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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for GCG
check button Gene summary
Basic gene informationGene symbolGCG
Gene nameglucagon
SynonymsGLP1|GLP2|GRPP
CytomapUCSC genome browser: 2q36-q37
Type of geneprotein-coding
RefGenesNM_002054.4,
Descriptionglicentin-related polypeptideglucagon-like peptide 1glucagon-like peptide 2preproglucagon
Modification date20141207
dbXrefs MIM : 138030
HGNC : HGNC
Ensembl : ENSG00000115263
HPRD : 00676
Vega : OTTHUMG00000153892
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GCG
BioGPS: 2641
PathwayNCI Pathway Interaction Database: GCG
KEGG: GCG
REACTOME: GCG
Pathway Commons: GCG
ContextiHOP: GCG
ligand binding site mutation search in PubMed: GCG
UCL Cancer Institute: GCG
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of GCG
Description by TissGene annotationsTissgsKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for GCG

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD1.0706453247.491156862-6.4205115381.70E-147.16E-13


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TissGene-miRNA for GCG

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for GCG
TissGeneSNV for GCG

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E118KSKCM2
p.Y5CCOAD1
p.R144HESCA1
p.S152FSKCM1
p.W77LSTAD1
p.M155ISKCM1
p.G128ESKCM1
p.R21CGBM1
p.R91HSTAD1
p.K51NUCEC1
p.S150FSKCM1
p.Q76XCOAD1
p.D43NLUSC1
p.W170CLUAD1
p.D43YLUAD1
p.K82NESCA1
p.E96XESCA1
p.S63RCESC1
p.A115VSKCM1
p.R83SLUSC1
p.F58VLUSC1
p.N156SSKCM1
p.S3IUCEC1
p.Q37PLUAD1
p.Y65CSTAD1
p.E27KCESC1
p.T81NESCA1
p.R91CSTAD1
p.Q55*LUAD1
p.D50ELUAD1
p.D73YUCEC1
p.R91HESCA1
p.I4THNSC1
p.L159PSTAD1
p.N161HCOAD1
p.W170LLUAD1
p.E154DCESC1
p.M79ISKCM1
p.E96QCESC1


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TissGeneCNV for GCG

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for GCG

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE969791GCG-CPA1chr2:163008737chr7:130023244
Chimerdb3.0ChiTaRsNAAW582982GCG-GCGchr2:163000677chr2:162999392
TCGAfusionPortalPRADABRCATCGA-EW-A6S9-01APMS1-GCGOut-of-frameChr2:190670480Chr2:163004024


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TissGeneNet for GCG

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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COAD (tumor)COAD (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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HNSC (tumor)HNSC (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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KICH (tumor)KICH (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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KIRC (tumor)KIRC (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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KIRP (tumor)KIRP (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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LIHC (tumor)LIHC (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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LUAD (tumor)LUAD (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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LUSC (tumor)LUSC (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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PRAD (tumor)PRAD (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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STAD (tumor)STAD (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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THCA (tumor)THCA (normal)
GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (tumor)GCG, CTSL1, MEP1B, MEP1A, GLP1R, GIPR, CPE, GCGR, GLP2R (normal)
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TissGeneProg for GCG

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for GCG
TissGeneDrug for GCG

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for GCG

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent89BeFree,CTD_human,GAD
umls:C0011849Diabetes Mellitus50BeFree,GAD
umls:C0011847Diabetes41BeFree
umls:C0020456Hyperglycemia27BeFree,CTD_human
umls:C0028754Obesity27BeFree,CTD_human,GAD
umls:C0020615Hypoglycemia20BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent12BeFree
umls:C0270952Muscular Dystrophy, Oculopharyngeal11BeFree
umls:C0020459Hyperinsulinism7BeFree,CTD_human
umls:C0271650Impaired glucose tolerance5BeFree,LHGDN
umls:C0428977Bradycardia5CTD_human
umls:C0017689Glucagonoma4BeFree
umls:C0021670insulinoma4BeFree
umls:C0004153Atherosclerosis3BeFree,GAD
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0149521Pancreatitis, Chronic3BeFree
umls:C0235974Pancreatic carcinoma3BeFree
umls:C0346647Malignant neoplasm of pancreas3BeFree
umls:C0524620Metabolic Syndrome X3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0003850Arteriosclerosis2BeFree
umls:C0007102Malignant tumor of colon2BeFree
umls:C0007222Cardiovascular Diseases2BeFree
umls:C0009319Colitis2BeFree,CTD_human
umls:C0020538Hypertensive disease2BeFree,CTD_human
umls:C0020649Hypotension2CTD_human
umls:C0022104Irritable Bowel Syndrome2BeFree,LHGDN
umls:C0027627Neoplasm Metastasis2BeFree,LHGDN
umls:C0031511Pheochromocytoma2BeFree
umls:C0032002Pituitary Diseases2BeFree
umls:C0036992Short Bowel Syndrome2BeFree,LHGDN
umls:C0155626Acute myocardial infarction2BeFree
umls:C0206754Neuroendocrine Tumors2BeFree
umls:C0242339Dyslipidemias2BeFree
umls:C0342276Maturity onset diabetes mellitus in young2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0400966Non-alcoholic Fatty Liver Disease2BeFree
umls:C1834014Oculopharyngodistal Myopathy2BeFree
umls:C1956346Coronary Artery Disease2BeFree
umls:C0001418Adenocarcinoma1LHGDN
umls:C0003125Anorexia Nervosa1LHGDN
umls:C0004509Azoospermia1BeFree
umls:C0007107Malignant neoplasm of larynx1BeFree
umls:C0007193Cardiomyopathy, Dilated1BeFree
umls:C0007370Catalepsy1CTD_human
umls:C0009375Colonic Neoplasms1CTD_human
umls:C0009421Comatose1CTD_human
umls:C0009806Constipation1CTD_human
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0010346Crohn Disease1BeFree
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0011991Diarrhea1BeFree
umls:C0016057Fibrosarcoma1BeFree
umls:C0016470Food Allergy1LHGDN
umls:C0018799Heart Diseases1CTD_human
umls:C0018801Heart failure1CTD_human
umls:C0019562Von Hippel-Lindau Syndrome1BeFree
umls:C0020473Hyperlipidemia1CTD_human
umls:C0020672Hypothermia, natural1CTD_human
umls:C0021831Intestinal Diseases1BeFree
umls:C0021841Intestinal Neoplasms1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0023895Liver diseases1BeFree
umls:C0025267Multiple Endocrine Neoplasia Type 11BeFree
umls:C0025268Multiple Endocrine Neoplasia Type 2a1BeFree
umls:C0025286Meningioma1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0026847Spinal Muscular Atrophy1BeFree
umls:C0027051Myocardial Infarction1LHGDN
umls:C0027819Neuroblastoma1BeFree
umls:C0028259Nodule1BeFree
umls:C0032584polyps1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0037763Spasm1CTD_human
umls:C0038354Stomach Diseases1CTD_human
umls:C0038522Subacute Sclerosing Panencephalitis1BeFree
umls:C0038580Substance Dependence1BeFree
umls:C0039231Tachycardia1CTD_human
umls:C0039239Sinus Tachycardia1CTD_human
umls:C0042373Vascular Diseases1CTD_human
umls:C0085110Severe Combined Immunodeficiency1BeFree
umls:C0085207Gestational Diabetes1BeFree
umls:C0162429Malnutrition1BeFree
umls:C0205734Diabetes, Autoimmune1BeFree
umls:C0206624Hepatoblastoma1BeFree
umls:C0238198Gastrointestinal Stromal Tumors1BeFree
umls:C0271708Fasting Hypoglycemia1BeFree
umls:C0271710Reactive hypoglycemia1BeFree
umls:C0281784Benign Meningioma1BeFree
umls:C0333297Chronic ulcer1BeFree
umls:C0339273Corneal dystrophy, Lattice type 31BeFree
umls:C0342277Diabetes mellitus autosomal dominant type II (disorder)1BeFree
umls:C0342289Diabetes-deafness syndrome maternally transmitted (disorder)1BeFree
umls:C0424295Hyperactive behavior1CTD_human
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0600260Lung Diseases, Obstructive1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0730345Microalbuminuria1BeFree
umls:C0858600Taste sweet1BeFree
umls:C0878500Intraepithelial Neoplasia1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1318485Liver regeneration disorder1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1510472Drug Dependence1BeFree
umls:C1565489Renal Insufficiency1LHGDN
umls:C1623038Cirrhosis1BeFree
umls:C1859486BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY1BeFree
umls:C1879526Aberrant Crypt Foci1CTD_human
umls:C2239176Liver carcinoma1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C3714619Insulin resistance syndrome1BeFree