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| TissGeneSummary for HAVCR1 |
 Gene summary |
| Basic gene information | Gene symbol | HAVCR1 |
| Gene name | hepatitis A virus cellular receptor 1 | |
| Synonyms | HAVCR|HAVCR-1|KIM-1|KIM1|TIM|TIM-1|TIM1|TIMD-1|TIMD1 | |
| Cytomap | UCSC genome browser: 5q33.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001099414.1, NM_001173393.1,NM_012206.2, | |
| Description | T cell immunoglobin domain and mucin domain protein 1T-cell immunoglobulin mucin family member 1T-cell immunoglobulin mucin receptor 1T-cell membrane protein 1kidney injury molecule 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 606518 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113249 | ||
| HPRD : 09404 | ||
| Vega : OTTHUMG00000163466 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HAVCR1 | |
| BioGPS: 26762 | ||
| Pathway | NCI Pathway Interaction Database: HAVCR1 | |
| KEGG: HAVCR1 | ||
| REACTOME: HAVCR1 | ||
| Pathway Commons: HAVCR1 | ||
| Context | iHOP: HAVCR1 | |
| ligand binding site mutation search in PubMed: HAVCR1 | ||
| UCL Cancer Institute: HAVCR1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICH | |
| Reference showing the relevant tissue of HAVCR1 | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HAVCR1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 7.347620336 | 4.634435613 | 2.713184722 | 1.74E-12 | 7.26E-12 |
| KICH | -0.908494275 | 3.536061725 | -4.444556 | 2.97E-12 | 3.19E-11 |
| KIRP | 7.5254311 | 4.6532561 | 2.872175 | 5.91E-07 | 3.16E-06 |
| LUAD | 1.074516552 | -1.372436896 | 2.446953448 | 3.65E-09 | 1.75E-08 |
| STAD | 0.51663735 | -1.0226314 | 1.53926875 | 0.00204 | 0.009287368 |
| COAD | 0.823125571 | 2.700721725 | -1.877596154 | 0.00184 | 0.004995589 |
| LIHC | 0.082775725 | -1.522626275 | 1.605402 | 5.67E-05 | 0.000208495 |
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| TissGene-miRNA for HAVCR1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HAVCR1 |
| TissGeneSNV for HAVCR1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M158I | LIHC | 2 |
| p.E123K | SKCM | 2 |
| p.S331L | SKCM | 2 |
| p.D82N | SKCM | 2 |
| p.N65D | ACC | 1 |
| p.S337F | BRCA | 1 |
| p.G111R | STAD | 1 |
| p.S359F | BLCA | 1 |
| p.T148N | LUAD | 1 |
| p.S147R | STAD | 1 |
| p.Y363S | HNSC | 1 |
| p.S189I | UCEC | 1 |
| p.P197L | SKCM | 1 |
| p.H37Q | OV | 1 |
| p.S230F | BLCA | 1 |
| p.T177A | STAD | 1 |
| p.M116I | SKCM | 1 |
| p.V42A | LUSC | 1 |
| p.S89F | SKCM | 1 |
| p.H391Y | SKCM | 1 |
| p.S228L | SKCM | 1 |
| p.G111R | LIHC | 1 |
| p.V141I | COAD | 1 |
| p.A290T | UCEC | 1 |
| p.G262V | LUAD | 1 |
| p.P254S | GBM | 1 |
| p.M182I | MESO | 1 |
| p.P197Q | LUAD | 1 |
| p.P203S | SKCM | 1 |
| p.N263S | HNSC | 1 |
| p.W63L | UCEC | 1 |
| p.T140I | LUAD | 1 |
| p.M158I | PAAD | 1 |
| p.C358R | LUAD | 1 |
| p.G60S | HNSC | 1 |
| p.P229L | LUAD | 1 |
| p.D99H | DLBC | 1 |
| p.S257Y | UCEC | 1 |
| p.L308R | LUAD | 1 |
| p.V120I | SARC | 1 |
| p.R106H | PRAD | 1 |
| p.R248K | SKCM | 1 |
| p.D115N | STAD | 1 |
| p.L308I | UCEC | 1 |
| p.P250S | ESCA | 1 |
| p.R145* | UCEC | 1 |
| p.H109N | THYM | 1 |
| p.N94H | UCEC | 1 |
| p.T265I | SKCM | 1 |
| p.M158I | KIRC | 1 |
| p.S359N | HNSC | 1 |
| p.R49S | LUSC | 1 |
| p.M158I | DLBC | 1 |
| p.S98F | PCPG | 1 |
| p.R145* | SKCM | 1 |
| p.L83I | LUAD | 1 |
| p.T146R | HNSC | 1 |
| p.P203S | PRAD | 1 |
| p.H222N | HNSC | 1 |
| p.Q389* | SKCM | 1 |
| p.S286I | HNSC | 1 |
| p.T289M | BRCA | 1 |
| p.T293I | LUAD | 1 |
| p.V344F | LUSC | 1 |
| p.T193P | LGG | 1 |
| p.G295E | SKCM | 1 |
| p.T152M | HNSC | 1 |
| p.V62L | LGG | 1 |
| p.D381Y | ACC | 1 |
| p.T152M | LUAD | 1 |
| p.T240M | LGG | 1 |
| p.D99G | UCEC | 1 |
| p.H37N | LUAD | 1 |
| p.T140I | KIRC | 1 |
| p.P35H | SARC | 1 |
| p.T199A | LUAD | 1 |
| p.T259S | LIHC | 1 |
| p.V204L | HNSC | 1 |
| p.V208I | SKCM | 1 |
| p.V141I | UCEC | 1 |
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| TissGeneCNV for HAVCR1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HAVCR1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW604191 | HAVCR1-HAVCR1 | chr5:156476160 | chr5:156485213 |
| Top |
| TissGeneNet for HAVCR1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
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| KICH (tumor) | KICH (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
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| STAD (tumor) | STAD (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| HAVCR1, HNF1A, UBQLN4, SEMA4A (tumor) | HAVCR1, HNF1A, UBQLN4, SEMA4A (normal) |
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| TissGeneProg for HAVCR1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HAVCR1 |
| TissGeneDrug for HAVCR1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HAVCR1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 25 | BeFree,GAD,LHGDN |
| umls:C0019159 | Hepatitis A | 10 | BeFree,LHGDN |
| umls:C2609414 | Acute kidney injury | 10 | CTD_human,RGD |
| umls:C0022658 | Kidney Diseases | 9 | BeFree,CTD_human |
| umls:C0003873 | Rheumatoid Arthritis | 7 | BeFree,GAD |
| umls:C0004364 | Autoimmune Diseases | 6 | BeFree,GAD |
| umls:C3539909 | Allergic disposition | 4 | BeFree |
| umls:C0013595 | Eczema | 3 | BeFree |
| umls:C0019196 | Hepatitis C | 3 | BeFree,GAD |
| umls:C0019693 | HIV Infections | 3 | BeFree,GAD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 3 | BeFree,GAD,LHGDN |
| umls:C0155877 | Allergic asthma | 3 | BeFree |
| umls:C0178874 | Tumor Progression | 3 | BeFree |
| umls:C0240035 | Interstitial fibrosis | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree,LHGDN |
| umls:C0011615 | Dermatitis, Atopic | 2 | BeFree,LHGDN |
| umls:C0011881 | Diabetic Nephropathy | 2 | BeFree,RGD |
| umls:C0022116 | Ischemia | 2 | BeFree |
| umls:C0032285 | Pneumonia | 2 | BeFree |
| umls:C0033687 | Proteinuria | 2 | CTD_human,RGD |
| umls:C0041755 | Adverse reaction to drug | 2 | CTD_human |
| umls:C0042769 | Virus Diseases | 2 | BeFree |
| umls:C0264408 | Childhood asthma | 2 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 2 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 2 | BeFree |
| umls:C1378703 | Renal carcinoma | 2 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 2 | BeFree |
| umls:C0001175 | Acquired Immunodeficiency Syndrome | 1 | GAD |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0004135 | Ataxia Telangiectasia | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0009319 | Colitis | 1 | RGD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
| umls:C0018621 | Hay fever | 1 | GAD |
| umls:C0020500 | Hyperoxaluria | 1 | BeFree,RGD |
| umls:C0020523 | Immediate hypersensitivity | 1 | GAD |
| umls:C0020538 | Hypertensive disease | 1 | RGD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024534 | Malaria, Cerebral | 1 | BeFree,GAD,LHGDN |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027540 | Necrosis | 1 | CTD_human |
| umls:C0027720 | Nephrosis | 1 | RGD |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0035410 | Rhabdomyolysis | 1 | RGD |
| umls:C0035457 | Rhinitis, Allergic, Perennial | 1 | GAD |
| umls:C0036202 | Sarcoidosis | 1 | BeFree |
| umls:C0085129 | Bronchial Hyperreactivity | 1 | GAD |
| umls:C0153633 | Malignant neoplasm of brain | 1 | BeFree |
| umls:C0162557 | Liver Failure, Acute | 1 | BeFree |
| umls:C0403447 | Chronic Kidney Insufficiency | 1 | RGD |
| umls:C0477474 | Dermatitis and eczema | 1 | GAD |
| umls:C0796074 | MOHR-TRANEBJAERG SYNDROME | 1 | BeFree |
| umls:C0854148 | Cells in urine | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
| umls:C1519680 | Tumor Immunity | 1 | BeFree |
| umls:C2242703 | Cardio-Renal Syndrome | 1 | RGD |
| umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
| umls:C1840253 | IgE RESPONSIVENESS, ATOPIC | 0 | CTD_human |
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