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| TissGeneSummary for GCKR |
 Gene summary |
| Basic gene information | Gene symbol | GCKR |
| Gene name | glucokinase (hexokinase 4) regulator | |
| Synonyms | FGQTL5|GKRP | |
| Cytomap | UCSC genome browser: 2p23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001486.3, | |
| Description | glucokinase regulatory protein | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 600842 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000084734 | ||
| HPRD : 02909 | ||
| Vega : OTTHUMG00000128426 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GCKR | |
| BioGPS: 2646 | ||
| Pathway | NCI Pathway Interaction Database: GCKR | |
| KEGG: GCKR | ||
| REACTOME: GCKR | ||
| Pathway Commons: GCKR | ||
| Context | iHOP: GCKR | |
| ligand binding site mutation search in PubMed: GCKR | ||
| UCL Cancer Institute: GCKR | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of GCKR | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009750 | response to fructose | 14627435 | GO:0033132 | negative regulation of glucokinase activity | 14627435 | GO:0009750 | response to fructose | 14627435 | GO:0033132 | negative regulation of glucokinase activity | 14627435 |
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| TissGeneExp for GCKR |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.208752148 | -1.453500977 | 2.662253125 | 1.23E-06 | 6.10E-06 |
| LUAD | -0.557798391 | -1.69676046 | 1.138962069 | 1.67E-05 | 4.76E-05 |
| THCA | -0.59096496 | -1.877212418 | 1.286247458 | 2.94E-09 | 1.58E-08 |
| LIHC | 6.678036023 | 8.967304023 | -2.289268 | 2.19E-07 | 1.40E-06 |
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| TissGene-miRNA for GCKR |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GCKR |
| TissGeneSNV for GCKR |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R227* | SKCM | 2 |
| p.R227X | SKCM | 2 |
| p.P448T | LUAD | 1 |
| p.G159R | SKCM | 1 |
| p.R361C | SKCM | 1 |
| p.Q562H | BLCA | 1 |
| p.R358L | READ | 1 |
| p.E599Q | BLCA | 1 |
| p.N415H | LUSC | 1 |
| p.G354A | BLCA | 1 |
| p.P608L | BRCA | 1 |
| p.E25K | SKCM | 1 |
| p.N196I | UCEC | 1 |
| p.P448H | LUAD | 1 |
| p.E586K | SKCM | 1 |
| p.P448N | LUAD | 1 |
| p.P218L | SKCM | 1 |
| p.D221H | CESC | 1 |
| p.E536K | STAD | 1 |
| p.R478H | DLBC | 1 |
| p.S258F | SKCM | 1 |
| p.E162K | SKCM | 1 |
| p.H158Q | BRCA | 1 |
| p.P383S | SKCM | 1 |
| p.L605I | LUAD | 1 |
| p.A114T | UCEC | 1 |
| p.Q289* | BLCA | 1 |
| p.S537N | SKCM | 1 |
| p.M371I | LUAD | 1 |
| p.G528R | SKCM | 1 |
| p.K611T | UCEC | 1 |
| p.Q228H | UCEC | 1 |
| p.R51Q | SKCM | 1 |
| p.L364F | SKCM | 1 |
| p.S558F | SKCM | 1 |
| p.K267N | UCS | 1 |
| p.S257F | SKCM | 1 |
| p.Q625* | CESC | 1 |
| p.E150K | UCEC | 1 |
| p.E467Q | CESC | 1 |
| p.E599K | HNSC | 1 |
| p.Q610H | BLCA | 1 |
| p.R227Q | BLCA | 1 |
| p.G108D | THYM | 1 |
| p.T401M | READ | 1 |
| p.T585S | BLCA | 1 |
| p.H560D | LUAD | 1 |
| p.K375E | SKCM | 1 |
| p.G3D | UCEC | 1 |
| p.R478L | LUSC | 1 |
| p.F408L | HNSC | 1 |
| p.T417R | PAAD | 1 |
| p.T272S | PCPG | 1 |
| p.K267N | UCEC | 1 |
| p.F580L | STAD | 1 |
| p.E20K | SKCM | 1 |
| p.E252K | SKCM | 1 |
| p.E294K | SKCM | 1 |
| p.P14L | KIRC | 1 |
| p.T225S | LUAD | 1 |
| p.R259W | LUSC | 1 |
| p.Q374H | ESCA | 1 |
| p.S224* | LUAD | 1 |
| p.R297Q | SKCM | 1 |
| p.S183_splice | UCEC | 1 |
| p.R540* | BLCA | 1 |
| p.L416F | COAD | 1 |
| p.R612S | SKCM | 1 |
| p.G169R | UCEC | 1 |
| p.P608L | LUAD | 1 |
| p.F115L | UCEC | 1 |
| p.R301Q | STAD | 1 |
| p.P251L | HNSC | 1 |
| p.D413N | SKCM | 1 |
| p.E59K | LUAD | 1 |
| p.S183Y | UCEC | 1 |
| p.G339A | KIRC | 1 |
| p.N35T | LUSC | 1 |
| p.S224L | SKCM | 1 |
| p.D551N | SKCM | 1 |
| p.R358Q | TGCT | 1 |
| p.G169W | ESCA | 1 |
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| TissGeneCNV for GCKR |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GCKR |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for GCKR |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| COAD (tumor) | COAD (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| KICH (tumor) | KICH (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| STAD (tumor) | STAD (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| THCA (tumor) | THCA (normal) |
| GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (tumor) | GCKR, HNF4A, UBC, CDKN1A, TRAF2, HNF1A, GCK, FGFR1 (normal) |
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| TissGeneProg for GCKR |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GCKR |
| TissGeneDrug for GCKR |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GCKR |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 32 | BeFree,CTD_human,GAD |
| umls:C0011849 | Diabetes Mellitus | 9 | BeFree,GAD |
| umls:C0524620 | Metabolic Syndrome X | 9 | BeFree,GAD,GWASCAT |
| umls:C0028754 | Obesity | 7 | BeFree |
| umls:C0242339 | Dyslipidemias | 7 | BeFree,GAD,LHGDN |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 7 | BeFree |
| umls:C0011847 | Diabetes | 6 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 5 | BeFree,GAD,GWASCAT |
| umls:C0020456 | Hyperglycemia | 5 | BeFree |
| umls:C0020557 | Hypertriglyceridemia | 5 | CTD_human,GAD,GWASCAT |
| umls:C1522137 | Hypertriglyceridemia result | 5 | GAD,GWASCAT |
| umls:C1561643 | Chronic Kidney Diseases | 5 | BeFree,GWASCAT |
| umls:C0015695 | Fatty Liver | 4 | BeFree |
| umls:C0010346 | Crohn Disease | 3 | GAD,GWASCAT |
| umls:C0018099 | Gout | 3 | GAD,GWASCAT |
| umls:C0004153 | Atherosclerosis | 2 | GAD |
| umls:C0021368 | Inflammation | 2 | GAD |
| umls:C0021655 | Insulin Resistance | 2 | GAD |
| umls:C0022658 | Kidney Diseases | 2 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree,GAD |
| umls:C0027051 | Myocardial Infarction | 2 | BeFree,GAD |
| umls:C2711227 | Steatohepatitis | 2 | BeFree |
| umls:C0001925 | Albuminuria | 1 | GAD |
| umls:C0003868 | Arthritis, Gouty | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | GAD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | GAD |
| umls:C0021670 | insulinoma | 1 | BeFree |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0085207 | Gestational Diabetes | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree,GAD |
| umls:C0154251 | Lipid Metabolism Disorders | 1 | GAD |
| umls:C0205734 | Diabetes, Autoimmune | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 1 | BeFree |
| umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
| umls:C0342277 | Diabetes mellitus autosomal dominant type II (disorder) | 1 | BeFree |
| umls:C0342886 | Primary hypertriglyceridemia | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0497327 | Dementia | 1 | GAD |
| umls:C0700634 | Serum uric acid observed | 1 | GAD |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | GAD |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
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