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| TissGeneSummary for STEAP1 |
 Gene summary |
| Basic gene information | Gene symbol | STEAP1 |
| Gene name | six transmembrane epithelial antigen of the prostate 1 | |
| Synonyms | PRSS24|STEAP | |
| Cytomap | UCSC genome browser: 7q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012449.2, | |
| Description | metalloreductase STEAP1six-transmembrane epithelial antigen of prostate 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604415 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164647 | ||
| HPRD : 05106 | ||
| Vega : OTTHUMG00000023006 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STEAP1 | |
| BioGPS: 26872 | ||
| Pathway | NCI Pathway Interaction Database: STEAP1 | |
| KEGG: STEAP1 | ||
| REACTOME: STEAP1 | ||
| Pathway Commons: STEAP1 | ||
| Context | iHOP: STEAP1 | |
| ligand binding site mutation search in PubMed: STEAP1 | ||
| UCL Cancer Institute: STEAP1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of STEAP1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for STEAP1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 4.226338492 | 2.810384646 | 1.415953846 | 1.88E-05 | 9.64E-05 |
| LUAD | 1.334979076 | -1.3962692 | 2.731248276 | 5.43E-18 | 7.47E-17 |
| BRCA | 0.192173782 | 1.334707116 | -1.142533333 | 4.19E-12 | 1.81E-11 |
| LUSC | 1.270991584 | -0.700280965 | 1.971272549 | 3.43E-12 | 1.51E-11 |
| ESCA | 1.364694436 | -0.056032837 | 1.420727273 | 0.00314 | 0.029843419 |
| KICH | -3.7777692 | -2.1125252 | -1.665244 | 0.00214 | 0.004367185 |
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| TissGene-miRNA for STEAP1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for STEAP1 |
| TissGeneSNV for STEAP1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D279H | BLCA | 1 |
| p.K5N | SKCM | 1 |
| p.Q103E | LUAD | 1 |
| p.V213I | LUSC | 1 |
| p.I267M | UCEC | 1 |
| p.P69T | UCEC | 1 |
| p.N115K | SKCM | 1 |
| p.E54K | BLCA | 1 |
| p.M16I | BLCA | 1 |
| p.R40T | BLCA | 1 |
| p.S337Y | GBM | 1 |
| p.P141L | BRCA | 1 |
| p.V220L | KIRC | 1 |
| p.H96Q | THYM | 1 |
| p.I80S | STAD | 1 |
| p.A207V | SKCM | 1 |
| p.V113I | STAD | 1 |
| p.K39R | LUAD | 1 |
| p.R186X | COAD | 1 |
| p.W214* | LUSC | 1 |
| p.H251Q | SARC | 1 |
| p.T32M | STAD | 1 |
| p.A172V | ESCA | 1 |
| p.I114V | HNSC | 1 |
| p.D56H | BLCA | 1 |
| p.L232P | GBM | 1 |
| p.E93D | STAD | 1 |
| p.A172V | UCEC | 1 |
| p.K316N | BLCA | 1 |
| p.E34D | LUAD | 1 |
| p.V42M | LAML | 1 |
| p.H251Y | SKCM | 1 |
| p.F86S | KIRC | 1 |
| p.P41H | OV | 1 |
| p.W195R | LGG | 1 |
| p.G258E | SKCM | 1 |
| p.L308I | UCEC | 1 |
| p.P183A | LGG | 1 |
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| TissGeneCNV for STEAP1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for STEAP1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for STEAP1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for STEAP1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for STEAP1 |
| TissGeneDrug for STEAP1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for STEAP1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0600139 | Prostate carcinoma | 9 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 8 | BeFree |
| umls:C0553580 | Ewings sarcoma | 4 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0346429 | Multiple malignancy | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree,GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0879615 | Stromal Neoplasm | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
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