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| TissGeneSummary for GREM1 |
 Gene summary |
| Basic gene information | Gene symbol | GREM1 |
| Gene name | gremlin 1, DAN family BMP antagonist | |
| Synonyms | C15DUPq|CKTSF1B1|CRAC1|CRCS4|DAND2|DRM|DUP15q|GREMLIN|HMPS|HMPS1|IHG-2|MPSH | |
| Cytomap | UCSC genome browser: 15q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001191322.1, NM_001191323.1,NM_013372.6, | |
| Description | DAN domain family member 2cell proliferation-inducing gene 2 proteincolorectal adenoma and carcinoma 1cysteine knot superfamily 1, BMP antagonist 1down-regulated in Mos-transformed cells proteingremlin 1, cysteine knot superfamily, homologgremlin 1- | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603054 | |
| HGNC : HGNC | ||
| HPRD : 07048 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GREM1 | |
| BioGPS: 26585 | ||
| Pathway | NCI Pathway Interaction Database: GREM1 | |
| KEGG: GREM1 | ||
| REACTOME: GREM1 | ||
| Pathway Commons: GREM1 | ||
| Context | iHOP: GREM1 | |
| ligand binding site mutation search in PubMed: GREM1 | ||
| UCL Cancer Institute: GREM1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLSKCM | |
| Reference showing the relevant tissue of GREM1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000902 | cell morphogenesis | 16545136 | GO:0008284 | positive regulation of cell proliferation | 16545136 | GO:0030514 | negative regulation of BMP signaling pathway | 15539560 | GO:0051973 | positive regulation of telomerase activity | 16545136 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation | 15539560 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 15539560 | GO:0000902 | cell morphogenesis | 16545136 | GO:0008284 | positive regulation of cell proliferation | 16545136 | GO:0030514 | negative regulation of BMP signaling pathway | 15539560 | GO:0051973 | positive regulation of telomerase activity | 16545136 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation | 15539560 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 15539560 |
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| TissGeneExp for GREM1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -5.225557906 | 0.256366094 | -5.481924 | 1.17E-10 | 8.89E-10 |
| LUSC | 2.55227629 | -1.907221749 | 4.459498039 | 6.49E-20 | 7.57E-19 |
| KIRC | -3.553734739 | -0.841173628 | -2.712561111 | 2.14E-08 | 6.27E-08 |
| HNSC | 2.51956749 | -0.360392975 | 2.879960465 | 3.26E-10 | 5.92E-09 |
| BRCA | 2.487247498 | 1.052160656 | 1.435086842 | 3.89E-11 | 1.59E-10 |
| LUAD | 2.31137575 | -2.512482871 | 4.823858621 | 8.61E-19 | 1.36E-17 |
| BLCA | 2.512096621 | 0.694101884 | 1.817994737 | 0.00469 | 0.025316893 |
| KIRP | -3.727726406 | -1.766907656 | -1.96081875 | 0.00541 | 0.012660981 |
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| TissGene-miRNA for GREM1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GREM1 |
| TissGeneSNV for GREM1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q30E | LUSC | 1 |
| p.I44L | SKCM | 1 |
| p.G63W | BLCA | 1 |
| p.S180F | SKCM | 1 |
| p.S110F | SKCM | 1 |
| p.E72G | CHOL | 1 |
| p.R46H | READ | 1 |
| p.R3H | LIHC | 1 |
| p.P50A | HNSC | 1 |
| p.V84A | COAD | 1 |
| p.S137F | SKCM | 1 |
| p.R116H | PRAD | 1 |
| p.R46S | READ | 1 |
| p.I114L | SKCM | 1 |
| p.W93R | HNSC | 1 |
| p.R91* | UCEC | 1 |
| p.G63R | SKCM | 1 |
| p.G24R | SKCM | 1 |
| p.R111P | BRCA | 1 |
| p.E23K | LUAD | 1 |
| p.E45D | ACC | 1 |
| p.Q62H | LUSC | 1 |
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| TissGeneCNV for GREM1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GREM1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CF129384 | GREM1-TP53RK | chr15:33025331 | chr20:45314925 |
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| TissGeneNet for GREM1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| COAD (tumor) | COAD (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| KICH (tumor) | KICH (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| STAD (tumor) | STAD (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| THCA (tumor) | THCA (normal) |
| GREM1, BMP2, YWHAH (tumor) | GREM1, BMP2, YWHAH (normal) |
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| TissGeneProg for GREM1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GREM1 |
| TissGeneDrug for GREM1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GREM1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1527249 | Colorectal Cancer | 14 | BeFree,GAD,GWASCAT |
| umls:C0009402 | Colorectal Carcinoma | 12 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 6 | BeFree,GAD,LHGDN |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 3 | BeFree,CTD_human |
| umls:C0019693 | HIV Infections | 3 | BeFree |
| umls:C0024115 | Lung diseases | 2 | BeFree,LHGDN |
| umls:C0032584 | polyps | 2 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 2 | BeFree,CTD_human |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0334108 | Multiple polyps | 2 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C3839507 | Diminished ovarian reserve | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005944 | Metabolic Bone Disorder | 1 | LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007117 | Basal cell carcinoma | 1 | LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0008924 | Cleft Lip | 1 | GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree,GAD |
| umls:C0014175 | Endometriosis | 1 | BeFree,LHGDN |
| umls:C0016059 | Fibrosis | 1 | LHGDN |
| umls:C0016663 | Pathological fracture | 1 | LHGDN |
| umls:C0020456 | Hyperglycemia | 1 | BeFree |
| umls:C0020542 | Pulmonary Hypertension | 1 | LHGDN |
| umls:C0021841 | Intestinal Neoplasms | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0026848 | Myopathy | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027697 | Nephritis | 1 | LHGDN |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human |
| umls:C0032897 | Prader-Willi Syndrome | 1 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0042580 | Vesico-Ureteral Reflux | 1 | BeFree |
| umls:C0239337 | Deformity of limb | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | BeFree |
| umls:C0345893 | Juvenile polyposis syndrome | 1 | BeFree |
| umls:C0346627 | Intestinal Cancer | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0740404 | Limb defects | 1 | BeFree |
| umls:C0848558 | Hypospadias | 1 | GWASCAT |
| umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
| umls:C1260894 | Hypertrophic obesity | 1 | BeFree |
| umls:C1266025 | Traditional Serrated Adenoma | 1 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1861538 | Nonsyndromic cleft lip with or without cleft palate | 1 | GAD |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
| umls:C2697932 | Loeys-Dietz Syndrome | 1 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
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