![]() |
TissGeneSummary for GC |
![]() |
Basic gene information | Gene symbol | GC |
Gene name | group-specific component (vitamin D binding protein) | |
Synonyms | DBP|DBP/GC|GRD3|HEL-S-51|VDBG|VDBP | |
Cytomap | UCSC genome browser: 4q12-q13 | |
Type of gene | protein-coding | |
RefGenes | NM_000583.3, NM_001204306.1,NM_001204307.1, | |
Description | VDBepididymis secretory protein Li 51gc-globulinvitamin D-binding alpha-globulinvitamin D-binding protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 139200 | |
HGNC : HGNC | ||
Ensembl : ENSG00000145321 | ||
HPRD : 00749 | ||
Vega : OTTHUMG00000129915 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GC | |
BioGPS: 2638 | ||
Pathway | NCI Pathway Interaction Database: GC | |
KEGG: GC | ||
REACTOME: GC | ||
Pathway Commons: GC | ||
Context | iHOP: GC | |
ligand binding site mutation search in PubMed: GC | ||
UCL Cancer Institute: GC | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of GC | Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta. Song YH, Ray K, Liebhaber SA, Cooke NE. J Biol Chem. 1998 Oct 23;273(43):28408-18. (pmid:9774468) go to article | |
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for GC |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.342252999 | 2.466551001 | -4.808804 | 9.92E-08 | 4.56E-07 |
LIHC | 12.759317 | 14.419339 | -1.660022 | 2.53E-07 | 1.57E-06 |
KIRP | -1.266282249 | 3.579839626 | -4.846121875 | 1.32E-09 | 1.22E-08 |
KIRC | 0.881594835 | 2.350967057 | -1.469372222 | 0.00969 | 0.01625396 |
Top |
TissGene-miRNA for GC |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for GC |
TissGeneSNV for GC |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G187X | KIRP | 2 |
p.G107C | LGG | 1 |
p.S6G | ESCA | 1 |
p.S181N | SKCM | 1 |
p.H464Y | STAD | 1 |
p.E118* | LUAD | 1 |
p.T401P | UCEC | 1 |
p.P458L | SKCM | 1 |
p.K19E | UCEC | 1 |
p.M306L | OV | 1 |
p.G116D | STAD | 1 |
p.E267K | BLCA | 1 |
p.E38K | SKCM | 1 |
p.P357S | SKCM | 1 |
p.F159S | UCEC | 1 |
p.D142N | SKCM | 1 |
p.T113N | UCS | 1 |
p.G135D | STAD | 1 |
p.F333V | STAD | 1 |
p.N26T | UCEC | 1 |
p.L474M | UCEC | 1 |
p.I261L | UCEC | 1 |
p.Y67F | UCEC | 1 |
p.C284X | STAD | 1 |
p.T196N | LUAD | 1 |
p.R251K | KIRC | 1 |
p.A79D | LUAD | 1 |
p.L236I | UCEC | 1 |
p.V283E | LUAD | 1 |
p.L54Q | LUSC | 1 |
p.H128P | BRCA | 1 |
p.E424G | HNSC | 1 |
p.S61N | LUAD | 1 |
p.S100Y | COAD | 1 |
p.A255T | HNSC | 1 |
p.C319R | UCEC | 1 |
p.C266Y | LUAD | 1 |
p.D298H | LUAD | 1 |
p.D344E | UCEC | 1 |
p.C265* | STAD | 1 |
p.A224T | HNSC | 1 |
p.D336Y | HNSC | 1 |
p.D250N | SKCM | 1 |
p.R50T | BLCA | 1 |
p.V283I | UCEC | 1 |
p.L254Q | COAD | 1 |
p.L406R | SARC | 1 |
p.L388V | GBM | 1 |
p.L384F | UCEC | 1 |
p.T414A | UCEC | 1 |
p.G338E | SKCM | 1 |
p.M185I | SKCM | 1 |
p.E366* | LUAD | 1 |
p.K419T | STAD | 1 |
p.L445P | GBM | 1 |
p.K94M | LUAD | 1 |
p.G473W | ESCA | 1 |
p.T132N | UCS | 1 |
p.S73R | LUSC | 1 |
p.E72* | HNSC | 1 |
p.D104G | STAD | 1 |
p.D336N | SKCM | 1 |
p.D377N | SKCM | 1 |
p.F314V | STAD | 1 |
p.S69C | HNSC | 1 |
p.Y48F | UCEC | 1 |
p.E24K | SKCM | 1 |
p.E377D | DLBC | 1 |
p.D85G | STAD | 1 |
p.L365F | UCEC | 1 |
p.M185T | OV | 1 |
p.C286Y | ACC | 1 |
p.T310A | LUSC | 1 |
p.S216* | HNSC | 1 |
p.L15H | LIHC | 1 |
p.R19T | BLCA | 1 |
p.E393K | LUSC | 1 |
p.G78R | LUAD | 1 |
p.C305Y | ACC | 1 |
p.L285H | UCEC | 1 |
p.C164Y | STAD | 1 |
p.K207* | HNSC | 1 |
p.D325E | UCEC | 1 |
p.V364G | UCEC | 1 |
p.E277* | LUAD | 1 |
p.K2N | BLCA | 1 |
Top |
TissGeneCNV for GC |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for GC |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI174810 | GC-GC | chr4:72611923 | chr4:72622540 |
Top |
TissGeneNet for GC |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for GC |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for GC |
TissGeneDrug for GC |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for GC |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024117 | Chronic Obstructive Airway Disease | 14 | BeFree,GAD,LHGDN |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 9 | BeFree,GAD,LHGDN |
umls:C0029456 | Osteoporosis | 8 | BeFree,LHGDN |
umls:C0020538 | Hypertensive disease | 7 | BeFree |
umls:C0004096 | Asthma | 6 | BeFree,GAD |
umls:C0028754 | Obesity | 6 | BeFree |
umls:C0041296 | Tuberculosis | 6 | BeFree,GAD,LHGDN |
umls:C0019693 | HIV Infections | 5 | BeFree |
umls:C0162557 | Liver Failure, Acute | 4 | CTD_human,LHGDN |
umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree,GAD |
umls:C0600139 | Prostate carcinoma | 4 | BeFree |
umls:C0002395 | Alzheimer's Disease | 3 | GAD |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree,CTD_human,GAD |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree,GAD |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
umls:C0018213 | Graves Disease | 3 | BeFree,CTD_human,GAD |
umls:C0025202 | melanoma | 3 | BeFree |
umls:C0026769 | Multiple Sclerosis | 3 | BeFree |
umls:C0042870 | Vitamin D Deficiency | 3 | BeFree,GAD,GWASCAT |
umls:C0497406 | Overweight | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C1527249 | Colorectal Cancer | 3 | BeFree |
umls:C0001175 | Acquired Immunodeficiency Syndrome | 2 | BeFree |
umls:C0003850 | Arteriosclerosis | 2 | BeFree |
umls:C0004153 | Atherosclerosis | 2 | BeFree |
umls:C0004364 | Autoimmune Diseases | 2 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree,GAD |
umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
umls:C0010674 | Cystic Fibrosis | 2 | BeFree,LHGDN |
umls:C0011436 | Dentinogenesis Imperfecta | 2 | BeFree |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
umls:C0014175 | Endometriosis | 2 | BeFree,LHGDN |
umls:C0019163 | Hepatitis B | 2 | BeFree |
umls:C0035579 | Rickets | 2 | BeFree |
umls:C0036341 | Schizophrenia | 2 | BeFree |
umls:C0149931 | Migraine Disorders | 2 | BeFree |
umls:C0151779 | Cutaneous Melanoma | 2 | BeFree |
umls:C0524910 | Hepatitis C, Chronic | 2 | BeFree |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree,LHGDN |
umls:C1956346 | Coronary Artery Disease | 2 | GAD |
umls:C2239176 | Liver carcinoma | 2 | BeFree,RGD |
umls:C0001857 | AIDS related complex | 1 | BeFree |
umls:C0003469 | Anxiety Disorders | 1 | BeFree |
umls:C0003864 | Arthritis | 1 | BeFree |
umls:C0004352 | Autistic Disorder | 1 | BeFree |
umls:C0005716 | Blastomycosis | 1 | BeFree |
umls:C0005944 | Metabolic Bone Disorder | 1 | CTD_human |
umls:C0006271 | Bronchiolitis | 1 | BeFree |
umls:C0006663 | Calcinosis | 1 | GAD |
umls:C0007125 | Carcinoma, Ehrlich Tumor | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0007786 | Brain Ischemia | 1 | RGD |
umls:C0008533 | Hemophilia B | 1 | BeFree |
umls:C0011570 | Mental Depression | 1 | GAD |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0015695 | Fatty Liver | 1 | BeFree |
umls:C0016059 | Fibrosis | 1 | LHGDN |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0018995 | Hemochromatosis | 1 | BeFree |
umls:C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
umls:C0020456 | Hyperglycemia | 1 | BeFree |
umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
umls:C0020542 | Pulmonary Hypertension | 1 | BeFree |
umls:C0021368 | Inflammation | 1 | GAD |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
umls:C0023890 | Liver Cirrhosis | 1 | CTD_human |
umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | CTD_human |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0025268 | Multiple Endocrine Neoplasia Type 2a | 1 | BeFree |
umls:C0027092 | Myopia | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0029458 | Osteoporosis, Postmenopausal | 1 | GAD |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0032969 | Pregnancy in Diabetics | 1 | RGD |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0035436 | Rheumatic Fever | 1 | BeFree |
umls:C0036572 | Seizures | 1 | BeFree |
umls:C0036983 | Septic Shock | 1 | CTD_human |
umls:C0038013 | Ankylosing spondylitis | 1 | BeFree |
umls:C0038443 | Stress, Psychological | 1 | BeFree |
umls:C0040147 | Thyroiditis | 1 | BeFree |
umls:C0041341 | Tuberous Sclerosis | 1 | BeFree |
umls:C0042164 | Uveitis | 1 | BeFree |
umls:C0085207 | Gestational Diabetes | 1 | BeFree |
umls:C0221757 | alpha 1-Antitrypsin Deficiency | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
umls:C0264408 | Childhood asthma | 1 | BeFree |
umls:C0264423 | Asthma, Occupational | 1 | BeFree |
umls:C0268450 | Gitelman Syndrome | 1 | BeFree |
umls:C0341439 | Chronic liver disease | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
umls:C0595921 | Intraocular pressure disorder | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
umls:C0878555 | Diffuse panbronchiolitis | 1 | BeFree |
umls:C1168279 | Melalgia | 1 | BeFree |
umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
umls:C1519346 | Skin Carcinogenesis | 1 | BeFree |
umls:C1861172 | Venous Thromboembolism | 1 | GAD |
umls:C2711227 | Steatohepatitis | 1 | BeFree |