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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for INTS6
check button Gene summary
Basic gene informationGene symbolINTS6
Gene nameintegrator complex subunit 6
SynonymsDBI-1|DDX26|DDX26A|DICE1|HDB|INT6|Notchl2
CytomapUCSC genome browser: 13q14.3
Type of geneprotein-coding
RefGenesNM_001039937.1,
NM_001039938.1,NM_012141.2,
DescriptionDEAD box proteinDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26RNA helicase HDBprotein deleted in cancer 1
Modification date20141207
dbXrefs MIM : 604331
HGNC : HGNC
Ensembl : ENSG00000102786
HPRD : 05063
Vega : OTTHUMG00000016945
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_INTS6
BioGPS: 26512
PathwayNCI Pathway Interaction Database: INTS6
KEGG: INTS6
REACTOME: INTS6
Pathway Commons: INTS6
ContextiHOP: INTS6
ligand binding site mutation search in PubMed: INTS6
UCL Cancer Institute: INTS6
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of INTS6
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0016180snRNA processing16239144
GO:0016180snRNA processing16239144


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TissGeneExp for INTS6

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


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TissGene-miRNA for INTS6

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-182-5pMIMAT00002590.0043-0.3760


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TissGeneMut for INTS6
TissGeneSNV for INTS6

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.K860NSTAD1
p.G362CLUAD1
p.N86SUCEC1
p.K572RDLBC1
p.K534ECOAD1
p.M36IBRCA1
p.L146SKIRC1
p.V352LLUAD1
p.N100HUCEC1
p.Q880RSTAD1
p.E76KCESC1
p.E68*UCEC1
p.A636TLGG1
p.H836NESCA1
p.E182*UCEC1
p.K826NCOAD1
p.D193NBLCA1
p.L52MESCA1
p.D511NLUAD1
p.P387AUCEC1
p.D779YUCEC1
p.I268LHNSC1
p.E781QBLCA1
p.P299SHNSC1
p.L532PKIRP1
p.A742DKIRC1
p.M74IREAD1
p.V635LBRCA1
p.P823TTHYM1
p.E576KREAD1
p.T158NBLCA1
p.S709LSKCM1
p.L765IUCEC1
p.Q225KESCA1
p.T129SSTAD1
p.R861*UCEC1
p.Q608XKIRC1
p.G277VPRAD1
p.T686AOV1
p.R568LHNSC1
p.R558TBLCA1
p.G239VLUSC1
p.Q782HUCEC1
p.Y111CLGG1
p.I653MLUSC1
p.D42NLUSC1
p.S253LCESC1
p.E746KOV1
p.Q502*SKCM1
p.R206HLUSC1
p.S724LSKCM1
p.E160KUCEC1
p.L552IUCEC1
p.W283CBRCA1
p.S295LUCEC1
p.R103IUCEC1
p.K797NUCEC1
p.S443IUCEC1
p.L834MPRAD1
p.V635GBRCA1
p.P823LSKCM1
p.N551KBRCA1
p.L601RBLCA1
p.A436TSTAD1
p.L505FSKCM1
p.S467FLUSC1
p.K813NUCEC1
p.M433IHNSC1
p.L697FSKCM1
p.S494LBLCA1
p.V227LLUAD1
p.E807KCESC1
p.R206CSKCM1


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TissGeneCNV for INTS6

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for INTS6

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACR736962INTS6-CEP44chr13:52028465chr4:175252629


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TissGeneNet for INTS6

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
INTS6, UPF2, POLR2A, POLR2D, PPP2R1A, POLR2G, NCBP1, SHFM1, NAIF1, INTS7, POLR2J, POLR2B, EIF4E, INTS4, INTS8, POLR2L, POLR2E, PPP1CB, ZMYND8, DDX26B, INTS2 (tumor)INTS6, EIF3A, POLR2H, POLR2A, PPP2R1A, MCM7, POLR2G, NCBP1, SHFM1, CPSF3L, INTS1, POLR2J, CTDP1, POLR2B, EIF4E, POLR2L, POLR2E, PPP1CB, ZMYND8, C7orf26, INTS2 (normal)
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COAD (tumor)COAD (normal)
INTS6, EIF3A, POLR2H, UPF2, POLR2A, UPF1, POLR2C, INTS3, MCM7, POLR2G, INTS12, EIF4G1, NAIF1, INTS7, INTS1, POLR2J, POLR2B, INTS4, POLR2L, DDX26B, INTS2 (tumor)INTS6, PRMT5, EIF3A, UPF2, INTS3, POLR2G, INTS12, NCBP1, PPP2R1B, CPSF3L, INTS7, INTS9, INTS5, CTDP1, INTS8, POLR2L, POLR2E, INTS10, PPP1CB, ZMYND8, ZNF687 (normal)
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HNSC (tumor)HNSC (normal)
INTS6, PRMT5, EIF3A, UPF2, POLR2A, INTS3, PPP2CA, MCM7, PPP2CB, NCBP1, PPP2R1B, CPSF3L, EIF4G1, INTS7, INTS9, POLR2J, EIF4E, INTS8, POLR2L, PPP1CB, INTS2 (tumor)INTS6, EIF3A, POLR2H, UPF2, POLR2A, PPP2R1A, MCM7, POLR2G, NCBP1, PPP2R1B, SHFM1, CPSF3L, EIF4G1, POLR2J, POLR2B, POLR2L, POLR2E, PPP1CB, ZMYND8, C7orf26, INTS2 (normal)
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KICH (tumor)KICH (normal)
INTS6, EIF3A, UPF2, POLR2A, POLR2C, POLR2D, INTS3, PPP2CA, PPP2CB, NCBP1, PPP2R1B, CPSF3L, EIF4G1, INTS5, POLR2J, POLR2L, POLR2E, PPP1CB, ZNF687, ZNF592, INTS2 (tumor)INTS6, EIF3A, POLR2H, UPF2, PPP2R1A, INTS12, PPP2CB, SHFM1, CPSF3L, NAIF1, INTS7, INTS5, INTS1, POLR2J, CTDP1, POLR2B, POLR2L, POLR2E, PPP1CB, C7orf26, INTS2 (normal)
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KIRC (tumor)KIRC (normal)
INTS6, EIF3A, POLR2H, UPF2, POLR2C, PPP2CA, INTS12, NCBP1, PPP2R1B, SHFM1, CPSF3L, INTS7, INTS1, POLR2J, CTDP1, POLR2B, EIF4E, INTS8, POLR2L, POLR2E, C7orf26 (tumor)INTS6, EIF3A, POLR2H, UPF2, POLR2A, PPP2R1A, POLR2G, NCBP1, PPP2R1B, SHFM1, CPSF3L, NAIF1, INTS7, INTS1, POLR2J, POLR2B, EIF4E, POLR2L, POLR2E, PPP1CB, INTS2 (normal)
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KIRP (tumor)KIRP (normal)
INTS6, PRMT5, EIF3A, POLR2A, UPF1, POLR2C, PPP2CA, POLR2G, NCBP1, PPP2R1B, SHFM1, EIF4G1, INTS9, POLR2J, CTDP1, EIF4E, POLR2L, POLR2E, PPP1CB, C7orf26, ZNF592 (tumor)INTS6, EIF3A, POLR2H, UPF2, POLR2A, PPP2R1A, POLR2G, NCBP1, SHFM1, CPSF3L, INTS7, INTS1, POLR2J, POLR2B, EIF4E, INTS8, POLR2L, ZMYND8, C7orf26, ZNF592, INTS2 (normal)
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LIHC (tumor)LIHC (normal)
INTS6, EIF3A, UPF2, POLR2A, POLR2D, PPP2CA, PPP2R1A, MCM7, POLR2G, PPP2CB, PPP2R1B, SHFM1, CPSF3L, NAIF1, INTS7, INTS1, POLR2J, EIF4E, POLR2L, POLR2E, PPP1CB (tumor)INTS6, EIF3A, POLR2H, UPF2, POLR2A, PPP2R1A, POLR2G, NCBP1, PPP2R1B, SHFM1, CPSF3L, NAIF1, INTS5, INTS1, POLR2J, POLR2B, EIF4E, POLR2L, POLR2E, PPP1CB, INTS2 (normal)
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LUAD (tumor)LUAD (normal)
INTS6, PRMT5, EIF3A, POLR2C, POLR2D, INTS3, PPP2CA, PPP2R1A, MCM7, POLR2G, PPP2CB, PPP2R1B, CPSF3L, EIF4G1, NAIF1, INTS9, POLR2J, EIF4E, POLR2L, POLR2E, C7orf26 (tumor)INTS6, PRMT5, EIF3A, UPF2, POLR2A, POLR2G, NCBP1, PPP2R1B, CPSF3L, EIF4G1, INTS7, INTS5, POLR2J, POLR2B, EIF4E, POLR2L, POLR2E, PPP1CB, C7orf26, ZNF592, INTS2 (normal)
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LUSC (tumor)LUSC (normal)
INTS6, EIF3A, POLR2D, INTS3, PPP2CA, PPP2R1A, MCM7, POLR2G, PPP2CB, PPP2R1B, CPSF3L, NAIF1, INTS9, POLR2J, EIF4E, INTS4, POLR2L, POLR2E, PPP1CB, ZMYND8, ZNF687 (tumor)INTS6, EIF3A, POLR2H, INTS3, PPP2R1A, POLR2G, INTS12, NCBP1, PPP2R1B, CPSF3L, EIF4G1, INTS9, INTS5, INTS1, CTDP1, INTS4, POLR2L, POLR2E, PPP1CB, ZNF687, INTS2 (normal)
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PRAD (tumor)PRAD (normal)
INTS6, EIF3A, POLR2H, UPF1, POLR2C, INTS3, PPP2CA, PPP2CB, NCBP1, PPP2R1B, SHFM1, CPSF3L, NAIF1, INTS7, INTS9, POLR2B, EIF4E, INTS4, INTS8, INTS10, ZNF592 (tumor)INTS6, EIF3A, POLR2H, UPF2, POLR2A, MCM7, POLR2G, NCBP1, PPP2R1B, SHFM1, CPSF3L, INTS7, INTS5, INTS1, POLR2J, POLR2B, POLR2L, POLR2E, PPP1CB, C7orf26, INTS2 (normal)
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STAD (tumor)STAD (normal)
INTS6, PRMT5, EIF3A, POLR2H, UPF2, POLR2A, POLR2C, INTS3, MCM7, PPP2CB, CPSF3L, INTS7, POLR2J, CTDP1, POLR2B, INTS8, POLR2L, POLR2E, PPP1CB, DDX26B, INTS2 (tumor)INTS6, PRMT5, UPF2, POLR2D, INTS3, PPP2R1A, NCBP1, PPP2R1B, INTS7, INTS5, POLR2J, CTDP1, POLR2B, INTS4, INTS8, POLR2L, POLR2E, PPP1CB, ZMYND8, C7orf26, INTS2 (normal)
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THCA (tumor)THCA (normal)
INTS6, EIF3A, POLR2H, POLR2A, PPP2CA, PPP2R1A, MCM7, POLR2G, PPP2CB, NCBP1, PPP2R1B, CPSF3L, EIF4G1, NAIF1, INTS9, POLR2J, CTDP1, POLR2B, POLR2L, POLR2E, INTS2 (tumor)INTS6, EIF3A, POLR2H, PPP2R1A, POLR2G, NCBP1, SHFM1, CPSF3L, EIF4G1, NAIF1, INTS7, INTS9, POLR2J, CTDP1, POLR2B, POLR2L, POLR2E, PPP1CB, C7orf26, ZNF592, INTS2 (normal)
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TissGeneProg for INTS6

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for INTS6
TissGeneDrug for INTS6

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for INTS6

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0678222Breast Carcinoma7BeFree
umls:C1458155Mammary Neoplasms6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0596263Carcinogenesis5BeFree
umls:C0007131Non-Small Cell Lung Carcinoma3BeFree
umls:C0007786Brain Ischemia3BeFree
umls:C0035335Retinoblastoma2BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0278504Non-small cell lung cancer stage I1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C1302401Adenoma of large intestine1BeFree
umls:C1512981Mammary Tumorigenesis1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree