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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for STEAP1
check button Gene summary
Basic gene informationGene symbolSTEAP1
Gene namesix transmembrane epithelial antigen of the prostate 1
SynonymsPRSS24|STEAP
CytomapUCSC genome browser: 7q21
Type of geneprotein-coding
RefGenesNM_012449.2,
Descriptionmetalloreductase STEAP1six-transmembrane epithelial antigen of prostate 1
Modification date20141207
dbXrefs MIM : 604415
HGNC : HGNC
Ensembl : ENSG00000164647
HPRD : 05106
Vega : OTTHUMG00000023006
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STEAP1
BioGPS: 26872
PathwayNCI Pathway Interaction Database: STEAP1
KEGG: STEAP1
REACTOME: STEAP1
Pathway Commons: STEAP1
ContextiHOP: STEAP1
ligand binding site mutation search in PubMed: STEAP1
UCL Cancer Institute: STEAP1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRAD
Reference showing the relevant tissue of STEAP1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for STEAP1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD4.2263384922.8103846461.4159538461.88E-059.64E-05
LUAD1.334979076-1.39626922.7312482765.43E-187.47E-17
BRCA0.1921737821.334707116-1.1425333334.19E-121.81E-11
LUSC1.270991584-0.7002809651.9712725493.43E-121.51E-11
ESCA1.364694436-0.0560328371.4207272730.003140.029843419
KICH-3.7777692-2.1125252-1.6652440.002140.004367185


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TissGene-miRNA for STEAP1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for STEAP1
TissGeneSNV for STEAP1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D279HBLCA1
p.K5NSKCM1
p.Q103ELUAD1
p.V213ILUSC1
p.I267MUCEC1
p.P69TUCEC1
p.N115KSKCM1
p.E54KBLCA1
p.M16IBLCA1
p.R40TBLCA1
p.S337YGBM1
p.P141LBRCA1
p.V220LKIRC1
p.H96QTHYM1
p.I80SSTAD1
p.A207VSKCM1
p.V113ISTAD1
p.K39RLUAD1
p.R186XCOAD1
p.W214*LUSC1
p.H251QSARC1
p.T32MSTAD1
p.A172VESCA1
p.I114VHNSC1
p.D56HBLCA1
p.L232PGBM1
p.E93DSTAD1
p.A172VUCEC1
p.K316NBLCA1
p.E34DLUAD1
p.V42MLAML1
p.H251YSKCM1
p.F86SKIRC1
p.P41HOV1
p.W195RLGG1
p.G258ESKCM1
p.L308IUCEC1
p.P183ALGG1


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TissGeneCNV for STEAP1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for STEAP1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for STEAP1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for STEAP1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for STEAP1
TissGeneDrug for STEAP1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for STEAP1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0600139Prostate carcinoma9BeFree
umls:C0376358Malignant neoplasm of prostate8BeFree
umls:C0553580Ewings sarcoma4BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0028754Obesity2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0346429Multiple malignancy2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree,GAD
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0879615Stromal Neoplasm1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree