TissGeneSummary for TSPAN16 |
Gene summary |
Basic gene information | Gene symbol | TSPAN16 |
Gene name | tetraspanin 16 | |
Synonyms | TM-8|TM4-B|TM4SF16 | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001282509.1, NM_001282510.1,NM_012466.3,NR_104199.1, | |
Description | tetraspanin TM4-Btetraspanin-16transmembrane 4 superfamily member 16tspan-16 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000130167 | ||
HPRD : 18197 | ||
Vega : OTTHUMG00000180833 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSPAN16 | |
BioGPS: 26526 | ||
Pathway | NCI Pathway Interaction Database: TSPAN16 | |
KEGG: TSPAN16 | ||
REACTOME: TSPAN16 | ||
Pathway Commons: TSPAN16 | ||
Context | iHOP: TSPAN16 | |
ligand binding site mutation search in PubMed: TSPAN16 | ||
UCL Cancer Institute: TSPAN16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TSPAN16 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TSPAN16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TSPAN16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TSPAN16 |
TissGeneSNV for TSPAN16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V57I | STAD | 1 |
p.V95A | UCEC | 1 |
p.H205Y | SKCM | 1 |
p.S221R | HNSC | 1 |
p.F124L | LUAD | 1 |
p.V107L | UCEC | 1 |
p.M169I | SKCM | 1 |
p.P7S | SKCM | 1 |
p.G164D | STAD | 1 |
p.D192G | PRAD | 1 |
p.R132S | LIHC | 1 |
p.V57D | SKCM | 1 |
p.T171M | COAD | 1 |
p.G155W | BLCA | 1 |
p.R132I | LIHC | 1 |
p.R132X | LIHC | 1 |
p.G33D | LGG | 1 |
p.G35S | SKCM | 1 |
p.A41V | OV | 1 |
p.R84K | KIRP | 1 |
p.Q200H | BLCA | 1 |
p.A104V | UCS | 1 |
p.L218P | ESCA | 1 |
p.V22L | THYM | 1 |
p.G58C | CHOL | 1 |
p.V63L | UCEC | 1 |
p.S16P | DLBC | 1 |
p.W76C | LUAD | 1 |
p.W144X | SKCM | 1 |
p.G40E | THYM | 1 |
p.G155R | GBM | 1 |
p.V95L | SKCM | 1 |
p.S185T | MESO | 1 |
p.T44M | GBM | 1 |
p.T123I | GBM | 1 |
p.V57I | SKCM | 1 |
p.V193M | LUAD | 1 |
p.W144* | SKCM | 1 |
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TissGeneCNV for TSPAN16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSPAN16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF133424 | TSPAN16-HADH | chr19:11437672 | chr4:108940694 | |
Chimerdb3.0 | ChiTaRs | NA | BG982427 | TSPAN16-TSPAN16 | chr19:11435280 | chr19:11434546 | |
Chimerdb3.0 | ChiTaRs | NA | AL044228 | TSPAN16-EP300 | chr19:11435261 | chr22:41573606 | |
Chimerdb3.0 | ChiTaRs | NA | BE008423 | TSPAN16-AHNAK | chr19:11433505 | chr11:62286790 |
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TissGeneNet for TSPAN16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSPAN16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSPAN16 |
TissGeneDrug for TSPAN16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSPAN16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |