for FGF21 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FGF21 |
| TissGeneSNV for FGF21 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R124Q | DLBC | 2 |
| p.V96I | STAD | 1 |
| p.L174P | BRCA | 1 |
| p.G169V | CESC | 1 |
| p.L174P | COAD | 1 |
| p.S191L | HNSC | 1 |
| p.Q55H | UCEC | 1 |
| p.P143S | SKCM | 1 |
| p.R100S | LUAD | 1 |
| p.P175L | SKCM | 1 |
| p.A157T | ACC | 1 |
| p.H115Y | SKCM | 1 |
| p.S137C | SKCM | 1 |
| p.D187N | PRAD | 1 |
| p.G71C | STAD | 1 |
| p.H140N | KIRP | 1 |
| p.P158H | LUAD | 1 |
| p.R45Q | LUAD | 1 |
| p.K84I | STAD | 1 |
| p.G179R | SKCM | 1 |
| p.G160R | SKCM | 1 |
| p.D52N | LIHC | 1 |
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| TissGeneCNV for FGF21 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FGF21 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for FGF21 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| COAD (tumor) | COAD (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| KICH (tumor) | KICH (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| STAD (tumor) | STAD (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| THCA (tumor) | THCA (normal) |
| FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (tumor) | FGF21, ELAVL1, NEDD4, MAPK7, CDC25A, CDH7, KLB (normal) |
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| TissGeneProg for FGF21 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FGF21 |
| TissGeneDrug for FGF21 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FGF21 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 24 | BeFree,CTD_human |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 13 | BeFree,LHGDN |
| umls:C0011847 | Diabetes | 9 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 9 | BeFree |
| umls:C0015695 | Fatty Liver | 6 | BeFree,CTD_human |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 6 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 5 | BeFree |
| umls:C0025517 | Metabolic Diseases | 4 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 3 | BeFree |
| umls:C0023787 | Lipodystrophy | 3 | BeFree |
| umls:C0751651 | Mitochondrial Diseases | 3 | BeFree |
| umls:C2711227 | Steatohepatitis | 3 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human,RGD |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0020459 | Hyperinsulinism | 2 | BeFree |
| umls:C0022638 | Ketosis | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0085207 | Gestational Diabetes | 2 | BeFree |
| umls:C0001339 | Acute pancreatitis | 1 | BeFree |
| umls:C0003125 | Anorexia Nervosa | 1 | LHGDN |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004134 | Ataxia | 1 | BeFree |
| umls:C0004138 | Ataxias, Hereditary | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| umls:C0020473 | Hyperlipidemia | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0026848 | Myopathy | 1 | BeFree |
| umls:C0027868 | Neuromuscular Diseases | 1 | BeFree |
| umls:C0085584 | Encephalopathies | 1 | BeFree |
| umls:C0087012 | Ataxia, Spinocerebellar | 1 | BeFree |
| umls:C0162429 | Malnutrition | 1 | BeFree |
| umls:C0162671 | MELAS Syndrome | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
| umls:C3554224 | LEPTIN DEFICIENCY OR DYSFUNCTION | 1 | BeFree |
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