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| TissGeneSummary for GDF10 |
 Gene summary |
| Basic gene information | Gene symbol | GDF10 |
| Gene name | growth differentiation factor 10 | |
| Synonyms | BMP-3b|BMP3B | |
| Cytomap | UCSC genome browser: 10q11.22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004962.3, | |
| Description | BIPGDF-10bone morphogenetic protein 3Bbone-inducing protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601361 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000266524 | ||
| HPRD : 03218 | ||
| Vega : OTTHUMG00000188319 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GDF10 | |
| BioGPS: 2662 | ||
| Pathway | NCI Pathway Interaction Database: GDF10 | |
| KEGG: GDF10 | ||
| REACTOME: GDF10 | ||
| Pathway Commons: GDF10 | ||
| Context | iHOP: GDF10 | |
| ligand binding site mutation search in PubMed: GDF10 | ||
| UCL Cancer Institute: GDF10 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTGCT | |
| Reference showing the relevant tissue of GDF10 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GDF10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.251541208 | 5.41255487 | -5.664096078 | 4.43E-25 | 9.88E-24 |
| BLCA | -2.472671652 | 1.181823085 | -3.654494737 | 8.45E-09 | 8.95E-07 |
| LUAD | 1.372660381 | 5.39562245 | -4.022962069 | 1.04E-26 | 5.69E-25 |
| PRAD | -0.780227219 | 1.115432397 | -1.895659615 | 2.22E-08 | 2.46E-07 |
| THCA | -0.416588334 | 3.980155734 | -4.396744068 | 2.73E-23 | 2.08E-21 |
| HNSC | -1.238881199 | 1.848574615 | -3.087455814 | 9.86E-10 | 1.60E-08 |
| BRCA | -0.190212003 | 4.016624839 | -4.206836842 | 2.07E-47 | 1.14E-45 |
| STAD | -0.552504382 | 1.175579993 | -1.728084375 | 0.00151 | 0.007334752 |
| COAD | -1.43864068 | 0.189063166 | -1.627703846 | 0.00012 | 0.000426818 |
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| TissGene-miRNA for GDF10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GDF10 |
| TissGeneSNV for GDF10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D267N | SKCM | 2 |
| p.G13R | SKCM | 1 |
| p.R366W | UCEC | 1 |
| p.D216N | SKCM | 1 |
| p.A315V | UCEC | 1 |
| p.E359K | SKCM | 1 |
| p.S207T | LUAD | 1 |
| p.M448I | SKCM | 1 |
| p.G272R | PRAD | 1 |
| p.G11A | CESC | 1 |
| p.H314Y | SKCM | 1 |
| p.S178L | MESO | 1 |
| p.E458D | LUAD | 1 |
| p.A406T | UCEC | 1 |
| p.R340H | UCEC | 1 |
| p.Q224E | LUSC | 1 |
| p.E229* | SKCM | 1 |
| p.V77A | STAD | 1 |
| p.R144Q | SKCM | 1 |
| p.R214H | UCEC | 1 |
| p.R460W | UCEC | 1 |
| p.P5L | SKCM | 1 |
| p.R277H | STAD | 1 |
| p.D307N | SKCM | 1 |
| p.R340C | PRAD | 1 |
| p.R198G | LUAD | 1 |
| p.D250N | SKCM | 1 |
| p.A406V | STAD | 1 |
| p.M362I | STAD | 1 |
| p.D300V | LUAD | 1 |
| p.Q202K | LUAD | 1 |
| p.S227Y | BLCA | 1 |
| p.W142X | SKCM | 1 |
| p.R144G | TGCT | 1 |
| p.A284E | COAD | 1 |
| p.R340H | LUAD | 1 |
| p.A313S | LUAD | 1 |
| p.I434M | LUAD | 1 |
| p.P14T | LUAD | 1 |
| p.A291D | LUSC | 1 |
| p.N459S | LGG | 1 |
| p.S258R | LUSC | 1 |
| p.P139S | SKCM | 1 |
| p.D205G | STAD | 1 |
| p.R230W | LIHC | 1 |
| p.A365T | HNSC | 1 |
| p.R366W | PAAD | 1 |
| p.R337C | LUAD | 1 |
| p.W142* | SKCM | 1 |
| p.L177F | LAML | 1 |
| p.E302K | UCEC | 1 |
| p.D307N | HNSC | 1 |
| p.R160C | LUAD | 1 |
| p.P304R | LUAD | 1 |
| p.P327L | SKCM | 1 |
| p.N421S | SKCM | 1 |
| p.R337C | UCEC | 1 |
| p.A278T | HNSC | 1 |
| p.E147Q | COAD | 1 |
| p.I395T | HNSC | 1 |
| p.R160H | STAD | 1 |
| p.E302K | SKCM | 1 |
| p.D226Y | BLCA | 1 |
| p.P152L | SKCM | 1 |
| p.G199V | LUAD | 1 |
| p.R460Q | STAD | 1 |
| p.R153W | COAD | 1 |
| p.S238C | LUAD | 1 |
| p.F318L | SKCM | 1 |
| p.S222F | SKCM | 1 |
| p.Q322K | LUAD | 1 |
| p.A182D | LUSC | 1 |
| p.R198H | STAD | 1 |
| p.W393* | SKCM | 1 |
| p.A292V | LGG | 1 |
| p.A313T | BLCA | 1 |
| p.R188H | GBM | 1 |
| p.A212T | LUAD | 1 |
| p.A194E | LUAD | 1 |
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| TissGeneCNV for GDF10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GDF10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for GDF10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for GDF10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GDF10 |
| TissGeneDrug for GDF10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GDF10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0003130 | Anoxia | 1 | LHGDN |
| umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0016057 | Fibrosarcoma | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0025500 | Mesothelioma | 1 | BeFree,CTD_human,LHGDN |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0362046 | Prediabetes syndrome | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | CTD_human |
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